CN103957879B - Composition for oral cavity - Google Patents

Abstract

The present invention provides a kind of gloss of dental surface and maintains effect and the excellent composition for oral cavity that bubbles.The composition for oral cavity is characterised by, contains (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) betaine type amphoteric surfac-tant and (D) xanthans.

Description

Composition for oral cavity

Technical field

Effect is maintained the present invention relates to a kind of gloss of dental surface and the excellent composition for oral cavity that bubbles.

Background technology

The brightness for maintaining tooth is one of major subjects of stomatologic esthetics.It is uneven by the micro concavo-convex for removing dental surface The external coloring factor formed with removal by food pigment etc., can maintain the brightness of tooth.For the uneven of dental surface Remove, although can be carried out by the mechanism of grinding agent, but presence will reduce the harmfulness to soft part in the oral cavities such as gum Such problem.Therefore, if in view of taken into account with use feeling, in the maintenance of tooth brightness, color stain is removed etc. it is outer The control of the color factor is important.

, can be identical with the uneven removal of the micro concavo-convex of dental surface for the removal of color stain, made by the machinery of grinding agent With and carry out, its problem is also same as described above.So far, applicant is in (the Japanese Patent Laid-Open 2002-47161 of patent document 1 Number publication) in propose the combination for removing flank of tooth spot by chemical action not against mechanism using Phenoxyethanol etc. Thing.As the composition containing geared surface, the Phenoxyethanol of lingual surface chemically cleaning base in patent document 1, describe in example 4 It is mixed with the mass % of N- sodium lauroyl glutamates 0.2, the mass % of lauroyl Sodium Glycinate 0.1, the matter of NaLS 1.0 Measure %, the mass % of tetrasodium pyrophosphate 4.0 and the mass % of sodium tripolyphosphate 1.5 liquid Dentrifice composition.But, although expect High gloss maintains effect in the embodiment, but stimulates strong, and use feeling also has room for improvement.

In addition, being used as the use true feeling for the composition for oral cavity for improving taste, it is desirable to which foaming is good.Helped as strength Useful composition is maintained in foaming and gloss, can be anionic surfactant, specifically, acylamino acid as is known Salt, alkyl sulfate.

But, although acylamino acid salt contributes to gloss to maintain effect and foaming good, but with the same of unique peculiar smell When, its lather quickness is individually difficult to obtain satisfied use feeling than alkylsurfuric acid salt error during mixing.On the other hand, although alkyl The gloss of sulfate maintains effect, lather quickness and foaming good, but compared with acyl amino hydrochlorate, it is present to oral mucosa The problem of stimulating strong.

According to the above, although it is believed that acyl amino hydrochlorate and alkyl sulfate and with being effective, but in such case Under, if increasing the combined amount of both compositions to improve effect, there is the peculiar smell and alkyl sulfate of acyl amino hydrochlorate Stimulation as problem.

Prior art literature

Patent document

Patent document 1：Japanese Patent Laid-Open 2002-47161 publications

The content of the invention

Invent problem to be solved

Thus, in the prior art in the presence of various problems as described above, it is difficult to give and take into account gloss maintenance effect and use The preparation of sense.Therefore, in composition for oral cavity, the gloss for taking into account dental surface maintains effect and use feeling just to turn into problem.

The invention that the present invention is in view of the foregoing and made, effect is maintained its object is to the gloss for providing a kind of dental surface Fruit and the excellent composition for oral cavity that bubbles.

The means solved the problems, such as

In order to achieve the above object, the present inventor has found through wholwe-hearted result of study, by mix (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) betaine type amphoteric surfac-tant and (D) xanthans, can obtain the gloss maintenance in dental surface The well upper excellent composition for oral cavity of effect and foaming.It has furthermore been found that the composition for oral cavity free from extraneous odour and stimulation, are used Sense is good.

In the present invention, by by composition (A) and (B) and use and combination be mixed into (C) and (D), can take into account and be drawn by chemical action The gloss of the dental surface risen maintains effect and improves foaming effect, and particularly, be prepared into dentifrice is used for by toothbrush During tooth, by chemical action and mechanism, the external coloring factors such as the color stain that is formed by food pigment etc. can be removed, and give High gloss is given to maintain effect.

Therefore, the present invention provides following composition for oral cavity.

