CN105360128B - A kind of bactericidal composition and its application containing mepanipyrim and Boscalid - Google Patents
A kind of bactericidal composition and its application containing mepanipyrim and Boscalid Download PDFInfo
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- CN105360128B CN105360128B CN201510753247.5A CN201510753247A CN105360128B CN 105360128 B CN105360128 B CN 105360128B CN 201510753247 A CN201510753247 A CN 201510753247A CN 105360128 B CN105360128 B CN 105360128B
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- boscalid
- mepanipyrim
- bactericidal composition
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- preventing
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- 239000005740 Boscalid Substances 0.000 title claims abstract description 63
- WYEMLYFITZORAB-UHFFFAOYSA-N boscalid Chemical compound C1=CC(Cl)=CC=C1C1=CC=CC=C1NC(=O)C1=CC=CN=C1Cl WYEMLYFITZORAB-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 229940118790 boscalid Drugs 0.000 title claims abstract description 63
- 239000005805 Mepanipyrim Substances 0.000 title claims abstract description 61
- CIFWZNRJIBNXRE-UHFFFAOYSA-N mepanipyrim Chemical compound CC#CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 CIFWZNRJIBNXRE-UHFFFAOYSA-N 0.000 title claims abstract description 60
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 21
- 208000031888 Mycoses Diseases 0.000 claims abstract description 11
- 241000221785 Erysiphales Species 0.000 claims abstract description 9
- 239000003814 drug Substances 0.000 claims abstract description 9
- 239000004480 active ingredient Substances 0.000 claims description 6
- 241000209140 Triticum Species 0.000 claims description 4
- 235000021307 Triticum Nutrition 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 15
- 230000002265 prevention Effects 0.000 abstract description 7
- 206010039509 Scab Diseases 0.000 abstract description 6
- 201000010099 disease Diseases 0.000 abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 6
- 230000009471 action Effects 0.000 abstract description 3
- 235000013339 cereals Nutrition 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 235000013399 edible fruits Nutrition 0.000 abstract description 3
- 230000002195 synergetic effect Effects 0.000 abstract description 3
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 230000003111 delayed effect Effects 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 24
- 238000000034 method Methods 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 239000003921 oil Substances 0.000 description 16
- 235000019198 oils Nutrition 0.000 description 16
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 12
- 239000002994 raw material Substances 0.000 description 11
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 10
- -1 Methyl mepanipyrim Chemical compound 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 239000004530 micro-emulsion Substances 0.000 description 9
- 238000002156 mixing Methods 0.000 description 9
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 8
- 239000000839 emulsion Substances 0.000 description 8
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- 239000000375 suspending agent Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
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- 238000002360 preparation method Methods 0.000 description 5
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- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 4
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- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
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- 229910052760 oxygen Inorganic materials 0.000 description 4
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- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
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- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
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- 241000894006 Bacteria Species 0.000 description 2
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- 241000220324 Pyrus Species 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
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- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
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- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 241001480061 Blumeria graminis Species 0.000 description 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 239000005759 Diethofencarb Substances 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
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- 229920001732 Lignosulfonate Polymers 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 244000061176 Nicotiana tabacum Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 241000233654 Oomycetes Species 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002518 antifoaming agent Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 description 1
- 235000017471 coenzyme Q10 Nutrition 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- LNJNFVJKDJYTEU-UHFFFAOYSA-N diethofencarb Chemical compound CCOC1=CC=C(NC(=O)OC(C)C)C=C1OCC LNJNFVJKDJYTEU-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000012990 dithiocarbamate Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
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- 150000002085 enols Chemical class 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
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- 230000008811 mitochondrial respiratory chain Effects 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
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- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing mepanipyrim and Boscalid and its application.The bactericidal composition is using mepanipyrim and Boscalid as principle active component, and wherein the mass ratio of mepanipyrim and Boscalid is 1~70：1~50.The bactericidal composition can be applied to prevent and treat Cereal, fruit tree, vegetable disease, has higher synergistic function, overcomes and delayed the resistance to the action of a drug of germ, and sterilization speed is fast, the lasting period is long, reduces application cost, and prevention effect is substantially better than the use of its single dose.The present invention can be used for preventing and treating the fungal disease on crops, it is particularly possible to which, for preventing and treating the fungal diseases such as gray mold, scab, powdery mildew, gray mold, rot, effect is better than single dose use.
