CN102813870B - Chinese herbal compound preparation used for treating alcoholism and gout and preparation method and application thereof - Google Patents

Abstract

The invention discloses a Chinese herbal compound preparation used for treating alcoholism and gout, mainly comprising the following components in parts by weight: 10-40 parts of kudzuvine root, 15-40 parts of hovenia acerba, 3-10 parts of pseudo-ginseng, 3-15 parts of phyllanthus emblica, 3-10 parts of fructus amomi, 35-10 parts of myristica fragrans, 3-15 parts of dchisandra chinensis, 4-15 parts of American olive, 10-20 parts of honeysuckle, 10-30 parts of rhizoma smilacis glabrae, 10-30 parts of coix seed, 10-30 parts of poria cocos, 10-20 parts of zaocys dhumnade, 10-20 parts of lucid ganoderma, 10-20 parts of American ginseng and 10-20 parts of turmeric. No hepatorenal dysfunction is caused when the compound preparation disclosed by the invention is used for treating hyperuricosuria, which shows that the preparation has no obvious toxic or side effect and mild medicine property, thus the preparation is beneficial to long-term administration. The inventor also knows that medicine taking compliance of patients and tolerance are good from some follow-up visited patients, annual attack frequency is reduced, and the preparation disclosed by the invention has obvious treatment effect on combined diabetes mellitus, hyperlipidemia and vascular hypertension, thus the preparation disclosed by the invention can be regarded as a safe Chinese herbal compound preparation which can be taken by a patient who is repeatedly attacked by acute gouty arthritis for a long time and can control symptoms and reduce attack frequency.

Description

A kind of compound Chinese medicinal preparation and preparation method and application for the treatment of alcoholism gout

Technical field

The invention belongs to Chinese medicine preparation technical field, relate to compound preparation chemical liver injury to protective effect, say more specifically a kind of compound Chinese medicinal preparation and preparation method and application for the treatment of alcoholism, gout.

Background technology

Gout is not single disease, but a kind of syndrome is a kind of and the closely-related disease of diet, and past attempts is considered to " wine disease of muscle ", " affluenza ".Modern medicine proves, gout is caused by a kind of substance metabolism disorder that is called purine in body.Take clinically the acute arthritis of repeatedly showing effect, merge that gout calculus, serum Uric Acid Concentration increase, joint deformity and nephropathy etc. are feature.Gout is a kind of and the closely-related metabolic disease of life.The pathogenic factor of gout is that the uric acid concentration in blood is too high, forms uric acid crystal and is deposited in tissue.As be deposited on joint and will cause arthritis, be deposited on kidney and will cause renal calculus.Gout is multiple is born in middle-aged and elderly people, overweight people and brain worker.Gout easily recurs, and repeatedly, after outbreak, can involve a plurality of joints, and cause joint deformity, also can cause serious renal function injury.For controlling gout outbreak symptom, the medicine of eliminating local joint pain mainly contains colchicine, indometacin, phenylbutazone class, ibuprofen class, piroxicam, adrenocortical hormone at present.Promote that the medicine of renal excretion uric acid mainly contains that Western medicine third yellowly relaxes, benzbromarone and sulphinpyrazone.The side effect of above medicine long-term taking is larger, is mainly to the irreversible infringement of hepatic and renal function.Goat is to need uric acid in life-time service medicine control volume to form, so the medicine of our employing mostly is the Chinese medicine of medicine-food two-purpose, life-time service does not produce damage to Liver and kidney.