(1) a kind of composition for oral cavity, it is characterised in that contain (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) Betaine type amphoteric surfac-tant and (D) xanthans.

(2) composition for oral cavity as described in (1), wherein, (A) acyl amino hydrochlorate is selected from acyl glutamate, acyl One or more of base aspartate and acylglycine salt.

(3) composition for oral cavity as described in (2), wherein, (A) acyl amino hydrochlorate is acyl glutamate.

(4) composition for oral cavity as described in (1), (2) or (3), wherein, (C) betaine type amphoteric surfac-tant is Fatty acid amide propyl glycine betaine system or alkyl imidazoline glycine betaine system amphoteric surfactant.

(5) composition for oral cavity as described in (4), wherein, (C) betaine type amphoteric surfac-tant is coconut oil fat Sour amido propyl betaine.

(6) composition for oral cavity as any one of (1)~(5), wherein, composition (A) and (B) combined amount altogether For 0.2~5.5 mass %.

(7) composition for oral cavity as described in (6), wherein, the combined amount of composition (A) is 0.1~2 mass %, composition (B) Combined amount be 0.1~3.5 mass %.

(8) composition for oral cavity as any one of (1)~(7), wherein, contain the mass % of composition (C) 0.1~1 With the mass % of composition (D) 0.3~2.

(9) composition for oral cavity as any one of (1)~(8), wherein, the composition for oral cavity is prepared into clean Tooth agent.

(10) a kind of Dentrifice composition, it is characterised in that be selected from acyl glutamate, acyl group asparagine containing (A) The acyl amino hydrochlorate and (B) alkyl sulfate of one or more of hydrochlorate and acylglycine salt amount to 0.2~5.5 matter Measure %, (C) fatty acid amide propyl glycine betaine system or the matter of amphoteric surfactant 0.1~1 of alkyl imidazoline glycine betaine system Measure the % and mass % of (D) xanthans 0.3~2.

Invention effect

The gloss that the present invention can provide a kind of dental surface maintains effect and the excellent composition for oral cavity that bubbles.Enter one Step, said preparation free from extraneous odour and stimulation, use feeling are good.

Embodiment

Hereinafter, the present invention is discussed in further detail.The composition for oral cavity of the present invention, it is characterised in that contain (A) acyl amino hydrochlorate, (B) alkyl sulfate, (C) betaine type amphoteric surfac-tant and (D) xanthans.

As the acyl amino hydrochlorate of composition (A), the carbon number of its acyl group is suitably 8~20, and particularly suitable 12~16. In addition, for amino acid group, glutamic acid, aspartic acid, glycine, methyl amimoacetic acid, alanine, methionine, phenylpropyl alcohol ammonia can be enumerated Acid, leucine and isoleucine etc., more preferably particularly preferred glutamic acid, aspartic acid and glycine, glutamic acid.For the salt, The alkali metal salts such as sodium, potassium, alkali salt and organic amine salt etc. can be enumerated.

As acyl amino hydrochlorate, for example, N- lauroyls-L-sodium, N- myristoyl-L- paddy ammonia can be enumerated The acyl glutamates such as sour sodium, N- coco-nut oil fatty acids acyl group-Monopotassium L-Glutamate, the acyl such as N- lauroyls-L-Aspartic acid sodium Base aspartate, the acylglycine salt such as N- coco-nut oil fatty acid acylglycine potassium etc..These can be with one kind or by two kinds The mode of combination of the above is mixed.

Specifically, trade name AminoSurfact ALMS-P1 (N- lauroyls-L-sodiums, the rising sun can be used Be melted into KCC (ケ ミ カ Le ズ Co., Ltd. of Asahi Chemical Industry)), Amisoft LS-11 (N- lauroyls-Pidolidone Sodium, aginomoto health supply Co., Ltd. (monosodium glutamate ヘ ル シ ー サ プ ラ イ Co., Ltd.)), AminoSurfact AMMS- P1 (N- myristoyls-L-sodium, Asahi Chemical Corp), Amisoft MS-11 (N- myristoyls-L- Sodium glutamate, aginomoto health supply Co., Ltd.), AminoFoamer FLDS-L (N- lauroyls-L-Aspartic acid sodium, Asahi Chemical Corp) and Amilite GCK-12K (N- coco-nut oil fatty acid acylglycine potassium, aginomoto health confession Answer Co., Ltd.) etc. commercialization acyl amino hydrochlorate.

