JPS6092208A - Dentifrice composition containing sodium chloride - Google Patents

Abstract

PURPOSE:The titled dentifrice, containing sodium alkyl sulfate and an N-acylglutamate together, and capable of improving the low foaming property of a dentifrice containing sodium chloride, and having preventing and remedial effect on periodontoses and further a good feeling of use. CONSTITUTION:A dentifrice, containing sodium chloride, and obtained by incorporating usually 0.1-3wt% each, preferably 0.5-3wt% sodium alkyl sulfate and preferably 0.2-1.0wt% N-acylglutamate as a foaming agent in a dentifrice containing usually 5-30wt% sodium chloride, and having improved foaming property even on incorporating sodium chloride having a preventing and treating effect on periodontoses, e.g. gingivitis or pyorrhea alveolaris, and further a good feeling of use without deteriorating a foaming assistant even in storage for a long period.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a dentifrice composition containing sodium chloride, and more particularly to a dentifrice composition containing a high concentration of sodium chloride and having good foaming properties.

It is well known that sodium chloride has preventive and therapeutic effects on periodontal diseases such as gingivitis and alveolar pyorrhea. It is a very useful method to use sodium chloride in combination with toothpaste, and it has been clinically observed that symptoms of periodontal disease are improved by this method.

By the way, a foaming agent is blended into toothpaste in order to enhance the cleaning effect and provide a good feeling of use through rich foaming. Usually, sodium alkyl sulfate is used as a blowing agent because of its high functionality and safety.

However, when a high concentration of sodium chloride is added to a toothpaste, the function of the sodium alkyl sulfate is significantly impaired due to the salting-out effect, resulting in a toothpaste with low foaming properties and a poor feeling of use.

In order to improve the low foaming properties of toothpaste containing sodium chloride, anionic surfactants such as sodium alkyl sulfate and albumin are combined (Japanese Unexamined Patent Publication No. 55-12
Attempts have been made to combine sodium alkyl sulfate with a nonionic surfactant (Japanese Unexamined Patent Publication No. 106606/1983). Even if alkyl vf, e sodium is used alone, the foaming properties can be improved to some extent if more than the usual amount (approximately 2% by weight) is added, but in that case, alkyl sulfate) IJum stimulates the oral mucosa and causes it to peel. There is a risk of increasing Therefore, it is desired to improve the foaming properties by adding other auxiliary agents without increasing the amount of alkyl sulfate.

However, in toothpastes that use albumin as a foaming aid, there is a risk that albumin will denature due to long-term storage, since albumin is a tan/quarium substance. Furthermore, in toothpastes that use nonionic surfactants as foaming aids, there are many that impair the flavor of the toothpaste.

Therefore, the present inventors conducted extensive research to find a foaming aid that would not deteriorate even after long-term storage and would not impair the feel of toothpaste. The present invention was completed based on the discovery that when N-acyl glutamate is combined with sodium alkyl sulfate, the foaming properties are synergistically improved, the feeling of use is good, and there is no denaturation even after long-term storage. did.

That is, the present invention uses sodium alkyl sulfate and N- as foaming agents in toothpaste containing sodium chloride.
A sodium chloride-containing dentifrice composition containing an acyl glutamate is provided.

Sodium alkyl sulfate and N-acyl glutamate used as blowing agents in the present invention are both anionic surfactants. It is stated that two or more types of surfactants can be used in combination. However, the same publication states that if sodium chloride, a strong electrolyte, is blended in a toothpaste composition at a high concentration,
It is stated that the foaming effect of any anionic surfactant is significantly impaired, and that this can only be improved in combination with albumin. In a dentifrice composition containing a high concentration of sodium chloride, it is not possible to obtain a dentifrice composition with good foaming properties even if one or a combination of two or more anionic surfactants is used. This was the current level of technology.

Under these circumstances, the present inventors have found that, among many non-anionic surfactants, when alkyl anti-acid sodium and N-acyl glutamate are used in combination, the foaming properties at high altitude sodium are synergistically improved. This is an extremely surprising new finding that was completely unexpected.

Examples of the sodium alkyl sulfate, which is one of the blowing agents used in the present invention, include sodium lauryl sulfate, sodium myristyl sulfate, and the like. Examples of N-acylglutamate include N-lauroylglutamate, ``-t-ristoylglutamate, N-
Examples of the salt include alkali metal salts such as sodium salts and potassium salts, ammonium salts, monoethanolamine salts, jetanolamine salts, triethanolamine salts, and arginine salts. can be mentioned.