Description
Technical field：
It is especially a kind of using mepanipyrim and Boscalid to be main living the present invention relates to a kind of bactericidal composition and application thereof
The bactericidal composition of property composition and its application.
Background technology
Mepanipyrim (Mepanioyrim), chemical name：4- Methyl-N-phenyls -6- (1- propinyls) -2- pyrilamines, molecule
Formula：C14H13N3.Structural formula is as follows：
The mechanism of action：There is mepanipyrim unique mechanism of action to suppress pathogen Protein secretion, including reduce
Enzyme level is hydrolyzed, these enzymes enter people host plant with pathogen and cause the necrosis of host tissue relevant by inference.Main preventing and treating
Prevent and treat brown rots such as apple and pear scab, cucumber, grape, strawberry and graw mold of tomato, peach, pears etc..Methyl mepanipyrim is the same as three
The no interactions resistance such as azole, dithiocarbamate, benzimidazole and diethofencarb, therefore it is to sensitive or resistance cause of disease
Bacterium has excellent activity.
Boscalid (Boscalid), molecular formula：C18H12Cl2N2O.Chemical name：The chloro- N- of 2- (4 '-chlorodiphenyl -2- bases)
Niacinamide.Structural formula：
Boscalid is the Novel tobacco acid amide fungicides developed by BASF Aktiengesellschaft, is mainly used in preventing and treating white powder
Disease, gray mold, various rots, brown rot and root rot etc., registered [1] in Britain, Germany and Switzerland in 2004.According to city
Field portion counts：The country has begun to largely use, and Boscalid belongs to butanedioic acid ubiquinone in mitochondrial respiratory chain and reduces enzyme level
Agent, the sprouting to spore have a very strong rejection ability, and with other bactericide no interactions resistances.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, with the change of pattern of farming, melon fruits and vegetables etc.
Industrial crops cultivated area progressively expands, and disease occurrence degree, generation quantity increase, and difficulty increases in preventing and treating；Separately
On the one hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the prevention effect of single dose is had a greatly reduced quality, plant
Disease control is faced with significant challenge.
The content of the invention：
The purpose of the present invention be for above-mentioned technical problem provide it is a kind of it is applied widely, cost is low, effect is good containing phonetic
The plant bactericidal composition of bacterium amine and Boscalid.
Cause answering on fungal disease in preventing and treating plant epiphyte it is a still further object of the present invention to provide the bactericidal composition
With the especially purposes on preventing and treating gray mold, scab, powdery mildew, gray mold, the fungal disease such as rot.
The purpose of the present invention is to be achieved through the following technical solutions：
A kind of bactericidal composition containing mepanipyrim and Boscalid, the bactericidal composition is based on mepanipyrim and Boscalid
Active ingredient is wanted, the wherein mass ratio of mepanipyrim and Boscalid is 1~70：1~50, wherein effective ingredient in bactericidal composition
It is present in enhancing effective amount in composition.
The mass ratio of described bactericidal composition, wherein mepanipyrim and Boscalid is preferably 1~50：1~20, further
Preferably 1~50：1~10, most preferably 10：1.
In the compositions of the present invention, the weight/mass percentage composition that composition is accounted for both mepanipyrim and Boscalid is 2~80%.
It is preferred that 10~40%.
Described bactericidal composition, wherein using mepanipyrim and Boscalid as principle active component and known auxiliary agent and tax
Shape agent is re-dubbed any one formulation allowed on agricultural chemicals.These known auxiliary agents, excipients have dispersant, diffusant, defoaming
Agent, wetting agent, disintegrant etc., calcium dodecyl benzene sulfonate, APES, benzyl phenol polyethenoxy can be used
Ether, phenethyl phenol polyethenoxy ether, AEO and its similar products, aliphatic amine polyoxyethylene ether, aliphatic acid ring
Oxidative ethane addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, NPE, tell
Warm series, AEO, polyethylene glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphite,
One or more of lignosulfonates, xanthans, phenol formaldehyde condensate, ammonium salt, quaternary etc. combine, and excipient includes
Cyclohexanone, dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as propane diols), deionized water.Above auxiliary agent, excipient and other
Auxiliary material can be with alone or be used in combination.
Described bactericidal composition, its formulation are that missible oil, wettable powder, suspending agent, aqueous emulsion, microemulsion or moisture dissipate
Granule.
Application of the above-mentioned bactericidal composition on preventing and treating fungal diseases of plants medicine is prepared.Especially in preventing and treating cereal
Application in terms of class, fruit tree, vegetable crop disease.