As composition (A), the particularly acyl glutamate such as acyl glutamic acid sodium, with the acyl with other amino acid residues Base amino-acid salt is compared, and its peculiar smell is small, more suitable in terms of use feeling.

From the viewpoint of the gloss for improving tooth maintains effect and foaming, the combined amount of composition (A) is preferably 0.1~ 2% (quality %, similarly hereinafter), more preferably 0.2~2.0%, more preferably 0.2~1.5%.Although combined amount is more, tooth The gloss of tooth maintains effect and foaming more to improve, but if more than 2%, then occurring peculiar smell, the situation that use feeling declines.

As composition (B) alkyl sulfate, the alkali gold of the alkylsurfuric acids such as lauryl sulfate, myristyl sulfate can be enumerated Belong to salt, can be used alone a kind of or use two or more.As alkyl sulfate, particularly suitable use NaLS.

For alkyl sulfate, the commercially available prod of Toho Chemical Industry Co., Ltd.'s manufacture can be used.

From the viewpoint of the gloss for improving tooth maintains effect and foaming, the combined amount of composition (B) is preferably 0.1~ 3.5%, more preferably 0.3~2%, more preferably 0.3~1.8%.Although combined amount is more, the gloss of tooth maintains effect Fruit and foaming are more improved, but if more than 3.5%, then occurring stimulation and peculiar smell, the situation that use feeling declines.

In the present invention, composition (A) and composition (B) and with for take into account gloss maintain effect and foaming be it is important, no When during containing composition (A) or without composition (B), gloss maintains effect and foaming poor, it is difficult to reach the purpose of the present invention.

Although acyl amino hydrochlorate and alkyl sulfate are favorably improved gloss and maintain effect and foaming, particularly acyl group Amino-acid salt is in terms of peculiar smell and alkyl sulfate has problem in terms of stimulation, it is difficult to be used in combination this two-component, and of the invention In, by using the paralled system of this two-component, gloss can be taken into account and maintain effect and foaming good.Further, also free from extraneous odour and Stimulate, can obtain good use feeling.

For composition (A) and (B), if especially balance well mixes this two-component, in free from extraneous odour and stimulation problem In the range of, it can further improve gloss and maintain effect and foaming, it is therefore, preferably to use.In this case, composition (A) (B) amount to combined amount can be 0.2~5.5% scope, preferably 0.7~3%, particularly gloss maintain effect side Face, more preferably 0.8~3%, more preferably 0.8~2%.If composition (A) and (B) combined amount that amounts to are 0.2% More than, then it can obtain more excellent gloss as composition and maintain effect and foaming good.If composition (A) and (B's) amounts to Peculiar smell then occurs more than 5.5% in combined amount, and use feeling declines.

As composition (C) betaine type amphoteric surfac-tant, lauryl dimethyl oxyneurine etc. can be enumerated The fatty acid amide propyl glycine betaine such as alkyl betaine system, coco-nut oil fatty acid amido propyl betaine system, 2- alkyl-N- carboxylic first The alkyl imidazoline glycine betaine system amphoteric surfactantes such as base-N- hydroxyethyl imidazole quinoline glycine betaines, these can with individually a kind of or The mode of two or more combinations is mixed.

Specifically, trade name RIKABION A-100 (lauryl dimethyl oxyneurine, new day can be used This physics and chemistry Co., Ltd.), TEGO Betain CK OK (coco-nut oil fatty acid amido propyl betaine, Ying Chuan companies (EVONIK Company)), the business such as Enagicol C-40H (2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole quinoline glycine betaines, Lion Corporation) The betaine type amphoteric surfac-tant of product.

As composition (C), preferably fatty acid amides CAB system and alkyl imidazoline glycine betaine system are more preferably fatty Sour amido propyl betaine system, the peculiar smell of particularly coco-nut oil fatty acid amido propyl betaine is weak, suitably uses.

From the viewpoint of foaming effect and raising gloss maintenance effect is improved, the betaine type amphoteric surface of composition (C) The combined amount of activating agent is preferably 0.1~1%, more preferably 0.4~1%, more preferably 0.4~0.8%.Although mixing Amount is more, and the gloss of tooth maintains effect and foaming more to improve, but if more than 1%, then peculiar smell occurs, use feeling declines.

