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CN103998077B - 具有向上拨动/向下拨动定量机构的基于扭力弹簧的卷紧自动注射器笔 - Google Patents

具有向上拨动/向下拨动定量机构的基于扭力弹簧的卷紧自动注射器笔 Download PDF

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CN103998077B
CN103998077B CN201280064872.3A CN201280064872A CN103998077B CN 103998077 B CN103998077 B CN 103998077B CN 201280064872 A CN201280064872 A CN 201280064872A CN 103998077 B CN103998077 B CN 103998077B
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CN103998077A (zh
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T.S.汉森
H.赫明格森
C.H.尼伊森
E.基勒里奇
M.阿韦伦德
M.梅兰德
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    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
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    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
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    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
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    • A61M2005/3125—Details specific display means, e.g. to indicate dose setting
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    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
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    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member

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Abstract

本发明涉及一种自动的基于扭力弹簧的注射装置，其具有向上拨动/向下拨动机构，利用向上拨动/向下拨动机构，可以通过在第一方向上旋转剂量设置构件来设置剂量，并且可以通过在第二相反方向上旋转同一剂量设置构件来减小剂量大小。向上拨动/向下拨动机构操作扭力弹簧，扭力弹簧在设置剂量时被张紧并且当在第二方向上旋转剂量设置元件时放松。为了在张紧时固定该扭力弹簧，遵循剂量设置元件在第一方向上旋转的棘轮臂（21）接合带齿元件（10）使得至少一个棘轮臂（21）与带齿元件（10）的齿（12）的接合防止扭力弹簧退绕，并且其中剂量设置构件在第一方向上旋转将棘轮臂（21）从一个齿（12）移动到带齿元件（10）的后面的齿（12），并且剂量设置构件在降低设置剂量的第二方向上旋转启动棘轮臂（21）以使带齿元件（10）的齿（12）脱离从而允许扭力弹簧在第二方向上移动棘轮臂(21)到前一齿（12）使得积聚于扭力弹簧中的力递增地减小。为了在向下拨动设置剂量时提供平稳移动，至少一个棘轮臂（21）设置于棘轮管（20）上，棘轮管（20）带有摩擦齿（30），摩擦齿（30）与带齿元件的凸轮曲线（16）接合，利用扭力弹簧来阻尼棘轮臂（21）的移动。

Description

具有向上拨动/向下拨动定量机构的基于扭力弹簧的卷紧自 动注射器笔
技术领域
本发明涉及一种用于自动卷紧笔的向上拨动/向下拨动机构。特别地，本发明涉及一种用于扭力弹簧辅助的卷紧笔的整合的向上拨动/向下拨动机构。本发明还涉及一种合并了这种向上拨动/向下拨动机构的自动的基于扭力弹簧的注射装置和一种合并了防碰撞声（anti-rattling）器件的自动扭力弹簧装置。
背景技术
在基于扭力弹簧的已知的注射装置诸如卷紧笔中，使用者通常通过旋转常设置于注射装置端部处的剂量设置构件来张紧扭力弹簧。因此由使用者在剂量设置期间施加的旋转力积聚于扭力弹簧中以在后来释放。
采用扭力弹簧的已知的卷紧笔的示例可以见于US5,104,380中。在这种卷紧笔中，剂量设置构件位于近端处并且以这种方式工作使得:当使用者旋转该剂量设置构件时，扭力弹簧被张紧并且维持在这个张紧位置直到使用者通过启动闩锁而释放所设置的剂量。公开于US 5,104,380中的卷紧笔具有以下缺点：如果使用者设置了大于预期剂量的剂量，则不能减小设置的剂量。那么使用者必须释放闩锁机构从而排出整个设置的剂量，之后可以设置并且递送新的正确剂量。
使用者可以实际上减小设置剂量的卷紧笔，其例如从WO 2006/045526、WO 2007/063342、WO 2010/046394和WO 2010/089418已知。
这些自动注射装置是基于扭力弹簧，在剂量设置期间，扭力弹簧被拧紧，并且之后被释放以注射所设置的剂量。如果使用者错误地设置高于所需要的剂量，则这些注射装置能通过在相反旋转方向上旋转所述剂量设置构件来降低设置的剂量。这种向下拨动机构因此可以避免使用者因为错误的剂量设置而排出昂贵的药物。
在WO 2006/045526和WO 2010/046394中，向上拨动/向下拨动机构是基于柔性棘轮臂，柔性棘轮臂被锁定成与齿环成单向接合。当使用者设置一定剂量时，他旋转一种带齿布置中的柔性棘轮臂使得棘轮臂克服扭力弹簧的力锁定于齿环的后面的齿中，从而以递增的步骤张紧扭力弹簧。为了减小设置的大小，柔性臂被拉出脱离与齿环的接合，由此积聚于扭力弹簧中的力使棘轮臂快速向后旋转使得柔性臂接合着齿环中的前一齿从而以一个增量降低所设置的剂量。提供单独的元件，其当移动时旋转接合棘轮臂并且拉出棘轮臂脱离其与齿环的接合。如果使用者继续在向下拨动方向旋转剂量设置构件，那么棘轮臂将在扭力弹簧的影响下在齿环中以一系列递增步骤向下移动。
类似布置于公开于WO 2010/089418中，然而，在图2中所描绘的这种注射装置的向上拨动/向下拨动机构中，克服扭力弹簧的力而固定着所述棘轮臂的带齿元件具有指向外的齿并且棘轮臂指向注射装置的中心轴线。
在WO 2007/063342中所公开的布置中，存在图12所描绘的三个棘轮臂，这三个棘轮臂接合一种设置于传动齿轮中的齿环，从而将扭力弹簧固持在其张紧位置。这些棘轮臂可以在径向向内偏转使得当使用者希望减小所设置的剂量时，他简单地在相反方向上旋转所述剂量设置构件。
在上述向上拨动/向下拨动机构中的主要问题在于当使用者向下拨动设置剂量时，他实际上通过迫使棘轮臂脱离与带齿元件的接合而释放扭力弹簧并且利用扭力弹簧来执行实际向下拨动，即，棘轮臂的向后移动。
自动注射装置常常以预张紧的扭力弹簧而操作以便在扭力弹簧特征的范围内操作，在扭力弹簧特征的范围，扭力弹簧施加相对恒定和相对较大的力。这种结果导致由弹簧执行的棘轮臂的向后移动表现为相当粗糙和粗略。当在向下拨动方向上旋转剂量设置构件时因此略微感觉不舒服。
发明内容
本发明的目的在于提供一种用于自动卷紧笔的向上拨动/向下拨动机构，其克服了上述问题并且当向下拨动设置剂量时提供更平稳的感觉。
因此，在第一方面，本发明涉及一种用于多次注射可设置剂量的液体药物的一种自动的基于扭力弹簧的注射装置中的向上拨动/向下拨动机构。这种注射装置包括一种对于可旋转的剂量设置元件加以牢固固定的外壳，使用者可以利用可旋转的剂量设置元件来设置待注射的剂量大小。
此处自动表示注射装置包括扭力弹簧，在剂量设置期间通过在一个方向上旋转所述剂量设置元件而使扭力弹簧张紧，并且在注射期间，释放该弹簧以将液体药物从注射装置经由附连的注射针而驱出。
另外，一旦设置了特定剂量大小，其可以被调整，即，通过在相反方向（与剂量设置方向相反）上旋转所述剂量设置元件来降低，这使得扭力弹簧放松，即，减小了存在于扭力弹簧中的扭矩。
向上拨动/向下拨动机构辅助了设置并且调整（即，降低）剂量大小，为了将扭力弹簧固定在其拉紧位置，棘轮臂接合带齿元件，带齿元件牢固固定所述棘轮臂防止在一个方向上旋转。显然，可以提供多于一个棘轮臂，尽管此处仅描述为单个（in singularity）。棘轮臂联接到剂量设置元件使得当在一个方向上旋转所述剂量设置元件来设置一定剂量时，棘轮臂移动成其接合着带齿元件到后面的齿，从而递增地张紧扭力弹簧。为了减小设置的剂量，提供用于拉出棘轮臂以脱离与带齿元件的接合的器件使得积聚于扭力弹簧中的扭矩可以在相反方向上旋转棘轮臂，其中，其由带齿元件的前面的齿夹紧从而递减地减小扭力弹簧的扭矩并且因此减小剂量大小。为了利用扭力弹簧来控制并且阻尼/抑制棘轮臂的向后移动，在携载有棘轮臂的棘轮管与带齿元件之间的接合中提供摩擦齿。
当拉出棘轮臂使之脱离与带齿元件的接合时，在棘轮管与带齿元件之间并不存在这样的接合，但这两个部件可旋转地连接，例如，通过使在一个元件上的圆形脊接合着在另一元件上的类似圆形轨道，这本身造成某些摩擦。
摩擦齿可以设置于棘轮管上或者带齿元件上并且提供受控制的摩擦，这种受控制的摩擦大于当这两个元件相对于彼此旋转时将会通常存在的摩擦。当元件旋转或者以其它方式在接触的同时相对于彼此移动时，将总是发生某种程度的摩擦。然而，“摩擦齿”表示存在特殊齿，这种特殊齿被设计成提供高于固有摩擦的受控制的摩擦。
显然，也能具有设置于棘轮管和带齿元件上的摩擦齿。带齿元件可以例如具备与在棘轮管上的摩擦齿接合的一种凸轮曲线，从而形成另外的摩擦。凸轮曲线可以例如遵循传统的弦形曲线或者任何合适曲线。如果摩擦齿设置于带齿元件上，凸轮曲线可以替代地设置于棘轮管上。
如在例如WO 2010/046394和WO 2010/089418中所公开，优选地提供复位管（复位管在下文被称作一种联接套筒），其在剂量设置按钮与棘轮管之间形成/建立接触，剂量设置按钮可以与复位管一体，如果希望这样。
