JP2008143824A - Dentifrice composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dentifrice composition comprising a stably formulated dextranase, exhibiting excellent dental plaque removal effects with scarcely any off-taste and having a high actual feeling of cleaning after tooth brushing. <P>SOLUTION: The dentifrice composition comprises (A) the dextranase, (B) a polyoxyethylene hardened castor oil, (C) a polyoxyethylene alkyl ether and (D) at least one linear water-soluble polyphosphate represented by general formula (1): M<SB>n+2</SB>P<SB>n</SB>O<SB>3n+1</SB>(1) (wherein, M represents Na or K; and n represents an integer of 2-5) in an amount of 0.1-3 mass% based on the total composition. The polyoxyethylene hardened castor oil has 10-30 average molar addition number of ethylene oxides, and the polyoxyethylene alkyl ether has a 14-18C alkyl group and an average molar addition number of the ethylene oxides of 3-8. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a dentifrice composition that is excellent in the stability of dextranase in a preparation, has a less off-taste, and has a high cleaning feeling in the oral cavity after use.

  Dextranase exhibits a caries prevention effect by decomposing plaque, and is therefore blended in the oral composition as an active ingredient.

  On the other hand, surfactants are blended in the oral composition from the viewpoint of usability and usability, and in particular, a large amount of abrasive is blended in the dentifrice composition, ensuring sufficient foamability. Therefore, an anionic surfactant such as sodium lauryl sulfate is blended. However, a dentifrice composition containing an anionic surfactant such as sodium lauryl sulfate has the disadvantage that it is difficult to maintain the temporal stability of the enzyme due to its protein denaturing action, and a dentifrice containing a dextranase Also in the composition, a decrease in the aging stability of dextranase has been a problem.

  For this reason, in a dentifrice composition containing dextranase, a technology for stabilizing the dextranase enzyme is essential in the preparation, and a specific non-anionic surfactant is added for stabilization. Is known to be useful. For example, a carboxylic acid type amphoteric surfactant (Patent Document 1; JP 58-225007 A), polyoxyethylene alkyl ether (Patent Document 2; JP 61-176518 A), glycerin fatty acid ester (Patent Document) 3; Japanese Patent Laid-Open No. 3-181413), and examples in which fatty acid alkanolamides are blended (Patent Document 4; Japanese Patent Laid-Open No. 2005-187360).

  However, with these technical means, protein denaturation by sodium lauryl sulfate may be improved to some extent, but when a large amount of nonionic surfactant is added, a unique taste is produced and sufficient oral dispersibility of the preparation is ensured. Can not do it. Moreover, when an amphoteric surfactant is blended in a large amount, a peculiar bitter taste is generated, and the feeling of use tends to deteriorate.

  Further, in a composition for oral cavity containing glucanase and sodium lauryl sulfate, as a method for providing a dentifrice composition capable of ensuring enzyme stability while ensuring a good foaming amount of sodium lauryl sulfate, glucanase and A dentifrice composition containing sodium lauryl sulfate has a polyoxyethylene alkyl ether having an alkyl group having 14 to 18 carbon atoms and an ethylene oxide addition mole number of 3 to 8, and an ethylene oxide addition mole number. A technique of previously mixing and dispersing 10 to 80 polyoxyethylene hydrogenated castor oil is disclosed (Patent Document 5; JP-A-2005-41787).

  However, in the above proposal, there may be a bitter taste peculiar to nonionic surfactants, or it may be difficult to ensure a sufficient cleaning feeling after brushing the teeth, and a taste that greatly affects the feeling of use of the dentifrice and a feeling of cleaning after use. At the same time, it was sometimes difficult to maintain sufficiently.

  Accordingly, there has been a demand for a dentifrice composition that has high stability of dextranase, has almost no peculiar taste unique to nonionic surfactants, and provides a cleaning feeling after brushing.