The traditional Chinese medical science is divided into multiple pattern of syndrome by gout, as syndrome of accumulated dampness-heat, spleen asthenia and dampness retention card, damp and hot retardance card, the turbid retardance card of expectorant, caused by liver and kidney deficiency card etc.Syndrome analysis: wet three gas of wind and cold are mixed extremely, invasion and attack body, numbness resistance meridians, QI-blood circulation is not smooth, and stagnation of QI and blood may bring about pain, therefore be shown in limbs, arthralgia.The sickness rate of gout increases year by year in recent years, and youngster is more and more, closely related with dietary structure, be mainly because of feed wine, seafood, pluck etc. too much, damp and hot interior Sheng, make a bet joint meridians so that morbidity, clinically take damp-heat accumulation pattern of syndrome as main.The traditional Chinese medical science thinks that the kidney being the origin of congenital constitution, root of YIN and YANG, and the sun of taste, relies the warm of kidney yang entirely; The moon of taste, relies the nourishing of kidney yin entirely.If insufficiency of kidney-YANG, the not warm soil of fire, can cause deficiency of spleen-YANG, forms deficiency of spleen-YANG and kidneyYANG, and stomach loses the stomachache of replenishing vital QI with drugs of warm nature; If deficiency of kidney-YIN, kidney water can not be gone up Ji stomach-Yin, can cause deficiency of stomach-YIN, forms stomach deficiency of the kidney yin.Spleen and stomach phase the exterior and the interior, with placed in the middle burnt, play altogether and received the merit of transporting and transforming nutrients from foodstuff.Splenic qi tending to ascend, stomach-QI being apt to descend, being received of stomach become thoroughly decomposed, and relies the transporting the lucid yang sending up of spleen, so gastropathy is often involved in spleen, the splenopathy is often involved in stomach.If plain body is not enough, or overstrain, or injury due to diet, or excessively take cold and cool medicine, or prolonged illness taste are impaired.Therefore the invention reside on the basis of clinical experience side and add and subtract, according to the base therapy principle of Chinese traditional treatment gout, treat.The invention reside in and adopt that to take medicine-food two-purpose will be master, simultaneously selected can be for the Chinese medicine of Ricipe for health care food, concerning the gout patients of long-term prescription, untoward reaction is reduced to minimum degree, Liver and kidney is not caused to damage.Chinese medicine modern study shows from two aspects: side, all medicines reduce the formation of uric acid from different approach, promote urate excretion, thereby reaches the uric acid level reducing in body.In the general body of patient with gout, sugar and fatty metabolic function can obviously reduce, therefore quite easily send out and produce various gout complication, as diabetes, hypertension, hyperlipidemia, myocardial infarction, angina pectoris, cerebrovascular disorders etc., all medicines of writing out a prescription share has certain therapeutical effect to hypertension, hyperlipidemia, diabetes, cardiovascular diseases, also finds in addition that the removing dampness of prescription is amusing, hepatoprotective kidney tonifying, Detoxication can also be for crapulent treatment.

Summary of the invention

One object of the present invention is to disclose a kind of alcoholism for the treatment of, and prevents drunk compound Chinese medicinal preparation.

Another object of the present invention has been to disclose the compound Chinese medicinal preparation that a kind of acute alcoholism causes gout.

Another object of the present invention has been to disclose the preparation method for the treatment of alcoholism, gout compound Chinese medicinal preparation.

A further object of the present invention has been to disclose treatment alcoholism, gout is damaged the application in medicine preparation protection chemical liver.Application in the gout medicine particularly causing in preparation treatment acute alcoholism, and merge the application in hyperlipidemia, hyperglycemia medicine in preparation gout.

For achieving the above object, the invention discloses following technology contents:

Treat a compound Chinese medicinal preparation for alcoholism gout, it is characterized in that it mainly contains the Chinese crude drug of following portions by weight: Radix Puerariae 10-20, Semen Hoveniae (Fructus Hoveniae) 15-40, Radix Notoginseng 3-10, Fructus Phyllanthi 3-15, Fructus Amomi 3-10, Semen Myristicae 1-10, Fructus Schisandrae Chinensis 3-15, FRUCTUS TERMINALIAE IMMATURUS 4-15.This side prevents drunk for treating alcoholism.

