CN105360129B - A kind of bactericidal composition and its application containing mepanipyrim and cyazofamid - Google Patents
A kind of bactericidal composition and its application containing mepanipyrim and cyazofamid Download PDFInfo
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- CN105360129B CN105360129B CN201510753758.7A CN201510753758A CN105360129B CN 105360129 B CN105360129 B CN 105360129B CN 201510753758 A CN201510753758 A CN 201510753758A CN 105360129 B CN105360129 B CN 105360129B
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- cyazofamid
- mepanipyrim
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- 239000005754 Cyazofamid Substances 0.000 title claims abstract description 68
- YXKMMRDKEKCERS-UHFFFAOYSA-N cyazofamid Chemical compound CN(C)S(=O)(=O)N1C(C#N)=NC(Cl)=C1C1=CC=C(C)C=C1 YXKMMRDKEKCERS-UHFFFAOYSA-N 0.000 title claims abstract description 68
- 239000005805 Mepanipyrim Substances 0.000 title claims abstract description 65
- CIFWZNRJIBNXRE-UHFFFAOYSA-N mepanipyrim Chemical compound CC#CC1=CC(C)=NC(NC=2C=CC=CC=2)=N1 CIFWZNRJIBNXRE-UHFFFAOYSA-N 0.000 title claims abstract description 64
- 239000000203 mixture Substances 0.000 title claims abstract description 61
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 27
- 208000031888 Mycoses Diseases 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 10
- 241000233679 Peronosporaceae Species 0.000 claims abstract description 9
- 201000010099 disease Diseases 0.000 claims abstract description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000004530 micro-emulsion Substances 0.000 claims description 9
- 239000000839 emulsion Substances 0.000 claims description 8
- 239000000375 suspending agent Substances 0.000 claims description 8
- 239000004563 wettable powder Substances 0.000 claims description 8
- 238000009472 formulation Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 5
- 239000003905 agrochemical Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000002917 insecticide Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 18
- 230000002265 prevention Effects 0.000 abstract description 8
- 206010039509 Scab Diseases 0.000 abstract description 6
- 230000002195 synergetic effect Effects 0.000 abstract description 5
- 235000013339 cereals Nutrition 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract description 4
- 235000013311 vegetables Nutrition 0.000 abstract description 3
- 230000009471 action Effects 0.000 abstract description 2
- 230000003111 delayed effect Effects 0.000 abstract description 2
- 229940079593 drug Drugs 0.000 abstract description 2
- 230000002045 lasting effect Effects 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 25
- 238000000034 method Methods 0.000 description 16
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- 239000003921 oil Substances 0.000 description 13
- -1 Methyl mepanipyrim Chemical compound 0.000 description 12
- 239000003795 chemical substances by application Substances 0.000 description 11
- 239000002994 raw material Substances 0.000 description 11
- 238000002156 mixing Methods 0.000 description 10
- DMAXMXPDVWTIRV-UHFFFAOYSA-N 2-(2-phenylethyl)phenol Chemical compound OC1=CC=CC=C1CCC1=CC=CC=C1 DMAXMXPDVWTIRV-UHFFFAOYSA-N 0.000 description 9
- 239000004615 ingredient Substances 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 8
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 8
- 239000002904 solvent Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 230000001988 toxicity Effects 0.000 description 7
- 231100000419 toxicity Toxicity 0.000 description 7
- 241000196324 Embryophyta Species 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 210000000481 breast Anatomy 0.000 description 5
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- 102000004190 Enzymes Human genes 0.000 description 4
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- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
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- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 244000052769 pathogen Species 0.000 description 4
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- 229920001285 xanthan gum Polymers 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 241000233654 Oomycetes Species 0.000 description 3
- 241001281803 Plasmopara viticola Species 0.000 description 3
