CN105358128A - Elimination agent for oral cavity biofilm and oral cavity composition - Google Patents
Elimination agent for oral cavity biofilm and oral cavity composition Download PDFInfo
- Publication number
- CN105358128A CN105358128A CN201480038713.5A CN201480038713A CN105358128A CN 105358128 A CN105358128 A CN 105358128A CN 201480038713 A CN201480038713 A CN 201480038713A CN 105358128 A CN105358128 A CN 105358128A
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- composition
- oral cavity
- oral
- biological film
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- Prior art date
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- 239000000203 mixture Substances 0.000 title claims abstract description 227
- 210000000214 mouth Anatomy 0.000 title claims abstract description 57
- 230000008030 elimination Effects 0.000 title abstract 3
- 238000003379 elimination reaction Methods 0.000 title abstract 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 28
- 239000002280 amphoteric surfactant Substances 0.000 claims abstract description 23
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 20
- 239000010452 phosphate Substances 0.000 claims abstract description 20
- -1 alkyl betaine Chemical compound 0.000 claims description 21
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims description 16
- 239000002324 mouth wash Substances 0.000 claims description 15
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 14
- 239000000194 fatty acid Substances 0.000 claims description 14
- 229930195729 fatty acid Natural products 0.000 claims description 14
- 239000004386 Erythritol Substances 0.000 claims description 13
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 13
- 235000019414 erythritol Nutrition 0.000 claims description 13
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 13
- 229940009714 erythritol Drugs 0.000 claims description 13
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
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- 229910052700 potassium Inorganic materials 0.000 description 4
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- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- OQZCJRJRGMMSGK-UHFFFAOYSA-M potassium metaphosphate Chemical compound [K+].[O-]P(=O)=O OQZCJRJRGMMSGK-UHFFFAOYSA-M 0.000 description 1
- 229940099402 potassium metaphosphate Drugs 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 239000010670 sage oil Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- HLBBKKJFGFRGMU-UHFFFAOYSA-M sodium formate Chemical compound [Na+].[O-]C=O HLBBKKJFGFRGMU-UHFFFAOYSA-M 0.000 description 1
- 235000019254 sodium formate Nutrition 0.000 description 1
- 235000019983 sodium metaphosphate Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 1
- 229960002799 stannous fluoride Drugs 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 229940013618 stevioside Drugs 0.000 description 1
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940031008 streptococcus mutans Drugs 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 description 1
- 238000009210 therapy by ultrasound Methods 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 description 1
- 229960000401 tranexamic acid Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 239000003039 volatile agent Substances 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- GFQYVLUOOAAOGM-UHFFFAOYSA-N zirconium(iv) silicate Chemical compound [Zr+4].[O-][Si]([O-])([O-])[O-] GFQYVLUOOAAOGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
- A61K8/442—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
Abstract
Provided are: an elimination agent that is for oral cavity biofilms and that comprises (A) an [alpha]-olefin sulfonate and (B) a condensed phosphate (B-1) and/or an amphoteric surfactant (B-2); and an oral cavity composition comprising component (A) and component (B) and having a high elimination effect with respect to oral cavity biofilms.
Description
Technical field
The present invention relates to the biomembranous oral biological film remover and composition for oral cavity that chemically remove efficiently as the reason of dental caries.
Background technology
In the past, removed technology as the dental plaque (tartar) in dentifrice, the physical property removing that the cleaning agent with grinding agent etc. causes, the biochemical removing etc. that enzyme etc. cause.
When use cleaning agent removes, needing to increase the amount of grinding agent in order to play its effect, improving hardness, but rise along with abrasive power, have the hazardness being easy to produce tooth and gingival lesions etc., irritating possibility.On the other hand, in order to stable mixed enzyme, need and use various stabilizing agent, having the situation of the use senses such as impact foaming and taste.
In addition, in recent years, if tartar can be caught as biomembrane, removing biomembrane, then more effectively can remove denude.For the intraoral biomembrane of removing, not only use the physical method of toothbrush useful, and the chemical method of the biomembrane removing that toothbrush cannot be able to be touched is also useful.Biomembrane is made up of the coaggregant of various oral cavity bacterium and extracellular polysaccharide class.Therefore, as chemistry removing method, there will be a known the erythritol that uses and have and suppress aggregation effect and, use the protease of enzyme or the method for glucanase, change dextranase etc. that decompose extracellular polysaccharide, but the space that its effect is also improved.
In addition, known surface activating agent has cleaning function, can as detergent use in composition for oral cavity.In this case, known lauryl sulfoacetate sodium is the activating agent (patent documentation 1: Japanese Patent Laid-Open 6-72836 publication) without the distinctive stimulation of anionic surfactant.
But, present situation is all the time surfactant, from its osmosis, the viewpoint that clean surface turns into is considered, although only there is slight effect but think that it has tartar removing effect, but there is when not thinking and be used alone surfactant sufficient tartar and even biomembrane removing effect.
In addition, disclose in patent documentation 2 (Japan Patent spy table 2008-519043 publication) and use the alkali metal salts or ammonium salt of sulfoacetic acid alkyl and the method for water-soluble zinc salt, but sulfoacetic acid alkyl salt is the constringent compound for reducing zinc salt, do not show biomembranous removing effect.Further, patent documentation 3 (Japanese Patent Laid-Open 9-508120 publication) discloses the composition for oral cavity of the toothpaste containing lauryl sulfoacetate sodium as the stimulation alleviated oral mucosa, but does not relate to raising biomembrane removing effect.
On the other hand, known condensed phosphate has the effect (patent documentation 4: Japanese Patent Laid-Open 9-175966 publication) of the removing tooth spot of chemical, but has sufficient tartar and biomembrane removing effect when not thinking and be used alone condensed phosphate.