Radix Puerariae wherein refers to Pachyrhizua angulatus and Chai Ge, and Pachyrhizua angulatus is mainly used for pulverizing; Chai Ge is used for extracting.The ratio of weight and number of Pachyrhizua angulatus and Chai Ge is generally 0.5-1:2,

According to also containing the Chinese crude drug of following portions by weight in the above-mentioned prescription of the difference of therapeutic purposes: Flos Lonicerae 10-20, Rhizoma Smilacis Glabrae 10-30, Semen Coicis 10-30, Poria 10-30, Zaocys 10-20, Ganoderma 10-20, Rhizoma Curcumae Longae 10-20, Radix Panacis Quinquefolii 10-20, be mainly used to treat gout, hyperlipidemia, hypertension, the diabetes that alcoholism causes.

Typical prescription:

Flos Lonicerae 10-20, Radix Puerariae (Chai Ge and Pachyrhizua angulatus) 10-30, Rhizoma Smilacis Glabrae 10-30, Semen Coicis 10-30, Poria 10-30, Semen Hoveniae (Fructus Hoveniae) 15-40, Radix Notoginseng 5-10, Zaocys 10-20, Rhizoma Curcumae Longae 10-20, Fructus Phyllanthi 5-15, Fructus Amomi 5-10, Semen Myristicae 5-10, Radix Panacis Quinquefolii 10-20, Ganoderma 10-20, Fructus Schisandrae Chinensis 5-15, FRUCTUS TERMINALIAE IMMATURUS 10-15 form.

Compound Chinese medicinal preparation of the present invention, compound preparation is wherein: solid preparation, liquid preparation or health preparation.

Solid preparation, health preparation can be made capsule, soft capsule, tablet, buccal tablet, granule or drop pill; Liquid preparation can be made oral liquid or liniment.

Disclosed by the invention for preventing, treat the preparation method of the drunk compound Chinese medicinal preparation that alcoholism causes:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Radix Notoginseng powder to be broken into fine powder;

(2) select Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Chai Ge and Fructus Schisandrae Chinensis to be ground into respectively coarse powder, 30～50% (w/w) ethanol of doubly measuring with medical material weight 5-10 respectively or water extraction 2-3 time; Each 1-2 hour, filters, merging filtrate, filtrate is condensed into proportion 1.2-1.35(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Radix Notoginseng fine powder, dry, pulverize into fine powder, mix, add appropriate amount of auxiliary materials to granulate, make solid preparation or liquid preparation.

The preparation method that is used for the treatment of gout, hyperlipidemia, hypertension, Chinese medicine for treating diabetes compound preparation disclosed by the invention, it is to be undertaken by following step:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Ophidia black snake powder to be broken into fine powder;

(2) select Flos Lonicerae, Rhizoma Smilacis Glabrae, Chai Ge, Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Fructus Schisandrae Chinensis, Ganoderma and Rhizoma Curcumae Longae to be ground into respectively coarse powder, 30～50% (w/w) ethanol of doubly measuring with medical material weight 5-10 respectively or water extraction 2-3 time; Each 1-2 hour, filters, merging filtrate, filtrate is condensed into proportion 1.2-1.35(80 ~ 90 ℃) thick paste;

(3) add selected Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Zaocys fine powder, dry, pulverize into fine powder, mix, add appropriate amount of auxiliary materials to granulate, make solid preparation or liquid preparation.

The present invention with Flos Lonicerae, Radix Puerariae, Rhizoma Smilacis Glabrae, Semen Coicis, Poria and the dispelling wind and removing obstruction in the collateral relieving convulsion of clearing heat, detoxicating, dispelling dampness, tonneau two just, the Semen Hoveniae (Fructus Hoveniae) of dispelling toxicity, detoxicating is main, be aided with Radix Notoginseng, Zaocys, Rhizoma Curcumae Longae blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain, assistant acts on clearing away heat and cooling blood, removing dampness circulation of qi promoting with Fructus Phyllanthi, Fructus Amomi, Semen Myristicae, Ganoderma, stomach function regulating is amusing, the effect of digesting and appetizing.Radix Panacis Quinquefolii, Fructus Schisandrae Chinensis, FRUCTUS TERMINALIAE IMMATURUS, the liver and the kidney tonifying, promoting the production of body fluid to quench thirst, all medicines share and play altogether heat-clearing and toxic substances removing damp eliminating, promoting blood circulation, dredging meridian and relieving pain, the effect of removing dampness circulation of qi promoting spleen invigorating.For uric acid resisting, blood fat reducing, blood pressure lowering, alcoholic intoxication.

