CN111417381B

CN111417381B - Oral scale remover, oral scale formation inhibitor, and oral composition

Info

Publication number: CN111417381B
Application number: CN201880076794.6A
Authority: CN
Inventors: 川延勇介; 高桥康彦
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2017-11-30
Filing date: 2018-11-27
Publication date: 2023-06-30
Anticipated expiration: 2038-11-27
Also published as: WO2019107332A1; JP7173043B2; CN111417381A; KR20200093439A; JPWO2019107332A1

Abstract

Provided are an oral cavity dirt remover with excellent effect of removing oral cavity dirt, an oral cavity dirt formation inhibitor with excellent effect of inhibiting oral cavity dirt formation, and an oral cavity composition containing the same. An oral cavity soil remover comprising (a) a polyacrylate salt having a weight average molecular weight of 1,000 to 20,000; an oral cavity soil remover comprising the component (a) and (b) a chelating agent selected from 1 or more of condensed phosphoric acid, phytic acid, edetic acid, citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof, wherein the pH of the 1 mass% aqueous solution at 25 ℃ is 1 to 11; and an oral composition comprising the above components (a) and (b). An inhibitor for oral cavity soil formation comprising the component (a), an inhibitor for oral cavity soil formation comprising the component (a) and at least 1 alginic acid derivative selected from the group consisting of an alginate and an alginic acid ester, and an oral cavity composition comprising the components (a) and (c).

Description

Oral scale remover, oral scale formation inhibitor, and oral composition

Technical Field

The present invention relates to an oral scale remover, an oral scale formation inhibitor, and an oral composition containing the same, which are effective in inhibiting the adhesion of scale to teeth and are useful for whitening teeth.

Background

The stains, which are one type of stains for teeth, are formed by a film containing a coloring component contained in saliva, foods, beverages, and foods, and hobbies, which adhere to the tooth surface, causing a coloring reaction, and being laminated and deposited with time and fixed to the tooth surface, and become strong stains. As a means for suppressing the adhesion of dirt to solve this problem, a method of removing dirt and a method of suppressing the formation of dirt can be considered.

Conventionally, in the means for removing colored stains, polishing removal by physical action of a polishing agent mixed in a composition is a common means, but there is a limit in that problems such as abrasion of oral mucosa and dentin at a suitable site may occur due to an increase in the polishing agent amount. Further, it is also known to impart a soil removal effect by using a condensed phosphate such as sodium polyphosphate, however, there are cases where such: if the amount of the condensed phosphate to be mixed is not relatively large, the effect cannot be exhibited, and further, as the amount to be mixed increases, there is a problem that the oral mucosa becomes more irritating.

Patent document 1 (WO 2016/194645) proposes: by combining condensed phosphate and fatty acid or fatty acid ester having a specific branched structure, a technique of removing dirt by chemical action while relaxing oral mucosa irritation is proposed in patent document 2 (japanese unexamined patent publication No. 9-175966), and a technique of removing dirt stains on the tooth surface by chemical action while mixing water-soluble pyrophosphate and polyphosphate is proposed, but there is room for improvement in the removal effect.

In addition, a technique for preventing the formation of dirt in advance has been attracting attention, and establishment of a technique for suppressing the formation of dirt has been desired.

As a method for suppressing the formation of dirt, patent documents 3 to 5 (japanese patent application laid-open publication No. 2003-81797, japanese patent application laid-open publication No. 2013-142061, japanese patent application laid-open publication No. 2015-174830) propose a method using various surfactants, but there are cases in which: if the amount of the surfactant to be mixed is not relatively large, the effect cannot be exhibited, and the odor derived from the surfactant is generated.

On the other hand, patent document 6 (japanese patent application laid-open No. 2000-247851) proposes: as a coloring-inhibiting coating agent for inhibiting the coloring of teeth caused by accumulation of stains, a technique of using polyacrylic acid or the like having a molecular weight of 2 ten thousand or more is proposed in patent document 7 (japanese patent publication No. 7-29907): polyacrylic acid polymers or polyacrylic acid copolymers having a weight average molecular weight of about 3,500 to 7,500 are mixed in an oral composition in an amount of about 2.5% or more as an anticalculus agent.

Prior art literature

Patent literature

WO2016/194645 [ patent document 1 ]

Japanese patent application laid-open No. 9-175966

Japanese patent application laid-open No. 2003-81797 (patent document 3)

Japanese patent application laid-open No. 2013-142061 (patent document 4)

Japanese patent application laid-open No. 2015-174830

Japanese patent application laid-open No. 2000-247851

Japanese patent publication No. 7-29907

Disclosure of Invention

Problems to be solved by the invention

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide a novel oral stain adhesion inhibitor for inhibiting stains from adhering to teeth, and an oral composition containing the inhibitor.

[ means for solving the problems ]

The present inventors have conducted intensive studies in order to achieve the above object, and as a result, found that: the polyacrylate having a weight average molecular weight in a specific range has an intraoral scale removal effect and a scale formation inhibition effect, thereby exhibiting an excellent scale adhesion inhibition effect. It has further been found that when the polyacrylate having a weight average molecular weight in a specific range and a specific chelating agent and/or a specific alginic acid derivative are used in combination, the effect of inhibiting the removal of dirt and/or the formation of dirt in the oral cavity is improved, and the effect of inhibiting the adhesion of dirt is further improved.

It has been found that, in particular, by mixing the above-mentioned combination system into an oral composition, a high scale removal effect and/or a scale formation inhibition effect can be imparted, an excellent scale adhesion inhibition effect can be imparted, and further, a good feel in use and a satisfactory effect feeling (sense of realism of effect) can be imparted, thereby completing the present invention.

Further, the present inventors have found that a polyacrylate having a weight average molecular weight of a specific value or less has an excellent stain removing effect in the oral cavity as a stain firmly fixed to teeth, and further found that the action of the polyacrylate is enhanced and the stain removing effect is remarkably improved when a specific chelating agent is used in combination. Then, it was found that a combination system of the polyacrylate and a specific chelating agent is mixed with the oral composition to provide an excellent stain removing effect, and further to suppress oral irritation in the oral cavity, particularly to mucous membranes, and to provide a feeling of use with a good flavor and taste, thereby completing the first invention.

As a binder for an oral composition, polyacrylic acid or a salt thereof is known, and usually, a crosslinked polyacrylic acid or a salt thereof having a weight average molecular weight of 10 ten thousand or more, usually about 30 ten thousand or more is used. The stains are obtained by forming a colored film on the surface of teeth, which is caused by saliva components, food and drink, and the like, and further laminating, depositing, and firmly constructing the colored film.