Prior art document
Patent documentation
Patent documentation 1: Japanese Patent Laid-Open 6-72836 publication
Patent documentation 2: Japan Patent spy table 2008-519043 publication
Patent documentation 3: Japanese Patent Laid-Open 9-508120 publication
Patent documentation 4: Japanese Patent Laid-Open 9-175966 publication
Summary of the invention
The problem that invention will solve
Problem of the present invention provides a kind of in view of the foregoing chemically to remove biomembranous oral biological film remover as the reason of dental caries and composition for oral cavity efficiently.
Solve the means of problem
The present invention, in order to the problem reaching the invention described above is through further investigation, found that by and can solve above-mentioned problem with (A) alpha-alkene sulfonate and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2).
Specifically, the present inventors finds, by combination (A) alpha-alkene sulfonate and (B) condensed phosphate (B-1), the removing effect of oral biological film can be significantly improved, and the distinctive bitterness of (A) composition can be suppressed, suitable foaming (I invention) can be given in addition.
In I invention, when the mass ratio of (A) composition and (B-1) composition, particularly (A)/(B-1) is in the scope of 0.1 ~ 10, special and work synergistically, strengthen the effect of dispersion removing oral biological film.In addition, the bitterness being derived from (A) composition can be suppressed, give the suitable foaming caused by (A) composition.
That is, as shown in aftermentioned embodiment and comparative example, when being used alone the alpha-alkene sulfonate of (A) composition, the biomembranous removal rate of making is stuck in less than 70%.In addition, even if the biomembrane removal rate in discovery condensed phosphate (B-1) is less than 50%, not there is sufficient biomembrane removing effect yet, but time also with (A) composition and (B-1) composition, unexpectedly two kinds of composition co-action, can obtain sufficient biomembrane removing effect.In addition, find in this case, even if by the anionic surfactant beyond (A) composition, such as sodium lauryl sulfate, to use with condensed phosphate, also cannot obtain sufficient biomembrane removing effect, above-mentioned biomembrane removing effect be (A) composition with (B-1) composition and when special action effect.Further, alpha-alkene sulfonate has bitterness, in the past, although disclose its use in the literature, reality is the material belonging to avoidance in oral preparation, and the present inventors finds (A) composition and (B-1) composition and the used time, the bitterness being derived from (A) composition can be suppressed, give good use sense, maintain the suitable foaming that (A) composition causes, make and be applicable to the actual preparation used, thus complete the present invention.
In addition, the present inventors is in order to reach the problem of the invention described above through further investigation, found that by combination (A) alpha-alkene sulfonate and (B) amphoteric surfactant (B-2), the removing effect of oral biological film can be significantly improved, and the distinctive bitterness of (A) composition can be suppressed, suitable foaming (II invention) can be given in addition.
In (II) invention, (A) composition and (B-2) composition, when particularly the mass ratio of (A)/(B-2) is in the scope of 0.2 ~ 8, special and work synergistically, strengthen the effect of dispersion removing oral biological film.In addition, the bitterness being derived from (A) composition can be suppressed, give the suitable foaming caused by (A) composition.
That is, as shown in aftermentioned embodiment and comparative example, when being used alone the alpha-alkene sulfonate of (A) composition, the biomembranous removal rate of making is stuck in less than 70%.In addition, although the biomembrane removal rate in discovery amphoteric surfactant (B-2) is less than 50%, not there is sufficient biomembrane removing effect, even if with itself and other surfactant is used, do not think that biomembrane can be made to remove effect to be improved yet, but by (A) composition and (B-2) composition and the used time, unexpectedly two kinds of compositions work synergistically, can obtain sufficient biomembrane removing effect by surfactant system.In addition, find in this case, even if by the anionic surfactant beyond (A) composition, such as sodium lauryl sulfate, to use with amphoteric surfactant, also sufficient biomembrane removing effect cannot be obtained, special action effect when above-mentioned biomembrane removing effect is and uses (A) composition and (B-2) composition.Find further, alpha-alkene sulfonate has bitterness, although disclosed its use in the literature in the past, but in fact its use is avoided, but when and with (A) composition and (B-2) composition time, the bitterness being derived from (A) composition can be suppressed, give good use sense, in addition can maintain the suitable foaming that (A) composition causes, make and be applicable to the actual preparation used, complete the present invention.
In II invention, when mixing (C) quaternary ammonium salt, (D) xylitol and/or erythritol further, more excellent oral biological film removing effect can be given specifically.
In this case, more preferably containing (A) composition, (B-2) composition, Dentrifice composition further preferably containing (C) composition, or more preferably containing (A) composition, (B-2) composition, the mouthrinse composition further preferably containing (D) composition.
Therefore, the present invention (I invention) provides following oral biological film remover and composition for oral cavity.
(I-1) a kind of oral biological film remover, containing (A) alpha-alkene sulfonate and (B-1) condensed phosphate.
The oral biological film remover that (I-2) records as (I-1), wherein, the mass ratio of (A)/(B-1) is 0.1 ~ 10.
The oral biological film remover that (I-3) records as (I-1) or (I-2), wherein, the alpha-alkene sulfonate of (A) composition to be carbon number be 14 ~ 16 alpha-alkene sulfonate.
(I-4) a kind of composition for oral cavity, is characterized in that, containing (A) alpha-alkene sulfonate and (B-1) condensed phosphate.
The composition for oral cavity that (I-5) records as (I-4), wherein, the mass ratio of (A)/(B-1) is 0.1 ~ 10.
The composition for oral cavity that (I-6) records as (I-4) or (I-5), wherein, containing (A) composition alpha-alkene sulfonate 0.3 ~ 5 quality %.
The composition for oral cavity that (I-7) records as (1-4), (I-5) or (I-6), wherein, containing (B-1) composition condensed phosphate 0.1 ~ 5 quality %.
The composition for oral cavity that (I-8) records as any one of (I-4) ~ (I-7) is Dentrifice composition or mouthrinse composition.