棘轮管可以与剂量指示器一体地形成或者其可以本身为剂量指示器。在另一实施例中，可以提供单独的剂量指示器套筒。这种剂量指示器套筒优选地通过键和凹槽连接而键接到棘轮管使得剂量指示器套筒可以随棘轮管一起旋转，但相对于棘轮管在轴向移动，即，当剂量指示器套筒随着棘轮管移动时，剂量指示器套筒可以在轴向滑动。可以例如通过使剂量指示器套筒接合一种在外壳内侧所提供的螺旋螺纹而实现同时旋转和轴向移动。为了使剂量指示器套筒在轴向滑动，键和凹槽连接的公差必须允许这种轴向移动。
然而这造成了剂量指示器套筒在移动期间可能发出碰撞声的问题。为了防止这种碰撞声，在棘轮管与剂量指示器套筒之间提供防碰撞声器件，诸如多个柔性腿。
在第二方面，本发明涉及一种用于多次注射可设置剂量的液体药物的自动的基于扭力弹簧的注射装置，其包括：外壳，其保持着液体药物；可旋转的剂量设置元件，其用来设置剂量大小；以及，本文描述的向上拨动/向下拨动机构。可旋转的剂量设置构件张紧扭力弹簧和放松扭力弹簧并且优选地直接地或者通过另一部件而可旋转地牢固固定到外壳。
在第三方面，本发明涉及一种合并了所描述的防碰撞声器件的基于扭力弹簧的注射装置。这种基于扭力弹簧的注射装置无需/并不一定必须合并上文所公开的摩擦齿。
在一实施例中，这些防碰撞声器件可以设置为柔性腿，柔性腿设置于剂量指示器套筒与棘轮管之间。柔性腿可以设置于抵接着另一个的剂量指示器套筒或棘轮管中任一个上。替代地，腿可以设置于抵接着另一元件的两个元件上。
定义：
“注射笔”通常是注射设备或装置，其具有长圆形或细长形状，略微类似于书写笔。尽管这种笔通常具有管状截面，它们可以容易地具有不同截面，诸如三角形、矩形或者正方形或者围绕这些几何形状的任何变型。
如本文所用的术语“药物”意谓涵盖能通过诸如中空针的递送器件以受控方式传递的任何含药物的可流动的药品，诸如液体、溶液、凝胶或细微悬浮液。代表性药物包括诸如下列的药剂：肽、蛋白质（例如，胰岛素、胰岛素类似物和C肽）和荷尔蒙、生物派生或活性剂、基于荷尔蒙和基因的制剂、营养配方和呈固体（分配/配方）或液体形式的其它物质。
“筒”是用来描述包含药物的容器的术语。筒通常由玻璃制成但也可以由任何合适聚合物模制而成。筒或安瓿优选地在一端处被一种可刺穿的膜所密封，可刺穿的膜被称作“隔膜”，其可以例如由针套管的后端刺穿。相反端通常被柱塞或活塞闭合，柱塞或活塞由橡胶或合适聚合物制成。柱塞或活塞可以在筒内侧滑动，在可刺穿的膜与可移动的柱塞之间的空间保持药物，在柱塞减小保持着药物的空间体积时压出药物。然而，可以使用任何类型的容器，刚性或柔性，来容纳药物。
另外，术语“注射针”限定了一种刺穿构件，其适于穿透受检者的皮肤以用于递送或移除液体的目的。
“剂量指示器套筒”优选地表示圆柱形中空元件，略微类似于衬衣的袖子，带有标记，向注射笔的使用者指示选定剂量大小。“标记”表示合并任何类型的印刷或以其它方式提供的符号，例如雕刻或粘附的符号。
结合注射装置使用术语“自动”表示注射装置能执行注射而无需注射装置的使用者在定量期间递送排出药物所需的力。力通常由自动器件（诸如电动马达或弹簧）自动递送。弹簧通常在剂量设置期间由使用者张紧，然而这种弹簧通常被预张紧以避免递送很小剂量的问题。替代地，弹簧可以由制造商完全预加载有足以通过多个剂量而排空整个药物筒的预载。通常，使用者启动一种闩锁机构（例如在注射装置上呈按钮形式）以在执行注射时释放积聚于弹簧中的力。
本文所引用的所有参考，包括公告、专利申请和专利以它们全文引用的方式并入到本文中到如同每个参考个别地并且具体地指示为以引用的方式并入到本文中并且以其全文在本文中陈述的程度。
在本文中使用所有标题和副标题只是为了方便起见并且不应被理解为以任何方式限制本发明。
使用本文所提供的任何和所有示例或示例性语言（例如，诸如）仅为了更好地说明本发明而不对本发明的范围施加限制，除非另外要求保护。在说明书中的语言不应理解为指示任何非要求保护的元件为实践本发明至关重要的。在本文中引用和并入专利文献只是为了方便起见并且不反映这些专利文献的有效性、专利性和/或可执行性的任何观点。
本发明包括可适用的法律所允许的、在所附权利要求中所陈述的主题的所有修改和等效物。
附图说明
下面将结合优选实施例并且参考附图来更全面解释本发明，在附图中：
图1示出了现有技术向上拨动/向下拨动机构的示例。
图2示出了图1的向上拨动/向下拨动机构的截面图。
图3示出了呈环形配置的现有技术固定元件的视图。
图4示出了现有技术棘轮管的视图。
图5示出了现有技术复位管的视图。
图6示出了根据本发明的棘轮管的透视图。
图7示出了与剂量指示器套筒一起的棘轮管的截面图。
图8示出了向上拨动/向下拨动机构的视图。
图9示出了向上拨动/向下拨动机构的截面图。
为了清楚起见，附图为示意性的并且被简化，并且它们仅示出了对于理解本发明而言至关重要的细节，而省略了其它细节。在全文中，相同的附图标记用于相同或相对应的零件。
具体实施方式
当在下文中使用诸如“上部”与“下部”，“右”与“左”，“水平”和“竖直”，“顺时针”和“逆时针”、或类似相对表述的术语时，它们仅参考附图且未必参考实际使用情形。图示附图是示意性表示，因此，不同结构的配置以及其相对尺寸预期只是用于说明目的。
在上下文中，可以方便地定义为附图中术语“远端”意在指代包括环形元件10的向上拨动、向下拨动机构的端部，而术语“近端”意在指代背向环形元件10的相反端部。
在图1至图5中公开了从WO 2010/046394已知的现有技术向下拨动机构。
其包括三个部分：固定元件或环10；剂量设置元件或棘轮管20；以及，复位管40。
如在图3中可以看出，构成驱动机构的一部分的环10在其外表面上具有多个接合器件，诸如翅片11，利用这些接合器件，环10不可旋转地联接到注射装置的未图示的外壳上。环10可以替代地以多种不同方式附连到外壳上，然而如在下文中所解释，环形元件10必须能相对于外壳在轴向滑动以便释放积聚于扭力弹簧中的扭矩。
未图示的扭力弹簧在一端处牢固固定到棘轮管20并且在另一端处牢固固定到外壳使得每当在向上拨动方向上旋转棘轮管20（参看图2）时拧紧该扭力弹簧。棘轮管20被布置成使得当使用者设置待递送的剂量时其遵循剂量设置构件的旋转。
在其内表面上，环10具备多个齿12，这些齿12在一个方向上具有陡边缘13并且在相反方向上具有倾斜边缘14使得防止棘轮管20的棘轮臂21在一个方向上旋转但允许在相反方向上旋转。这在图2中最佳地看出。
在图4中详细地公开的棘轮管20在其远端上具有圆形部分，圆形部分具有装配到环10内侧的周围外表面22。这个外表面22具备圆形凹部23，圆形凹部23与环10上的类似圆形元件15接合使得环10和棘轮管20在轴向方向锁定到彼此但可以相对于彼此旋转。
周围外表面22具备柔性棘轮臂21，柔性棘轮臂21终止于陡表面24。棘轮臂21在其周围表面上具备指向外的突起25。陡表面24的一部分还合并了突起25。突起25还具备倾斜表面26，倾斜表面26向下至棘轮臂21倾斜，如在图2中最佳地看出。
一旦如在图2中所公开那样使棘轮管20与环10接合，棘轮臂21的陡表面24接合着在环10上的陡边缘13使得棘轮管20可以仅在一个方向（其在图2中为在顺时针方向）上相对于环10旋转。
每当棘轮管20在如图2中的“向上拨动”箭头所示的顺时针方向上旋转时（从近端位置观察），扭力弹簧被张紧并且通过在棘轮臂21的陡表面24与环10上的齿12的陡边缘13之间的接合而被保持在这种张紧位置。
以此方式，使用者可以张紧扭力弹簧并且由此通过相对于环10在顺时针方向上旋转棘轮管20来设置剂量，并且所描述的接合24、13使得扭力弹簧不能使棘轮管20往回旋转。
为了提供使用者向下拨动设置剂量的可能性，提供复位管40。关于图5，复位管40具备延伸部分41，延伸部分41具有指向前的复位元件42，复位元件42沿循所述延伸部分41的周围。在其近端处，复位管40具备用于接合一种剂量设置按钮的器件47。替代地，剂量设置按钮可以与复位管40一体。
一旦组装了注射装置，复位管40装配于棘轮管20内侧使得复位元件42位于棘轮臂21上方，如在图1和图2中所描绘。在此位置，在棘轮管20与复位管40之间的轴向接合由复位管40的突起43牢固固定，复位管40的突起43接合于棘轮管20的前表面29前方。
复位管40的延伸部分41还具备在顺时针方向上的第一表面44和在逆时针方向上的第二表面45。另外，复位元件42具备在逆时针方向上的复位表面46。
第一表面44接合了在棘轮管20上的类似的向上拨动表面57使得复位管40在顺时针方向（例如，在图2中）上的旋转直接地被变换到棘轮管20，表示当使用者在顺时针方向上拨动复位管40以设置一定剂量时，棘轮管20遵循这种旋转并且相对于环10旋转。
第二表面45接合弹簧元件58，在顺时针方向上推压复位管40，而复位元件42的复位表面46接合棘轮臂21的突起25的倾斜表面26。
当如上文所解释那样设置一定剂量时，使用者旋转复位管40，这种旋转传递到棘轮管20，同样允许棘轮管20相对于环10在顺时针方向上旋转，从而张紧扭力弹簧。
当使用者后悔设置的剂量并且想要减小设置的剂量时，通过在逆时针方向上旋转复位管40来这样做。通过这样做（如图2所描绘），复位结构46被压靠在凸起25的倾斜表面26上，这将陡表面24拉出，脱离与齿12的陡边缘13的接合。这允许扭力弹簧被释放并且在积聚于扭力弹簧的扭矩的影响下在逆时针方向上快速驱使棘轮管20。由于储存于扭力弹簧中的扭矩大小，棘轮管20将比复位管40更快移动，由此突起25的倾斜表面26将不再具有复位表面46搁置于其上的压力并且柔性棘轮臂21将挠曲到其初始位置并且陡表面24将接合前一齿12的前一陡边缘13。通过复位管40的继续逆时针旋转，陡表面24将以持续移动从齿12移动到齿12从而递增地降低在扭力弹簧中所储存的扭矩。
一旦获得正确设置，储存在扭力弹簧中的扭矩通过在轴向移动所述环10脱离与外壳的接合而释放，由此扭力弹簧在逆时针方向上往回旋转所有三个元件10、20、40。在环10的轴向移动中，其移动成与驱动器接合，然后驱动器随着其它元件10、20、40一起旋转以向前驱动所述系统的活塞杆。
为了使棘轮管20的和因此棘轮臂21的向下拨动移动平稳进行，棘轮管20具备用于在棘轮管20与环10之间形成一种受控制的摩擦的器件。这些摩擦器件优选地被设置为接合着齿10的多个摩擦齿30，如在图6和图9中所描绘。
如在图8和图9中可以看出，与棘轮管20的圆形凹部23接合着的环10的圆形元件15具备凸轮曲线16。这个凸轮曲线16由摩擦齿30接合，摩擦齿30设置于棘轮管20的圆形凹部23中。
棘轮管20在其外表面上具备多个轴向伸展的凸脊31。这些脊31接合着设置于一种剂量指示器套筒50内壁上的多个类似凹槽51，该指示器套筒50具有印刷于其表面上的标记用于示出设置剂量的大小，如在注射装置中公知的那样。
剂量指示器套筒50优选地具备螺纹52，螺纹52接合着外壳中的类似螺纹，即螺旋轨道，使得剂量指示器套筒50在旋转时螺旋地移动。
为了防止这种剂量指示器套筒50在旋转期间发出碰撞声，棘轮管20还具备多个柔性腿32，柔性腿31压靠在标度转筒50的内表面上。这些腿在图6中最佳地看出。