In contrast, in the present first invention, it has been found that (a) a polyacrylate having a weight average molecular weight of 1,000 to 20,000, particularly a linear polyacrylate, has: the heretofore unknown effect of removing strong stains already adhering to the tooth surface is achieved, whereby an exceptionally significant effect is obtained which cannot be achieved by polyacrylate having a weight average molecular weight of more than 20,000 or polyacrylic acid having a weight average molecular weight of 20,000 or less but not in the form of a salt.

As shown in comparative example I in tables 1 and 5, which will be described later, the soil removal effect by sodium polyacrylate having a weight average molecular weight of 300,000 or polyacrylic acid having a weight average molecular weight of 6,000 was X, while the soil removal effect by component (a) was O or more, as shown in examples in tables 1 to 5, excellent.

In addition, the removal rate of the scale by the chelating agent was low, and the removal effect was hardly observed (comparative example in table 5 described below). However, as shown in example I in tables 3 to 5, in the first invention, when the specific chelating agent (a) and the specific chelating agent (b) are used together, the synergistic effect between the components is generated, the soil removing effect is remarkably enhanced, and the unpleasant odor caused by the component (a) or the oral cavity irritation and odor caused by the component (b) can be suppressed, and the excellent feeling of use can be maintained.

Further, although the detailed mechanism of action of removing dirt in the first invention is not clear, it is presumed that the component (a) reacts specifically with dirt, and the dirt is easily lifted up, thereby removing dirt. Further, it is presumed that the above-mentioned action is enhanced when the component (b) is further used in combination.

The present inventors have found that, as a second invention, a polyacrylate having a weight average molecular weight of a specific value or less has an effect of inhibiting the formation of scale in the oral cavity, and has an excellent effect of inhibiting the formation of scale, and have further found that, when a specific alginic acid derivative (alginate or alginic acid ester) is used in combination, the effect of the polyacrylate is enhanced and the effect of inhibiting the formation of scale is remarkably improved. Then, it was found that by mixing the above-mentioned polyacrylate and alginic acid derivative in a combination system in an oral composition, an excellent scale formation inhibiting effect can be provided, and further, a satisfactory effect feeling can be provided, and the second invention has been completed.

In the second invention, it is clear that (a) a polyacrylate, particularly a linear polyacrylate, having a weight average molecular weight of 1,000 to 20,000 has: such hitherto unknown action effects of inhibiting the formation of stains on the tooth surfaces in the oral cavity are obtained, and thus, an extremely remarkable action effect which cannot be achieved by polyacrylate having a weight average molecular weight of more than 20,000 or polyacrylic acid having a weight average molecular weight of 20,000 or less but not in the form of a salt is obtained.

As shown in comparative example II in tables 6 and 8, which will be described later, the effect of inhibiting the formation of scale by sodium polyacrylate having a weight average molecular weight of 300,000 or polyacrylic acid having a weight average molecular weight of 6,000 was all x, but as shown in example II in tables 6 and 7, the effect of inhibiting the formation of scale by component (a) was all o or excellent.

As shown in comparative examples in table 8 described below, although the scale formation inhibitory effect by alginate or alginate ester was hardly observed, the scale formation inhibitory effect was remarkably enhanced by the synergistic effect of the component (a) and the component (c) of at least 1 type of alginic acid derivative selected from the group consisting of alginate and alginate ester in the second invention, as shown in examples in tables 6 and 7, and the following effect was felt: after continued use, the tooth surface was perceived to be smooth, and the actual perception was substantially inhibited from scale formation.

Further, the mechanism of action of the inhibition of the formation of stains in the second invention is not clear, but it is presumed that the formation of a colored thin film by binding of saliva components, metal ions from foods and beverages, and the like to the tooth surface is chemically inhibited by the action peculiar to the component (a), and the formation of stains can be inhibited by preventing the accumulation. Further, it is presumed that when component (c) is used in combination, the above effect is remarkably improved, and the adsorption and residue of component (c) on the tooth surface are improved, and the formation of scale can be continuously suppressed even after continuous use, thereby improving the effect feeling.

The invention of patent document 6 is to inhibit staining by coating and to hydrophilize the tooth surface after coating, thereby facilitating removal of a stained film (stained film) and preventing accumulation. The invention of patent document 7 is that the effect can be achieved by using a use amount of about 2.5% or more by suppressing dental calculus by a polyacrylic acid polymer or the like.

In contrast, the present invention is as follows: the effect of the polyacrylate in a non-salt form is poor in the case of the polyacrylate having a specific molecular weight of (a) in the removal of dirt and the inhibition of the formation of dirt, and the adhesion of dirt by these, and on the other hand, the effect is excellent even when the amount of the component (a) in the oral composition is 1 mass% or less.

Accordingly, the present invention provides the following oral cavity soil remover, oral cavity soil formation inhibitor and oral cavity composition.

[ 1 ] an oral cavity soil remover comprising:

(a) A polyacrylate having a weight average molecular weight of 1,000 to 20,000.

[ 2 ] an oral cavity soil remover comprising:

(a) A polyacrylate having a weight average molecular weight of 1,000 to 20,000, and

(b) Chelating agent selected from 1 or more of condensed phosphoric acid, phytic acid (phytic acid), edetic acid (edetic acid), citric acid, malic acid, succinic acid, dicarboxylic acid and their salts with 1 mass% aqueous solution at 25deg.C and pH of 1-11.

The oral cavity soil remover according to [ 2 ], wherein (a)/(b) is 0.01 to 50 in terms of mass ratio.

The oral soil remover according to any of [ 1 ] to [ 3 ], wherein the polyacrylate of component (a) has a weight average molecular weight of 1,000 to 10,000.

[ 5 ] an oral composition comprising:

(b) Chelating agent selected from 1 or more of condensed phosphoric acid, phytic acid, edetic acid, citric acid, malic acid, succinic acid, dicarboxylic acid and their salts with 1 mass% aqueous solution at 25 ℃ and pH of 1-11.

The composition for oral cavity according to [ 5 ], wherein the polyacrylate of the component (a) has a weight average molecular weight of 1,000 to 10,000.

The composition for oral cavity according to [ 5 ] or [ 6 ], wherein (a)/(b) is 0.01 to 50 in terms of mass ratio.

The composition for oral cavity according to any one of [ 5 ] to [ 7 ], wherein the composition for oral cavity contains 0.01 to 2% by mass of the component (a) and 0.03 to 3% by mass of the component (b).