The composition for oral cavity that (I-9) records as any one of (I-4) ~ (I-8) is oral biological film removing composition for oral cavity.
Therefore, the present invention (II invention) provides following oral biological film remover and composition for oral cavity.
(II-1) a kind of oral biological film remover, containing (A) alpha-alkene sulfonate and (B-2) amphoteric surfactant.
The oral biological film remover that (II-2) records as (II-1), wherein, the mass ratio of (A)/(B-2) is 0.2 ~ 8.
The oral biological film remover that (II-3) records as (II-1) or (II-2), wherein, the amphoteric surfactant of (B-2) composition is the betanin system amphoteric surfactant of more than a kind that selects from fatty acid amide alkyl betaine, imidazolinium betaine and oxyneurine.
The oral biological film remover that (II-4) records as (II-1), (II-2) or (II-3), wherein, the alpha-alkene sulfonate of (A) composition to be carbon number be 14 ~ 16 alpha-alkene sulfonate.
The oral biological film remover that (II-5) records any one of (II-1) ~ (II-4), wherein, further containing (C) quaternary ammonium salt.
The oral biological film remover that (II-6) records as (II-5), wherein, the quaternary ammonium salt of (C) composition is more than a kind that is selected from cetylpyridinium chloride, benzalkonium chloride and benzethonium chloride.
The oral biological film remover that (II-7) records any one of (II-1) ~ (II-6), wherein, further containing (D) xylitol and/or erythritol.
(II-8) a kind of composition for oral cavity, is characterized in that, containing (A) alpha-alkene sulfonate and (B-2) amphoteric surfactant.
The composition for oral cavity that (II-9) records as (II-8), wherein, the mass ratio of (A)/(B-2) is 0.2 ~ 8.
The composition for oral cavity that (II-10) records as (II-8) or (II-9), wherein, containing (A) composition alpha-alkene sulfonate 0.1 ~ 3 quality %, (B-2) composition amphoteric surfactant 0.05 ~ 5 quality %.
The composition for oral cavity that (II-11) records as (II-8), (II-9) or (II-10), wherein, further containing (C) quaternary ammonium salt 0.003 ~ 0.05 quality %.
The composition for oral cavity that (II-12) records any one of (II-8) ~ (II-11), wherein, further containing (D) xylitol and/or erythritol 0.1 ~ 2 quality %.
The composition for oral cavity that (II-13) records any one of (II-8) ~ (II-12), it is Dentrifice composition or mouthrinse composition.
The composition for oral cavity that (II-14) records any one of (II-8) ~ (II-13), it is oral biological film removing composition for oral cavity.
The effect of invention
Oral biological film remover of the present invention and composition for oral cavity, chemically removing excellent effect in the oral biological film as the reason of dental caries.In addition, bitterness can be suppressed to give good use sense, give suitable foaming.
Detailed description of the invention
Below, the present invention is further elaborated.
The present invention is the oral biological film remover containing (A) alpha-alkene sulfonate and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2).In addition, the present invention is the composition for oral cavity containing above-mentioned (A) and (B) composition.
In the present invention, the feature of I invention is, and with (A) alpha-alkene sulfonate and as the condensed phosphate (B-1) of (B) composition.
By also with (A) alpha-alkene sulfonate and (B-1) composition, biomembranous dispersion removing effect can be significantly improved, in addition, the bitterness of (A) composition can be suppressed, suitably can give foaming characteristic.
As (A) alpha-alkene sulfonate, carbon number can be used to be the alkali metal salt such as sodium, potassium of the alpha-olefin sulfonic acid of 14 ~ 16, the alpha-alkene sulfonate of preferred carbon number 14.These can be the commercially available products that can be used for oral preparations that can obtain.
Condensed phosphate (B-1) and (A) composition of (B) composition used in I invention used time, biomembrane removing effect improves, and in addition, suppresses bitterness, gives suitable foaming characteristic.
As the condensed phosphate of (B) composition, the water-soluble poly-phosphate of the straight-chain shown in following general formula (1) can be used.Such as, the Polymeric sodium metaphosphate. or potassium metaphosphate etc. of the tetrasodium pyrophosphate of polymerization degree n=2 or potassium pyrophosphate, the sodium tripolyphosphate of n=3 or PTPP (potassium tripolyphosphate), the sodium tetrapolyphosphate of n=4 or four PA 800K, five polyphosphate sodiums of n=5, further high polymerization degree can be enumerated.These can be used alone a kind or combine two or more use, wherein, from the viewpoint of effect embody, be suitably tetrasodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate, particularly preferably sodium tripolyphosphate.
M
n+2P
nO3
n+1(1)
(in formula, M represents Na or K, n≤2.)
Tetrasodium pyrophosphate (peaceful Chemical Industries Co., Ltd. system can be used particularly, northeast KCC system), potassium pyrophosphate (peaceful Chemical Industries Co., Ltd. system, East Asia synthetic chemistry Co., Ltd. system), sodium tripolyphosphate (peaceful Chemical Industries Co., Ltd. system, Central Xiao Zi Co., Ltd. (セ Application ト ラ Le nitre (strain)) makes, builder Co., Ltd. of Japan (Japanese PVC ル ダ ー (strain)) system), PTPP (potassium tripolyphosphate) (peaceful Chemical Industries Co., Ltd. system), sodium tetrapolyphosphate (peaceful Chemical Industries Co., Ltd. system), five polyphosphate sodiums (peaceful Chemical Industries Co., Ltd. system) etc.
In I invention, the mixed proportion of (A) composition and (B-1) composition is when particular range, and oral biological film removing effect is more excellent.(A) ratio of/(B-1) is not particularly limited, but as mass ratio preferably 0.1 ~ 10, is more preferably 0.2 ~ 5, is preferably 0.6 ~ 3 further, is particularly preferably 1.2 ~ 3.