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- WMGSQTMJHBYJMQ-UHFFFAOYSA-N aluminum;magnesium;silicate Chemical compound [Mg+2].[Al+3].[O-][Si]([O-])([O-])[O-] WMGSQTMJHBYJMQ-UHFFFAOYSA-N 0.000 description 3
- 239000012752 auxiliary agent Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
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- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 3
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- 241000220324 Pyrus Species 0.000 description 2
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical compound C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000008485 antagonism Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910021538 borax Inorganic materials 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000593 microemulsion method Methods 0.000 description 2
- IXQGCWUGDFDQMF-UHFFFAOYSA-N o-Hydroxyethylbenzene Natural products CCC1=CC=CC=C1O IXQGCWUGDFDQMF-UHFFFAOYSA-N 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 239000004328 sodium tetraborate Substances 0.000 description 2
- 235000010339 sodium tetraborate Nutrition 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 description 1
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 241000221198 Basidiomycota Species 0.000 description 1
- 235000011331 Brassica Nutrition 0.000 description 1
- 241000219198 Brassica Species 0.000 description 1
- 241000219112 Cucumis Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 239000005759 Diethofencarb Substances 0.000 description 1
- 102000015782 Electron Transport Complex III Human genes 0.000 description 1
- 108010024882 Electron Transport Complex III Proteins 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 241000233614 Phytophthora Species 0.000 description 1
- 241001503464 Plasmodiophora Species 0.000 description 1
- 241001503460 Plasmodiophorida Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000002079 cooperative effect Effects 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- LNJNFVJKDJYTEU-UHFFFAOYSA-N diethofencarb Chemical compound CCOC1=CC=C(NC(=O)OC(C)C)C=C1OCC LNJNFVJKDJYTEU-UHFFFAOYSA-N 0.000 description 1
- 239000007884 disintegrant Substances 0.000 description 1
- 239000012990 dithiocarbamate Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 150000002085 enols Chemical class 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- SLGWESQGEUXWJQ-UHFFFAOYSA-N formaldehyde;phenol Chemical compound O=C.OC1=CC=CC=C1 SLGWESQGEUXWJQ-UHFFFAOYSA-N 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
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- 239000002068 microbial inoculum Substances 0.000 description 1
- LCRMGUFGEDUSOG-UHFFFAOYSA-N naphthalen-1-ylsulfonyloxymethyl naphthalene-1-sulfonate;sodium Chemical compound [Na].C1=CC=C2C(S(=O)(OCOS(=O)(=O)C=3C4=CC=CC=C4C=CC=3)=O)=CC=CC2=C1 LCRMGUFGEDUSOG-UHFFFAOYSA-N 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 230000000361 pesticidal effect Effects 0.000 description 1
- 229920001568 phenolic resin Polymers 0.000 description 1
- OJMIONKXNSYLSR-UHFFFAOYSA-N phosphorous acid Chemical compound OP(O)O OJMIONKXNSYLSR-UHFFFAOYSA-N 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
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- 229960004257 sulfaguanidine Drugs 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing mepanipyrim and cyazofamid and its application.The bactericidal composition is using mepanipyrim and cyazofamid as principle active component, and wherein the mass ratio of mepanipyrim and cyazofamid is 1~70：1~50.The bactericidal composition can be applied to prevent and treat Cereal, fruit tree, vegetable disease, has higher synergistic function, overcomes and delayed the resistance to the action of a drug of germ, and sterilization speed is fast, the lasting period is long, reduces application cost, and prevention effect is substantially better than the use of its single dose.The present invention can be used for preventing and treating the fungal disease on crops, it is particularly possible to which, for preventing and treating the fungal diseases such as gray mold, brown rot, scab, downy mildew, late blight, effect is better than single dose use.
Description
Technical field：
The present invention relates to a kind of bactericidal composition and application thereof, and especially one kind is using mepanipyrim and cyazofamid as chief active
The bactericidal composition of composition and its application.