The composition for oral cavity according to any one of [ 5 ] to [ 8 ], wherein the composition for oral cavity further comprises 0.05 to 2% by mass of (c) 1 or more alginic acid derivatives selected from the group consisting of alginic acid salts and alginic acid esters.

The composition for oral cavity according to any one of [ 5 ] to [ 9 ], which is for removing dirt.

The oral composition according to any one of [ 5 ] to [ 10 ], which is a dentifrice composition.

[ 12 ] an inhibitor of oral cavity scale formation, which comprises (a) a polyacrylate having a weight average molecular weight of 1,000 to 20,000.

[ 13 ] an inhibitor of oral scale formation, comprising:

(c) More than 1 alginic acid derivative selected from alginate and alginic acid ester.

The inhibitor for oral cavity scale formation according to [ 13 ], wherein (a)/(c) is 0.05 to 5 in terms of mass ratio.

The inhibitor for oral cavity scale formation according to any one of [ 12 ] to [ 14 ], wherein the polyacrylate has a weight average molecular weight of 1,000 to 10,000.

[ 16 ] an oral composition comprising:

The composition for oral cavity according to [ 17 ], wherein the polyacrylate has a weight average molecular weight of 1,000 to 10,000.

The composition for oral cavity according to [ 16 ] or [ 17 ], wherein (a)/(c) is 0.05 to 5 in terms of mass ratio.

The oral composition according to any one of [ 16 ] to [ 18 ], wherein the oral composition contains 0.01 to 2% by mass of the component (a) and 0.05 to 2% by mass of the component (c).

The composition for oral cavity according to any one of [ 16 ] to [ 19 ], which is for inhibiting scale formation.

The oral composition according to any one of [ 16 ] to [ 20 ], which is a dentifrice composition.

[ Effect of the invention ]

The present invention provides an oral soil remover, an oral soil formation inhibitor, and an oral composition containing the same, each having an effect of inhibiting the removal of dirt and/or the formation of dirt in the oral cavity.

That is, according to the present invention, as a first invention, an oral cavity soil remover excellent in the effect of removing oral cavity soil and an oral cavity composition containing the remover can be provided. The composition for oral cavity has high dirt removing effect and good use feeling, and can effectively inhibit dirt, thereby being suitable for whitening in oral cavity and preventing or inhibiting oral diseases.

Further, as the second invention, an oral scale formation inhibitor excellent in the effect of inhibiting the formation of scales in the oral cavity and an oral composition containing the inhibitor can be provided. The composition for oral cavity has high effect of inhibiting the formation of dirt and can give satisfactory effect feeling, so that the composition for oral cavity can effectively inhibit the formation of dirt, and is effective for whitening in oral cavity and preventing or inhibiting oral diseases.

Detailed Description

The present invention will be described in further detail below.

The oral cavity dirt remover and the oral cavity dirt formation inhibitor of the invention comprise the following components: (a) The polyacrylate having a weight average molecular weight of 1,000 to 20,000 is preferably composed of: component (a) and (b) are selected from 1 or more chelating agents selected from 1 or more of condensed phosphoric acid, phytic acid, edetic acid, citric acid, malic acid, succinic acid, dicarboxylic acid and salts thereof having a pH of 1 to 11 at 25 ℃ in a 1 mass% aqueous solution and/or (c) are selected from 1 or more alginic acid derivatives selected from alginate and alginic acid esters.

That is, the oral cavity soil remover of the first invention contains the component (a), preferably contains the components (a) and (b), and the component (a) (preferably the components (a) and (b)) is an effective component for removing the soil. The oral cavity scale formation inhibitor of the second invention contains a component (a), preferably contains a component (a) and a component (c), and the component (a) (preferably the component (a) and the component (c)) is an active component for inhibiting the scale formation. Thus, in the present invention, the component (a) is used; the components (a) and (b), or the components (a), (b) and (c), thereby having a soil removing effect and/or a soil formation inhibiting effect, and exerting an excellent effect of inhibiting the adhesion of the soil by their effect.

In the present invention, the term "dirt adhering" means a state where dirt adheres, and the term "dirt adhering inhibition" means a state where dirt does not adhere. "soil removal" refers to removal of formed fixed soil, and "soil formation inhibition" refers to prevention of fixation of soil.

(a) The polyacrylate of the component (A) has a weight average molecular weight (Mw) of 1,000 to 20,000. In this case, the weight average molecular weight is 1,000 or more, preferably 2,000 or more, and 20,000 or less, preferably 10,000 or less, more preferably 8,000 or less, from the viewpoints of the soil removal effect and the soil formation inhibition effect. When the weight average molecular weight is less than 1,000, the soil removal effect and the soil formation inhibition effect are poor. When the weight average molecular weight is more than 20,000, the soil removal effect and the soil formation inhibition effect are reduced, and sufficient effects cannot be obtained.

The measurement of the weight average molecular weight was performed by GPC (gel permeation chromatography) under the method and measurement conditions described in japanese patent No. 5740859. Specifically, the following is described (the same applies hereinafter).

A method for measuring weight average molecular weight;

the weight average molecular weight is a value measured using a gel permeation chromatograph/multi-angle laser light scattering detector (GPC-MALLS), and the measurement conditions are as follows.

Mobile phase: 0.3M NaClO ₄

NaN ₃ Aqueous chromatographic column: TSKgel alpha-M2 root

Front column: TSKguardcolumnα

Standard substance: polyethylene glycol

From the viewpoints of the soil removal effect and the soil formation inhibition effect, the polyacrylate of the component (a) is preferably a linear polyacrylate.

The salt is preferably a monovalent salt, more preferably an alkali metal salt or an ammonium salt, further preferably an alkali metal salt such as a sodium salt or a potassium salt, and particularly preferably a sodium salt.

As such polyacrylate, commercially available products sold by Polyscience corporation, toyama Synthesis Co., ltd.

As specific commercial products, sodium polyacrylate (Mw: 1,000) can be used: straight, manufactured by Polyscience corporation; sodium polyacrylate (Mw: 6,000): straight chain, manufactured by Toyama Synthesis Co., ltd., AC-10NP, AC-10NPD, aron T-50; sodium polyacrylate (Mw: 8,000): straight, manufactured by Polyscience corporation; sodium polyacrylate (Mw: 20,000): straight chain, aron A-20UN, manufactured by Toyama Synthesis Co., ltd.

The polyacrylate of the component (a) has a weight average molecular weight lower than that of the polyacrylate of a binder used in a usual dentifrice, and is different from the polyacrylate known as a binder.