In the present invention, by the way that the xanthans of composition (D) is mixed jointly with composition (C), by being used in combination for composition (A) and (B) System makes foaming improve effect and gloss maintenance effect increase, so as to reach the purpose of the present invention.

The commercializations such as trade name Monat Gum DA (Si Bikai can company (CP Kelco companies)) can be used in xanthans Commercially available prod.

The combined amount of composition (D) is preferably 0.3~2%, more preferably 0.5~2%, more preferably 0.5~ 1.5%.Although combined amount is more, the gloss of tooth maintains effect and foaming more to improve, but if more than 2%, then having preparation The situation that dispersiveness declines and use feeling declines.

The composition for oral cavity of the present invention, is particularly suitable for being prepared into toothpaste, liquid dentifrice, liquid dentifrice, wet-milling clean The dentifrices such as tooth agent.In this case, can be as needed, be mixed into mentioned component other formulations it is corresponding known in into Point.For example, grinding agent, adhesion agent, adhesive, surfactant can be mixed into, further as needed, can also be mixed into sweetener, Preservative, colouring agent, spices, various active ingredients etc..

As grinding agent, the silica based abrasives such as silica gel, precipitability silica, alumina silicate, phosphoric acid hydrogen can be enumerated The series of calcium phosphate compound, carbonic acid such as calcium dihydrate and anhydride, tricalcium phosphate, tricresyl phosphate magnesium, tetracalcium phosphate, calcium pyrophosphate Calcium, aluminium hydroxide, aluminum oxide, magnesium carbonate, zirconium silicate, hydroxyapatite, synthetic resin based abrasive etc..

The combined amount of these grinding agents is usually the 0~50% of whole composition, particularly it can mix 10 in toothpaste~ 50%, 0~30% can be mixed in liquid dentifrice.

As adhesion agent, the sugar alcohols such as D-sorbite, xylitol can be enumerated, the polyalcohol such as glycerine, propane diols.These mixing Amount is usually 5~50%, specifically for 20~45%.

As adhesive, in addition to xanthans, for example, can also enumerate sodium carboxymethylcellulose, hydroxyethyl cellulose, angle Pitch dish glue, guar gum, sodium alginate, cationized cellulose, tackifying silica, montmorillonite, gelatin and polyacrylic acid Sodium etc..The combined amount of these adhesives is suitably inside 0.3~5% comprising composition (D).

As surfactant, in addition to composition (A), (B) and (C), for example, can also mix nonionic surfactant Surfactant known to agent, cationic surfactant etc..Specifically, as nonionic surfactant, it can make With the sugar fatty acid esters such as sucrose fatty ester, fatty ester of maltose, milk sugar fats acid esters, maltitol fatty acid ester, lactose The sugar alcohol fatty acid esters such as alcohol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyethenoxy sorbitan list are hard The polyoxyethylene sorbitan fatty acid esters such as resin acid ester, the polyoxyethylene fatty acid ester, bay such as Crodaret Sour list or diglycollic amide, fatty acid esters of sorbitan, polyoxyethylene higher alcohol ether, poloxalkol, Polyoxyethylene polyoxypropylene fatty acid ester etc..As cationic surfactant, alkylammonium etc. can be enumerated.

Wish the scope for being 1~5% in the combined amount of these surfactants inside comprising composition (A), (B) and (C), it is special Be not 1.5~4% scope.

As sweetener, saccharin sodium etc. can be enumerated；As preservative, p-hydroxybenzoate, sodium benzoate etc. can be enumerated.

As colouring agent, blueness 1, yellow 4, titanium dioxide etc. can be enumerated.