另外，额外腿53可以设置于剂量指示器套筒50上并且抵接棘轮管20。这些腿可以作为腿32的替代提供于棘轮管20上或者它们可以作为腿32的补充提供。
每当扭力弹簧在向下拨动方向上移动棘轮管20时，摩擦齿30使得这种旋转移动略微较慢，这在使用者向下拨动所述设置剂量时向使用者提供更柔软的感觉，同时柔性腿32阻尼/抑制标度转筒50发出的碰撞声。替代地，一组柔性臂53可以设置于压靠在棘轮管20的外表面上的标度转筒50上。
摩擦齿30在它们抵靠环元件10的凸轮曲线16滑动时提供摩擦，然而摩擦阻尼可以以替代方式提供。
在前文示出中示出了某些优选实施例，但应强调的是本发明并不限于这些实施例，而是可在下面的权利要求所限定的主题内以其它方式来实施。必须特别地指出的是摩擦器件和防碰撞声器件可以同时设置到同一自动的基于扭力弹簧的注射装置上或者它们可以个别地施加到这些注射装置。

Claims (8)

1.一种用于自动的基于扭力弹簧的注射装置的向上拨动/向下拨动机构，所述注射装置用于多次注射液体药物的可设置和可调整的剂量大小，所述注射装置包括扭力弹簧，当通过相对于外壳在第一方向上旋转一种剂量设置元件而设置一定剂量时扭力弹簧张紧，并且当在与所述第一方向相反的第二方向上旋转所述剂量设置元件时所述扭力弹簧放松，所述向上拨动/向下拨动机构包括：
至少一个棘轮臂（21），其布置成当设置一定剂量时遵循所述剂量设置元件在所述第一方向上的旋转，
带齿元件（10），其克服所述扭力弹簧的偏压而牢固固定所述至少一个棘轮臂（21）使得所述至少一个棘轮臂（21）与所述带齿元件（10）的齿（12）的接合防止所述扭力弹簧退绕，并且其中所述剂量设置元件在所述第一方向上的旋转将所述棘轮臂（21）从一个齿（12）移动到所述带齿元件（10）的后面的齿（12），以及
所述剂量设置元件在降低所述设置剂量的第二方向上的旋转启动所述至少一个棘轮臂（21）以使所述带齿元件（10）的所述齿（12）脱离且从而允许所述扭力弹簧在第二方向上移动所述棘轮臂（21）到前一齿（12）使得积聚于所述扭力弹簧中的力累计地减小，
其特征在于，
所述至少一个棘轮臂（21）设置于棘轮管（20）上，所述棘轮管（20）还通过多个摩擦齿（30）与所述带齿元件（10）接合从而当所述至少一个棘轮臂（21）脱离所述带齿元件（10）的齿（12）时阻尼由所述扭力弹簧执行的所述棘轮臂（21）的移动。
2.根据权利要求1所述的向上拨动/向下拨动机构，所述棘轮管（20）携载有摩擦齿（30）。
3.根据权利要求2所述的向上拨动/向下拨动机构，接合着所述摩擦齿（30）的所述带齿元件（10）的部分构成凸轮曲线（16）。
4.根据权利要求1至3中任一项所述的向上拨动/向下拨动机构，其特征在于，复位管（40）联接于所述棘轮管（20）与所述剂量设置元件之间，所述复位管（40）启动所述至少一个棘轮臂（21）以使所述带齿元件（10）的齿（12）脱离。
5.根据权利要求1至3中任一项所述的向上拨动/向下拨动机构，其特征在于，所述棘轮管（20）通过键（31）和凹槽（51）连接而键接到剂量指示器套筒（50）。
6.根据权利要求1至3中任一项所述的向上拨动/向下拨动机构，其特征在于，所述棘轮管（20）具备防止所述剂量指示器套筒（50）发出碰撞声的器件。
7.根据权利要求6所述的向上拨动/向下拨动机构，其特征在于，防止所述剂量指示器套筒（50）发出碰撞声的器件为设置于所述棘轮管（20）与所述剂量指示器套筒（50）之间的多个柔性腿(32, 53)。
8.一种用于多次注射液体药物的可设置和可调整的剂量大小的自动的基于扭力弹簧的注射装置，包括：
外壳，其保持着所述液体药物，
可旋转的剂量设置元件，其用于设置所述剂量大小，从而张紧一种扭力弹簧，并且还包括
根据权利要求1至7中任一项所述的向上拨动/向下拨动机构。
CN201280064872.3A 2011-12-29 2012-12-20 具有向上拨动/向下拨动定量机构的基于扭力弹簧的卷紧自动注射器笔 Expired - Fee Related CN103998077B (zh)

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Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
AU2005298944B2 (en) 2004-10-21 2010-12-23 Novo Nordisk A/S Dial-down mechanism for wind-up pen
MX2014013842A (es) 2012-05-31 2015-02-18 Novo Nordisk As Mecanismo de seleccion descendente para pluma giratoria ascendente.
EP2916890B1 (en) * 2012-11-08 2021-08-18 Sanofi-Aventis Deutschland GmbH Dose setting mechanism for a drug delivery device
DE202013001350U1 (de) * 2013-02-08 2014-05-09 Haselmeier Gmbh Injektionsgerät
AR097821A1 (es) * 2013-09-03 2016-04-20 Sanofi Sa Mecanismo de accionamiento
JP2017529973A (ja) * 2014-10-08 2017-10-12 ノボ・ノルデイスク・エー／エス 注射装置のためのねじりばね及びそのようなねじりばねを備えた注射装置
JP6840075B2 (ja) * 2014-11-24 2021-03-10 サノフイＳａｎｏｆｉ 用量設定機構、およびラチェット機構を有する薬物送達デバイス
CN107249669B (zh) * 2015-02-27 2020-12-08 诺和诺德股份有限公司 带剂量重置机构的药物输送装置
WO2016174213A1 (en) * 2015-04-29 2016-11-03 Novo Nordisk A/S Drug delivery device with spring mechanism
DE102015111878A1 (de) * 2015-07-22 2017-01-26 Aesculap Ag Platzsparende Ratscheinheit mit Freilauf
CN110461392B (zh) * 2017-01-23 2022-07-12 赛诺菲 用于扭转弹簧辅助卷紧式注射装置的拨选的传动系
US20210146060A1 (en) * 2017-06-27 2021-05-20 Novo Nordisk A/S A torsion spring driven injection device
JP7408398B2 (ja) 2017-07-14 2024-01-05 アムジエン・インコーポレーテツド 二重ねじりばねシステムを有する針挿入後退システム
WO2019058382A1 (en) 2017-09-19 2019-03-28 Bharat Serums And Vaccines Ltd AUTOMATED MULTI-PURPOSE INJECTION SYSTEM FOR ADMINISTRATION OF INJECTABLE MEDICINES
US12226618B2 (en) * 2018-03-13 2025-02-18 Sanofi Drive train for dial of a torsion-spring assisted wind-up injection device
AU2019284885A1 (en) * 2018-06-14 2020-12-24 Smith & Nephew Asia Pacific Pte. Limited Weightless traction system
CN109172948B (zh) * 2018-10-16 2024-08-20 甘肃成纪生物药业有限公司 一种剂量调节保险限位机构
EP4007624B1 (en) * 2019-08-01 2025-12-10 Medtrum Technologies Inc. Driving apparatus and drug infusion device
KR102271959B1 (ko) * 2020-11-03 2021-07-02 (주)풍림파마텍 도즈 다이얼을 통해 회전력이 가해진 토션 스프링의 꼬임을 일시적으로 유지하게 하는 약물 투입 조절 장치
CN117563085B (zh) * 2024-01-16 2024-03-15 苏州嘉树医疗科技有限公司 一种注射笔及其剂量调节机构
CN120361357B (zh) * 2025-06-30 2025-10-03 苏州嘉树医疗科技有限公司 一种注射装置的剂量调节机构和注射装置
CN120900055B (zh) * 2025-10-11 2025-12-26 江苏英捷信医疗科技有限公司 一种药物输送装置的剂量调节正反转结构

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008031239A1 (de) * 2006-09-15 2008-03-20 Tecpharma Licensing Ag Injektionsgerät mit mehreren kupplungen
US20080306445A1 (en) * 2005-09-14 2008-12-11 Stefan Burren Injection device with a two-way slip coupling
WO2010046394A1 (en) * 2008-10-24 2010-04-29 Novo Nordisk A/S Dial-down mechanism for wind-up pen
WO2011025448A1 (en) * 2009-08-24 2011-03-03 Shl Group Ab Dose reset mechanism
WO2011136718A1 (en) * 2010-04-26 2011-11-03 Shl Group Ab Medicament delivery device

Family Cites Families (418)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US854390A (en) 1906-08-16 1907-05-21 Twitchell Co S Apparatus for carbonating liquids.