When a polyacrylate other than the component (a) or a polyacrylic acid in a form other than a salt is used instead of the component (a), the effect of removing dirt and inhibiting the formation of dirt is poor, and even if the component (b) is further used in combination, the effect is poor, and even if the component (c) is further used in combination, the effect is poor, and the effect feeling is poor, so that the object of the present invention cannot be achieved.

In the present invention, the oral cavity soil remover of the first invention is preferably used in combination with the specific chelating agent (b) in addition to the component (a) as an active ingredient. When the components (a) and (b) are used in combination, the soil removing effect is further improved.

(b) The component (b) is a chelating agent selected from the following (b 1) to (b 5). They may be used alone or in combination of 1 kind or 2 or more kinds. In addition, 2 or more of the components (b 1) to (b 5) may be used in combination.

(b1) The method comprises the following steps More than 1 kind selected from condensed phosphoric acid and its salt with 1 mass% water solution at 25 ℃ and pH of 1-11

(b2) The method comprises the following steps More than 1 selected from phytic acid and its salt

(b3) The method comprises the following steps More than 1 kind selected from edetic acid and its salt

(b4) The method comprises the following steps More than 1 selected from citric acid and its salt

(b5) The method comprises the following steps More than 1 selected from malic acid, succinic acid, dicarboxylic acid and their salts

The types of the salts in (b 1) to (b 5) are not particularly limited, and examples thereof include metal salts such as sodium salts and potassium salts, and sodium salts are particularly preferred.

(b1) The 1% by mass aqueous solution of the condensed phosphoric acid and a salt thereof has a pH of 11 or less, particularly preferably 10 or less at 25 ℃, and the lower limit is not particularly limited, but may be 1 or more and 7 or more.

As the condensed phosphate, sodium salt and potassium salt are preferable.

Specifically, linear or cyclic polyphosphates such as sodium or potassium pyrophosphate, sodium or potassium tripolyphosphate, sodium or potassium tetrapolyphosphate, sodium or potassium metaphosphate, sodium or potassium superphosphate (ultraphosphate sodium or potassium) and the like can be used.

Among them, sodium tripolyphosphate (1% by mass aqueous solution, pH7 to 10 at 25 ℃), sodium pyrophosphate (1% by mass aqueous solution, pH7 to 11 at 25 ℃), sodium metaphosphate (1% by mass aqueous solution, pH1 to 8 at 25 ℃) and sodium superphosphate (1% by mass aqueous solution, pH1 to 7 at 25 ℃) are preferable, and sodium tripolyphosphate is more preferable.

(b2) Particularly preferred are phytic acid and (b 3) particularly preferred are edetate salts, especially preferred are disodium edetate. (b4) Citric acid and sodium citrate are particularly preferable, and citric acid is particularly preferable.

(b5) Is 1 or more than 2 kinds selected from malic acid, succinic acid, dicarboxylic acid and their salts.

Examples of dicarboxylic acids include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, azelaic acid, sebacic acid, phthalic acid, isophthalic acid, and terephthalic acid.

(b5) Particularly preferred are compounds selected from the group consisting of malic acid, succinic acid and salts thereof. In this case, it is preferable to use a compound containing these compounds.

Further, the ratio of (a)/(b) representing the amount of the component (a) to the component (b) is preferably 0.01 to 50, more preferably 0.01 to 10, particularly preferably 0.01 to 8 in terms of mass ratio. By making this range, the scale removing effect and the feeling of use (oral cavity irritation, smell, taste) are more excellent.

The oral soil remover of the first invention can be obtained by: the component (a) is preferably used alone, and the component (b) is further used in combination, and the above components are mixed. Further, if necessary, a known component for other oral use may be contained, and in this case, a known component may be mixed within a range that does not hinder the effect of the present invention.

In the present invention, in the oral cavity scale formation inhibitor of the second invention, it is preferable that (c) at least 1 kind of alginic acid derivative selected from the group consisting of alginic acid salts and alginic acid esters is used in combination as the active ingredient in addition to the component (a). When the components (a) and (c) are used in combination, the scale formation inhibitory effect is further improved.

(c) The component (a) is a salt or ester of alginic acid as a polysaccharide.

The alginate may be any alginate that is generally used in oral compositions, and sodium alginate may be used. The sodium alginate is preferably sodium alginate having a viscosity of 1 mass% aqueous solution (BL type viscometer, rotor No. 3, 12rpm,20 ℃ C., measurement time of 3 minutes) of 1,000 to 4,000 mPas. For example, a commercially available product such as KIMICA ALGIN from KIMICA corporation may be used.

As the alginic acid ester, any alginic acid ester may be used as long as it is used in a usual oral composition, but propylene glycol alginate is particularly preferable. Among them, an acrylic acid ester having a viscosity of a 1 mass% aqueous solution (BL type viscometer, rotor No. 2, 60rpm,20 ℃ C., measurement time of 3 minutes) of 10 to 200 mPas is preferable. For example, commercially available products such as KIMILOID BF from KIMICA Co., ltd.

Further, the ratio of the amounts of the component (a) and the component (c), (a)/(c), may be 0.005 to 20 in terms of mass ratio, and from the viewpoint of the scale formation inhibitory effect, it is preferably 0.05 to 5, more preferably 0.1 to 2. Within this range, the scale formation suppressing effect and effect feeling are more excellent.

The oral scale formation inhibitor of the second invention can be obtained by: as the active ingredient, the component (a) is used alone, and it is preferable to further mix the above components together with the component (c). Further, if necessary, a known component for other oral use may be contained, and in this case, a known component may be mixed within a range that does not hinder the effect of the present invention.

In the present invention, when the components (a), (b) and (c) are used in combination as the active ingredient, the effect of removing dirt and inhibiting the formation of dirt is improved, the effect of inhibiting the adhesion of dirt is further improved, and a more excellent effect can be provided, and the composition is also suitable as an oral dirt adhesion inhibitor.

The oral composition of the present invention contains a component (a) and a component (b) and/or a component (c).

In the present invention, the first oral composition contains the components (a) and (b), and the second oral composition contains the components (a) and (c). When the oral composition of the present invention contains the components (a), (b) and (c), it is more preferable from the viewpoints of the stain removing effect and the stain formation inhibiting effect.

Specifically, the oral composition may be suitably mixed with a paste, gel or liquid dentifrice (paste dentifrice, gel dentifrice, liquid dentifrice, etc.), mouthwash, oral spray, coating agent, patch, etc. Among these, dentifrice compositions are particularly suitable as paste dentifrice compositions. The first invention is suitable as an oral composition for removing dirt because of its excellent dirt removing effect, and the second invention is suitable as an oral composition for inhibiting dirt formation because of its excellent dirt formation inhibiting effect. The oral composition of the present invention has excellent stain removing effect and stain formation inhibiting effect, and is therefore also suitable as an oral composition for inhibiting the adhesion of stains.