Background technology
Mepanipyrim (Mepanioyrim), chemical name：4- Methyl-N-phenyls -6- (1- propinyls) -2- pyrilamines, molecule
Formula：C14H13N3.Structural formula is as follows：
The mechanism of action：There is mepanipyrim unique mechanism of action to suppress pathogen Protein secretion, including reduce
Enzyme level is hydrolyzed, these enzymes enter people host plant with pathogen and cause the necrosis of host tissue relevant by inference.Main preventing and treating
Prevent and treat brown rots such as apple and pear scab, cucumber, grape, strawberry and graw mold of tomato, peach, pears etc..Methyl mepanipyrim is the same as three
The no interactions resistance such as azole, dithiocarbamate, benzimidazole and diethofencarb, therefore it is to sensitive or resistance cause of disease
Bacterium has excellent activity.
Cyazofamid (Cyazofamid), molecular formula：C13H13ClN4O2S, chemical name：Chloro- 2- cyano group-N, the N- diformazans of 4-
Base -5- p-methylphenyl imidazoles -1- sulfonamide.Structural formula：
Cyazofamid belongs to sulphaguanidine azoles fungicide.It is mould to Oomycete fungal such as phytophthora, downy mildew, Pseudo peronospara, corruption
The plasmodiophora brassica bacteria of bacterium and Plasmodiophoromycetes has very high bioactivity.Mechanism of action is to block line grain in Oomycete germ body
The electron transmission of cytochrome bc1 complexs carrys out the supply of interfering energy, and its binding site is the Q1 centers of enzyme, with its homicide
Microbial inoculum is without cross tolerance.Its high selection activity to pathogen is probably because target enzymes cause to the sensitivity difference of medicament
's.Field information has high prevention effect to late blight and downy mildew.
The difficulty of prevention and cure of phytopathogen is increasing at present, on the one hand, with the change of pattern of farming, melon fruits and vegetables etc.
Industrial crops cultivated area progressively expands, and disease occurrence degree, generation quantity increase, and difficulty increases in preventing and treating；Separately
On the one hand, the resistance of pathogen rises year by year under lasting medicament selection pressure, and the prevention effect of single dose is had a greatly reduced quality, plant
Disease control is faced with significant challenge.
The content of the invention：
The purpose of the present invention be for above-mentioned technical problem provide it is a kind of it is applied widely, cost is low, effect is good containing phonetic
The plant bactericidal composition of bacterium amine and cyazofamid.
Cause answering on fungal disease in preventing and treating plant epiphyte it is a still further object of the present invention to provide the bactericidal composition
With the especially purposes on preventing and treating gray mold, brown rot, scab, downy mildew, the fungal disease such as late blight.
The purpose of the present invention is to be achieved through the following technical solutions：
A kind of bactericidal composition containing mepanipyrim and cyazofamid, the bactericidal composition is using mepanipyrim and cyazofamid mainly to have
Composition is imitated, the wherein mass ratio of mepanipyrim and cyazofamid is 1~70：1~50, effective ingredient is with synergy wherein in bactericidal composition
Effective dose is present in composition.
The mass ratio of described bactericidal composition, wherein mepanipyrim and cyazofamid is preferably 1~50：1~50, it is further excellent
Elect 1~30 as：1~20, most preferably 1~30：1~10.
In the compositions of the present invention, the weight/mass percentage composition that composition is accounted for both mepanipyrim and cyazofamid is 2~80%.It is excellent
Select 10~40%.
Described bactericidal composition, wherein using mepanipyrim and cyazofamid as principle active component and known auxiliary agent and figuration
Agent is re-dubbed any one formulation allowed on agricultural chemicals.These known auxiliary agents, excipients have dispersant, diffusant, defoamer,
Wetting agent, disintegrant etc., calcium dodecyl benzene sulfonate, APES, Ben-zylphenol Polyoxyethyl Ether, benzene can be used
Ethyl phenol polyethenoxy ether, AEO and its similar products, aliphatic amine polyoxyethylene ether, fatty acid ethylene oxide
Addition product, polyoxyethylene polyoxy propylene block compound, castor oil polyoxyethylene ether, NPE, TWEEN Series,
AEO, polyethylene glycol series, Sulfonates, carboxylate, sulfate, phosphate, phosphite, sulfomethylated lignin
One or more of hydrochlorate, xanthans, phenol formaldehyde condensate, ammonium salt, quaternary etc. combine, excipient include cyclohexanone,
Dimethylbenzene, various solvent naphthas, water, antifreezing agent (such as propane diols), deionized water.Above auxiliary agent, excipient and other auxiliary materials can
With alone or be used in combination.