GB574705A (en) 1940-04-26 1946-01-17 Boulton Aircraft Ltd Improvements in and relating to machine guns
US2392196A (en) 1945-02-24 1946-01-01 Arthur E Smith Syringe
GB664044A (en) 1948-03-02 1951-01-02 Becton Dickinson Co Injection device
US2956563A (en) 1958-10-02 1960-10-18 Cartrix Corp Hypodermic syringe devices
US3110310A (en) 1961-07-20 1963-11-12 Ideal Instr & Mfg Co Inc Metering hypodermic syringe
US3144178A (en) 1962-03-12 1964-08-11 Stanley J Sarnoff Cartridge holder
US3115135A (en) 1962-03-12 1963-12-24 Stanley J Sarnoff Aspirating piston and plunger coupling
US3556099A (en) 1968-05-27 1971-01-19 Johnson & Johnson Hypodermic syringe assembly
US3729003A (en) 1971-02-11 1973-04-24 Ampoules Inc Variable dosage ampoule applicator
CH563690A5 (zh) 1973-03-09 1975-06-30 Radioelectrique Comp Ind
US3880162A (en) 1973-04-25 1975-04-29 Lee G Simmons Pole-syringe for injecting from a remote distance
JPS5733Y2 (zh) 1975-01-21 1982-01-05
US4026288A (en) 1975-10-21 1977-05-31 Insulin Injector Inc. Syringe injecting device
US4634431A (en) 1976-11-12 1987-01-06 Whitney Douglass G Syringe injector
DE2812729A1 (de) 1978-03-23 1979-09-27 Michael Becker Injektionsvorrichtung zur intramuskulaeren einspritzung, vornehmlich von insulin
US4430079A (en) 1978-11-08 1984-02-07 Minnesota Mining And Manufacturing Company Fluid dispensing device
US4298000A (en) 1978-11-08 1981-11-03 Minnesota Mining And Manufacturing Company Fluid dispensing device
WO1980001643A1 (en) 1979-02-12 1980-08-21 American Hospital Supply Corp Capacitive switching circuit for energizing remote controlled device
DE2906830C2 (de) 1979-02-22 1981-07-16 B. Braun Melsungen Ag, 3508 Melsungen Gerät für Dauerinfusionen
NL7901750A (nl) 1979-03-06 1980-09-09 Stamicarbon Inrichting voor het mengen van twee fluida.
US4277227A (en) 1979-07-02 1981-07-07 Imed Corporation Apparatus for converting a pump to a controller
USRE31315E (en) 1979-07-02 1983-07-19 Imed Corporation Apparatus for converting a pump to a controller
US4275727A (en) 1980-01-07 1981-06-30 Keeri Szanto Michael Device for monitoring and controlling self-administered intravenous drug dosage
US4368731A (en) 1980-02-12 1983-01-18 Schramm Heinrich W Pistol-type syringe
US4313439A (en) 1980-03-24 1982-02-02 Biotek, Inc. Automated, spring-powered medicament infusion system
US4314556A (en) 1980-04-21 1982-02-09 Ma Austin C Emergency syringe
JPS56163486U (zh) 1980-05-09 1981-12-04
DE3048135A1 (de) 1980-12-19 1982-07-15 Imed Corp., 92131 San Diego, Calif. Regelvorrichtung
IT1168101B (it) 1981-01-15 1987-05-20 Domenico Colombo Siringa a pressione manuale perfezionata, per uso odontoiatrico
IE52621B1 (en) 1981-02-12 1988-01-06 Turner Robert Charles Dose metering plunger devices for use with syringes
US4393723A (en) 1981-04-16 1983-07-19 Glen Brand Fluid flow meter
AR228395A1 (es) 1981-05-07 1983-02-28 Merck & Co Inc Jeringa para regular la cantidad suministrada de una sustancia plastica
US4568335A (en) 1981-08-28 1986-02-04 Markwell Medical Institute, Inc. Device for the controlled infusion of medications
DE3204178C2 (de) 1982-02-06 1986-03-20 Eppendorf Gerätebau Netheler + Hinz GmbH, 2000 Hamburg Pipettiervorrichtung
US4515584A (en) 1982-07-06 1985-05-07 Fujisawa Pharmaceutical Co., Ltd. Artificial pancreas
DE3236374A1 (de) 1982-10-01 1984-04-05 Brown, Boveri & Cie Ag, 6800 Mannheim Sicherheitspapier
US4465478A (en) 1982-10-14 1984-08-14 Collagen Corporation Syringe force amplification device
US4493704A (en) 1982-11-29 1985-01-15 Oximetrix, Inc. Portable fluid infusion apparatus
EP0143895B1 (de) 1983-09-07 1987-12-23 Disetronic Ag Tragbares Infusionsgerät
US4648872A (en) 1983-11-15 1987-03-10 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4749109A (en) 1983-11-15 1988-06-07 Kamen Dean L Volumetric pump with replaceable reservoir assembly
US4584439A (en) 1983-12-01 1986-04-22 Floating Membranes, Inc. Audio transducer with controlled flexibility diaphragm
AU595723B2 (en) 1983-12-13 1990-04-05 John Brent Moetteli Socket set for ratchet wrench
ES277095Y (es) 1984-01-25 1985-02-16 Fernandez-Tresguerres Hernandez Jesus A. Suministrador-dosificador de productos inyectables
US4676122A (en) 1984-06-15 1987-06-30 Daltex Medical Sciences, Inc. Fail-safe mechanical drive for syringe
CH657015A5 (de) 1984-06-27 1986-08-15 Ciba Geigy Ag Motten- und kaeferschutzmittel.
WO1986001728A2 (fr) 1984-09-07 1986-03-27 Wolfgang Wagner Dispositif d'injection avec detecteur
CA1254091A (en) 1984-09-28 1989-05-16 Vladimir Feingold Implantable medication infusion system
US4812724A (en) 1984-11-13 1989-03-14 Liebel-Flarsheim Corporation Injector control
FR2583291A1 (fr) 1985-06-14 1986-12-19 Hazon Bernard Dispositif d'avancement pas a pas du piston de seringues par double vis coaxiale avec controle du debit d'injection. application aux injections medicamenteuses intra-dermiques repetitives
BR8606965A (pt) 1985-11-08 1987-11-03 Disetronic Ag Aparelho injetor
DE3609555A1 (de) 1986-03-21 1987-09-24 Josef Porner Blutentnahmespritze
DE3638984C3 (de) 1986-11-14 1993-11-18 Haselmeier Wilhelm Fa Injektionsgerät
US5716990A (en) 1987-03-09 1998-02-10 Cancer Research Campaign Technology Limited Drug delivery systems
NL8701091A (nl) 1987-05-08 1988-12-01 Spruyt Hillen Bv Injectiepen.
GB8713810D0 (en) 1987-06-12 1987-07-15 Hypoguard Uk Ltd Measured dose dispensing device
US4838860A (en) 1987-06-26 1989-06-13 Pump Controller Corporation Infusion pump
GB8720477D0 (en) 1987-08-29 1987-10-07 Bick P A Resynchronisation of body clock
FR2622457A1 (fr) 1987-11-03 1989-05-05 Piccinali Eric Injecteur mesotherapique a microprocesseur
US4919596A (en) 1987-12-04 1990-04-24 Pacesetter Infusion, Ltd. Fluid delivery control and monitoring apparatus for a medication infusion system
JPH0322957Y2 (zh) 1987-12-22 1991-05-20
US4833379A (en) 1988-01-13 1989-05-23 Sherwood Medical Company Motor control fail-safe circuit
CH675078A5 (zh) 1988-01-22 1990-08-31 Nosta Ag
US4898578A (en) 1988-01-26 1990-02-06 Baxter International Inc. Drug infusion system with calculator
DE8801613U1 (de) 1988-02-09 1988-04-21 Wegu Gummi- und Kunststoffwerke Walter Dräbing KG, 3500 Kassel Gummilager für Federn, Achsen und ähnliche Teile an Kraftfahrzeugen
DK166948B1 (da) 1988-02-10 1993-08-09 Dcp Af 1988 As Doseringsenhed til dosering af et antal afmaalte maengder af en vaeske, saasom insulin, fra en glastubule
US4973318A (en) 1988-02-10 1990-11-27 D.C.P. Af 1988 A/S Disposable syringe
GB8809115D0 (en) 1988-04-18 1988-05-18 Turner R C Syringes
JP2717808B2 (ja) 1988-08-10 1998-02-25 テルモ株式会社 シリンジポンプ
DE3833821A1 (de) 1988-10-05 1990-04-12 Braun Melsungen Ag Injektionsvorrichtung
US5244465A (en) 1988-10-19 1993-09-14 Byk Gulden Lomberg Chemische Fabrik Gmbh Reusable injection device for distributing a preselected dose
JPH02126184A (ja) 1988-11-04 1990-05-15 Casio Comput Co Ltd ストップウォッチ装置
JPH02182267A (ja) 1989-01-06 1990-07-16 Oriental Kiden Kk 点滴監視装置
FR2642786B1 (fr) 1989-02-07 1991-05-10 Europ Agence Spatiale Dispositif de verrouillage lineaire ou circulaire, du type dit a cliquet, autobloquant et a deblocage automatique
DK68789A (da) 1989-02-14 1990-08-15 Novo Nordisk As Injektionspen
GB2229497B (en) 1989-03-10 1992-06-03 Graseby Medical Ltd Infusion pump
DE3908892A1 (de) 1989-03-17 1990-09-20 Siemens Ag Schaltungsanordnung und vorrichtung zur kontaktlosen sollwertvorgabe fuer einen mit nichtmagnetischem werkstoff umhuellten integrierten schaltkreis
US4924737A (en) 1989-03-20 1990-05-15 Gummow Tool Company Positive drive ratchet
US4994033A (en) 1989-05-25 1991-02-19 Schneider (Usa) Inc. Intravascular drug delivery dilatation catheter
US5226895A (en) 1989-06-05 1993-07-13 Eli Lilly And Company Multiple dose injection pen
DE3923079A1 (de) 1989-07-13 1991-01-24 Fresenius Ag Verfahren und vorrichtung zum messen der fuellstandshoehe von elektrisch leitenden fluessigkeiten
US5011479A (en) 1989-10-06 1991-04-30 Son Le Cover and connector for hypodermic needle
DE3933542A1 (de) 1989-10-07 1991-04-18 Kg Catts Ges Fuer Erkennungs & Kodeanordnung und vorrichtungen zum lesen sowie zum kodieren derselben
US4990142A (en) 1989-10-23 1991-02-05 Gte Products Corporation Hypodermic syringe
US5002537A (en) 1989-10-23 1991-03-26 Gte Products Corporation Hypodermic syringe
US5122317A (en) 1990-01-12 1992-06-16 The Regents Of The University Of Michigan Method of superplastically deforming zirconia materials
DE4001238A1 (de) 1990-01-18 1991-07-25 Basf Ag Verfahren zur anreicherung bzw. reinigung von biomolekuelen
DK17890A (da) 1990-01-22 1991-07-23 Novo Nordisk As Fremgangsmaade og apparat til opblanding og injicering af et laegemiddel
US4998922A (en) 1990-02-23 1991-03-12 Kuracina Thomas C Safety syringe cap minimizing needle-stick probability
US5064098A (en) 1990-02-23 1991-11-12 Physical Systems, Inc. Dual component dispenser gun
GB9007113D0 (en) 1990-03-29 1990-05-30 Sams Bernard Dispensing device
US5207752A (en) 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5492534A (en) 1990-04-02 1996-02-20 Pharmetrix Corporation Controlled release portable pump
US5318540A (en) 1990-04-02 1994-06-07 Pharmetrix Corporation Controlled release infusion device
US5226896A (en) 1990-04-04 1993-07-13 Eli Lilly And Company Dose indicating injection pen
US5097122A (en) 1990-04-16 1992-03-17 Pacesetter Infusion, Ltd. Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US5104388A (en) 1990-05-08 1992-04-14 Fbk International Corporation Membrane splittable tubing
US5257987A (en) 1990-05-21 1993-11-02 Pharmetrix Corporation Controlled release osmotic infusion system
JPH0634825Y2 (ja) 1990-07-20 1994-09-14 株式会社栗本鐵工所 多段式ロール粉砕機
US5113869A (en) 1990-08-21 1992-05-19 Telectronics Pacing Systems, Inc. Implantable ambulatory electrocardiogram monitor
DE69129001T2 (de) 1990-10-19 1998-10-29 Patrizio Falconara Compagnucci Eine Einwegspritze mit einer eingebauten Gleitschutzkappe für die Nadel
US5284480A (en) 1990-11-09 1994-02-08 Medtronic, Inc. Inflation/deflation syringe with threaded plunger
GB9026191D0 (en) 1990-12-01 1991-01-16 Harris Pharma Ltd Breath actuated dispensing device
US5331954A (en) 1990-12-21 1994-07-26 Novo Nordisk A/S Device for nasal delivery of liquid medications
JPH04256757A (ja) 1991-02-07 1992-09-11 Terumo Corp 定量分与器
DE69203472T2 (de) 1991-02-07 1996-01-04 Terumo Corp Dosiereinrichtung für Injektor.