JP 58-225007 A JP-A 61-176518 JP-A-3-181413 JP 2005-187360 A JP 2005-41787 A JP 9-175966 A Japanese Patent Laid-Open No. 10-182389 JP 2002-068947 A

  The present invention has been made in view of the above circumstances, and a dentifrice composition that exhibits excellent plaque removal effect by blending with dextranase in a stable manner, has less off-taste, and has a high cleaning feeling after toothpaste. The purpose is to provide.

  As a result of diligent studies to achieve the above object, the present inventors, as a result, (A) dextranase, (B) polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 10 to 30 mol, ( C) a polyoxyethylene alkyl ether having an alkyl group having 14 to 18 carbon atoms and an average addition mole number of ethylene oxide of 3 to 8 moles, and (D) a straight chain represented by the following general formula (1) By blending with at least one of these water-soluble polyphosphates, dextranase can be stabilized and formulated over time, exhibiting excellent plaque removal effect, and having a good feeling of use with almost no off-flavor And it discovered that the cleaning feeling after tooth brushing was also high, and came to make this invention.

  In addition, linear polyphosphates such as sodium pyrophosphate are known as components for removing tooth stains (Patent Document 6: JP-A-9-175966, Patent Document 7: JP-A-10-182389). In addition, it is also known that a colored pellicle removal effect can be obtained by blending with an oral composition in combination with particles (see Patent Document 8: JP 2002-068947 A). However, in the present invention, by combining the components (A) to (C) and the component (D), the dextranase can be stably blended as will be apparent from the examples described later, and the nonionic surface activity It is possible to achieve a special operational effect that it has a good feeling of use with almost no off-taste derived from the agent and a high cleaning feeling after tooth brushing, and in particular contains linear polyphosphate This is considered to be derived from the improvement in plaque removal power of dextranase and the removal effect of linear polyphosphate.

Therefore, the present invention
(A) dextranase,
(B) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 10 to 30 mol,
(C) a polyoxyethylene alkyl ether having an alkyl group having 14 to 18 carbon atoms and an average added mole number of ethylene oxide of 3 to 8 moles, and (D) the following general formula (1)
M _{n + 2} P _n O _{3n + 1} (1)
(However, M represents Na or K, and n is an integer of 2 to 5.)
0.1 to 3% by mass of the total amount of the linear water-soluble polyphosphate represented by
The dentifrice composition characterized by containing this.

  The dentifrice composition of the present invention is stabilized and formulated with dextranase, exhibits an excellent plaque removing effect, has almost no off-taste, and has a high cleaning feeling after brushing.

Hereinafter, the present invention will be described in more detail. The dentifrice composition of the present invention is prepared as a dentifrice such as a toothpaste and a liquid dentifrice.
(A) dextranase,
(B) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 10 to 30 mol,
(C) polyoxyethylene alkyl ether having an alkyl group having 14 to 18 carbon atoms and an average added mole number of ethylene oxide of 3 to 8 mol, and (D) a linear water-soluble polyphosphate It is made.

  (A) Examples of dextranase include dextranase obtained by known methods from known dextranase-producing bacteria belonging to the genus Ketomium, Penicillium, Aspergillus, Spicaria, Lactobacillus, Servibrio, etc. Also, dextranase produced from other microorganisms can be used, and commercially available products such as those manufactured by Sankyo Co., Ltd. can be used.

  The blending amount of dextranase is preferably 2 to 200 units / g (U / g), particularly 10 to 50 units / g in the composition. If it is less than 2 units / g, a sufficient plaque removing effect cannot be obtained, and if it exceeds 200 units / g, the stability may not be sufficient. Here, 1 unit of dextranase is the amount of dextranase that produces free reducing sugar corresponding to 1 μmol of glucose per minute when the reaction is carried out using dextran as a substrate. Usually, when 13,000 units / g are used, the amount of dextranase is 0.0154 to 1.54% (mass%, the same applies hereinafter) of the entire composition.

  Next, as polyoxyethylene hydrogenated castor oil, those having an average added mole number of ethylene oxide of 10 to 30, preferably 20 to 30 are used in terms of dentifrice stability and dextranase stabilization effect. To do. If the average added mole number of ethylene oxide is less than 10 moles, the appearance may deteriorate due to liquid separation of the preparation, and if the added mole number exceeds 30, the dextranase stabilizing effect is inferior.