In this case, when the components (a) and (b) are used in combination, the scale removing effect is excellent, and thus (a)/(b) is preferably defined at the above-mentioned specific ratio. The mixing amounts of the component (a) and the component (b) are preferably in the ranges described below, respectively, from the viewpoints of the scale removing effect and the feeling of use, and the above-mentioned components are preferably used in concentrations satisfying these ranges.

When the components (a) and (c) are used in combination, the scale (a)/(c) is preferably the above-mentioned specific ratio gauge because the scale formation inhibitory effect is excellent. The mixing amounts of the component (a) and the component (c) are preferably in the ranges described below, respectively, from the viewpoints of the scale formation inhibitory effect and the effect feeling, and the above-mentioned components are preferably used in concentrations satisfying these ranges.

When the components (a), (b) and (c) are used in combination, the scale removal effect and the scale formation inhibition effect are excellent, and therefore, it is more preferable to define the specific ratios (a)/(b), (a)/(c), respectively. The mixing amounts of the components (a), (b) and (c) are preferably in the ranges described below, respectively, from the viewpoints of the soil removal effect, the soil formation inhibition effect, the feeling of use and the effect feeling, and the above-mentioned components may be used in concentrations satisfying these ranges.

(a) The mixing amount of the components is preferably 0.01 to 2% by mass (the same applies hereinafter) of the whole composition. When the mixing amount is 0.01% or more, a sufficient scale removal effect and scale formation inhibition effect can be obtained. When the mixing amount is 2% or less, the odor derived from the component (a) can be sufficiently suppressed.

Further, when the component (a) and the component (b) are used in combination, the mixing amount of the component (a) is preferably 0.01 to 2%, more preferably 0.03 to 1%, still more preferably 0.03 to 0.8% of the entire composition. When the mixing amount is 0.01% or more, a sufficient scale removal effect can be obtained. When the mixing amount is 2% or less, the odor derived from the component (a) can be sufficiently suppressed.

When the component (a) and the component (c) are used in combination, the mixing amount of the component (a) is preferably 0.01 to 2%, more preferably 0.05 to 1%, still more preferably 0.1 to 0.8% of the entire composition. When the mixing amount is 0.01% or more, a sufficient scale formation inhibiting effect can be obtained. When the mixing amount is 2% or less, a sufficient scale formation inhibiting effect can be obtained, and the odor derived from the component (a) can be sufficiently inhibited.

(b) The mixing amount of the components is preferably 0.03 to 3%, more preferably 0.1 to 3% of the entire composition. When the mixing amount is 0.03% or more, a sufficient scale removal effect can be obtained. When the amount is 3% or less, oral irritation can be suppressed, and a feeling of use with good smell and taste can be imparted.

In addition, in the range of the mixing amount of the component (b), when the component (b 1) is mixed as the component (b), the preferable mixing amount of the component (b 1) is 0.03 to 1%, particularly 0.03 to 0.5% of the whole composition. When the components (b 2) to (b 5) are mixed as the component (b), the preferable mixing amount is 0.03 to 3%, particularly 0.1 to 3% of the whole composition. The components (b 1) to (b 5) may be used in an amount of 1 kind within the above range, or 2 or more kinds may be used in a total amount of the component (b).

(c) The mixing amount of the components is preferably 0.05 to 2%, more preferably 0.1 to 1% of the entire composition. When the mixing amount is 0.05% or more, a sufficient scale formation inhibiting effect can be obtained. When the mixing amount is 2% or less, a sufficient effect feeling can be obtained, and the feeling in use is also good. If the component (c) is more than 2%, the stringiness may be enhanced and the effect may be reduced.

In the oral composition of the present invention, in addition to the above-mentioned component (a), further components (b) and (c), a known component corresponding to a dosage form or the like may be added as an optional component other than these components as required within a range not to impair the effects of the present invention. Specifically, the dentifrice can be produced by blending an abrasive, a binder, a thickener, and a surfactant, and further blending a sweetener, a preservative, a colorant, a flavor, and an active ingredient with water.

Examples of the polishing agent include: silica-based abrasives such as silicic anhydride, crystalline silica, amorphous silica, silica gel (silica gel), and aluminum silicate; calcium phosphate-based abrasives such as tricalcium phosphate, tetracalcium phosphate, anhydrous dicalcium phosphate, dibasic calcium phosphate dihydrate; a zeolite; calcium pyrophosphate; calcium carbonate; sodium bicarbonate; aluminum hydroxide; alumina; magnesium carbonate; tri-magnesium phosphate; zirconium silicate; hydroxyapatite; synthetic resin polishing agent. Among these, from the viewpoints of oral mucosa irritation and usability, silica-based abrasives such as silicic anhydride and calcium phosphate-based abrasives are preferable, and silicic anhydride is particularly preferable.

The mixing amount of the polishing agent is preferably 0 to 60% of the entire composition, and in the case of mixing, 3 to 60% is preferable, and 5 to 55% is particularly preferable. The upper limit is preferably 20% or less, or 15% or less. The amount of abrasive in the paste dentifrice is preferably 10 to 55% of the entire composition, and the amount of abrasive in the mouthwash is preferably 0 to 10% of the entire composition, particularly preferably 0 to 5%.

The oral composition of the present invention has excellent stain-removing effect even without mixing abrasives.

A binder, which may be mixed with gums such as xanthan gum, tragacanth gum, gellan gum, karaya gum, acacia gum and the like; cellulose derivatives such as crosslinked polyacrylate, carrageenan, sodium carboxymethyl cellulose, methylcellulose, hydroxyethyl cellulose, sodium carboxymethyl hydroxyethyl cellulose and the like with a weight average molecular weight of more than 20,000; organic binders such as polyvinyl alcohol, carboxyvinyl polymer, polyvinylpyrrolidone and the like; inorganic binders such as silica gel, alumina silica gel, magnesium aluminum silicate (veegum), and lithium magnesium silicate (laponite) (the mixing amount is usually 0.3 to 10%).

Examples of the thickener include sugar alcohols such as sorbitol, maltitol, lactitol, erythritol and xylitol; the polyhydric alcohol such as propylene glycol may be mixed with 1 or 2 or more (the mixing amount is usually 5 to 70%).

As the surfactant, an anionic surfactant, a nonionic surfactant, and an amphoteric surfactant may be mixed. They may be used in an amount of 1 or 2 or more.