Described bactericidal composition, its formulation are that missible oil, wettable powder, suspending agent, aqueous emulsion, microemulsion or moisture dissipate
Granule.
Application of the above-mentioned bactericidal composition on preventing and treating fungal diseases of plants medicine is prepared.Especially in preventing and treating cereal
Application in terms of class, fruit tree, vegetable crop disease.
Above-mentioned application, described fungal diseases of plants are in gray mold, brown rot, scab, downy mildew, late blight
It is at least one.
Beneficial effects of the present invention：
1st, the mepanipyrim and cyazofamid used in the present invention, the mechanism of action are different, mutual mixture will not produce it is low touch, can cooperate with
Synergy, dosage is reduced, reduces cost.
2nd, the present composition scope of application increase, suitable for preventing and treating Cereal, fruit tree, vegetables refractory fungal disease,
Particularly preventing and treating gray mold, brown rot, scab, downy mildew, late blight etc. has significant effect.Bactericidal composition of the present invention
There is good prevention effect to sac fungus, basidiomycetes, Fungi Imperfecti and Oomycete fungal disease；And suppress insect or fungi to list
The drug-fast generation of one preparation (mepanipyrim and cyazofamid are any).Bactericidal composition of the present invention can produce higher Synergistic
Effect, and the dosage of the amount ratio independent reactive compound of the mixture substantially reduces, i.e., and the activity of mixture is more than independent
The activity of component.
Beneficial effects of the present invention compared with prior art：(1) compared with single dose, said composition antagonism fungal disease is such as
The fungal diseases such as gray mold, brown rot, scab, downy mildew, late blight have obvious synergistic function, overcome and have delayed anti-
The property of medicine, expand preventing and treating spectrum, hence it is evident that improve prevention effect；(2) preventing and treating recruitment, drug cost are reduced；(3) alternative routine and easily
Produce the agricultural chemicals of resistance；(4) compared with single dose, production and use cost reduce；(5) the drug-fast generation of fungi is suppressed, it is imitated
Fruit uses apparently higher than its single dose.
Embodiment
The invention will be further described with reference to embodiments, and the preparation method of formulation is conventional side in embodiment
Method, " % " of the present invention is mass percent.
Indoor biometricses are tested：
Mycelial growth rate method, EC of the measure different agents to bacterial strain are used indoors50Value, using co-toxicity coefficient calculating side
Method, the co-toxicity coefficient (CTC) of mixture is calculated, determines the building performance of mixture, circular is as follows：
EC (is generally selected as standard agent using a certain single dose in mixture50Junior), calculated：
Single dose toxicity index=standard agent EC50/ certain single dose EC50×100
The toxicity index of the toxicity index of theoretical toxicity index=A single doses × A single doses proportion+B single doses in mixture
× B single doses proportion in mixture
Survey the EC of toxicity index=standard single dose50The EC of value/mixture50Value × 100
Co-toxicity coefficient=actual measurement toxicity index/theoretical toxicity index × 100
Co-toxicity coefficient is classified：Mixture has synergetic when CTC is more than 120, is antagonism when CTC is less than 80, CTC exists
It is summation action between 80-120.
According to active ingredient mepanipyrim (A)：Cyazofamid (B) quality proportioning is：70：1、50：1、30：1、20：1、10：1、5：
1、2.5：1、1：1、1：2、1：4、1：6、1：10、1：20、1：30、1：50 are tested, and determine it to Plasmopara viticola
The co-toxicity coefficient of (Plasmopara viticola).