  As such polyoxyethylene hydrogenated castor oil, for example, HCO-10, HCO-20, HCO-30 manufactured by Nikko Chemicals Co., Ltd., HC-10, HC-20, HC-30 manufactured by Nihon Emulsion Co., Ltd., Examples include BLAUNON RCW-20 manufactured by Aoki Oil & Fat Co., Ltd.

  The blending amount of the polyoxyethylene hydrogenated castor oil is preferably 0.3 to 5%, particularly 0.5 to 2% of the entire composition. If the blending amount is less than 0.3%, the dextranase stability may be lowered. If the blending amount exceeds 5%, there may be a problem in the feeling of use due to the special taste.

The polyoxyethylene alkyl ether used in the dentifrice composition of the present invention includes the following general formula (2)
R—O— (EO) _n H (2)
(However, R represents an alkyl group having 14 to 18 carbon atoms, n represents 3 to 8, and EO represents ethylene oxide.)
The one shown in is used.

As the polyoxyethylene alkyl ether, those having an alkyl group having 14 to 18 carbon atoms, preferably 16 to 18 carbon atoms, are used in terms of the stability of dentifrice and the stability of dextranase. When the carbon number of the alkyl group is less than 14, the stability of the preparation and the stability of dextranase are poor, and when the carbon number of the alkyl group exceeds 18, the dextranase stability is poor.
Specific examples of such polyoxyethylene alkyl ether include polyoxyethylene cetyl ether, polyoxyethylene myristyl ether, polyoxyethylene stearyl ether, and the like, and polyoxyethylene stearyl ether is particularly preferable.

  Moreover, the average addition mole number of the ethylene oxide of the said polyoxyethylene alkyl ether is the range of 3-8 mol from the point of stability of a dentifrice, and dextranase stability, Preferably it is the range of 5-8 mol. When the average number of added moles is lower than 3 moles, liquid separation may occur in the preparation, resulting in poor dextranase stability. Moreover, when it exceeds 8 mol, it is inferior to dextranase stability.

  A commercial item can be used as such a polyoxyethylene alkyl ether. Examples of commercially available products include polyoxyethylene (3) cetyl ether (EMALEX 103), polyoxyethylene (5) cetyl ether (EMALEX 105), polyoxyethylene (7) cetyl ether (EMALEX 107) and poly Examples thereof include oxyethylene (3) stearyl ether (EMALEX 603), polyoxyethylene (5) stearyl ether (EMALEX 605), polyoxyethylene (6) stearyl ether (EMALEX 606), polyoxyethylene (8) stearyl ether (EMALEX 608) and the like. . Among these, from the viewpoint of the stability and usability of dextranase, those having an ethylene oxide average addition mole number of 5 to 8 moles and an alkyl chain length of 16 to 18 carbon atoms are particularly preferred.

  The blending amount of the polyoxyethylene alkyl ether is preferably 0.3 to 5%, particularly 0.5 to 2% of the entire composition. If the blending amount is less than 0.3%, the dextranase stability may decrease, and if it exceeds 5%, the feeling of use tends to deteriorate and liquid separation may occur in the preparation.

Next, the linear water-soluble polyphosphate has the following general formula (1):
M _{n + 2} P _n O _{3n + 1} (1)
(However, M represents Na or K, and n is an integer of 2 to 5.)
The sodium pyrophosphate having a polymerization degree of n = 2 (made by Taihei Chemical Sangyo Co., Ltd., Tohoku Chemical Co., Ltd.) or potassium pyrophosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Toa Gosei Chemical Co., Ltd.) Etc.), n = 3 sodium tripolyphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd., Central Glass Co., Ltd., Nippon Builder Co., Ltd.) and potassium tripolyphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd.) , N = 4 sodium tetrapolyphosphate (produced by Taihei Chemical Sangyo Co., Ltd.), n = 5 sodium pentapolyphosphate (produced by Taihei Chemical Sangyo Co., Ltd.) and the like. Alternatively, two or more kinds can be used in combination. When n is less than 2, a unique taste of nonionic surfactant is produced, and the cleaning feeling after brushing tends to be inferior. If n exceeds 5, the cleaning feeling after brushing tends to be inferior, and the stability of the preparation becomes poor. Among these, sodium tripolyphosphate (manufactured by Taihei Chemical Industry Co., Ltd.) is particularly preferable from the viewpoint of effects.