Examples of the anionic surfactant include alkyl sulfates having an alkyl group having 12 to 14 carbon atoms (particularly 12), acyl amino acid salts, acyl taurates, and the like. The acyl groups of the acyl amino acid salt and the acyl taurate are each preferably 12 to 14 carbon atoms, and particularly preferably 12 carbon atoms.

Specifically, as the alkyl sulfate, there may be mentioned: lauryl sulfate, myristyl sulfate; as the acyl amino acid salt, there may be mentioned: acyl glutamate such as lauroyl glutamate, acyl sarcosinate such as myristoyl glutamate, and the like; as acyl taurates, lauroyl methyl taurates are exemplified. The salt is preferably an alkali metal salt such as sodium salt or potassium salt. Alkyl sulphates, acyl sarcosinates and acyl taurates are particularly preferred. Among them, anionic surfactants having a hydrocarbon group (lauryl group) of 12 carbon atoms are preferable, and alkyl sulfate (sodium salt) is more preferable in particular from the viewpoint of being superior to other surfactants in terms of taste.

Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated castor oil, polyoxyethylene ether of glyceride, sucrose fatty acid ester, alkanolamide, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, and glycerin fatty acid ester. Among them, polyoxyethylene alkyl ether, polyoxyethylene hydrogenated castor oil, alkanolamide, sorbitan fatty acid ester are suitable from the viewpoint of versatility. The polyoxyethylene alkyl ether has preferably 14 to 30 carbon atoms in the alkyl chain, and preferably 3 to 30 moles of ethylene oxide added on average (average addition of EO). The average addition EO of the polyoxyethylene hydrogenated castor oil is preferably 10 to 100. The number of carbon atoms of the alkyl chain of the alkanolamide is preferably 12 to 14. The fatty acid of the sorbitan fatty acid ester preferably has 12 to 18 carbon atoms; the polyoxyethylene sorbitan fatty acid ester has preferably 16 to 18 carbon atoms in the fatty acid, and preferably 10 to 40 average EO addition.

The amphoteric surfactant includes acylaminoacetic acid betaine having an acyl group having 12 to 14 carbon atoms and fatty acid amidopropyl betaine. Examples of the acylaminoacetic acid betaine include lauroyl dimethylaminoacetic acid betaine and the like; as the fatty acid amidopropyl betaine, coco fatty acid amidopropyl betaine and the like are exemplified.

The mixing amount of the surfactant is preferably 0 to 15%, particularly preferably 0.01 to 10%. The mixing amount of the anionic surfactant is preferably 0.1 to 3%, particularly preferably 0.5 to 2%, and the mixing amount of the nonionic surfactant is preferably 0.01 to 10%.

In the present invention, when a nonionic surfactant, particularly polyoxyethylene hydrogenated castor oil, is used in combination with the component (a), the odor and taste may be deteriorated depending on the amount of the nonionic surfactant added, and when the nonionic surfactant is added together with an anionic surfactant such as an alkyl sulfate, the deterioration of the odor and taste may be prevented, and the scale removal effect and scale formation inhibition effect may be further improved without reducing the feeling of use.

The sweetener may be saccharin sodium, stevioside, dipotassium glycyrrhizinate, perilla herba pepsin (Thaumatin), neohesperidin dihydrochalcone, or aspartyl phenylalanine methyl ester. Examples of the preservative include parahydroxybenzoate and sodium benzoate.

Examples of the colorant include blue No. 1, yellow No. 4, and titanium dioxide.

Fragrances, which may be used: peppermint oil (peppermint oil), spearmint oil, fennel oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, orange oil (mandarin oil), lime oil, lavender oil, rosemary oil, bay oil, chamomile oil, caraway oil, oregano oil (marjoram oil), bay leaf oil, lemon grass oil, oregano oil, pine needle oil, orange flower oil, rose oil, jasmine oil, iris extract, peppermint oil, rose absolute, orange flower absolute and the like, and perfumes obtained by processing (front cut, rear cut, fractional distillation, liquid-liquid extraction, rectification, perfume powdering and the like) of these natural perfumes, and single flavors such as menthol, carvone, anethole, methyl salicylate, cinnamaldehyde, 3-l-menthoxypropane-1, 2-diol, linalool acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, pulegone, carvone acetate, anisyl aldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexyl propionate, methyl anthranilate, ethyl methyl phenyl glycidate, vanillin, undecalactone, hexanal, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenone, furfural, trimethyl pyrazine, ethyl lactate, ethyl thioacetate, and further, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, pineapple flavor, the known flavor materials used in oral compositions such as butter flavor essence, milk flavor essence, mixed fruit flavor essence, and blended flavors such as tropical fruit flavor essence are not limited to the flavors of examples.

The above-mentioned perfume raw material is preferably used in an amount of 0.000001 to 1% of the entire composition. The flavoring agent using the above-mentioned flavoring material is preferably used in an amount of 0.001 to 2.0% in the composition.

Any active ingredient may be mentioned: nonionic bactericides such as isopropyl methyl phenol; cetylpyridinium chloride (cetylpyridinium chloride) and other cationic bactericides; enzymes such as dextranase (dextranase), mutanase (mutanase), lysozyme (lysozyme), amylase, protease, lysozyme, and SOD (superoxide dismutase); alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; fluoride such as sodium fluoride and stannous fluoride; antiinflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, allantoin aluminum hydroxychloride, dihydrocholesterol, glycyrrhizic acid, glycyrrhetinic acid, etc.; a hyperesthesia improving agent such as potassium nitrate and aluminum lactate; glycerophosphate; chlorophyll; sodium chloride; zinc compounds such as zinc chloride, zinc oxide, and zinc citrate; copper compounds such as gluconic acid ketone and copper sulfate; vitamins such as vitamin A, vitamin B group, vitamin C, and vitamin E; cortex Phellodendri, tea, etc. The number of these active ingredients may be 1 or 2 or more, and an effective amount of these active ingredients may be mixed within a range that does not hinder the effects of the present invention.

The pH (25 ℃) of the oral composition may be in a usual range, and is preferably from 5 to 9, particularly preferably from 6 to 8. In addition, a known pH adjuster may be added to adjust the pH, and hydrochloric acid may be used, for example; or an alkali metal hydroxide such as sodium hydroxide.

Further, preferred embodiments of the first and second inventions are as follows.

[ example ]

The present invention will be specifically described below by way of examples and comparative examples, but the present invention is not limited to the examples described below. In the following examples,% represents% by mass unless otherwise specified.