Furthermore, in the present invention, as sodium chloride, in addition to ordinary reagents, edible salt, rock salt, sea salt, etc. can be used.

As other components of the dentifrice composition of the present invention, known components commonly used in dentifrices can be used. for example,
Abrasives such as dibasic calcium phosphate, calcium carbonate, calcium billuphosphate, insoluble sodium metaphosphate, and silicic anhydride; Wetting agents such as glycerin, sorbitol, zoropylene glycol, and ethylene glycol nat; calxoxymethyl cellulose, carrageenan, sodium alginate, and Viga 7 − Mu, hydroxyethyl cellulose, ? Binder such as ribinyl alcohol; sweetener such as saccharin sodium, glycyrrhizin salts, stevioside, asno-9 luteme;
Flavors such as menthol, carline, anethole, etc.: lysozyme chloride, dextranase, lytic enzyme, mutanase, chlorhexicine, sorbic acid, alexicin, hinokitiol, cetylpyrizonium, alkylglycine, alkyldiaminoethylglycine salt, monofluorophosphate Sodium, sodium fluoride, water-soluble primary or secondary
Medicinal ingredients such as phosphates and quaternary ammonium compounds are used.

In the dentifrice composition of the present invention, the blending ratio of 7 um chloride is usually 5 to 30 um by weight. In addition, the blending ratio of sodium alkyl sulfate was 0.
1 to 3 weights, preferably 0.5 to 3 weights,
The blending ratio of N-acylglutamate is 0.1 to 3 to -1, preferably 0.2 to 1. It is set to ON.

As mentioned above, the dentifrice composition of the present invention exhibits foaming properties even when containing a high concentration of sodium chloride, has a good feeling of use, and is effective in preventing and treating periodontal diseases such as alveolar pyorrhea. Extremely useful.

The present invention will be explained in detail below using test examples and examples.

Experiment 1 A toothpaste using sodium diwalyl sulfate alone as a foaming agent and a toothpaste using a combination of sodium lauryl sulfate and sodium N-lawaloylglutanate were prepared as shown in Table 1, and the foaming state was measured by the amount of foaming. I made a good judgment. Also, the amount of sodium chloride was varied in the range of 0 to 30% by weight.

Table 1 To measure the foaming amount, first dilute the test toothpaste (invention toothpaste 1 and comparative toothpaste 1) three times with purified water, and then dilute the diluted solution 1001
1j into a 40017 graduated cylinder (inner diameter 6.5 tx
) and placed in a thermostat at 30°C with an inverted stirrer (1
1000rP.

The mixture was inverted every 6 seconds and stirred for 3 minutes using a 4-blade screw (diameter & 0 vice). The foaming amount was expressed as the difference between the diluted liquid volume before stirring and the apparent liquid volume immediately after stirring was stopped, as shown in the following equation.

Foaming 11 (WLt) - (apparent capacity (-) immediately after stirring)
- (Volume before stirring (red)) Chloride in toothpaste) The relationship between the amount of IJ wam mixed and the amount of foaming is shown in Figure 1. From this result, it was found that as the amount of lavalyl sulfate (sodium chloride is used alone, it is chlorinated) as a blowing agent, the foaming properties decrease significantly as the amount of lavalyl sulfate (sodium chloride is chlorinated) increases. When royl sodium glutamate was combined in a ratio of 3:1, the foaming property decreased very little. In Figure 1, 0-0 is a mixture of 1.5% by weight of sodium lavalyl sulfate and 0.5% by weight of sodium N-lawaloyl glutamate, and -4 is a mixture of 2.0% sodium lavalyl sulfate. shows.

Test Example 2 Toothpaste using sodium lavalyl sulfate alone as a foaming agent (comparative toothpaste 2), toothpaste using sodium lavalyl sulfate in combination with sodium N-lawalyl glutamate (present invention 81I11I brush 2), and sodium lavalyl sulfate with N
- LAWLOY 12 - A toothpaste combining rusarcosine powder sodium worm (comparative toothpaste 3) and a nine-time brushing combining sodium lawalyl sulfate and α-olefin sulfonate sodium worm (comparative toothpaste 4) were prepared as in No. 2, respectively. The amount of foaming was measured when the amount of sodium lawalyl sulfate was varied in the range of 0 to 2.4 weight. The results are shown in FIG.