US5078698A (en) 1991-02-19 1992-01-07 Sterling Drug Inc. Axial eject hypodermic syringe holder
US5176646A (en) 1991-02-19 1993-01-05 Takayuki Kuroda Motorized syringe pump
US5135485A (en) 1991-02-25 1992-08-04 Louis Cohen Capacitance-type fluid level sensor for i.v. and catheter bags
DE4112259A1 (de) 1991-04-15 1992-10-22 Medico Dev Investment Co Injektionsgeraet
DK68991D0 (da) 1991-04-17 1991-04-17 Novo Nordisk As Manifold
US5645052A (en) 1991-04-26 1997-07-08 The Boc Group Plc Anaesthetic vaporizer with expandable/contractable reservoir for pumping liquid anaesthetic
US5270685A (en) 1991-07-02 1993-12-14 Mallinckrodt Medical, Inc. Syringe pressure monitor
EP0525525B1 (de) 1991-07-24 1995-05-03 Medico Development Investment Company Injektor
IL102941A0 (en) 1991-08-27 1993-01-31 Thomas R Johnson Injection syringe
DK175491D0 (da) 1991-10-18 1991-10-18 Novo Nordisk As Apparat
US5163904A (en) 1991-11-12 1992-11-17 Merit Medical Systems, Inc. Syringe apparatus with attached pressure gauge
DK194291D0 (da) 1991-11-29 1991-11-29 Novo Nordisk As Sproejte til automatisk injektion.
DE69214835T2 (de) 1991-11-29 1997-04-03 Novonordisk As Stiftförmige spritze
US5221268A (en) 1991-12-06 1993-06-22 Block Medical, Inc. Multiple dose control apparatus
US5246417A (en) 1991-12-11 1993-09-21 Alza Corporation Indicator for iontophoresis system
US5279585A (en) 1992-02-04 1994-01-18 Becton, Dickinson And Company Medication delivery pen having improved dose delivery features
CH682806A5 (de) 1992-02-21 1993-11-30 Medimpex Ets Injektionsgerät.
WO1993018812A1 (en) 1992-03-25 1993-09-30 Tebro S.A. Powder jet dispenser for medicament inhalation therapies
US5271527A (en) 1992-04-02 1993-12-21 Habley Medical Technology Corporation Reusable pharmaceutical dispenser with full stroke indicator
US5281198A (en) 1992-05-04 1994-01-25 Habley Medical Technology Corporation Pharmaceutical component-mixing delivery assembly
GB9219849D0 (en) 1992-09-19 1992-10-28 Hypoguard Uk Ltd Device
WO1994008647A1 (en) 1992-10-15 1994-04-28 The General Hospital Corporation An infusion pump with an electronically loadable drug library
US5545147A (en) 1992-10-20 1996-08-13 Eli Lilly And Company Anti-backup improvement for hypodermic syringes
FR2697434A1 (fr) 1992-11-02 1994-05-06 Godillon Jean Francois Dispositif pour actionner le poussoir d'une seringue en vue d'y créer une dépression, système et procédé en faisant application pour la mise en place temporaire d'un cathéter et/ou d'un fil guide.
US5378233A (en) 1992-11-18 1995-01-03 Habley Medical Technology Corporation Selected dose pharmaceutical dispenser
DK145792D0 (da) 1992-12-03 1992-12-03 Dumex Ltd As Vaeskedispenseringsapparat
US5320609A (en) 1992-12-07 1994-06-14 Habley Medical Technology Corporation Automatic pharmaceutical dispensing syringe
GB9226423D0 (en) 1992-12-18 1993-02-10 Sams Bernard Incrementing mechanisms
JP2530150Y2 (ja) 1993-01-06 1997-03-26 城田電気炉材株式会社 歯科用の麻酔剤等の注射装置
US5383865A (en) 1993-03-15 1995-01-24 Eli Lilly And Company Medication dispensing device
US5383856A (en) 1993-03-19 1995-01-24 Bersin; Robert M. Helical spiral balloon catheter
US5584815A (en) 1993-04-02 1996-12-17 Eli Lilly And Company Multi-cartridge medication injection device
ZA941881B (en) 1993-04-02 1995-09-18 Lilly Co Eli Manifold medication injection apparatus and method
US5292976A (en) 1993-04-27 1994-03-08 Mobil Oil Corporation Process for the selective conversion of naphtha to aromatics and olefins
SE9301494D0 (sv) 1993-04-30 1993-04-30 Kabi Pharmacia Ab A device for dosing liquid preparation
GB9309151D0 (en) 1993-05-04 1993-06-16 Zeneca Ltd Syringes and syringe pumps
EP0635277B1 (en) 1993-06-30 2001-11-21 Hamilton Company, Inc. Manual dispensing aid for a syringe
DK83093D0 (da) 1993-07-09 1993-07-09 Novo Nordisk As Fremgangsmaade
US5957889A (en) 1993-09-27 1999-09-28 Novo Nordisk A/S Displacement system for controlled infusion of a liquid
CA2129284C (en) 1993-11-24 1999-03-09 Kenneth J. Niehoff Controlling plunger drives for fluid injection in animals
JPH09510775A (ja) 1993-12-22 1997-10-28 アイティーティー・オートモーティブ・ヨーロップ・ゲーエムベーハー 回転あるいは角運動を検出するための装置
US5505697A (en) 1994-01-14 1996-04-09 Mckinnon, Jr.; Charles N. Electrically powered jet injector
AUPM348594A0 (en) 1994-01-21 1994-02-17 University Of Melbourne, The Improvements in syringe pumps
US5478316A (en) 1994-02-02 1995-12-26 Becton, Dickinson And Company Automatic self-injection device
US5562623A (en) 1994-02-14 1996-10-08 Univec Single-use syringe assembly including spring clip lock and plunger
US5514097A (en) 1994-02-14 1996-05-07 Genentech, Inc. Self administered injection pen apparatus and method
US5536249A (en) 1994-03-09 1996-07-16 Visionary Medical Products, Inc. Pen-type injector with a microprocessor and blood characteristic monitor
DE4414744C1 (de) 1994-04-27 1995-11-02 Eppendorf Geraetebau Netheler Repetierpipette
EP1228777B1 (de) 1994-05-30 2003-10-29 B D Medico S.a.r.l. Injektionsgerät
DE4419235C2 (de) 1994-06-01 1999-03-11 Thomas Braeger Injektionsspritze mit einem Aufnahmebehälter
AU1595395A (en) 1994-06-15 1996-01-05 Interventional Research Technologies, Inc. Locking device for syringe or like instrument
US5827232A (en) 1994-06-22 1998-10-27 Becton Dickinson And Company Quick connect medication delivery pen
US5725508A (en) 1994-06-22 1998-03-10 Becton Dickinson And Company Quick connect medication delivery pen
US5720733A (en) 1994-07-22 1998-02-24 Raya Systems, Inc. Apparatus for determining and recording injection doses in syringes using electrical capacitance measurements
US6110148A (en) 1994-07-22 2000-08-29 Health Hero Network, Inc. Capacitance-based dose measurements in syringes
US5496286A (en) 1994-08-17 1996-03-05 Sterling Winthrop Hypodermic syringe holder with disposable body
US5440976A (en) 1994-08-23 1995-08-15 Fred Giuliano Adjustable dispensing stirrer for soluble sweeteners
WO1996005878A1 (en) 1994-08-24 1996-02-29 Eli Lilly Japan Kabushiki Kaisha Injection apparatus
GB9418122D0 (en) 1994-09-08 1994-10-26 Owen Mumford Ltd Improvements relating to injection devices
US5549575A (en) 1994-09-13 1996-08-27 Becton Dickinson And Company Cartridge retainer assembly for medication delivery pen
US5582598A (en) 1994-09-19 1996-12-10 Becton Dickinson And Company Medication delivery pen with variable increment dose scale
WO1996008974A1 (en) 1994-09-20 1996-03-28 Novo Nordisk A/S Method for treating an aqueous protein solution to kill microorganisms therein without causing coagulation
ZA958073B (en) 1994-09-28 1996-04-23 Anthony William Manicom Method of and apparatus for administering a drug to a patient
US5533970A (en) 1994-09-28 1996-07-09 Becton, Dickinson And Company Retractable needle syringe
US5512549A (en) 1994-10-18 1996-04-30 Eli Lilly And Company Glucagon-like insulinotropic peptide analogs, compositions, and methods of use
US5637095A (en) 1995-01-13 1997-06-10 Minimed Inc. Medication infusion pump with flexible drive plunger
DE19503230A1 (de) 1995-02-02 1996-08-08 Dietmar Dr Med Enk Spritze mit einer in den Kolben integrierten Dämpfungs- und Druckmeßeinrichtung und Verfahren zur vergleichmäßigten und druckkontrollierten Injektion mittels dieser Spritze
GB9503969D0 (en) 1995-02-28 1995-04-19 Sams Bernard Incrementing mechanism
CA2213682C (en) 1995-03-07 2009-10-06 Eli Lilly And Company Recyclable medication dispensing device
JP3017167U (ja) 1995-04-19 1995-10-24 澄夫 中川 残存時間表示腕時計
GB2309644B (en) 1995-05-22 2000-05-31 Wolfgang Wagner A method and device for diagnosis and injection
PL181217B1 (pl) 1995-06-02 2001-06-29 Novo Nordisk As Strzykawka
US5700904A (en) 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder
DE29513214U1 (de) 1995-08-21 1997-01-02 Adamaszek, Franz-Heinz, 70193 Stuttgart Dosier- und automatisches Injektionssystem
US5779675A (en) 1995-08-25 1998-07-14 Medrad, Inc. Front load pressure jacket system with syringe holder
AU1860697A (en) 1995-09-08 1997-07-28 Visionary Medical Products Corporation Pen-type injector drive mechanism
US5688251A (en) 1995-09-19 1997-11-18 Becton Dickinson And Company Cartridge loading and priming mechanism for a pen injector
US5674204A (en) 1995-09-19 1997-10-07 Becton Dickinson And Company Medication delivery pen cap actuated dose delivery clutch
US5989221A (en) 1995-10-20 1999-11-23 Pharmacia & Upjohn Ab Arrangement in electronically controlled injection devices
US6159161A (en) 1995-10-20 2000-12-12 Hodosh; Milton Microprocessor-controlled fluid dispensing apparatus
US5807334A (en) 1995-10-20 1998-09-15 Hodosh; Milton Fluid dispensing apparatus
US5741211A (en) 1995-10-26 1998-04-21 Medtronic, Inc. System and method for continuous monitoring of diabetes-related blood constituents
FR2740345A1 (fr) 1995-10-26 1997-04-30 Neftel Frederic Dispositif d'automedication
US5899879A (en) 1995-12-19 1999-05-04 Genesis Medical Technologies, Inc. Spring-actuated needleless injector
JPH09166474A (ja) 1995-12-19 1997-06-24 Omron Corp 残量センサ
US5628309A (en) 1996-01-25 1997-05-13 Raya Systems, Inc. Meter for electrically measuring and recording injection syringe doses
US5814022A (en) 1996-02-06 1998-09-29 Plasmaseal Llc Method and apparatus for applying tissue sealant
BR9707598A (pt) 1996-02-23 1999-07-27 Novo Nordisk As Seringa
FR2745637B1 (fr) 1996-03-04 1998-05-22 Motorola Semiconducteurs Dispositif capteur chimique a semiconducteur et procede de formation d'un thermocouple pour ce dispositif
CN1177623C (zh) 1996-03-12 2004-12-01 诺沃挪第克公司 带有预定剂量的电子显示的注射装置
US20010016571A1 (en) 1996-03-13 2001-08-23 Fujisawa Pharmaceutical Co., Ltd. N-[ (R) -1-{3- (4- piperidyl) propionyl } -3-piperidylcarbonyl] -2 (S) -acetylamino-beta -alanine as fibrinogen receptor antagonist
JP2000506534A (ja) 1996-03-15 2000-05-30 ノボ ノルディスク アクティーゼルスカブ タンパク質含有溶液からのタンパク質の精製方法
PT831947E (pt) 1996-04-02 2003-02-28 Disetronic Licensing Ag Dispositivo de injeccao
US6086567A (en) 1996-04-02 2000-07-11 Disetronic Licensing Ag Injection device
DE29606540U1 (de) 1996-04-10 1997-08-07 Mühlbauer, Ernst, 22547 Hamburg Applikationsgerät für Dentalmasse
ES2152662T3 (es) 1996-04-24 2001-02-01 Novo Nordisk As Aguja para inyeccion.