  The amount of the water-soluble polyphosphate is 0.1 to 3%, preferably 0.3 to 2%, more preferably 0.3 to 1.5% of the entire composition. If the blending amount is less than 0.1%, a peculiar taste of nonionic surfactant is generated, or the cleaning feeling after brushing is inferior. If it exceeds 3%, irritation occurs in the oral mucosa, and dextranase Stability deteriorates.

  The dentifrice composition of the present invention can contain other additives as optional components in addition to the above essential components as long as the effects of the present invention are not impaired. For example, abrasives, thickeners, binders, surfactants, sweeteners, preservatives, active ingredients, pigments, fragrances and the like can be blended, and these ingredients can be mixed with water for production.

  As abrasives, dicalcium phosphate dihydrate, anhydrous dibasic calcium phosphate, calcium pyrophosphate, aluminum hydroxide, alumina, titanium dioxide, crystalline zirconium silicate, polymethyl methacrylate, insoluble calcium metaphosphate, light calcium carbonate , Heavy calcium carbonate, magnesium carbonate, tribasic magnesium phosphate, zeolite, zirconium silicate, tricalcium phosphate, hydroxyapatite, fluoroapatite, calcium deficient apatite, tricalcium phosphate, tetracalcium phosphate, eighth calcium phosphate, synthetic resin system Abrasives, precipitated silica, silica gel, aluminosilicate, zirconosilicate and the like can be mentioned. Among these abrasives, silica-based abrasives and aluminum hydroxide are preferably used as abrasives from the viewpoint of dextranase stability. Usually, the total amount of these abrasives is about 10 to 50%.

  As the thickening agent, at least one of glycerin, sorbit, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6000, ethylene glycol, polyvalent alcohol such as reduced starch saccharified product, and the like can be used. Usually, the compounding quantity of these thickeners is 10 to 40% of the whole composition.

  As binders, inorganic binders such as sodium alginate, propylene glycol alginate, carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, sodium polyacrylate, xanthan gum, carbopol, guar gum, gelatin, avicel, montmorillonite, kaolin, bentonite, etc. Agents and the like. Usually, the compounding quantity of these binders is 0.5 to 3% of the whole composition.

  As the surfactant, in addition to the essential component (B) specific polyoxyethylene hydrogenated castor oil and (C) specific polyoxyethylene alkyl ether, other surfactants can be added. For example, examples of the anionic surfactant include lauryl sulfate such as sodium lauryl sulfate, lauroyl sarcosine salt, myristyl sarcosine salt, polyoxyethylene alkyl sulfate, N-lauroyl taurine salt, and α-olefin sulfonate. Nonionic surfactants include, for example, alkyl glycosides having 8 to 16 carbon atoms in the alkyl group, sucrose fatty acid esters having 12 to 18 carbon atoms in the fatty acid group such as sucrose mono and dilaurate, lactose fatty acid esters, and lactitol. Fatty acid ester, maltitol fatty acid ester, stearic acid monoglyceride, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, alkyloyl ethanolamide such as lauroyl diethanolamide, polyoxyethylene polyoxypropylene glycol, decaglyceryl laurate Etc. Examples of the amphoteric surfactant include alkyldimethylaminoacetic acid betaine, fatty acid amidopropyl betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine and the like.

  These other surfactants as optional components can be blended singly or in combination of two or more, and the blending amount is usually 0.1 to 5% with respect to the total amount of the composition, (B) It is preferable to mix | blend in the range with which the total compounding quantity of surfactant of (C) component and above-mentioned other surfactant becomes 0.7 to 10% of the whole composition.