Further, the weight average molecular weight (Mw) was measured by the same method and measurement conditions as described above using a gel permeation chromatograph/multi-angle laser light scattering detector (GPC-MALLS).

Example I, comparative example I

Oral preparations were prepared in which the polyacrylate salts were mixed in the types and amounts shown in tables 1 to 3 and the component (b) was further mixed, and the scale removal effect was evaluated by the following method. The results are shown in tables 1 to 3.

Dentifrice compositions (paste dentifrices) having the compositions shown in tables 4 and 5 were prepared by a usual method, and filled into aluminum tube containers. Soil removal effect and feel in use were evaluated as follows. The results are shown in tables 4 and 5.

(1) Method for evaluating soil removal effect

A hydroxyapatite plate (manufactured by HOYA corporation, diameter Φ7.0mm×thickness 3.5mm, hereinafter abbreviated as HAP plate) having a surface polished by sand blasting was immersed in each of the following solutions for 30 minutes at room temperature in this order in order as 1 cycle: (i) 0.5% aqueous albumin solution; (ii) Extracting tannin solution (Japanese Tea (brand: laoSong) 50g, black Tea Bag (Brisk Tea Bag, manufactured by Liton Corp.) 5 g with hot water, cooling, adding 12g of coffee powder (manufactured by Nelumbo Corp.) to prepare 1,200mL solution with purified water, repeating the operation of immersing in ammonium solution of 0.56% ferric (III) citrate for 1 cycle for 8-9 times for 1 day until the dirt is sufficiently adhered to HAP plate, and continuing for about 30 days to form firm dirt.

Measurement of L Using a spectrocolorimeter (manufactured by Nippon Denshoku Co., ltd., SE-2000) ^* The value was used to determine the degree of adhesion of dirt. L of HAP plate before treatment ₀ ^* The value is taken as the initial valuePost-reason L ₁ ^* The value is taken as a blank value. Next, the scale-adhering HAP plate was immersed in artificial saliva (50mM KCl,1mM CaCl) ₂ ，0.1mM MgCl ₂ ，1mM KH ₂ PO ₄ Ph 7.0) was diluted 3-fold for 2.5 minutes in the dentifrice solution, and then subjected to a brushing treatment in the same test solution using a plate grinder. 200 times of brushing treatment were performed. Washing with water after brushing, and measuring L ₂ ^* Values. The soil removal rate was calculated according to the following formula, and the soil removal effect was evaluated.

Soil removal rate (%) =

{((L ₁ ^* -L ₀ ^* )-(L ₂ ^* -L ₀ ^* ))/(L ₁ ^* -L ₀ ^* )}×100

Evaluation criteria for soil removal Effect

Very good: the dirt removal rate is above 50%

Very good: the dirt removal rate is more than 40% and less than 50%

Very good: the dirt removal rate is more than 30% and less than 40%

And (3) the following materials: the dirt removal rate is more than 25% and less than 30%

O: the dirt removal rate is more than 20% and less than 25%

Delta: the dirt removal rate is more than 10% and less than 20%

X: the dirt removal rate is less than 10 percent

(2) Method for evaluating sensation of use (oral cavity irritation, smell, taste)

10 panelists placed the dentifrice composition on a toothbrush and brushed their teeth for 3 minutes to clean the oral cavity. The sense of use (oral cavity irritation, smell, taste) at this time was evaluated by sensory evaluation according to the following scoring criteria. The average of scores of 10 persons was calculated, and oral cavity irritation, smell, and taste were determined based on the following evaluation criteria.

Scoring criteria for oral cavity irritation

4, the following steps: no stimulus is felt in the oral cavity

3, the method comprises the following steps: hardly stimulating in the oral cavity

2, the method comprises the following steps: slightly perceived irritation in the oral cavity

1, the method comprises the following steps: intraoral sensory stimulation

Evaluation criteria for oral irritation

And (3) the following materials: average 3.0 to 4.0

O: average 2.5 min or more and less than 3.0 min

Delta: average 1.5 min or more and less than 2.5 min

X: average score is less than 1.5 minutes

Odor scoring criteria

4, the following steps: uncomfortable odors are not perceived in the mouth

3, the method comprises the following steps: hardly perceivable unpleasant smell in the oral cavity

2, the method comprises the following steps: slightly uncomfortable odors were felt in the mouth

1, the method comprises the following steps: uncomfortable odors are perceived in the mouth

Evaluation criteria for odor

And (3) the following materials: average 3.5 to 4.0 minutes

O: average 3.0 min or more and less than 3.5 min

Delta: average score of 2.0 or more and less than 3.0

X: average score less than 2.0

Taste scoring criteria

4, the following steps: no bad smell is felt in the oral cavity

3, the method comprises the following steps: hardly feel peculiar smell in oral cavity

2, the method comprises the following steps: slightly perceived bad smell in the oral cavity

1, the method comprises the following steps: bad smell is felt in the oral cavity

Evaluation criteria for taste

And (3) the following materials: average 3.5 to 4.0 minutes

O: average 3.0 min or more and less than 3.5 min

Delta: average score of 2.0 or more and less than 3.0

X: average score less than 2.0

Details of the raw materials used are as follows.

(a) Sodium polyacrylate (Mw: 1,000)

Straight chain, manufactured by Polyscience Co

(a) Sodium polyacrylate (Mw: 6,000)

Straight chain, manufactured by Toyama Synthesis Co., ltd., AC-10NP

(a) Sodium polyacrylate (Mw: 8,000)

Straight chain, manufactured by Polyscience Co

(a) Sodium polyacrylate (Mw: 20,000)

Straight chain, manufactured by Toyama Synthesis Co., ltd., aron A-20UN

Sodium polyacrylate (Mw: 300,000, comparative composition)

Cross-linking type manufactured by Polyscience Co

Polyacrylic acid (Mw: 6,000, comparative composition)

Straight chain, aron A-10SL manufactured by east Asia Synthesis Co., ltd

(b) Citric acid

Hibiscus chemical industry Co., ltd., product name: refined citric acid (Crystal)

(b) Malic acid (DL-malic acid)

Hibiscus chemical industry Co., ltd., product name: malic acid FUSO

(b) Phytic acid (50% liquid)

Hibiscus chemical industry Co., ltd., product name: phytic acid

(b) Edetic acid disodium salt

Manufactured by pure chemical Co., ltd

(b) Sodium tripolyphosphate

Manufactured by Taiping chemical industry Co Ltd

(b) Sodium metaphosphate

Manufactured by Taiping chemical industry Co Ltd

[ Table 1 ]

[ Table 2 ]

[ Table 3 ]

* : the amount of phytic acid to be mixed was the amount of the pure component (the same applies hereinafter).