Above-mentioned application, described fungal diseases of plants are in gray mold, scab, powdery mildew, gray mold, rot
It is at least one.
Beneficial effects of the present invention：
1st, the mepanipyrim and Boscalid used in the present invention, the mechanism of action are different, mutual mixture will not produce it is low touch, can assist
Same synergy, dosage is reduced, reduces cost.
2nd, the present composition scope of application increase, suitable for preventing and treating Cereal, fruit tree, vegetables refractory fungal disease,
Particularly preventing and treating gray mold, scab, powdery mildew, gray mold, rot etc. has significant effect.Bactericidal composition of the present invention
There is good prevention effect to sac fungus, basidiomycetes, Fungi Imperfecti and Oomycete fungal disease；And suppress insect or fungi to list
The drug-fast generation of one preparation (mepanipyrim and Boscalid are any).Bactericidal composition of the present invention can produce higher collaboration and increase
Effect acts on, and the dosage of the amount ratio independent reactive compound of the mixture substantially reduces, i.e., the activity of mixture is more than single
The activity of only component.
Beneficial effects of the present invention compared with prior art：(1) compared with single dose, said composition antagonism fungal disease is such as
The fungal diseases such as powdery mildew, gray mold, brown rot, scab have obvious synergistic function, overcome and have delayed the resistance to the action of a drug, expand
Big preventing and treating spectrum, hence it is evident that improve prevention effect；(2) preventing and treating recruitment, drug cost are reduced；(3) alternative routine and be also easy to produce it is anti-
The agricultural chemicals of property；(4) compared with single dose, production and use cost reduce；(5) the drug-fast generation of fungi, its positive effect are suppressed
Used higher than its single dose.
Embodiment
The invention will be further described with reference to embodiments, and the preparation method of formulation is conventional side in embodiment
Method, " % " of the present invention is mass percent.
Indoor biometricses are tested：
Mycelial growth rate method, EC of the measure different agents to bacterial strain are used indoors50Value, using co-toxicity coefficient calculating side
Method, the co-toxicity coefficient (CTC) of mixture is calculated, determines the building performance of mixture, circular is as follows：
EC (is generally selected as standard agent using a certain single dose in mixture50Junior), calculated：
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
The toxicity index of the toxicity index of theoretical toxicity index=A single doses × A single doses proportion+B single doses in mixture
× B single doses proportion in mixture
Survey the EC of toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：Mixture has synergetic when CTC is more than 120, is antagonism when CTC is less than 80, CTC exists
It is summation action between 80-120.
According to active ingredient mepanipyrim (A)：Boscalid (B) quality proportioning is：70：1、50：1、30：1、20：1、10：1、
5：1、2.5：1、1：1、1：2、1：4、1：6、1：10、1：20、1：30、1：50 are tested, and determine it to wheat powdery mildew
The co-toxicity coefficient of (Erysiphe graminis D.c.f.sp.tritici E.Marchal).
Table 1：Indoor biometricses result of the mepanipyrim+Boscalid different ratio to wheat powdery mildew
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 10% mepanipyrim SC | Y=2.456X+2.303 | 12.535 | - |
| 50% Boscalid WG | Y=2.564X+1.966 | 15.251 | - |
| A:B=70:1 | Y=2.221X+2.661 | 11.301 | 111.198 |
| A:B=50:1 | Y=1.654X+3.404 | 9.224 | 136.372 |
| A:B=30:1 | Y=1.904X+3.182 | 9.012 | 139.896 |
| A:B=20:1 | Y=2.548X+2.253 | 11.970 | 105.616 |
| A:B=10:1 | Y=1.324X+3.806 | 7.977 | 159.725 |
| A:B=5:1 | Y=2.014X+2.958 | 10.325 | 125.118 |
| A:B=2.5:1 | Y=1.978X+2.937 | 11.040 | 119.629 |
| A:B=1:1 | Y=1.635X+3.427 | 9.164 | 150.156 |
| A:B=1:2 | Y=2.904X+2.033 | 10.512 | 135.309 |
| A:B=1:4 | Y=2.320X+2.406 | 13.125 | 111.372 |
| A:B=1:6 | Y=1.914X+2.751 | 14.963 | 98.865 |
| A:B=1:10 | Y=1.524X+3.235 | 14.393 | 103.810 |
| A:B=1:20 | Y=2.635X+2.304 | 10.548 | 143.110 |
| A:B=1:30 | Y=1.112X+3.789 | 12.275 | 123.382 |
| A:B=1:50 | Y=2.632X+2.072 | 12.956 | 117.216 |
Field control effectiveness test：
The pesticidal preparations preventing and treating wheat powdery mildew experiment made from above-described embodiment.