Table 1：Indoor biometricses result of the mepanipyrim+cyazofamid different ratio to Plasmopara viticola
| Medicament | Virulence regression equation | EC50(mg/L) | Co-toxicity coefficient |
| 10% mepanipyrim SC | Y=1.554X+3.553 | 8.536 | - |
| 10% cyazofamid SC | Y=2.452X+3.048 | 6.254 | - |
| A:B=70:1 | Y=1.701X+3.627 | 6.418 | 132.32 |
| A:B=50:1 | Y=1.325X+3.999 | 5.698 | 148.75 |
| A:B=30:1 | Y=2.398X+3.461 | 4.384 | 192.46 |
| A:B=20:1 | Y=1.147X+4.171 | 5.285 | 158.76 |
| A:B=10:1 | Y=1.532X+3.934 | 4.967 | 166.35 |
| A:B=5:1 | Y=2.014X+3.726 | 4.292 | 187.47 |
| A:B=2.5:1 | Y=1.903X+3.518 | 6.018 | 128.46 |
| A:B=1:1 | Y=1.855X+3.961 | 3.632 | 198.75 |
| A:B=1:2 | Y=2.325X+3.582 | 4.074 | 168.54 |
| A:B=1:4 | Y=2.140X+3.773 | 3.743 | 176.53 |
| A:B=1:6 | Y=1.965X+3.801 | 4.075 | 159.56 |
| A:B=1:10 | Y=2.002X+2.271 | 3.513 | 182.45 |
| A:B=1:20 | Y=1.587X+4.103 | 3.675 | 172.35 |
| A:B=1:30 | Y=2.024X+3.649 | 4.651 | 135.64 |
| A:B=1:50 | Y=1.965X+3.763 | 4.263 | 147.48 |
In addition, inventor is it has been investigated that work as A:B numerical value is more than 70 or A:B numerical value is less than 1:50, now two groups
Point with the use of being no cooperative effect, and it is computed co-toxicity coefficient and is respectively less than 120.
Field control effectiveness test：
The pesticidal preparations preventing and treating downy mildew of garpe experiment made from above-described embodiment.
1st, test process：This test medicine dosage sets three concentration for the treatment of, comparison medicine respectively according to the difference of each composition
Agent is the mepanipyrim SC of agricultural chemicals single dose 10% and 10% cyazofamid SC and blank clean water experiment respectively.
2nd, each plot area of test method is 66.7m2, it is repeated 3 times；Investigation drug effect side after investigating and prevent and treat before dispenser
Method is：5 points of grab sample in test process area, severity Scaling is carried out according to national field test relevant criterion, calculates preventive effect.
Result of the test is shown in Table 2：
The field test effect of table 2
Shown by indoor biometricses and field efficacy result, mepanipyrim has obvious Synergistic with cyazofamid composition
Effect, the prevention effect of composition is excellent, and prevention effect is better than single dose kind, has application value in agricultural is applied.
Two kinds of reactive compounds can be processed into any one formulation of permission, illustrate two kinds below with specific embodiment
The preparation that active ingredient is processed into, but the preparation that can process of the two kinds of active components be not limited only to it is set forth below.
Embodiment 1：15% mepanipyrim cyazofamid wettable powder (1:2)
By mepanipyrim 5g, cyazofamid 10g, detergent LS (to methoxyl group aliphatic acid amido benzene sulfonic acid sodium salt) 2g, dispersing agent NNO
(sodium methylene bis-naphthalene sulfonate) 4g, white carbon 5g, kaolin add to 100g mixtures and carry out air-flow crushing, and active ingredient matter is made
Amount percentage is 15% mepanipyrim cyazofamid wettable powder.
Embodiment 2：15% mepanipyrim cyazofamid wettable powder (1:4)
By mepanipyrim 3g, cyazofamid 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds
Air-flow crushing is carried out to 100g mixtures, it is 15% mepanipyrim cyazofamid wettable powder that active ingredient mass percent, which is made,
Agent.