The base therapy principle of gout: heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.The treatment of gout is based on to toxin expelling, removing toxic substances, removing toxic substances.Therefore, lead to stool, diuresis, make heresy have outlet.The first-selected Semen Hoveniae (Fructus Hoveniae) of logical convenience urine, clearing heat, detoxicating, dispelling dampness is selected medicine Flos Lonicerae, Radix Puerariae, Rhizoma Smilacis Glabrae, Semen Coicis, Poria etc.; Compatibility of drugs can reach to be cleansed the intestines and stomach, relieving constipation and lets out turbidly, makes evil in just going out; Weed out the old and bring forth the new again, blood circulation promoting and blood stasis dispelling, detumescence removing obstruction in the collateral to relieve pain, select Radix Notoginseng, Zaocys, Rhizoma Curcumae Longae simultaneously, and for the complication of gout, our employing, the liver and the kidney tonifying, promote the production of body fluid, circulation of qi promoting, spleen invigorating, the medicine that quenches the thirst.

The present invention's adjuvant used refers to the compound that pharmaceutically acceptable carrier, excipient and other additive form, can adopt lactose or starch to do carrier, gelatin, sodium carboxymethyl cellulose, methylcellulose, polyvinylpyrrolidone etc. is suitable bonding agent or becomes granular agent.As disintegrating agent, can select starch or microcrystalline Cellulose, often with Pulvis Talci, santocedl, tristerin, calcium stearate or magnesium etc. are as suitable antiadhesives and lubricant.For example, can prepare tablet by compacting wet granular.Active component and carrier and optionally with a disintegrate additive composition mixture; the aqueous solution of this mixture and binding agent; alcohol or aqueous alcohol solution carry out granulating in suitable equipment; dried particles adds other disintegrating agent subsequently, and lubricant and antiplastering aid are by this mixture tabletting.

In prescription of the present invention, Each performs its own functions for all medicines, and each medicine effect is as follows:

Flos Lonicerae: sweet, cold.Return lung, the heart, stomach warp.Heat-clearing and toxic substances removing, dispelling wind and heat pathogens.For carbuncle, treat skin ulcer, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.Modern pharmacological research shows to have the effects such as antiinflammatory and refrigeration function, booster immunization function, blood fat reducing.

Radix Puerariae (Pachyrhizua angulatus and Chai Ge): Radix Puerariae is the plant that the medicine food of China's Ministry of Public Health approval has both, have the title of " Asia Radix Ginseng ", and the effect of its mystery is the Flavonoid substances of contained 12% left and right.These compounds are mainly planted effective component by Semen sojae atricolor (Semen Glycines) glycoside, daidzein, puerarin etc. more than 10 and are formed.Radix Puerariae sweet in the mouth is pungent, and property is flat, returns taste warp.Function with cure mainly expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.Particularly aspect uric acid resisting treatment gout, can stop the synthetic of uric acid by suppressing the activity of xanthine oxidase.

Semen Hoveniae (Fructus Hoveniae): sweet, flat.GUIXIN, spleen channel.Its function: the relieving restlessness of quenching the thirst, disappear damp and hot, alcoholic intoxication.Cure mainly: for alcoholism, excessive thirst vomiting, difficulty in urination and defecation.Its medicinal < < Tang materia medica > > that sees the earliest.Li Shizhen (1518-1593 A.D.) < < Compendium of Materia Medica > > says that its ＂ sweet in the mouth, property are flat, nontoxic, there is the relieving restlessness of quenching the thirst, go heat on diaphragm, moistening five ZANG-organs, profit defecation, merit has significant diuresis with Mel ＂, and Semen Hoveniae (Fructus Hoveniae) Saponin has hypotensive effect, and Semen Hoveniae (Fructus Hoveniae) homogenate has lipoid peroxidization resistant and strengthens cold-resistant and heat-resisting function.In Semen Hoveniae (Fructus Hoveniae), contain a large amount of calcium and Semen Hoveniae (Fructus Hoveniae) Saponin, there is central inhibitory action, can convulsion, prevent tetany spasm, can be used to treat the disease of rheumatic arthralgia numbness.