ATE286756T1 (de) 1996-07-05 2005-01-15 Novo Nordisk As Biegsame kolbenstange
DE69724784T2 (de) 1996-07-05 2004-07-15 Novo Nordisk A/S Vorrichtung zur automatischen einführung einer nadel
CZ433798A3 (cs) 1996-07-05 1999-05-12 Novo Nordisk A/S Dávkovací zařízení
DE19632402C1 (de) 1996-08-02 1998-04-09 Schering Ag Verfahren zur Herstellung einer vorgefüllten, sterilen Spritze
US5709662A (en) 1996-08-23 1998-01-20 Becton Dickinson France, S.A. Cartridge for an injection device
US5843036A (en) 1996-08-23 1998-12-01 Becton Dickinson And Company Non-dosing cartridge for an injection device
CN1145500C (zh) 1996-09-13 2004-04-14 诺沃挪第克公司 注射器的剂量指示器
US6110149A (en) 1996-09-13 2000-08-29 Novo Nordisk A/S Syringe
US5947934A (en) 1996-09-13 1999-09-07 Novo Nordisk A/S Dose display for an injection syringe
US6379339B1 (en) 1996-09-13 2002-04-30 Nova Nordisk A/S Syringe
US5830194A (en) 1996-09-20 1998-11-03 Azam Anwar Power syringe
US6030368A (en) 1996-09-20 2000-02-29 Azam Anwar Power syringe having a base and a lever
ES2169380T3 (es) 1996-09-20 2002-07-01 Novo Nordisk As Cilindro de maniobra.
US6146361A (en) 1996-09-26 2000-11-14 Becton Dickinson And Company Medication delivery pen having a 31 gauge needle
US5954689A (en) 1996-12-20 1999-09-21 Novo Nordisk A/S Jet injector
GB2321419B (en) 1997-01-27 2001-02-07 Medic Aid Ltd Atomizer
EP0971760A1 (en) 1997-02-04 2000-01-19 Novo Nordisk A/S A device for the administration of a liquid medicament suspension
DE29703820U1 (de) 1997-03-03 1998-07-02 Medico Development Investment Co., Ascona Injektionsgerät
US5898028A (en) 1997-03-20 1999-04-27 Novo Nordisk A/S Method for producing powder formulation comprising an insulin
US20010020155A1 (en) 1997-03-25 2001-09-06 Soren Mikkelsen Injection system
RU2111019C1 (ru) 1997-05-22 1998-05-20 Сергей Александрович Хворостов Универсальный инъектор
DE19723647C1 (de) 1997-06-05 1998-12-24 Disetronic Licensing Ag Rücksetzbare Anzeigeeinrichtung einer Vorrichtung zur dosierten Abgabe eines Medikamentfluids
US6003736A (en) 1997-06-09 1999-12-21 Novo Nordisk A/S Device for controlled dispensing of a dose of a liquid contained in a cartridge
US6074372A (en) 1997-06-09 2000-06-13 Novo Nordisk A/S Dose setting mechanism and an injection syringe having such a dose setting mechanism
US5961496A (en) 1997-06-17 1999-10-05 Novo Nordisk A/S Syringe with tiltable nut for quick piston disengagement
US6796970B1 (en) 1997-06-17 2004-09-28 Novo Nordisk A/S Dose setting device
WO1999002210A1 (en) 1997-07-11 1999-01-21 Novo Nordisk A/S An apparatus for the registration of the setting of a medical device
EP0996476B1 (en) 1997-07-14 2003-05-21 Novo Nordisk A/S Cylinder ampoule
EP0996477B1 (en) 1997-07-14 2004-01-14 Novo Nordisk A/S Injection member
DE19730999C1 (de) 1997-07-18 1998-12-10 Disetronic Licensing Ag Dosierknopfsicherung an einer Vorrichtung zur dosierten Verabreichung eines injizierbaren Produkts
SE9702872D0 (sv) 1997-08-06 1997-08-06 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US6171276B1 (en) 1997-08-06 2001-01-09 Pharmacia & Upjohn Ab Automated delivery device and method for its operation
US5921966A (en) 1997-08-11 1999-07-13 Becton Dickinson And Company Medication delivery pen having an improved clutch assembly
FR2767479B1 (fr) 1997-08-22 1999-10-22 Aguettant Lab Dispositif d'injection de medicament
AU9202398A (en) 1997-09-29 1999-04-23 Becton Dickinson & Company Injection device and drug cartridge for preventing cross-use of the device and drug cartridge
CH692543A5 (de) 1997-09-25 2002-07-31 Disetronic Licensing Ag Abgabevorrichtung mit Signalgeber.
US5896789A (en) 1997-10-09 1999-04-27 Chicago Pneumatic Tool Company Ratchet wrench head
US6312413B1 (en) 1997-10-30 2001-11-06 Novo Nordisk A/S Cylinder ampoule
US5954700A (en) 1998-01-13 1999-09-21 Minimed Inc. Medication cartridge for an electronic pen-type injector, or the like, and method of making the same
KR100574630B1 (ko) 1998-01-30 2006-04-27 노보 노르디스크 에이/에스 주입 주사기
EP1061987B1 (en) 1998-02-13 2006-05-17 Bioniche Life Sciences Inc. Drug delivery system
US6221053B1 (en) 1998-02-20 2001-04-24 Becton, Dickinson And Company Multi-featured medication delivery pen
US5961495A (en) 1998-02-20 1999-10-05 Becton, Dickinson And Company Medication delivery pen having a priming mechanism
US6248095B1 (en) 1998-02-23 2001-06-19 Becton, Dickinson And Company Low-cost medication delivery pen
JP3436683B2 (ja) 1998-03-17 2003-08-11 株式会社日立ユニシアオートモティブ 回動角検出装置
WO1999048546A1 (en) 1998-03-23 1999-09-30 Elan Corporation, Plc Drug delivery device
US6391005B1 (en) 1998-03-30 2002-05-21 Agilent Technologies, Inc. Apparatus and method for penetration with shaft having a sensor for sensing penetration depth
DE19822031C2 (de) 1998-05-15 2000-03-23 Disetronic Licensing Ag Autoinjektionsgerät
US6281225B1 (en) 1998-06-11 2001-08-28 Cerus Corporation Inhibiting proliferation of arterial smooth muscle cells
GB9812472D0 (en) 1998-06-11 1998-08-05 Owen Mumford Ltd A dose setting device for medical injectors
AU4565299A (en) 1998-06-15 2000-01-05 Medrad, Inc. Encoding of syringe information
US6743202B2 (en) 1998-06-15 2004-06-01 Medrad, Inc. Encoding of syringe information
US5933671A (en) 1998-07-07 1999-08-03 Eastman Kodak Company Camera with touch sensitive switch
PL345336A1 (en) 1998-07-08 2001-12-17 Novo Nordisk As A medical delivery device and a cartridge assembly for use in the same
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US5993423A (en) 1998-08-18 1999-11-30 Choi; Soo Bong Portable automatic syringe device and injection needle unit thereof
DE19838760A1 (de) 1998-08-26 2000-04-20 Bauer Jlona Injektionsgerät zur Applikation von flüssigen Substanzen
CN1317967A (zh) 1998-09-17 2001-10-17 伊莱利利公司 蛋白质制剂
US6033376A (en) 1998-09-30 2000-03-07 Allergan Sales, Inc. Wound shaper sleeve
US6605067B1 (en) 1998-11-20 2003-08-12 Novo Nordisk A/S Injection needle
DK1140148T3 (da) 1998-12-22 2006-01-30 Lilly Co Eli Lagerholdbar formulering af glucagon-agtigt peptid-1
EP1144029A1 (en) 1998-12-22 2001-10-17 Alcor Medical Instruments Method and device for monitoring fluid level
DE19900792C1 (de) 1999-01-12 2000-06-15 Disetronic Licensing Ag Vorrichtung zur Verabreichung eines injizierbaren Produkts
DE29900482U1 (de) 1999-01-14 2000-08-31 Medico Development Investment Co., Ascona Injektionsgerät
US6036675A (en) 1999-02-03 2000-03-14 Specialized Health Products, Inc. Safety sterile cartride unit apparatus and methods
JP2000237308A (ja) 1999-02-22 2000-09-05 Ckd Corp 輸液ポンプ
US6258062B1 (en) 1999-02-25 2001-07-10 Joseph M. Thielen Enclosed container power supply for a needleless injector
DE19909602A1 (de) 1999-03-05 2000-09-07 Roche Diagnostics Gmbh Gerät zur Entnahme von Blut für Diagnosezwecke
WO2000051668A1 (en) 1999-03-05 2000-09-08 Accumed Systems, Inc. High pressure syringe
US6245046B1 (en) 1999-05-03 2001-06-12 University Of New Mexico Reciprocating syringes
SE9901736D0 (sv) 1999-05-12 1999-05-12 Pharmacia & Upjohn Ab Injectino device and method for ITS operation
JP4290366B2 (ja) 1999-08-05 2009-07-01 ベクトン・ディキンソン・アンド・カンパニー 薬剤送出ペン
US6277099B1 (en) 1999-08-06 2001-08-21 Becton, Dickinson And Company Medication delivery pen
TW453884B (en) 1999-09-16 2001-09-11 Novo Nordisk As Dose setting limiter
MXPA02003671A (es) 1999-10-12 2002-08-30 Novo Nordisk As Mecanismo de disparo con aire comprimido para dispositivos de inyeccion electronica.