Time within the scope of aforementioned proportion, biomembrane removing effect is more excellent.In addition, from suppression bitterness, give good foaming aspect and consider, preferred proportion value is less than 10.
In addition, in the present invention, the feature of II invention is, and with (A) alpha-alkene sulfonate and as the amphoteric surfactant (B-2) of (B) composition.
By also with (A) alpha-alkene sulfonate and (B-2) composition, biomembranous dispersion removing effect can be significantly improved, in addition, the bitterness of (A) composition can be suppressed, suitably can give foaming characteristic.
In this case, (A) composition is invented identical with above-mentioned I.
(B) composition amphoteric surfactant (B-2) used in II invention, by with (A) composition and use, the dispersion removing Be very effective of oral biological film improves, and in addition, suppresses bitterness, gives suitable foaming characteristic.
As amphoteric surfactant, betanin system can be used, such as fatty acid amide alkyl betaine, imidazolinium betaine, oxyneurine.Wherein, the carbon number of fatty acid is 8 ~ 18, and the carbon number of preferred alkyl is the fatty acid amide alkyl betaine of 1 ~ 5, more preferably fatty acid amide propyl betanin.As such fatty acid amide propyl betanin, the fatty acid distribution of coconut oil amido propyl betaine that exogenesis rule (medicine part outer article raw material standard) is recorded can be used.
Amphoteric surfactant can be the commercially available product that can be used for oral preparations that can obtain.Particularly, as fatty acid distribution of coconut oil amido propyl betaine, commercially available trade name TEGOBetainCKOK (EVONIK Inc.) can be enumerated.
In II invention, the mixed proportion of (A) composition and (B-2) composition is when particular range, and oral biological film removing effect is more excellent.In this case, preferably (A)/(B-2) is 0.2 ~ 8 than by quality ratio, is more preferably 0.4 ~ 5, more preferably 0.4 ~ 4, be particularly preferably 0.5 ~ 3.1.Time within the scope of aforementioned proportion, biomembrane removing effect is more excellent.In addition, from giving better foaming, the aspect of bitterness is suppressed to be considered further, preferably less than 8.
The present invention, particularly II invention, preferably mixes (C) quaternary ammonium salt further, and during mixing (C) quaternary ammonium salt, the dispersion removing effect of oral biological film improves further.In addition, foaming improves further.
As the quaternary ammonium salt of (C) composition, can enumerate cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride etc., these can use a kind or use two or more, particularly from the viewpoint of biomembrane removing effect, more preferably cetylpyridinium chloride.
During mixing (C) composition, from the viewpoint of raising biomembrane removing effect, preferably (A)/(C) mixes by quality ratio in the scope of 10 ~ 500.
The present invention, particularly II invention, preferably mixes (D) xylitol and/or erythritol further, and when mixing (D) xylitol and/or erythritol, the dispersion removing effect of oral biological film improves further.In addition, as (D) composition, xylitol or erythritol can be mixed separately, also can mix xylitol and erythritol.
During mixing (D) composition, from the viewpoint of raising biomembrane removing effect, preferably (A)/(D) mixes by quality ratio in the scope of 0.01 ~ 5.
The oral biological film remover of I invention can suitably be mixed in composition for oral cavity.In this case, in the composition for oral cavity of I invention, the combined amount of (A) composition be preferably composition in its entirety 0.3 ~ 5% (quality %, lower with.), more preferably 0.5 ~ 5.0%.Combined amount is more, and biomembrane removing effect is higher, time more than 0.3%, can give sufficient biomembrane removing effect.In addition, good foaming characteristic can be given.Time below 5%, bitterness can not grow, in use preferably.
In addition, in the composition for oral cavity of I invention, the combined amount of (B-1) composition is preferably 0.1 ~ 5% of composition in its entirety, and more preferably 0.2 ~ 5%, further preferably 0.3 ~ 5%.(B-1) combined amount of composition is more, and biomembrane removing effect is higher, but from the bitterness that is inhibited, gives good foaming, obtains using upper preferred material aspect to consider, and preferably less than 5%.
The oral biological film remover of II invention is suitable for being mixed in composition for oral cavity, it contains (A) alpha-alkene sulfonate and the amphoteric surfactant (B-2) as (B) composition, further preferably containing (C) quaternary ammonium salt, in addition further preferably containing (D) xylitol and/or erythritol.If especially containing (A) composition, (B-2) composition, Dentrifice composition further preferably containing (C) composition, or containing (A) composition, (B-2) composition, when preferably containing the mouthrinse composition of (D) composition further, oral biological film removing effect improves further.
In the composition for oral cavity of II invention, the combined amount of (A) composition is preferably 0.1 ~ 3% of composition in its entirety.In this case, particularly in Dentrifice composition, preferably mixing (A) composition 0.3 ~ 3%, particularly preferably mixes 0.5 ~ 2.5%.In addition, in mouthrinse composition, preferably mixing (A) composition 0.1 ~ 3%, particularly preferably mixes 0.1 ~ 2.5%, especially preferably mixes 0.1 ~ 1%.Combined amount is more, and biomembrane removing effect is higher, time more than 0.1%, can give sufficient biomembrane removing effect.In addition, good foaming characteristic can be given.Time below 3%, bitterness can not grow, in use preferably.
In addition, in the composition for oral cavity of II invention, the combined amount of (B-2) composition is preferably 0.05 ~ 5% of composition in its entirety, is particularly preferably 0.1 ~ 5%, is more preferably 0.3 ~ 5%, and further preferably 0.5 ~ 3%.(B-2) combined amount of composition is more, and biomembrane removing effect is higher, gives good foaming in addition, but in order to not produce bitterness, preferably below 5%.
During mixing (C) quaternary ammonium salt, particularly in II invention in the Dentrifice composition that relates to, 0.003 ~ 0.05% of its combined amount preferred composition entirety, more preferably 0.005 ~ 0.01%.Combined amount is more, and biomembrane removing effect is higher.In order to not produce the mucous membrane irritation of quaternary ammonium salt, preferably less than 0.05%.