Rhizoma Smilacis Glabrae: sweet, light, flat.Return liver, stomach warp.Removing toxic substances, dehumidifying, easing joint movement.For the limbs contracture due to syphilis and mercurialism, bones and muscles pain; Damp and hot stranguria with turbid discharge, leukorrhagia, carbuncle, scrofula, scabies.Modern pharmacological research shows that Rhizoma Smilacis Glabrae has certain practical value to prevent liver cancer; Treatment acute and chronic nephritis.Can reduce uric acid in body.

Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Promoting diuresis to eliminate damp pathogen, spleen invigorating, mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Modern pharmacological research shows there is diuresis, sedation, and Poria water extractum processed and ethanol extract have hypoglycemic activity to rabbit; Poria water, ethanol, ether extract all have the contraction of enhancing, accelerate heart rate function isolated frog heart.4, Poria has significant protective effect to the caused mouse liver injury of carbon tetrachloride, can make gpt activity obviously reduce, and prevents hepatic necrosis.5, antitumor, antitumaous effect

Semen Coicis: sweet, light, cool.Return spleen, stomach, lung meridian promoting diuresis to eliminate damp pathogen, invigorating the spleen to arrest diarrhea, eliminating impediment, evacuation of pus, detoxicating and resolving stagnation of pathogens.For edema, beriberi, dysuria, diarrhea due to hypofunction of the spleen, arthralgia chiefly caused by damp pathogen contracture, lung abscess, acute appendicitis, wart, cancerous protuberance.Modern pharmacological research shows to have calmness, analgesia and refrigeration function; Can make lung blood vessel significantly expand; Coixol subcutaneous injection can make blood glucose slightly decline; Semen Coicis has inhibitory action to cancerous cell.

Radix Notoginseng: sweet, micro-hardship, temperature.Return liver, stomach warp.Dissipating blood stasis hemostasis, subduing swelling and relieving pain.For various hemorrhage, breast ventral spine pain, tumbling and swelling.Modern pharmacological research shows there is blood vessel dilating, reduces blood pressure, and improves microcirculation, increases blood flow, prevention and treatment heart and brain tissues ischemia, anoxia; Promote protein, ribonucleic acid (RNA), DNA (deoxyribonucleic acid) (DNA) to synthesize, building body; Promote blood cell metabolism, balance adjustment blood cell; Two-ways regulation nervus centralis, improves mentally, strengthens learning and memory ability; Enhancing human body immunity function, antitumor; Blood circulation promoting and blood stasis dispelling; Protect the liver, antiinflammatory; Slow down aging.

Rhizoma Curcumae Longae: pungent, bitter, temperature.Return spleen, Liver Channel.Removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.For the twinge of the breast side of body, obstruction of qi in the chest and cardialgia, dysmenorrhea amenorrhea, abdominal mass abdominal mass, rheumatism shoulder arm pain, tumbling and swelling.Modern pharmacological research shows there is effect for reducing blood fat; Antitumor action; Antiinflammatory action; Resisting pathogenic microbes effect; Choleretic effect; Antioxidation.

Zaocys: sweet, flat.Return Liver Channel.Dispel the wind, dredging collateral, relieving convulsion.For rheumatoid arthritis stubborn, numbness contracture, middle air port eye fish sticking its mouth out of the water tiltedly, hemiplegia, tic spasm, tetanus, leprosy, scabies.Modern clinic is applied to treat apoplexy; Treatment arthromyodynia; Treatment sciatica; Treatment facial paralysis; Treatment chronic urticaria; Treatment scabies; Treatment damp-heat type psoriasis; Treatment psoriasis arthropathica; Treatment metatarsalgia.