US6514230B1 (en) 1999-10-12 2003-02-04 Novo Nordisk A/S Air shot mechanism for electronic injection devices
CN1236826C (zh) 1999-10-22 2006-01-18 安塔雷斯制药公司 医用注射器以及用于该注射器中的药物装载系统
US6585698B1 (en) 1999-11-01 2003-07-01 Becton, Dickinson & Company Electronic medical delivery pen having a multifunction actuator
US6673033B1 (en) 1999-11-24 2004-01-06 Medrad, Inc. Injectors, injector systems and injector control
WO2001060311A1 (de) 2000-02-16 2001-08-23 B D Medico S.A.R.L. Verfahren zur rekonstitution einer injektionsflüssigkeit, und injektionsgerät zur durchführung eines solchen verfahrens
GB0007071D0 (en) 2000-03-24 2000-05-17 Sams Bernard One-way clutch mechanisms and injector devices
US6485465B2 (en) 2000-03-29 2002-11-26 Medtronic Minimed, Inc. Methods, apparatuses, and uses for infusion pump fluid pressure and force detection
DE10018827A1 (de) 2000-04-15 2001-10-25 Vetter & Co Apotheker Spritze für medizinische Zwecke
US6558382B2 (en) 2000-04-27 2003-05-06 Medtronic, Inc. Suction stabilized epicardial ablation devices
US6692472B2 (en) 2000-05-04 2004-02-17 Novo Nordisk A/S Injection device, a preassembled dose setting and injection mechanism for an injection device, and a method of assembling an injection device
US6547763B2 (en) 2000-05-18 2003-04-15 Novo Nordisk A/S Dose display for injection device
US6716198B2 (en) 2000-05-18 2004-04-06 Novo Nordisk A/S Injection device
US6547764B2 (en) 2000-05-31 2003-04-15 Novo Nordisk A/S Double pointed injection needle
US6663602B2 (en) 2000-06-16 2003-12-16 Novo Nordisk A/S Injection device
EP1409042B1 (en) 2000-07-14 2008-02-20 Novo Nordisk A/S A liquid medication delivery device and a method of reducing dripping
BR0112825A (pt) 2000-07-28 2003-07-01 Mdc Invest Holdings Inc Processo para injetar medicamento a partir de um dispositivo médico que tem uma agulha com uma ponta afiada, e, dispositivo médico
WO2002011629A1 (de) 2000-08-10 2002-02-14 Synthes Ag Chur Vorrichtung zum einführen von medizinischen mitteln
US6994261B2 (en) 2000-08-10 2006-02-07 Novo Nirdisk A/S Support for a cartridge for transferring an electronically readable item of information from the cartridge to an electronic circuit
WO2002024257A1 (en) 2000-09-22 2002-03-28 Novo Nordisk A/S A medication delivery device
JP4975208B2 (ja) 2000-10-03 2012-07-11 株式会社根本杏林堂 自動注入装置
US6537251B2 (en) 2000-10-05 2003-03-25 Novo Nordisk A/S Medication delivery device with bended piston rod
US7500959B2 (en) 2000-10-05 2009-03-10 Novo Nordisk A/S Medication delivery system with improved dose accuracy
WO2002055127A2 (en) 2000-11-24 2002-07-18 Ckm Diagnostics, Inc. Nerve stimulator output control needle with depth determination capability and method of use
CA2710367C (en) 2000-12-21 2012-09-11 Rentech, Inc. Biomass gasification system and method
US6461328B2 (en) 2000-12-21 2002-10-08 Uniqsafe Medical Technology Group Ltd. Safety syringe
US6599323B2 (en) 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
US6899699B2 (en) 2001-01-05 2005-05-31 Novo Nordisk A/S Automatic injection device with reset feature
EP2319565A3 (en) 2001-02-14 2013-07-17 Novo Nordisk A/S Electronically controlled device
GB0107601D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to and injection device
GB0107607D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to an injection device
GB0107600D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to an injection device
GB0107604D0 (en) 2001-03-27 2001-05-16 Dca Design Int Ltd Improvements in and relating to injection device
US6854620B2 (en) 2001-04-13 2005-02-15 Nipro Diabetes, Systems, Inc. Drive system for an infusion pump
DE60218452T2 (de) 2001-05-16 2007-11-15 Eli Lilly And Co., Indianapolis Arzneimitteleinspritzvorrichtung mit rückstellung erleichternder antriebsanordnung
GB0113881D0 (en) 2001-06-07 2001-08-01 Innovate Biomed Ltd Foil cutting system
US6752781B2 (en) 2001-06-08 2004-06-22 Sergio Landau Durable hypodermic jet injector apparatus and method
US7080936B1 (en) 2001-06-13 2006-07-25 Simpson Frank B Wrap spring clutch syringe ram and frit mixer
DE10133216B4 (de) 2001-07-09 2005-01-27 Tecpharma Licensing Ag Positionsdetektion
DE10163326A1 (de) 2001-07-30 2003-02-27 Disetronic Licensing Ag Verabreichungsgerät mit Dosiervorrichtung
US7235063B2 (en) 2001-08-21 2007-06-26 D'antonio Consultants International, Inc. Hypodermic injection system
DK200100240U3 (da) 2001-09-18 2001-11-23 Niels Tessing Hvidløgsknuser
EP2319564B1 (en) 2001-12-13 2013-07-17 Panasonic Corporation Administration instrument for medical use
GB0130138D0 (en) 2001-12-18 2002-02-06 Dca Design Int Ltd Improvements in an relating to a medicament injection apparatus
DE20209051U1 (de) 2001-12-21 2003-04-24 Disetronic Licensing Ag, Burgdorf Injektionsgerät mit endpositionsblockiertem Dosiseinstellglied
GB0200444D0 (en) 2002-01-10 2002-02-27 Owen Mumford Ltd Improvements relating to medical injection devices
GB0200637D0 (en) 2002-01-12 2002-02-27 Dca Design Int Ltd Improvements in and relating to medicament injection apparatus
DE10201875C1 (de) 2002-01-18 2003-05-22 Austriamicrosystems Ag Sensorsystem und Verfahren zum Betrieb des Sensorsystems
US7169107B2 (en) 2002-01-25 2007-01-30 Karen Jersey-Willuhn Conductivity reconstruction based on inverse finite element measurements in a tissue monitoring system
EP1490031A1 (en) 2002-03-07 2004-12-29 Vectura Limited Fast melt multiparticulate formulations for oral delivery
JP4350525B2 (ja) 2002-03-18 2009-10-21 イーライ リリー アンド カンパニー 機械的利点を与えるギヤーセット付き薬剤分与装置
JP4064138B2 (ja) 2002-03-28 2008-03-19 スーガン株式会社 医療用チューブ開閉装置
US20040010204A1 (en) 2002-03-28 2004-01-15 Pearl Technology Holdings, Llc Electronic/fiberoptic tissue differentiation instrumentation
JP2003296915A (ja) 2002-03-29 2003-10-17 Tdk Corp 磁気記録媒体
AU2003233504A1 (en) 2002-05-24 2003-12-12 Eli Lilly And Company Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism
DE10226643A1 (de) 2002-06-14 2004-01-15 Disetronic Licensing Ag Kolbenstopfen für Injektionsvorrichtung, Produktbehälter und Injektionsvorrichtung
DE10229122B4 (de) 2002-06-28 2006-09-07 Tecpharma Licensing Ag Verabreichungsgerät mit rücksetzbarer Betätigungssperre
US7328064B2 (en) 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
US6945961B2 (en) 2002-07-10 2005-09-20 Novo Nordisk A/S Injection device
JP2005532129A (ja) 2002-07-10 2005-10-27 ノボ・ノルデイスク・エー／エス 投与量設定リミッタを備える注入器
EP1536853A1 (en) 2002-07-10 2005-06-08 Novo Nordisk A/S An injection device
EP1391794A1 (en) 2002-07-23 2004-02-25 Novo Nordisk A/S Device with time indicating means
US6929619B2 (en) 2002-08-02 2005-08-16 Liebel-Flarshiem Company Injector
DE10237258B4 (de) 2002-08-14 2006-09-21 Tecpharma Licensing Ag Injektionsvorrichtung
WO2004020026A1 (en) 2002-08-29 2004-03-11 Novo Nordisk A/S Frontloaded injection device
DE10240165A1 (de) 2002-08-30 2004-03-18 Disetronic Licensing Ag Vorrichtung zum dosierten Ausstoßen eines flüssigen Wirkstoffes und Infusionspumpe
DE10240166A1 (de) 2002-08-30 2004-03-18 Disetronic Licensing Ag Vorrichtung zur kontrollierten Ausschüttung einer injizierbaren Flüssigkeit
US20040051368A1 (en) 2002-09-17 2004-03-18 Jimmy Caputo Systems and methods for programming pumps
ATE434455T1 (de) 2002-09-24 2009-07-15 Shl Group Ab Injektionsvorrichtung
CN1684674B (zh) 2002-09-26 2012-05-30 独立行政法人科学技术振兴机构 粘膜组织收缩性治疗剂、注射器及治疗装置
AU2003279714A1 (en) 2002-10-15 2004-05-04 Eli Lilly And Company Medication dispensing apparatus with squeezable actuator
GB0229345D0 (en) 2002-12-17 2003-01-22 Safe T Ltd Hollow needle applicators
WO2004066939A2 (en) 2003-01-27 2004-08-12 Sarnoff Corporation Controlled-release drug delivery system
US8016798B2 (en) 2003-02-24 2011-09-13 Integrated Sensing Systems, Inc. Fluid delivery system and sensing unit therefor