When mixing (D) xylitol and/or erythritol, particularly invent at II in the mouthrinse composition related to, preferably its combined amount is 0.1 ~ 2% of composition in its entirety, is more preferably 0.3 ~ 1%.Combined amount more biomembranes removing effect is higher.In order to not produce bitterness, preferably below 2%.
Composition for oral cavity of the present invention can be prepared into the form of liquid, aqueous, paste etc., can be prepared into toothpaste, liquid dentifrice, aqueous dentifrice, profit dentifrice (Run System Dentistry grind by usual way) etc. dentifrice, collutory etc.
In this case, except mentioned component, in the scope not damaging effect of the present invention, other any composition can also be mixed according to dosage form as required.Particularly, can the solvent, pH adjusting agent etc. of mixed-abrasive, binding agent, thickening agent, surfactant, sweeting agent, antiseptic, spice, pigment, various effective ingredient, water etc. when dentifrice.In addition, wetting agent, surfactant, solvent, pH adjusting agent, antiseptic, antibacterial, spice, sweeting agent, pigment, various effective ingredient etc. can be mixed when collutory.
Below show the object lesson of any composition, but the composition that can mix in compositions of the present invention is not limited to these compositions.
As grinding agent, the silicon dioxide based abrasives such as crystalline silicon dioxide, amorphous silicon di-oxide, silica gel, aluminium silicate can be enumerated, zeolite, calcium phosphate dibasic anhydrous, calcium phosphate dibasic dihydrate, calcium pyrophosphate, calcium carbonate, aluminium hydroxide, aluminium oxide, magnesium carbonate, tricresyl phosphate magnesium, Zirconium orthosilicate., tricalcium phosphate, hydroxyapatite, tetracalcium phosphate, synthetic resin based abrasive etc.When dentifrice, these grinding agents usually can blend compositions entirety 5 ~ 70%, particularly can blend compositions entirety 10 ~ 50%.
As binding agent, pulullan polysaccharide, gelatin, methylcellulose, hydroxyethyl-cellulose, hydroxypropyl cellulose, sodium carboxymethyl cellulose, carrageenan, sodium alginate, xanthan gum, sodium polyacrylate, arabic gum, guar gum, locust bean gum, polyvinyl alcohol, polyvinylpyrrolidone etc. can be enumerated, can be used alone a kind or combine two or more use.These binding agents usually can blend compositions entirety 0 ~ 10%, particularly 0.1 ~ 5%.
As thickening agent (wetting agent), can enumerate Sorbitol or, the polyhydric alcohol such as propylene glycol, butanediol, glycerol, Polyethylene Glycol.The combined amount of these thickening agents is generally 0 ~ 70% of composition in its entirety, and particularly 3 ~ 50%.
As surfactant, the anionic surfactant beyond (A) composition, nonionic surfactant can be mixed, such as, the anionic surfactants such as the sulfate of alkyl sulfate, fatty acid glyceride can be used, the nonionic surfactants such as polyoxyethylene alkyl ether, polyox-yethylene-polyoxypropylene block copolymer, polyoxyethylene hydrogenated Oleum Ricini, polyoxyethylene glycerol fatty acid esters, sucrose fatty acid ester, fatty acid alkyl alcohol amide.These surfactants can use one kind or two or more, usually can blend compositions entirety 0 ~ 10%, particularly 0.1 ~ 5%.In addition, the combined amount of the anionic surfactant beyond (A) composition can be 0%, when mixing, preferably 0.1 ~ 1.5%, particularly preferably 0.1 ~ 1.0%.
As sweeting agent, saccharin sodium, stevioside, neohesperidin dihydrochalcone etc. can be enumerated.As antiseptic, can the p-Hydroxybenzoate etc. such as benzene mixed sodium formate, methyl parahydroxybenzoate, ethylparaben.
As spice, mentha piperita oil (ペ パ ー ミ Application ト oil can be combinationally used), oleum menthae viridis, Oleum Anisi Stellati, eucalyptus oil, wintergreen oil, Oleum Cinnamomi, Oleum Caryophylli, thyme oil, sage oil, Fructus Citri Limoniae oil, orange oil, Oleum menthae (Ha ッ カ oil), Cardamom oil, Fructus Coriandri oil, mandarin oil, lime oil, Essential lavender oil, oil of rosemary, laurel fat, Flos Matricariae chamomillae oil, caraway oil, Majorana hortensis oil, laurel fat, Indian oil of verbena, Herba Origani oil, pinke needle oil, orange blossom oil, Oleum Rosae Rugosae, Jasmin oil, oil of grapefruit, platinum Fructus Citri grandis oil (ス ウ ィ ー テ ィ ー oil), Fructus Citri grandis oil, concrete of iris, Mentha piperita quintessence oil, Flos Rosae Rugosae quintessence oil, the natural perfume materials such as orange blossom, and processed is carried out (except front-end volatiles to these natural perfume materials, except tails, fractional distillation, liquid-liquid extraction, refine, spice powder-processed) spice that obtains, and l-menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, acetaminol, 3-l-menthoxypropane-1,2-glycol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-replacement-to terpane-3-Methanamide, pinene, octanal, citral, pulegone, carvacryl acetate, anisaldehyde, ethyl acetate, ethyl n-butyrate., allyl cyclohexyl propionate, methyl 2-aminobenzoate, ethyl methylphenylglycidate, vanillin, undecalactone, hexanal, butanols, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenyl ketone, bran aldehyde, trimethylpyrazine, ethyl lactate, the single spice such as ethyl thioacetate, also have, strawberry flavor, apple aroma, banana flavor, Fructus Ananadis comosi taste, grape flavor, Fructus Mangifera Indicae taste, butter taste, milk taste, fruit mixing taste, the compounding fragrances etc. such as tropical fruit (tree) taste can be used for the known spice material of composition for oral cavity.