1st, test process：This test medicine dosage sets three concentration for the treatment of, comparison medicine respectively according to the difference of each composition
Agent is the mepanipyrim SC of agricultural chemicals single dose 10% and 50% Boscalid WG and blank clean water experiment respectively.
2nd, each plot area of test method is 66.7m2, it is repeated 3 times；Investigation drug effect side after investigating and prevent and treat before dispenser
Method is：5 points of grab sample in test process area, severity Scaling is carried out according to national field test relevant criterion, calculates preventive effect.
Result of the test is shown in Table 2：
The field test effect of table 2
Shown by indoor biometricses and field efficacy result, mepanipyrim has with Boscalid composition significantly cooperates with increasing
Effect acts on, and the prevention effect of composition is excellent, and prevention effect is better than single dose kind, has application value in agricultural is applied.
Two kinds of reactive compounds can be processed into any one formulation of permission, illustrate two kinds below with specific embodiment
The preparation that active ingredient is processed into, but the preparation that can process of the two kinds of active components be not limited only to it is set forth below.
Embodiment 1：15% mepanipyrim Boscalid wettable powder (1:2)
By mepanipyrim 5g, Boscalid 10g, detergent LS (to methoxyl group aliphatic acid amido benzene sulfonic acid sodium salt) 2g, diffusant
NNO (sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin add to 100g mixtures carry out air-flow crushing, be made effectively into
It is 15% mepanipyrim Boscalid wettable powder to divide mass percent.
Embodiment 2：15% mepanipyrim Boscalid wettable powder (1:4)
By mepanipyrim 3g, Boscalid 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin
Add to 100g mixtures and carry out air-flow crushing, it is 15% mepanipyrim Boscalid wettable that active ingredient mass percent, which is made,
Pulvis.
Embodiment 3：14% mepanipyrim Boscalid wettable powder (1:6)
By mepanipyrim 2g, Boscalid 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin
Add to 100g mixtures and carry out air-flow crushing, it is 14% mepanipyrim Boscalid wettable that active ingredient mass percent, which is made,
Pulvis.
Embodiment 4：20% mepanipyrim Boscalid suspending agent (1:1)
Weigh 10g mepanipyrims, 10g Boscalids, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g,
Ethylene glycol 5g, poly- silica ethane 0.10g, aluminium-magnesium silicate 0.5g, 100g is complemented to water, is made in the presence of sand mill effectively
Ingredient percent is 20% mepanipyrim Boscalid suspending agent.
Embodiment 5：55% mepanipyrim Boscalid aqueous emulsion (1:10)
Weigh 5g mepanipyrims, 50g Boscalids, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol
APEO 1g, solvent naphtha 13g, adds water to 100g.The method that above raw material is routinely prepared to aqueous emulsion puts into mixing kettle
High speed mixes, and it is 55% mepanipyrim Boscalid aqueous emulsion that effective ingredient percent, which is made,.
Embodiment 6：42% mepanipyrim Boscalid missible oil (1:20)
Weigh 2g mepanipyrims, 40g Boscalids, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent
Oil is to 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil, effective composition quality percentage is made
Than for 42% mepanipyrim Boscalid missible oil.
Embodiment 7：70% mepanipyrim Boscalid missible oil (2.5:1)
Weigh 50g mepanipyrims, 20g Boscalids, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor
Sesame oil APEO 2g, solvent naphtha to 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil,
It is 70% mepanipyrim Boscalid missible oil that effective ingredient percent, which is made,.
Embodiment 8：18% mepanipyrim Boscalid water dispersion granule (5：1)
15g mepanipyrims, 3g Boscalids are weighed, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, is gathered
Vinyl alcohol 5g, borax 2g, diatomite 28g complement to 100g, and above raw material is formed with into effect composition by water dispersible granular agent method
Mass percent is 18% mepanipyrim Boscalid water dispersion granule.
Embodiment 9：11% mepanipyrim Boscalid missible oil (10:1)
Weigh 10g mepanipyrims, 1g Boscalids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent
Oil is to 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil, effective composition quality percentage is made
Than for 11% mepanipyrim Boscalid missible oil.