  Sweeteners include saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perilartin, etc., and preservatives include parabens such as butylparaben and ethylparaben, paraoxybenzoates And sodium benzoate.

  As various active ingredients, in addition to the essential ingredient (A) dextranase, other active ingredients can be added. For example, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, sodium monofluorophosphate, water-soluble phosphate compounds such as potassium salt and sodium salt of orthophosphoric acid, tranexamic acid, Epsilon-aminocaproic acid, allantoinchlorohydroxyaluminum, hinokitiol, ascorbic acid, sodium chloride, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, triclosan, isopropylmethylphenol, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium, chlorophyll, glycero Chelating phosphate compounds such as phosphate, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid And derivatives thereof, zeolite, methoxyethylene, maleic anhydride copolymer, polyvinylpyrrolidone, epidihydrocholesterine, benzethonium chloride, sodium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, sweet cherry extract, buckwheat extract, chamomile, Extracts such as clove, rosemary, ougon, safflower and the like can be mentioned. In addition, the addition amount of these active ingredients can be made into an effective amount in the range which does not prevent the effect of this invention.

  As preservatives, various parabens, nonionic antibacterial agents such as sodium benzoate and triclosan, cationic antibacterial agents such as benzethonium chloride, benzalkonium chloride and cetylpyridinium chloride, and essential oil components can be blended.

Perfumes are peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime Oil, lavender oil, rosemary oil, laurel oil, camomil oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris concrete, absolute peppermint , Natural roses such as absolute rose and orange flower, and fragrances processed with these natural fragrances (front reservoir cut, rear reservoir cut, fractional distillation, liquid extraction, essence, powder fragrance, etc.), menthol, carvone , Anethole, cineol, methyl salicylate, syn Mic aldehyde, eugenol, 3-l-mentoxypropane-1.2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramentane-3-carboxamide, pinene, octylaldehyde, citral , Pulegone, carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, Isoamyl alcohol, hexenol, dimethyl sulfide, cycloten, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, ethyl Single-flavored ingredients such as o-acetate, as well as fragrances such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, tropical fruit flavor, and dentifrice composition The well-known perfume material used for can be used, and it is not limited to the perfume of an Example.
Moreover, although the compounding quantity of a fragrance | flavor is not specifically limited, It is preferable to use said fragrance | flavor raw material 0.000001 to 1% in a formulation composition. Moreover, as a fragrance | flavor for fragrance | flavor using the said fragrance | flavor raw material, it is preferable to use 0.1 to 2.0% in a formulation composition.

  As colorants, Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3 No. is exemplified. In addition, the compounding quantity of these components can be made into a normal quantity in the range which does not prevent the effect of this invention.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, the blending amount is mass%.

[Example 1, Comparative Examples 1-14]
Dentifrice compositions having the compositions shown in Tables 1 and 2 were prepared by the following methods, and the dextranase stabilizing effect, tastelessness, and cleaning feeling after use were evaluated by the following methods. The results are shown in Tables 1 and 2.

(1) Preparation of test dentifrice composition A dentifrice composition having the composition shown in Tables 1 and 2 was prepared, and 50 g was filled in a 26 mm diameter laminated tube whose innermost layer was made of linear low density polyethylene. The stability of the enzyme, the absence of taste during use, and the cleaning feeling after use were evaluated.
The preparation of the dentifrice composition was prepared by adding a linear aqueous solution represented by M _{n + 2} P _n O _{3n + 1} (where M represents Na or K, and n is an integer of 2 to 5) in purified water. Water-soluble substances such as water-soluble polyphosphate, sodium saccharin, and sorbit are dissolved, and then propylene glycol solution in which a binder such as sodium alginate is dispersed is added, and polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether are added. And stirred. Then, the fragrance | flavor, the abrasive | polishing agent, the dextranase, and the anionic surfactant were added in order, and also it stirred under reduced pressure (40 mmHg), and obtained the dentifrice composition. In addition, the unimixer (FM-SR-25, POWEX CORPORATION) was used for manufacture.