[ Table 4 ]

[ Table 5 ]

Example II, comparative example II

An oral preparation containing polyacrylate or alginate in an amount and a type shown in Table 6 was produced by a usual method, and the scale formation inhibitory effect was evaluated in the following manner. The results are shown in Table 6.

Dentifrice compositions (paste dentifrices) having the compositions shown in tables 7 and 8 were prepared by a usual method, and filled into aluminum tube containers. The scale formation inhibitory effect and effect feel were evaluated as follows. The results are shown in tables 7 and 8.

(3) Method for evaluating scale formation inhibition effect

The hydroxyapatite plate (manufactured by HOYA corporation, diameter phi 7.0mm x thickness 3.5mm, hereinafter abbreviated as HA plate) after the surface was polished by sand blasting was measured by a spectrocolorimeter (manufactured by japan electric color corporation, SE-2000) to obtain a Δe value (Δe ₀ ). The above HA plate was immersed in (i) a test solution (supernatant obtained by centrifugation of a 3-fold dilution of artificial saliva of an oral preparation), and allowed to stand in a constant temperature bath at 50℃for 10 minutes. Taking out the HA plate and removing the HA plate tableThe water content of the dough was immersed in each of the following solutions at room temperature for 10 minutes in this order, and immersed in a constant temperature bath at 50 ℃): (ii) 0.5% aqueous albumin; (iii) Extracting tannin solution (Japanese Tea (brand: laoSong) 50g, black Tea Bag (Brisk Tea Bag, manufactured by Liton Corp.) 5 g with hot water, cooling, adding 12g of coffee powder (manufactured by Nelumbo Corp.) to obtain 1,200mL solution, mixing with purified water, (iv) 0.56% ferric (III) ammonium citrate aqueous solution, repeating the soaking operation of (i) to (iv) 7 times, drying the HA plate surface, and measuring the ΔE value (ΔE) of the HA plate surface ₁ )。

When the same treatment was carried out using purified water instead of the test solution, the respective ΔE values (ΔE before treatment of the fouling preparation solution) were measured in the same manner _0b After the dirt preparation liquid is treated: ΔE _1b ) The scale formation inhibition rate was calculated according to the following formula, and the scale formation inhibition effect was evaluated.

Scale formation inhibition rate (%) =

[(ΔE _1b -ΔE _0b )-(ΔE ₁ -ΔE ₀ )]/(ΔE _1b -ΔE _0b )×100

Evaluation criteria for inhibitory Effect of Scale formation

Very good: a scale formation inhibition rate of 70% or more

And (3) the following materials: the scale formation inhibition rate is more than 60% and less than 70%

O: a scale formation inhibition rate of 50% or more and less than 60%

Delta: the scale formation inhibition rate is more than 40% and less than 50%

X: the inhibition rate of scale formation is less than 40%

(4) Method for evaluating effect sense

About 1g of the dentifrice composition was put on a toothbrush by 10 subject commentators, and after brushing for 3 minutes over 1 day and 2 times, the feeling of smoothness of the tooth surface was evaluated on 4 scales according to the following evaluation criteria after continuous use for 30 days. The average score of 10 persons was calculated, and the effect feeling (the effect feeling that the tooth surface became smooth) was judged based on the following judgment criteria. An evaluation of o or @, was determined as: the smooth feeling of the tooth surface can be continuously felt, and the effect is good.

Evaluation criteria for Effect feel

4, the following steps: very good feel of

3, the method comprises the following steps: slightly feel to

2, the method comprises the following steps: less feel of

1, the method comprises the following steps: not feel it

Judgment criterion for smooth feeling and continuous feeling

And (3) the following materials: average is more than 3.5 minutes

O: average division into more than 3.0 and less than 3.5

Delta: average division into more than 2.0 and less than 3.0

X: average score less than 2.0

Details of the raw materials used are as follows.

The component (a), sodium polyacrylate (comparative product) and polyacrylic acid (comparative product) used were the same as those described above.

(c) Sodium alginate

KIMICA ALGIN manufactured by Kimica Co., ltd

(c) Propylene glycol alginate

Kimica corporation, kimiloid BF

[ Table 6 ]

[ Table 7 ]

The dentifrices 12 to 19 of example II in table 7 were excellent in the effect of inhibiting the formation of scale and also had a high effect feeling. In addition, the composition has no peculiar smell derived from the component (a), no stringiness and good use feeling.

[ Table 8 ]

The dentifrice compositions (2-1) to (2-13) of example I in table 4 were evaluated for the effect of inhibiting the formation of dirt by the same method as the method (3) described above, and all were excellent.

Claims

1. An oral soil remover comprising:

(a) A polyacrylate having a weight average molecular weight of 2,000 to 8,000, and

(b) 1 or more chelating agents selected from condensed phosphoric acid, phytic acid, edetic acid, citric acid, malic acid and their salts in 1 mass% aqueous solution at 25 ℃ with a pH of 1-11.

2. The oral soil remover according to claim 1, wherein (a)/(b) is 0.01 to 50 in terms of mass ratio.

3. An oral composition comprising:

(b) 1 or more chelating agents selected from condensed phosphoric acid, phytic acid, edetic acid, citric acid, malic acid, and salts thereof, which are 1 mass% aqueous solutions having a pH of 1 to 11 at 25 ℃.

4. The oral composition according to claim 3, wherein (a)/(b) is 0.01 to 50 in terms of mass ratio.

5. The oral composition according to claim 3 or 4, wherein the oral composition contains 0.01 to 2 mass% of the component (a) and 0.03 to 3 mass% of the component (b).

6. The oral composition according to claim 3 or 4, wherein the oral composition further comprises 0.05 to 2 mass% of (c) 1 or more alginic acid derivatives selected from the group consisting of alginate and alginic acid esters.

7. The oral composition of claim 3 or 4, wherein the oral composition is for soil removal.

8. The oral composition of claim 3 or 4, wherein the oral composition is a dentifrice composition.

9. An oral scale formation inhibitor comprising:

(c) More than 1 alginic acid derivative selected from alginate and alginic acid ester,

the mass ratio of (a)/(c) is 1 to 5.

10. An oral composition comprising:

the mass ratio of (a)/(c) is 0.05-5.

11. The oral composition according to claim 10, wherein the oral composition contains 0.01 to 2 mass% of the component (a) and 0.05 to 2 mass% of the component (c).

12. The oral composition of claim 10, wherein the oral composition is for inhibiting scale formation.

13. The oral composition of claim 10, wherein the oral composition is a dentifrice composition.