As spices, it can be combined and use the following known spices material used in composition for oral cavity：Peppermint Oil, spearmint oil, fennel oil, eucalyptus oil, wintergreen, cinnamon oil, caryophyllus oil, thyme linaloe oil, sage oil, lemon oil, orange oil, Peppermint oil (Ha ッ カ oil), cardamom oil, coriander oil, tangerine oil, lime oil, lavender oil, rosemary oil, bay oil, ocean are sweet Elecampane oil, caraway seed oil, marjoram oil, laurel, lemongrass oil, origanum oil, pinke needle oil, neroli oil, attar of rose, jasmine oil, Oil of grapefruit, Sweetie oil (ス ウ ィ ー テ ィ ー oil), grape-fruit seed oil, concrete of iris, peppermint absolute oil, rose absolute, Orange Blossom etc. Natural perfume material and to the working processes of these natural perfume materials (front-end volatiles removal, tails removal, fractionation, liquid-liquid extraction, refine, Powdered flavour etc.) after spices；And menthol, carvol, anethole, cineole, gaultherolin, cinnamic acid, Ding Zi Fragrant phenol, 3-L- menthoxypropanes -1,2- glycol, thymol, linalool, bergamio, limonene, menthones, acetic acid are thin Lotus ester, N- substitution-to terpane -3- formamides, firpene, octanal, citral, pulegone, methyl acetate, anisaldehyde, acetic acid Ethyl ester, ethyl butyrate, allyl cyclohexane propionic ester, methyl anthranilate, ethyl methyl phenyl glycidol, vanilla Aldehyde, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, furfural, trimethyl The single spices such as pyrazine, ethyl lactate, ethylenebis dithiocarbamate acetic acid esters；Also strawberry essence, flavoring apple essence, flavoring banana essence, pineapple are fragrant Mediation spices such as essence, grape essence, mango essence, butter flavor, milk flavour, fruit mixing essence, tropical fruit (tree) essence etc..

As various active ingredients, the fluorides such as sodium fluoride, sodium monofluorophosphate, ortho-phosphoric sylvite, sodium salt etc. can be enumerated Water-soluble phosphoric acid compound, dextranase, becomes the dextranase such as dextranase, allantoin chlorine hydroxy Al, chamenol, ascorbic acid, Lysozyme chloride, glycyrrhizic acid and its esters, sodium chloride, tranexamic acid, ε-aminocaproic acid, DL- tocopherol acetates, α-opopanax Alcohol, isopropyl methyl phenol, chlorohexidene salt, cetylpyridinium chloride, Azulene, enoxolone, sodium copper chlorophyllin, glucose The copper compounds such as sour copper, aluctyl, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivative, sodium tripolyphosphate, boiling Stone, amylase, methoxy-ethylene, copolymer-maleic anhydride, PVP, epidihydrocholesterol, benzethonium chloride, two Hydrogen cholesterol, trichlorocarbanilide, zinc citrate, the soft extract of Radix Angelicae Sinensis, phellodendron extract is cloves, rosemary, radix scutellariae, red The extracts such as flower.In addition, above-mentioned active ingredient can be mixed with the effective dose in the range of without prejudice to effect of the present invention.

Embodiment

Below, by enumerating embodiment and comparative example, the present invention is specifically described.But the invention is not limited under State embodiment.In addition, in following examples, if not otherwise specified, % represents quality %.

[embodiment and comparative example] prepares Dentrifice composition as shown in Tables 1 and 2 by the following method, and is commented Valency.As a result as shown in Tables 1 and 2.

The preparation method of preparation：

The preparation of Dentrifice composition is that the water-soluble substanceses such as sodium fluoride, D-sorbitol solution are dissolved in after pure water, in addition The liquid for making the adhesives such as xanthans be scattered in propane diols is added, is stirred and forms.Then, spices, grinding agent, acyl are added Base amino-acid salt, NaLS etc., and stirred under reduced pressure under (pressure 4kPa), obtain Dentrifice composition.Manufacture In, use 1.5L kneaders (commercial firm of tor work institute manufactures).

Use raw material：

The details of each composition used in Dentrifice composition preparation is as described below.

(A) N- lauroyls-L-sodium：

AminoSurfact ALMS-P1 (Asahi Chemical Corp)

(A) N- lauroyls-L-Aspartic acid sodium：

AminoFoamer FLDS-L (Asahi Chemical Corp)

(A) N- coco-nut oil fatty acids-cocounut oil acyl glycine potassium：

Amilite GCK-12K (aginomoto health supply Co., Ltd.)