Embodiment 3：14% mepanipyrim cyazofamid wettable powder (1:6)
By mepanipyrim 2g, cyazofamid 12g, lauryl sodium sulfate 3g, dispersing agent NNO 4g, white carbon 5g, kaolin adds
Air-flow crushing is carried out to 100g mixtures, it is 14% mepanipyrim cyazofamid wettable powder that active ingredient mass percent, which is made,
Agent.
Embodiment 4：20% mepanipyrim cyazofamid suspending agent (1:1)
Weigh 10g mepanipyrims, 10g cyazofamids, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, second
Glycol 5g, poly- silica ethane 0.10g, aluminium-magnesium silicate 0.5g, 100g is complemented to water, be made in the presence of sand mill effectively into
It is 20% mepanipyrim cyazofamid suspending agent to divide mass percent.
Embodiment 5：55% mepanipyrim cyazofamid aqueous emulsion (1:10)
5g mepanipyrims, 50g cyazofamids, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol is weighed to gather
Oxygen vinethene 1g, solvent naphtha 13g, adds water to 100g.In the method input mixing kettle that above raw material is routinely prepared to aqueous emulsion
Mixed at high speed, it is 55% mepanipyrim cyazofamid aqueous emulsion that effective ingredient percent, which is made,.
Embodiment 6：42% mepanipyrim cyazofamid missible oil (1:20)
Weigh 2g mepanipyrims, 40g cyazofamids, calcium dodecyl benzene sulfonate 8g, phenethyl phenol polyethenoxy ether 5g, solvent naphtha
To 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil, effective ingredient percent is made
For 42% mepanipyrim cyazofamid missible oil.
Embodiment 7：70% mepanipyrim cyazofamid missible oil (2.5:1)
Weigh 50g mepanipyrims, 20g cyazofamids, calcium dodecyl benzene sulfonate 5g, phenethyl phenol polyethenoxy ether 2g, castor-oil plant
Oily APEO 2g, solvent naphtha to 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil, is made
It is 70% mepanipyrim cyazofamid missible oil into active ingredient mass percent.
Embodiment 8：18% mepanipyrim cyazofamid water dispersion granule (5：1)
Weigh 15g mepanipyrims, 3g cyazofamids, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, poly- second
Enol 5g, borax 2g, diatomite 28g complement to 100g, and above raw material is formed with into effect into sub-prime by water dispersible granular agent method
Amount percentage is 18% mepanipyrim cyazofamid water dispersion granule.
Embodiment 9：11% mepanipyrim cyazofamid missible oil (10:1)
Weigh 10g mepanipyrims, 1g cyazofamids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 7g, solvent naphtha
To 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil, effective ingredient percent is made
For 11% mepanipyrim cyazofamid missible oil.
Embodiment 10：31.5% mepanipyrim cyazofamid microemulsion (20:1)
Weigh 30g mepanipyrims, 1.5g cyazofamids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate
3g, agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely prepared into micro emulsion
Mixed in the method input mixing kettle of agent, it is 31.5% mepanipyrim cyazofamid microemulsion that effective ingredient percent, which is made,.
Embodiment 11：31% mepanipyrim cyazofamid missible oil (30:1)
Weigh 30g mepanipyrims, 1g cyazofamids, calcium dodecyl benzene sulfonate 4g, phenethyl phenol polyethenoxy ether 4g, solvent naphtha
To 100g.Above raw material is routinely prepared and mixed in the method input mixing kettle of missible oil, effective ingredient percent is made
For 31% mepanipyrim cyazofamid missible oil.
Embodiment 12：51% mepanipyrim cyazofamid suspending agent (50:1)
Weigh 50g mepanipyrims, 1g cyazofamids, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, second two
Alcohol 5g, poly- silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complements to 100g with water, active ingredient is made in the presence of sand mill
Mass percent is 51% mepanipyrim cyazofamid suspending agent.