As pigment, the pigment that can be used in composition for oral cavity can be used according to target tone.As food coloring, include, for example gorgeous indigo plant, tartrazines etc., can titanium oxide etc. be enumerated as pigment.
As effective ingredient (medicinal ingredient), such as chlorhexidine can be used by effective dose in the scope that pharmaceutics is allowed, triclosan, isopropyl methyl phenol, zinc gluconate, the sterilizations such as zinc citrate or antibacterial, the dental calculus preventive such as ethanehydroxy bisphosphate, tranexamic acid, glycyrrhizic acid and salt thereof, the antiinflammatories such as allantoin aluminium chlorhydroxide, sodium fluoride, the fluorides such as sodium monofluorophosphate, the coating agents such as hydroxyethyl-cellulose dimethyl diallyl ammonium chloride, glucanase, mutase, the enzyme agent such as lysozyme chloride, ascorbic acid, the vitaminss such as tocopheryl acetate, the astringents such as sodium chloride, aluctyl., strontium chloride, the hyperesthesia inhibitor such as potassium nitrate, sodium fluoride, sodium monofluorophosphate, the fluorides etc. such as stannous fluoride.
In addition, can mixed ethanol, water etc. as solvent.
When composition for oral cavity is Dentrifice composition, preferred solvent is water, and the content of preferred water is less than 60% of composition in its entirety.In addition, composition for oral cavity is the situation of mouthrinse composition, and preferred solvent is water, or the mixed solvent of water and ethanol, and preferred alcohol is less than 10% of composition in its entirety.
The pH of compositions can be the scope of common composition for oral cavity, but preferably 25 DEG C time pH be 5.5 ~ 8.5, more preferably 6 ~ 8.In addition, pH adjusting agent can be used as required to regulate pH, sodium hydroxide, hydrochloric acid, sodium carbonate, sodium bicarbonate, boric acid or its salt etc. can be enumerated as pH adjusting agent, wherein, be suitably sodium hydroxide, potassium hydroxide, hydrochloric acid.As long as pH value can be adjusted in above-mentioned scope by the combined amount of these pH adjusting agents.
[embodiment]
Below, display embodiment and comparative example, prescription example, specifically describe the present invention, but the present invention is not limited to following embodiment.In addition, in following example, % represents quality % when being not particularly limited.
[example I, Comparative Example I]
According to the Dentrifice composition of component shown in following shown method preparation table 1,2, use following method evaluation.Result is recorded in table 1,2 in the lump.
The preparation method of Dentrifice composition:
First, (B-1) composition condensed phosphate, water soluble ingredient used be mixed at normal temperatures after in the purified water containing thickening agents such as D-sorbitol solutions, further mixed adhesive, stabilizing agent, disperse with dispersion machine.Add dispersion liquid, grinding agent mixing in kneader after, add spice, (A) composition alpha-alkene sulfonate.Carrying out deaeration by being decompressed to about 5kPa in kneader, continuing further to be mixed to get Dentrifice composition.In addition, the compositions of comparative example is prepared according to the method described above.
The evaluation methodology > of < oral biological film removing effect
(1) manufacture method of model organism film
By hydroxyapatite (HA) plate (Asahi Lite Optical Co., Ltd's system) of diameter 7mm × thick 3.5mm, 4 hours are processed with the non-stimulated saliva of people through 0.45 μm of metre filter, as the carrier of model organism film production, culture fluid uses minimal buffering methanol (ベ イ サ Le メ デ ィ ウ system system チ Application) culture fluid (BMM)
* 1.Actinomyces viscosus (Actinomycesviscosus) ATCC43146 bought from American type culture collection (AmericanTypeCultureCollection) is used for the biomembranous bacterial strain of analogue formation, little Wei Rong Shi coccus (Veillonellaparvula) ATCC17745, core Fusobacterium (Fusobacteriumnucleatum) ATCC10953, Streptococcus oralis (Streptococcusoralis) ATCC10557, Streptococcus mutans (Streptococcusmutans) ATCC25175.By these 5 kinds of bacterial strains respectively with 1 × 10
7the mode of cfu/mL (cfu: colony-forming units) is inoculated into add in advance to be had in the rotating circular disk reactor (culture tank) of BMM3000mL, together with the HA carrier processed through saliva 37 DEG C, under anaerobic condition (5vol% carbon dioxide, 95vol% nitrogen) cultivate 24 hours.Then, at identical conditions with replacement rate 5vol%/hour ratio supply BMM culture medium culturing continuously 10 days, form the model organism film of 5 kinds of strains mixing on HA surface.
(2) the removing effect of model organism film
The model organism film of formation is transferred to 24 hole porous plates (Sumitomo Bakelite company (Sumitomo ベ ー Network ラ イ ト society) system), add Dentrifice composition prepared by 2mL and (utilize the centrifuged supernatant (10000rpm gathered from the saliva dilution 3 times of Healthy People, 10 minutes)), flood 3 minutes (will the group sample in contrast of Dentrifice composition do not added).Then use PBS (with light pure pharmaceutical worker's industry Inc.) 1mL to wash 6 times, disperseed by ultrasonic Treatment (200 μ A, 10 seconds) in the test tube (diameter 13mm × 10mm) being added with identical PBS2mL.Measure the turbidity (OD) of this dispersion liquid at wavelength 550nm, thus measure biomembrane remaining quantity.
The biomembrane removing effect of subject composition, obtains the removal rate relative to matched group by following formula, judges oral biological film removing effect according to following benchmark from this removal rate.