Embodiment 10：31.5% mepanipyrim Boscalid microemulsion (20:1)
Weigh 30g mepanipyrims, 1.5g Boscalids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphoric acid
Ester 3g, agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely prepared micro-
Mixed in the method input mixing kettle of emulsion, it is 31.5% mepanipyrim Boscalid micro emulsion that effective ingredient percent, which is made,
Agent.
Embodiment 11：31% mepanipyrim Boscalid missible oil (30:1)
Weigh 30g mepanipyrims, 1g Boscalids, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent
Oil is to 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil, effective composition quality percentage is made
Than for 31% mepanipyrim Boscalid missible oil.
Embodiment 12：51% mepanipyrim Boscalid suspending agent (50:1)
Weigh 50g mepanipyrims, 1g Boscalids, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, second
Glycol 5g, poly- silica ethane 0.10g, aluminium-magnesium silicate 0.5g, 100g is complemented to water, be made in the presence of sand mill effectively into
It is 51% mepanipyrim Boscalid suspending agent to divide mass percent.
Embodiment 13：32% mepanipyrim Boscalid microemulsion (1:15)
Weigh 2g mepanipyrims, 30g Boscalids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate
3g, agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely prepared into micro emulsion
Mixed in the method input mixing kettle of agent, it is 32% mepanipyrim Boscalid microemulsion that effective ingredient percent, which is made,.
Embodiment 14：6% mepanipyrim Boscalid aqueous emulsion (1:5)
1g mepanipyrims, 5g Boscalids, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol is weighed to gather
Oxygen vinethene 1g, solvent naphtha 13g, adds water to 100g.In the method input mixing kettle that above raw material is routinely prepared to aqueous emulsion
Mixed at high speed, it is 6% mepanipyrim Boscalid aqueous emulsion that effective ingredient percent, which is made,.
Embodiment 15：62% mepanipyrim Boscalid microemulsion (1:30)
Weigh 2g mepanipyrims, 60g Boscalids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate
3g, agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely prepared into micro emulsion
Mixed in the method input mixing kettle of agent, it is 62% mepanipyrim Boscalid microemulsion that effective ingredient percent, which is made,.
Embodiment 16：51% mepanipyrim Boscalid suspending agent (1:50)
Weigh 1g mepanipyrims, 50g Boscalids, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, second
Glycol 5g, poly- silica ethane 0.10g, aluminium-magnesium silicate 0.5g, 100g is complemented to water, be made in the presence of sand mill effectively into
It is 51% mepanipyrim Boscalid suspending agent to divide mass percent.
Embodiment 17：7% mepanipyrim Boscalid water dispersion granule (1：2.5)
Weigh 2g mepanipyrims, 5g Boscalids, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, poly- second
Enol 5g, borax 2g, white carbon 3g, diatomite complement to 100g, and above raw material is formed with imitating by water dispersible granular agent method
Ingredient percent is 7% mepanipyrim Boscalid water dispersion granule.
Claims (1)
1. a kind of bactericidal composition exists as the application on the fungal disease medicine for preparing preventing and treating wheat powdery mildew, its feature
In：The bactericidal composition is using mepanipyrim and Boscalid as active ingredient, and wherein the mass ratio of mepanipyrim and Boscalid is 50：
1、30：1、10：1、5：1、1：1、1：2、1：20 or 1：30.
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Citations (2)
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|---|---|---|---|---|
| CN1282208A (en) * | 1997-12-18 | 2001-01-31 | 巴斯福股份公司 | Fungicide mixtures based on amide compounds and pyridine derivatives |
| CN101808521A (en) * | 2007-09-26 | 2010-08-18 | 巴斯夫欧洲公司 | ternary fungicidal compositions comprising boscalid and chlorothalonil |
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| JP2012051843A (en) * | 2010-09-02 | 2012-03-15 | Nissan Chem Ind Ltd | Composition for insecticide, mitecide, nematocide, molluscicide, germicide, or bactreiacide, and method of controlling pest |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1282208A (en) * | 1997-12-18 | 2001-01-31 | 巴斯福股份公司 | Fungicide mixtures based on amide compounds and pyridine derivatives |
| CN101808521A (en) * | 2007-09-26 | 2010-08-18 | 巴斯夫欧洲公司 | ternary fungicidal compositions comprising boscalid and chlorothalonil |
Non-Patent Citations (1)
| Title |
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| 嘧啶胺类杀菌剂的作用机制;马忠华 等;《农药科学与管理》;19970215(第1期);第30-32页 * |
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