(B) NaLS：Toho Chemical Industry Co., Ltd. (JP) Tokyo-To, Japan manufactures

(C) coco-nut oil fatty acid amido propyl betaine：

TEGO Betain CK OK (30% product, Ying Chuan companies)

(C) 2- alkyl-N- carboxymethyls-N- hydroxyethyl imidazole quinoline glycine betaines：

Enagicol C-40H (30% product, Lion Corporation)

(D) xanthans：

Monat Gum DA (Si Bikai can company)

For other compositions, the material for meeting medicine part outer article raw material specification 2006 is used

In addition, as without especially record, the combined amount described in table is purity scaled value.

Evaluation method

(1) gloss maintains effect

(1-1) test method

To untreated hydroapatite particles (HAP) surface, (HOYA Corp. manufactures, diameter 7mm × thickness 3.5mm) after blasting treatment, cleaned in the neutral cleaners aqueous solution with supersonic wave cleaning machine.After air-drying, gloss is used (electricity Se Industrial Co., Ltd of Japan system makes meter, model：VG2000 glossiness Δ Gs values) are determined, and regard the value as Δ Gs0. At 50 DEG C, by the HAP plates with the order of ironic citrate (III) ammonium salt solution of 0.5% albumin solution → tannin extract solution → 0.6% Impregnated, every time dipping 10 minutes.Tannin extract solution is prepared by the following method：In the ion exchange water of boiling Japanese tea (trade mark is put into 1200mL：Lao Song) (Amada Co., Ltd. of Uniliver manufactures, BRISK tea bags (Block リ for 50g, black tea ス Network テ ィ ー バ ッ Network)) 5 bags and instant coffee (Amada Co., Ltd. of nest manufactures, trade name Nescafe) 12g, place one Evening, filtering removes Japanese tea and black tea.

Repeat after aforesaid operations 2 times, after being cleaned with pure water, at 37 DEG C, the HAP plates are impregnated in the dispersion liquid that cleans the teeth 3 minutes.The dispersion liquid that cleans the teeth refers to the Dentrifice composition that it is as shown in the table is diluted into 3 times with pure water, with 3000rpm centrifugations 10 Supernatant obtained from minute.Then, HAP plates are scrubbed.It is 100 times to scrub number of times, and the toothbrush used in scrub is Clinica4 row microcephaly (Lion Corporation's manufacture), the slurry that cleans the teeth is by 3 times of Dentrifice composition dilution, by the water by pure water Solution 30g is added into 100mL Epton (エ プ ト Application) pipe, every 10 seconds up-down vibrations 20 times and prepare.For brush machine, Using being embodied in based on ISO11609 V-8 horizontal machines and HAP plates can be fixed on improvement brush machine (the strain formula meeting of any part She Gong rivers shop is manufactured).

After HAP plates after scrub processing are cleaned through pure water, from the dipping of albumin solution to a succession of behaviour for scrubbing processing Progress 2 times is repeated, is air-dried after HAP plates, the Δ Gs on surface is determined again, and regard the Δ Gs after processing as Δ Gs1.

Gloss is calculated according to below equation and maintains effect (%), and is evaluated according to following standards.

Gloss maintains effect (%)=100- [(Δ Gs0- Δ Gs1)/Δ Gs0 × 100]

(1-2) gloss maintains the evaluation criterion of effect

◎：More than 70%

○：More than 60% and less than 70%

△：More than 50% and less than 60%

×：Less than 50%

(2) foaming when brushing teeth

(2-1) test method

Using 10 subjects, glued on toothbrush and take about 1g Dentrifice compositions, rising when being brushed teeth for 3 minutes for progress Steep, obtain the answer that (i) foaming very good, (ii) is soaked, (iii) bubbles slightly less with 4 grades as (iv) foaming less. In the answer, will foaming is very good is counted as 4 points, act to soak being counted as 3 points, foaming is slightly counted as 2 points less, and foaming is counted as 1 point less, according to The average mark of 10 simultaneously bubbles according to following standard evaluation.

The evaluation criterion of (2-2) foaming

◎：It is equally divided into more than 3.5 points, less than 4.0 points

○：It is equally divided into more than 3.0 points and less than 3.5 points

△：It is equally divided into more than 2.0 points and less than 3.0 points

×：It is equally divided into more than 1.0 points and less than 2.0 points

(3) stimulation when brushing teeth

(3-1) test method

Using 10 subjects, glued on toothbrush and take about 1g Dentrifice compositions, stimulation when being brushed teeth for 3 minutes for progress Degree, obtains the answer of 4 grades.In the answer, (i) is strongly perceived stimulation and is counted as 1 point, (ii) feels that stimulation is counted as 2 points, (iii) almost it is imperceptible stimulation be counted as 3 points, (iv) imperceptible stimulation is counted as 4 points, according to the average marks of 10 and according to Lower standard, the excitant to oral mucosa is evaluated.