Turbidity × 100 of biomembrane removal rate (%)=(turbidity of the turbidity-subject composition of matched group)/matched group
The determinating reference of oral biological film removing effect
◎ ◎: biomembrane removal rate is more than 95%
◎: biomembrane removal rate is less than 95% more than 90%
Zero: biomembrane removal rate is less than 90% more than 80%
△: biomembrane removal rate is less than 80% more than 70%
×: biomembrane removal rate is less than 70% more than 50%
××: biomembrane removal rate is less than 50%
* 1the component of BMM: by the quality representation in 1 liter.
Peptone (BectonandDickinson Inc.): 4g/L
Tryptone (BectonandDickinson Inc.): 2g/L
Yeast extract (BectonandDickinson Inc.): 2g/L
Mucin (Sigma Inc.): 5g/L
Chlorhematin (Sigma Inc.): 2.5mg/L
Vitamin K (with light pure pharmaceutical worker's industry Inc.): 0.5mg/L
KCl (with light pure pharmaceutical worker's industry Inc.): 1g/L
Cysteine (with light pure pharmaceutical worker's industry Inc.): 0.2g/L
Distilled water: (mode reaching 1L with total amount carries out standardize solution to surplus, autoclave process 20 minutes at 121 DEG C.)
The evaluation methodology > of the quality of the presence or absence that < hardship is hidden and foaming
The presence or absence of the bitterness of the Dentrifice composition shown in table and the quality of foaming carry out sensory evaluation by following method.
Get Dentrifice composition 1g on toothbrush, brush teeth and evaluate according to following scoring benchmark for 3 minutes.The presence or absence of bitterness and the quality of foaming is evaluated based on following metewand by 6 estimators.
The presence or absence of bitterness
Metewand
5: do not feel bitterness
4: almost imperceptible bitterness
3: feel that hardship is hidden a little
2: feel that hardship is hidden
1: feel that powerful hardship is hidden
Metewand
◎: meansigma methods more than 4 points less than 5 points
Zero: meansigma methods is less than 4 points more than 3 points
△: meansigma methods is less than 3 points more than 2 points
×: meansigma methods is less than 2 points more than 1 point
The quality of bubbling
Metewand
5: bubble very good
4: bubble slightly well
3: bubble general
2: bubble slightly poor
1: bubble very poor
Metewand
◎: meansigma methods more than 4 points less than 5 points
Zero: meansigma methods is less than 4 points more than 3 points
△: meansigma methods is less than 3 points more than 2 points
×: meansigma methods is less than 2 points more than 1 point
Use shown in being described in detail as follows of raw material.
(A) composition
Tetradecene sodium sulfonate (alpha-olefin (C14) sodium sulfonate): Lion Corporation's system
(B) composition
(B-1) sodium tripolyphosphate: peaceful Chemical Industries Co., Ltd. system
(B-1) tetrasodium pyrophosphate: peaceful Chemical Industries Co., Ltd. system
(B-1) potassium pyrophosphate: peaceful Chemical Industries Co., Ltd. system
[table 1]
[table 2]
[example II, Comparative Example I I]
According to the composition for oral cavity (table 3,4 is Dentrifice composition, and table 5,6 is mouthrinse composition) of component shown in following shown method preparation table 3 ~ 6, evaluate by method same as described above.Result is recorded in table 3 ~ 6 in the lump.
In addition, sensory evaluation is carried out by the quality of following method to the presence or absence of the bitterness of mouthrinse composition and foaming.
Collutory 10mL is washed one's face and rinsed one's mouth 20 seconds containing in entrance, judges the presence or absence of bitterness when gargling based on above-mentioned scoring benchmark.Based on above-mentioned metewand on average evaluating according to 6 estimators.
The preparation method of Dentrifice composition:
First, at normal temperatures the water soluble ingredients used such as sodium fluoride are mixed in the purified water of the thickening agent containing D-sorbitol solution etc., then mixed adhesive and (B-2) composition while of further, mixing (C) composition, disperses with dispersion machine further.Add the powder body mixing of above-mentioned dispersion liquid, grinding agent etc. in kneader after, add spice, (A) composition.Carrying out deaeration by being decompressed to about 5kPa in kneader, continuing further to be mixed to get Dentrifice composition.
The preparation method of mouthwash agent composition:
The preparation of mouthrinse composition, joins stirring in purified water successively and makes its homogeneous dissolving by (A) composition, (B-2) composition, (D) composition and other raw materials.In addition, three-in-one motor (ス リ ー ワ ン モ ー タ ー is used in manufacture) (BL1200, HEIDON Inc.).
Dentrifice composition, the mouthrinse composition of comparative example are prepared according to the method described above.
Use shown in being described in detail as follows of raw material.
(A) composition
Tetradecene sodium sulfonate (alpha-olefin (C14) sodium sulfonate): Lion Corporation's system
(B) composition
(B-2) fatty acid distribution of coconut oil amido propyl betaine: 30% product (combined amount in each example is pure content), TEGOBetainCKOK, EVONIK Co., Ltd. system
(B-2) imidazolinium betaine: Nikko Chemicals Co., Ltd (daylight ケ ミ カ Le ズ (strain)) makes
(B-2) oxyneurine: Nikko Chemicals Co., Ltd's system
(C) cetylpyridinium chloride: Wako Pure Chemical Industries, Ltd.'s system
(C) benzalkonium chloride: Wako Pure Chemical Industries, Ltd.'s system
(C) benzethonium chloride: Japan Oil Co's system
(D) xylitol: ROCKET Amada Co., Ltd. (ロ ケ ッ ト ジ ャ パ Application (strain)) makes
(D) erythritol: Wako Pure Chemical Industries, Ltd.'s system
[table 3]
Dentrifice composition
[table 4]
Dentrifice composition
[table 5]
Mouthrinse composition
[table 6]
Mouthrinse composition
From the result in table, and during with (A) composition and (B) composition, oral biological film removing Be very effective improves.In addition, bitterness is inhibited.Further, composition for oral cavity, particularly Dentrifice composition have suitable foaming.
Below show prescription example.In addition, use raw material same as described above.