GB0304824D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304823D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
GB0304822D0 (en) 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
US20060178573A1 (en) 2003-03-06 2006-08-10 Kermani Mahyar Z System and method for piercing dermal tissue
GB0306642D0 (en) 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
ATE402688T1 (de) 2003-03-24 2008-08-15 Novo Nordisk As Transparentes elektronisches markieren eines medikamentenbehälters
US6932794B2 (en) 2003-04-03 2005-08-23 Becton, Dickinson And Company Medication delivery pen
GB0308267D0 (en) 2003-04-10 2003-05-14 Dca Design Int Ltd Improvements in and relating to a pen-type injector
AU2004232865A1 (en) 2003-04-23 2004-11-04 Vasogen Ireland Limited Dispensing systems
US7641668B2 (en) 2003-05-16 2010-01-05 Scimed Life Systems, Inc. Fluid delivery system and related methods of use
FR2857654B1 (fr) 2003-07-16 2007-04-27 Prodonta Dispositif d'ejection d'un produit liquide ou pateux
ES2721548T3 (es) 2003-08-12 2019-08-01 Lilly Co Eli Aparato de dispensado de medicamentos con roscas de tornillo triples para una ventaja mecánica
US7708732B2 (en) 2003-10-16 2010-05-04 Nps Pharmaceuticals, Inc. Methods of administering therapeutic injections
DK1689471T3 (da) 2003-10-16 2007-10-01 Lilly Co Eli Medikamentdispenseringsanordning med fast dosis
DE20317377U1 (de) 2003-11-03 2005-03-17 B D Medico S A R L Injektionsgerät
EP1541185A1 (en) 2003-12-08 2005-06-15 Novo Nordisk A/S Automatic syringe with priming mechanism
CN103143079B (zh) 2004-03-03 2016-09-28 株式会社根本杏林堂 药液注入系统
GB0406088D0 (en) 2004-03-18 2004-04-21 Smiths Group Plc Infusion apparatus and methods
CN100581607C (zh) 2004-03-30 2010-01-20 伊莱利利公司 具有由最终药剂的给药激活的弹簧驱动锁定零件的药物分配设备
DK1732629T3 (da) 2004-03-30 2019-06-17 Lilly Co Eli Lægemiddelafgivelsesanordning med fjederdrevet låseegenskab, der aktiveres ved administration af endelig dosis
DE202004006611U1 (de) 2004-04-23 2005-08-25 Tecpharma Licensing Ag Injektionsgerät zur Verabreichung eines injizierbaren Produkts mit gesicherter Dosiereinrichtung
GB2414399B (en) 2004-05-28 2008-12-31 Cilag Ag Int Injection device
US7448385B2 (en) 2004-06-07 2008-11-11 Purepharm Inc. Nasal adaptation of an oral inhaler device
CN100563738C (zh) 2004-07-05 2009-12-02 诺和诺德公司 具有信用卡尺寸的注射装置
JP4925828B2 (ja) 2004-07-14 2012-05-09 株式会社根本杏林堂 薬液注入システム
CA2583428A1 (en) 2004-09-03 2006-03-09 Plexxikon, Inc. Bicyclic heteroaryl pde4b inhibitors
DE102004046003A1 (de) 2004-09-17 2006-03-30 Arzneimittel Gmbh Apotheker Vetter & Co. Ravensburg Pharmazeutisches Packmittel und Verfahren zu dessen Herstellung
CA2582976C (en) 2004-10-04 2013-10-29 Sanofi-Aventis Deutschland Gmbh Drive mechanism for a drug delivery device
EP1645301A1 (en) 2004-10-11 2006-04-12 Novo Nordisk A/S Injection device
JP4964136B2 (ja) 2004-10-14 2012-06-27 ノボ・ノルデイスク・エー／エス 用量設定機構を備えた注射器
ATE452671T1 (de) 2004-10-21 2010-01-15 Novo Nordisk As Injektionsvorrichtung mit einem prozessor zur sammlung von ausstossinformationen
AU2005298944B2 (en) 2004-10-21 2010-12-23 Novo Nordisk A/S Dial-down mechanism for wind-up pen
JP4990151B2 (ja) 2004-10-21 2012-08-01 ノボ・ノルデイスク・エー／エス 内部投与量表示器を備えた注射器
CN101084028B (zh) 2004-10-21 2010-06-09 诺和诺德公司 具有扭转弹簧和可旋转显示器的注射设备
ITVR20040168A1 (it) 2004-10-25 2005-01-25 C M Tecnologie S R L Selettore, particolarmente ma non esclusivamente per distributori automatici di bevande
WO2006052737A1 (en) 2004-11-04 2006-05-18 Sid Technologies, Llc Automatic injector
DE102004063644A1 (de) 2004-12-31 2006-07-20 Tecpharma Licensing Ag Vorrichtung zur dosierten Verabreichung eines fluiden Produkts mit Drehfederantrieb
CA2594764C (en) 2005-01-21 2014-01-14 Novo Nordisk A/S An automatic injection device with a top release mechanism
JP2006250582A (ja) 2005-03-08 2006-09-21 Hitachi Plant Technologies Ltd 荷重センサ付きｒｆｉｄタグ
JP4979686B2 (ja) 2005-04-24 2012-07-18 ノボ・ノルデイスク・エー／エス 注入デバイス
WO2006114395A1 (en) 2005-04-24 2006-11-02 Novo Nordisk A/S An injection device with a gearbox
WO2006116997A1 (en) 2005-04-29 2006-11-09 Novo Nordisk A/S Handheld injection device with integrated force sensor
DK200500116U3 (da) 2005-05-23 2005-06-24 Novo Nordisk As Motordrevet injektionsapparat
CN101184519B (zh) 2005-05-31 2011-08-31 诺和诺德公司 带有可视的内容物排空指示的注射装置
DE602005008404D1 (de) 2005-06-01 2008-09-04 Shl Medical Ab Medikamentenabgabevorrichtung
US10220155B2 (en) 2005-07-27 2019-03-05 Novo Nordisk A/S Syringe device with a dose limiting mechanism and an additional safety mechanism
NO332933B1 (no) 2005-08-18 2013-02-04 Rolls Royce Marine As System for håndtering av en wire, kjetting og kabel ombord på et fartøy
US20090043253A1 (en) 2005-10-11 2009-02-12 Blake Podaima Smart medical compliance method and system
GB0524604D0 (en) 2005-12-02 2006-01-11 Owen Mumford Ltd Injection method and apparatus
US20070167916A1 (en) 2006-01-16 2007-07-19 Linfair Engineering (Hk) Co., Ltd. Outer barrel for a syringe
JP5183499B2 (ja) 2006-03-10 2013-04-17 ノボ・ノルデイスク・エー／エス 注射装置
WO2007104636A1 (en) 2006-03-10 2007-09-20 Novo Nordisk A/S An injection device and a method of changing a cartridge in the device
CN101405582B (zh) 2006-03-20 2012-09-05 诺沃—诺迪斯克有限公司 通过电容装置测定套筒容量
US9008764B2 (en) 2006-03-20 2015-04-14 Novo Nordisk A/S Determination of position of injection needle
DE602007004972D1 (de) 2006-05-16 2010-04-08 Novo Nordisk As Getriebemechanismus für ein injektionsgerät
WO2008003130A1 (en) 2006-07-05 2008-01-10 Kaliopi Papantoniou A method and composition for treating the scalp
US8052655B2 (en) 2006-09-29 2011-11-08 Novo Nordisk A/S Injection device with electronic detecting means
US8133198B2 (en) 2006-10-26 2012-03-13 Mallinckrodt Llc Medical fluid injector having a thermo-mechanical drive
US7621842B2 (en) 2007-02-14 2009-11-24 Shimano Inc. Bicycle hub assembly
DE102007016811A1 (de) * 2007-04-05 2008-10-09 Tecpharma Licensing Ag Vorrichtung zur Verabreichung eines fluiden Wirkstoffes aus einer Mehrkammerampulle
US20080306443A1 (en) 2007-06-06 2008-12-11 Mallinckrodt Inc. Medical Fluid Injector Having Wireless Pressure Monitoring Feature
US8992484B2 (en) 2008-01-23 2015-03-31 Novo Nordisk A/S Device for injecting apportioned doses of liquid drug
AT506690B1 (de) * 2008-06-16 2009-11-15 Pharma Consult Ges M B H & Co Injektionsvorrichtung
PL215310B1 (pl) * 2009-10-30 2013-11-29 Kappa Medilab Spolka Z Ograniczona Odpowiedzialnoscia Automatyczny aplikator, zwlaszcza do insuliny
EP2438940A1 (en) * 2010-10-08 2012-04-11 Sanofi-Aventis Deutschland GmbH Auto injector with a torsion spring
GB2484490A (en) 2010-10-12 2012-04-18 Owen Mumford Ltd Frangible needle shield for syringe
MX2014013842A (es) * 2012-05-31 2015-02-18 Novo Nordisk As Mecanismo de seleccion descendente para pluma giratoria ascendente.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080306445A1 (en) * 2005-09-14 2008-12-11 Stefan Burren Injection device with a two-way slip coupling
WO2008031239A1 (de) * 2006-09-15 2008-03-20 Tecpharma Licensing Ag Injektionsgerät mit mehreren kupplungen
WO2010046394A1 (en) * 2008-10-24 2010-04-29 Novo Nordisk A/S Dial-down mechanism for wind-up pen
WO2011025448A1 (en) * 2009-08-24 2011-03-03 Shl Group Ab Dose reset mechanism
WO2011136718A1 (en) * 2010-04-26 2011-11-03 Shl Group Ab Medicament delivery device

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MX2014007375A (es) 2014-08-22
AU2012361001A1 (en) 2014-06-26
BR112014016148A8 (pt) 2017-07-04
WO2013098194A3 (en) 2013-09-06
RU2014128518A (ru) 2016-02-20
JP2015503377A (ja) 2015-02-02
CN103998077A (zh) 2014-08-20
WO2013098194A2 (en) 2013-07-04
CA2861706A1 (en) 2013-07-04
JP6069351B2 (ja) 2017-02-01
US9533106B2 (en) 2017-01-03
EP2797650A2 (en) 2014-11-05
US20140350478A1 (en) 2014-11-27

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