Embodiment 13：32% mepanipyrim cyazofamid microemulsion (1:15)
Weigh 2g mepanipyrims, 30g cyazofamids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g,
Agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely prepared into microemulsion
Method input mixing kettle in mix, it is 32% mepanipyrim cyazofamid microemulsion that effective ingredient percent, which is made,.
Embodiment 14：6% mepanipyrim cyazofamid aqueous emulsion (1:5)
Weigh 1g mepanipyrims, 5g cyazofamids, phenethyl phenol polyethenoxy ether phosphate 3g, agriculture breast 33#2g, alkyl phenol polyoxy
Vinethene 1g, solvent naphtha 13g, adds water to 100g.Above raw material is routinely prepared high in the method input mixing kettle of aqueous emulsion
Speed mixing, it is 6% mepanipyrim cyazofamid aqueous emulsion that effective ingredient percent, which is made,.
Embodiment 15：62% mepanipyrim cyazofamid microemulsion (1:30)
Weigh 2g mepanipyrims, 60g cyazofamids, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether phosphate 3g,
Agriculture breast 33#2g, APES 1g, isopropanol 10g, add water to 100g.Above raw material is routinely prepared into microemulsion
Method input mixing kettle in mix, it is 62% mepanipyrim cyazofamid microemulsion that effective ingredient percent, which is made,.
Embodiment 16：51% mepanipyrim cyazofamid suspending agent (1:50)
Weigh 1g mepanipyrims, 50g cyazofamids, lignin 2g, polyoxyethylene poly-oxygen propylene aether 4g, xanthans 0.15g, second two
Alcohol 5g, poly- silica ethane 0.10g, aluminium-magnesium silicate 0.5g, complements to 100g with water, active ingredient is made in the presence of sand mill
Mass percent is 51% mepanipyrim cyazofamid suspending agent.
Embodiment 17：7% mepanipyrim cyazofamid water dispersion granule (1：2.5)
Weigh 2g mepanipyrims, 5g cyazofamids, sodium lignin sulfonate 8g, lauryl sodium sulfate 2g, ammonium sulfate 5g, polyethylene
Alcohol 5g, borax 2g, white carbon 3g, diatomite complement to 100g, by above raw material by water dispersible granular agent method be formed with effect into
It is 7% mepanipyrim cyazofamid water dispersion granule to divide mass percent.
Claims (9)
1. a kind of bactericidal composition containing mepanipyrim and cyazofamid, it is characterised in that the bactericidal composition is with mepanipyrim and cyazofamid
For principle active component, the wherein mass ratio of mepanipyrim and cyazofamid is 1 ~ 50：1~50.
2. bactericidal composition according to claim 1, it is characterised in that the mass ratio of the mepanipyrim and cyazofamid be 1 ~
30：1~20.
3. bactericidal composition according to claim 1, it is characterised in that the mass ratio of the mepanipyrim and cyazofamid be 1 ~
30：1~10.
4. bactericidal composition according to claim 1, it is characterised in that both described mepanipyrims and cyazofamid account for combination
The weight/mass percentage composition of thing is 2-80%.
5. bactericidal composition according to claim 4, it is characterised in that both described mepanipyrims and cyazofamid account for combination
The weight/mass percentage composition of thing is 10-40%.
6. bactericidal composition according to claim 1, it is characterised in that using mepanipyrim and cyazofamid as principle active component
Any one formulation for allowing on agricultural chemicals is configured to insecticides adjuvant.
7. bactericidal composition according to claim 6, it is characterised in that described formulation be missible oil, suspending agent, aqueous emulsion,
Wettable powder, microemulsion or water dispersion granule.
8. application of the bactericidal composition on preventing and treating fungal diseases of plants medicine is prepared described in claim 1.
9. application according to claim 8, it is characterised in that described fungal diseases of plants is gray mold, brown rot, black
At least one of star disease, downy mildew, late blight.
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