[prescription example I-1] collutory
(A)/(B-1) compare: 1.6
The oral biological film removing excellent effect of this collutory, bitterness is inhibited in addition, bubbles good.
[prescription example II-1] collutory
(A)/(B-2) compare: 3.0
The biomembrane removing excellent effect of this collutory, bitterness is inhibited in addition.
Claims (17)
1. an oral biological film remover, containing (A) alpha-alkene sulfonate and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2).
2. oral biological film remover as claimed in claim 1, wherein, (B) composition is condensed phosphate (B-1), and the mass ratio of (A)/(B-1) is 0.1 ~ 10.
3. oral biological film remover as claimed in claim 1, wherein, (B) composition is amphoteric surfactant (B-2), and the mass ratio of (A)/(B-2) is 0.2 ~ 8.
4. the oral biological film remover as described in claim 1 or 3, wherein, amphoteric surfactant (B-2) is the betanin system amphoteric surfactant of more than a kind that selects from fatty acid amide alkyl betaine, imidazolinium betaine and oxyneurine.
5. the oral biological film remover according to any one of Claims 1-4, wherein, the alpha-alkene sulfonate of (A) composition to be carbon number be 14 ~ 16 alpha-alkene sulfonate.
6. the oral biological film remover according to any one of claim 1 to 5, wherein, further containing (C) quaternary ammonium salt.
7. oral biological film remover as claimed in claim 6, wherein, the quaternary ammonium salt of (C) composition is more than a kind that is selected from cetylpyridinium chloride, benzalkonium chloride and benzethonium chloride.
8. the oral biological film remover according to any one of claim 1 to 7, wherein, further containing (D) xylitol and/or erythritol.
9. a composition for oral cavity, is characterized in that, containing (A) alpha-alkene sulfonate and (B) condensed phosphate (B-1) and/or amphoteric surfactant (B-2).
10. composition for oral cavity as claimed in claim 9, wherein, (B) composition is condensed phosphate (B-1), and the mass ratio of (A)/(B-1) is 0.1 ~ 10.
11. composition for oral cavity as described in claim 9 or 10, wherein, (B) composition is condensed phosphate (B-1), and described composition for oral cavity contains (A) composition alpha-alkene sulfonate 0.3 ~ 5 quality %, (B-1) composition 0.1 ~ 5 quality %.
12. composition for oral cavity as claimed in claim 9, wherein, (B) composition is amphoteric surfactant (B-2), and the mass ratio of (A)/(B-2) is 0.2 ~ 8.
13. composition for oral cavity as described in claim 9 or 12, wherein, (B) composition is amphoteric surfactant (B-2), and described composition for oral cavity contains (A) composition alpha-alkene sulfonate 0.1 ~ 3 quality %, (B-2) composition 0.05 ~ 5 quality %.
14. composition for oral cavity according to any one of claim 9 to 13, wherein, further containing (C) quaternary ammonium salt 0.003 ~ 0.05 quality %.
15. composition for oral cavity according to any one of claim 9 to 14, wherein, further containing (D) xylitol and/or erythritol 0.1 ~ 2 quality %.
16. composition for oral cavity according to any one of claim 9 to 15, it is Dentrifice composition or mouthrinse composition.
17. composition for oral cavity according to any one of claim 9 to 16, it is oral biological film removing composition for oral cavity.
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| CN201711248901.2A CN107875031B (en) | 2013-07-18 | 2014-07-17 | Oral biofilm remover and oral composition |
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| JP2013153142 | 2013-07-24 | ||
| PCT/JP2014/069020 WO2015008823A1 (en) | 2013-07-18 | 2014-07-17 | Elimination agent for oral cavity biofilm and oral cavity composition |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111050747A (en) * | 2017-11-29 | 2020-04-21 | 狮王株式会社 | Dentifrice composition |
| CN111417381A (en) * | 2017-11-30 | 2020-07-14 | 狮王株式会社 | Oral cavity dirt remover, oral cavity dirt formation inhibitor and oral cavity composition |
| CN113507966A (en) * | 2019-02-28 | 2021-10-15 | 花王株式会社 | Oral composition |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2016138047A (en) * | 2015-01-26 | 2016-08-04 | ライオン株式会社 | Dentifrice composition |
| CN108348412B (en) * | 2015-11-30 | 2021-08-06 | 狮王株式会社 | Oral composition |
| KR20180083300A (en) | 2015-11-30 | 2018-07-20 | 라이온 가부시키가이샤 | Oral composition |
| WO2017094579A1 (en) * | 2015-11-30 | 2017-06-08 | ライオン株式会社 | Dentifrice composition and oral biofilm removing agent |
| JP6874688B2 (en) * | 2015-11-30 | 2021-05-19 | ライオン株式会社 | Toothpaste composition and oral biofilm remover |
| JP6617535B2 (en) * | 2015-11-30 | 2019-12-11 | ライオン株式会社 | Dentifrice composition |
| WO2019130870A1 (en) * | 2017-12-27 | 2019-07-04 | 花王株式会社 | Oral composition |
| CN114502131B (en) * | 2019-09-30 | 2024-08-13 | 宝洁公司 | Oral care compositions comprising stannous ion source, neutral amino acids and polyphosphates |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015008824A1 (en) | 2015-01-22 |
| JP6269672B2 (en) | 2018-01-31 |
| JP6299761B2 (en) | 2018-03-28 |
| CN105358128B (en) | 2019-03-01 |
| JPWO2015008824A1 (en) | 2017-03-02 |
| JPWO2015008823A1 (en) | 2017-03-02 |
| KR102146681B1 (en) | 2020-08-21 |
| MY177921A (en) | 2020-09-26 |
| CN107875031B (en) | 2021-08-20 |
| KR20160031997A (en) | 2016-03-23 |
| WO2015008823A1 (en) | 2015-01-22 |
| CN107875031A (en) | 2018-04-06 |
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