  For preparation of these dentifrice compositions, sodium tripolyphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd.), disodium phosphate (manufactured by Taihei Chemical Sangyo Co., Ltd.), potassium metaphosphate (manufactured by Taihei Chemical Sangyo Co., Ltd.) Dextranase (manufactured by Sankyo Co., Ltd.), polyoxyethylene (20) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd., EMALEX HC-20), polyoxyethylene (5) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd.) EMALEX HC-5), polyoxyethylene (40) hydrogenated castor oil (Emulex HC-40 manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene (5) stearyl ether (EMALEX 605 manufactured by Nippon Emulsion Co., Ltd.), polyoxyethylene ( 2) Stearyl ether (EMALEX602 manufactured by Nippon Emulsion Co., Ltd.), Polio Xylethylene (11) stearyl ether (Emulex 611 manufactured by Japan Emulsion Co., Ltd.) and polyoxyethylene (5) oleyl ether (EMALEX 505H manufactured by Nihon Emulsion Co., Ltd.) were used. In addition, saccharin sodium, anhydrous silicic acid, xanthan gum, sodium alginate, sodium polyacrylate, propylene glycol, sorbit, benzalkonium chloride, sodium lauryl sulfate, water use cosmetic raw material standards, sodium fluoride is a quasi-drug. Raw material standard products were used. About Sorbit, dentifrice was prepared using the 70% aqueous solution product, and the compounding quantity of 70% aqueous solution was shown in the table | surface.

(2) Evaluation method of dextranase stabilizing effect The dentifrice composition is filled with 50 g in a 26 mm diameter laminated tube whose innermost layer is made of linear low density polyethylene, stored at 40 ° C. for 1 month, and then a dentifrice formulation 0.6 g was suspended in 15 mL of 0.1 M phosphate buffer, and the centrifuged supernatant was used as a test solution. 1 mL of this test solution was added to 2 mL of a 1% dextran solution, reacted in a constant temperature bath at 40 ° C. for exactly 10 minutes, and the amount of reducing sugar produced was measured using the Somogy Nelson method. One unit of dextranase was defined as the amount of dextranase that produces free reducing sugar corresponding to 1 μmol of glucose per minute, and the average of three repetitions was evaluated according to the following criteria.

Score criteria ◎: dextranase remaining rate 85% or more ○: dextranase remaining rate 75% or more and less than 85% Δ: dextranase remaining rate 60% or more and less than 75% ×: dextranase remaining rate 60% or less

(3) Evaluation method of tastelessness It evaluated by the sensory test using ten expert panelists. Brush about 1g of dentifrice on a commercial toothbrush and brush for 3 minutes. (I) No taste, (ii) Little, (iii) Somewhat (iv), 4 I got an answer at the stage. Among these answers, (i) 4 points for none, (ii) 3 points for little, (iii) 2 points for some, and (iv) 1 point for average, and average the results of 10 evaluations. What was evaluated as ◎ and ○ on the following criteria was judged to be a dentifrice composition having no taste.

(Evaluation criteria)
◎: 3.5 points to 4.0 points ○: 3.0 points to less than 3.5 points △: 2.0 points to less than 3.0 points ×: Less than 2.0 points

(4) Evaluation method of cleaning feeling after tooth brushing It evaluated by the sensory test using ten expert panelists. 1g of dentifrice is placed on a commercial toothbrush and brushed for 3 minutes, and the cleaning feeling felt after rinsing the mouth is (i) very, (ii) quite, (iii) somewhat, (iv) Responses were obtained in four stages, almost none. Of these answers, the average of the evaluation results of 10 people was (i) 4 points, very (ii) 3 points, (iii) 2 points, and (iv) 1 point. And it was judged that it was a dentifrice composition without taste that the evaluation of (double-circle) and (circle) was ensured on the following references | standards.
(Evaluation criteria)
◎: 3.5 points to 4.0 points ○: 3.0 points to less than 3.5 points △: 2.0 points to less than 3.0 points ×: Less than 2.0 points