The evaluation criterion that (3-2) is stimulated

◎：It is equally divided into more than 3.5 points, less than 4.0 points

○：It is equally divided into more than 3.0 points and less than 3.5 points

△：It is equally divided into more than 2.0 points and less than 3.0 points

×：It is equally divided into more than 1.0 points and less than 2.0 points

(4) peculiar smell when brushing teeth

(4-1) test method

Using 10 subjects, glued on toothbrush and take about 1g Dentrifice compositions, after brushing teeth about 3 minutes, for what is brushed teeth Peculiar smell degree, obtaining (i) imperceptible peculiar smell, (ii) completely, almost imperceptible peculiar smell, (iii) somewhat feel peculiar smell and (iv) Feel the answer of 4 grades of strong peculiar smell.In the answer, complete imperceptible peculiar smell is counted as 4 points, it is almost imperceptible different Taste is counted as 3 points, somewhat feels that peculiar smell is counted as 2 points, feels that strong peculiar smell is counted as 1 point, according to the average marks of 10 and according to following Standard evaluates use feeling.

The evaluation criterion of (4-2) peculiar smell

◎：It is equally divided into more than 3.5 points, less than 4.0 points

○：It is equally divided into more than 3.0 points and less than 3.5 points

△：It is equally divided into more than 2.0 points and less than 3.0 points

×：It is equally divided into more than 1.0 points and less than 2.0 points

[table 2]

Claims (7)

1. a kind of composition for oral cavity, it is characterised in that contain the mass % of (A) acyl amino hydrochlorate 0.2~2, (B) alkylsurfuric acid The mass % of salt 0.3~2, the mass % of (C) betaine type amphoteric surfac-tant 0.1~1 and the mass % of (D) xanthans 0.3~2,

(A) the acyl amino hydrochlorate is selected from：N- lauroyls-L-sodium, N- myristoyls-L-sodium, N- Coco-nut oil fatty acid acyl group-Monopotassium L-Glutamate, N- lauroyls-L-Aspartic acid sodium and N- coco-nut oil fatty acid acyl groups are sweet One or more of propylhomoserin potassium,

(B) alkyl sulfate is NaLS,

(C) betaine type amphoteric surfac-tant is coco-nut oil fatty acid amido propyl betaine or 2- alkyl-N- carboxylic first Base-N- hydroxyethyl imidazole quinoline glycine betaines.

2. composition for oral cavity as claimed in claim 1, wherein, (C) betaine type amphoteric surfac-tant is coconut grease Fat acid amido propyl betaine.

3. composition for oral cavity as claimed in claim 1 or 2, wherein, composition (A) and (B) combined amount that amounts to are 0.7~3 Quality %.

4. composition for oral cavity as claimed in claim 3, wherein, the combined amount of composition (A) is 0.2~1.5 mass %, composition (B) combined amount is 0.3~1.8 mass %.

5. the composition for oral cavity as any one of claim 1,2,4, wherein, contain the mass % of composition (C) 0.4~1 With the mass % of composition (D) 0.5~2.

6. the composition for oral cavity as any one of claim 1,2,4, wherein, the composition for oral cavity is prepared into clean Tooth agent.

7. a kind of Dentrifice composition, it is characterised in that be selected from N- lauroyls-L-sodium, N- myristoyls containing (A) Base-L-sodium, N- coco-nut oil fatty acids acyl group-Monopotassium L-Glutamate, N- lauroyls-L-Aspartic acid sodium and N- coconut palms The mass % of acyl amino hydrochlorate 0.2~2 and (B) alkyl sulfate of one or more of seed oil fatty acid acyl glycine potassium 0.3~2 mass %, (C) coco-nut oil fatty acid amido propyl betaine or 2- alkyl-N- carboxymethyl-N- hydroxyethyl imidazole quinoline sweet teas The mass % of dish alkali 0.1~1 and mass % of (D) xanthans 0.3~2,

(B) alkyl sulfate is NaLS.