In the margin below, in Fig. 2, ... indicates the foaming amount when sodium lauryl sulfate alone is blended. Comparative toothpaste 2), O
The amount of foaming is shown when 0.5 weight of N-Rawa pyl glutamate sodium wam is blended with lacrylic sodium sulfate wam (toothpaste 2 of the present invention). Furthermore, △-△ is 9 μm of sodium lauryl sulfate and 0 μm of sodium N-lavaloyl sarcosinate.
．． Foaming amount (comparative toothpaste 3) when 5 weight - is blended, L
-m indicates the amount of foaming (comparative toothpaste 4) when 0.5 weight of α-olefin sulfonic acid sodium wam is blended with diuryl sodium sulfate wam. The -1 line indicates the amount of foaming when N-Lawaloyldartazonate sodium wam was blended alone, and the amount of foaming when Lawalyl vLwl sodium wam was blended alone.

According to the results in Figure 2, if sodium lauryl sulfate and sodium N-lavaloyl glutamate are combined and the foaming amount is additive, the measured values should be on the same line. However, it is actually above O-0, and it can be seen that the foaming amount increased synergistically. In addition, a combination of sodium lavalyl sulfate and sodium N-lawaloyl glutamate has a much better foaming effect than a combination of anionic surfactants other than sodium lavalyl sulfate and sodium N-lawaloyl glutamate. You can see that

Practical Calcyloxymethylcellulose 1.0 (1% by weight) 16
- Glycerin 5.0 Sorbiturate solution (60%) 10.0 Dicalcium phosphate (dihydrate salt) 45.0 Silicic anhydride 1.0 Satucharin sodium worm 0.1 Lawalyl sodium sulfate 1.5 λ-lawa 4 glutami 4 sodium 0.5 salt 1
0.0 Preservative 0.05 Flavor 0.8 Purified water Appropriate amount 100.0 Example 2 1yh&xymethylcellulose 0.5 (weight-) carrageenan 0.5 Propylene glycol 3. .

Nruvit liquid (60 excellent) 15.0 Calcium carbonate 45.0 Silicic anhydride 1.5 Satucalin sodium 0.3 Sodium lawalyl sulfate 9M 168 Sodium N-millimethylglutamate 0.5 Salt
9.0 Preservative 0.05 Flavor 0.8 100.0 Implementation νl13 Calxymethylcellulose o,s (heavy jL superior) human-xyethylcellulose 0.3 Glycerin 7.0 Sorbiturate solution (60%) io.

Al2 hydroxide 40.0 Silicic anhydride 1.0 Sodium saccharin 9 M 0.3 Sodium myristyl sulfate 9 M 2. O N-Rawa μyl glutamic acid glutamic acid 0.5 Crude salt 15.0 Preservative 0.05 Flavor 0.8 100.0 Example 4 Calzexymethyl cellulose 0.8 (1P-) carrageenan 0.5 19- Glycerin 7.0 Bit liquid (60%) in 7 15.0 Dibasic calcium phosphate (dihydrate salt) 35.0 Silicic anhydride 1.5 Satucharin natrichum 0.1 Rawalil 5 & acid sodium 2. O N-ni lumitoylglutami Δsodium 0.5 Salt 10.0 Preservative 0.05 Flavor 0.8 100.0 For the toothpaste compositions of Examples 1 to 4, Test Example 10 Foaming amount measurement method The release N& test was carried out in the same manner, and furthermore, the feeling of use was evaluated on a 20-sensory scale by 5 NOQners. The results are shown in the third chapter.

As shown in Table 3 and above, the dentifrice compositions of Examples 1 to 4 were all good in terms of foaming amount and overall evaluation.

Therefore, the sodium chloride-containing toothpaste of the present invention is very effective in preventing and treating gingivitis.

[Brief explanation of the drawing]

FIG. 1 is a diagram showing the relationship between the amount of sodium chloride and the foaming amount, and FIG. 2 is a diagram showing the synergistic increase in the foaming amount of the toothpaste of the present invention.

Claims (1)

[Scope of Claims] 1. A sodium chloride-containing dentifrice composition which is specially formulated to contain sodium alkyl sulfate and N-acyl glutamate as foaming agents. 2. The dentifrice composition according to claim 1, which contains 5 to 30% by weight of sodium chloride. (v) A dentifrice composition according to claim 1 or 2, which contains 0.1 to 3% by weight of sodium alkyl sulfate. 4. The dentifrice composition according to any one of claims 1 to 3, which contains 0.1 to 3% by weight of N-acylglutamate.