As the components (A) to (D) and comparative components in the table, the following were used.
Dextonalase (13,000 U / g product) (Sankyo Co., Ltd .: Dextranase)
Polyoxyethylene (20) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-20)
Polyoxyethylene (5) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-5)
Polyoxyethylene (40) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-40)
Polyoxyethylene (5) stearyl ether (manufactured by Nippon Emulsion Co., Ltd .: EMALEX 605)
Polyoxyethylene (2) stearyl ether (manufactured by Nippon Emulsion Co., Ltd .: EMALEX 602)
Polyoxyethylene (11) stearyl ether (manufactured by Nippon Emulsion Co., Ltd .: EMALEX 611)
Polyoxyethylene (5) oleyl ether (manufactured by Nippon Emulsion Co., Ltd .: EMALEX 505H)
Sodium tripolyphosphate (Taihei Chemical Industry Co., Ltd .: sodium tripolyphosphate)
Disodium phosphate (manufactured by Taihei Chemical Sangyo Co., Ltd .: disodium phosphate)
Potassium metaphosphate (Taihei Chemical Industry Co., Ltd .: Potassium metaphosphate)

  From the results of Tables 1 and 2, the dentifrice composition (Example 1) of the present invention containing the components (A) to (D) not only has a dextranase stabilizing effect, but has a less off-flavor and is used. It was confirmed that the feeling of cleaning in the later oral cavity was high.

[Examples 2 to 14]
A dentifrice composition having the composition shown in Tables 3 and 4 was prepared in the same manner as in Example 1 and tested in the same manner. The dextranase stabilizing effect, the taste of the dentifrice composition, and the cleaning feeling after brushing. Evaluated. The results are shown in Tables 3 and 4.

As the components (A) to (D) and comparative components in the table, the following were used.
Dextonalase (13,000 U / g product) (Sankyo Co., Ltd .: Dextranase)
Polyoxyethylene (20) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-20)
Polyoxyethylene (10) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-10)
Polyoxyethylene (30) hydrogenated castor oil (manufactured by Nippon Emulsion Co., Ltd .: EMALEX HC-30)
Polyoxyethylene (5) stearyl ether (manufactured by Nippon Emulsion Co., Ltd .: EMALEX 605)
Polyoxyethylene (5) cetyl ether (manufactured by Nippon Emulsion Co., Ltd .: EMALEX 705)
Polyoxyethylene (3) stearyl ether (Nippon Emulsion Co., Ltd .: EMALEX 603)
Polyoxyethylene (8) stearyl ether (Nippon Emulsion Co., Ltd .: EMALEX608)
Sodium pyrophosphate (Taihei Chemical Industry Co., Ltd .: anhydrous sodium pyrophosphate)
Potassium pyrophosphate (Taihei Chemical Industry Co., Ltd .: Potassium pyrophosphate)
Sodium tripolyphosphate (Taihei Chemical Industry Co., Ltd .: sodium tripolyphosphate)
Potassium tripolyphosphate (Taihei Chemical Industry Co., Ltd .: potassium tripolyphosphate)

  From the results of Tables 3 and 4, the dentifrice compositions (Examples 2 to 14) of the present invention containing the components (A) to (D) not only have a dextranase stabilizing effect, but also have a small taste. It was confirmed that the cleaning feeling in the oral cavity after use was high.

Claims (1)

(A) dextranase,
(B) polyoxyethylene hydrogenated castor oil having an average addition mole number of ethylene oxide of 10 to 30 mol,
(C) a polyoxyethylene alkyl ether having an alkyl group having 14 to 18 carbon atoms and an average added mole number of ethylene oxide of 3 to 8 moles, and (D) the following general formula (1)
M _{n + 2} P _n O _{3n + 1} (1)
(However, M represents Na or K, and n is an integer of 2 to 5.)
0.1 to 3% by mass of the total amount of the linear water-soluble polyphosphate represented by
A dentifrice composition characterized by comprising.