Ganoderma: Ganoderma is medicinal plants precious in China's pools of traditional Chinese medicine, warm in nature, lightly seasoned, having calms the nerves supports essence, strengthening by means of tonics, the effect of relieving cough and asthma.Modern study shows to have the function of protecting liver and detoxication, and to treating various chronic hepatitiss, chronic poisoning has definite curative effect..

Fructus Schisandrae Chinensis: be the fruit with pungent, sweet, sour, bitter, salty five kinds of property of medicine, the fruit of this bittersweet, mutual generation of five phases, can be one of minority medical material of tool essence, gas, god's three large tonifications to human five internal organs's heart, liver, spleen, lung and kidney performance balanced action, the strong liver of energy QI invigorating, the efficiency of promoting cells exclude refuse, supply more oxygen, construction and uses energy, raising memory and property endurance.< < herbal classic > > records, Fructus Schisandrae Chinensis " main QI invigorating, tonifying for the deficiency, reinforcing YIN-essence, beneficial man's essence ".Schisandrin B, SALLRSIPA SAL ADNF-9 schizronol schisanhenol all have antioxidation, can remove free radical, suppress lipid peroxide formation, and Fructus Schisandrae Chinensis can reduce serum cholesterol, increases protein content in brain regulating liver-QI, all shows to have anti-aging effects.Effect in we is fat-reducing liver-protecting kidney tonifying.

Radix Panacis Quinquefolii: sweet, micro-hardship, cool.GUIXIN, lung, kidney channel.Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.For the deficiency of vital energy is cloudy, lose, deficiency-heat is tired tired, cough with asthma expectorant blood, and interior-heat is quenched one's thirst, dryness of the mouth and throat.Modern pharmacological research shows effectively to strengthen nervus centralis, reach with all worries set aside with fixed attention, the effect such as allaying tiredness, memory reinforcing; Protection cardiovascular system; Improve immunity antitumor; Promote blood vigor; Adjuvant therapy of diabetes reduces blood glucose, regulates insulin secretion, promotes carbohydrate metabolism and lipid metabolism.

Fructus Phyllanthi: sweet, sour, puckery, cool.Attach to the lung and stomach meridians.Clearing away heat and cooling blood, promoting digestion and invigorating the stomach, the cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, dyspepsia. abdominal distention, cough, laryngalgia, xerostomia.Modern pharmacological research shows to have anti-AIDS reverse transcriptase (HIV-1 RT) effect; Protective effect on cancer risk, antimutagenic, teratogenesis effect, antiinflammatory action, blood fat reducing and study of anti-atherogenic effect, antioxidation, anti-aging effects, hepatoprotective effect, to gastrointestinal effect, antiulcer action, diarrhea effect, immunoregulation effect, the regulating action to non-specific immunity, the potentiation to specific immune function, Detoxication, antibacterial action.

FRUCTUS TERMINALIAE IMMATURUS: sweet, sour, flat.Attach to the lung and stomach meridians.Heat-clearing and toxic substances removing, sore-throat relieving, promotes the production of body fluid.For laryngopharynx swelling and pain, cough expectorant is glutinous, and dysphoria with smothery sensation is thirsty, separates fish Eriocheir sinensis poisoning.Modern pharmacological research shows hypoglycemic activity.

Fructus Amomi: pungent, temperature.Return spleen, stomach, kidney channel.Removing dampness appetizing, warming spleen and stopping diarrha, regulate the flow of vital energy antiabortive.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.Modern pharmacological research shows to have following effect: Fructus Amomi can be promoted intestinal movement, and Fructus Amomi is anticoagulant obviously. antiulcer action.

Semen Myristicae: pungent, temperature.Return spleen, stomach, large intestine channel.Warming middle-JIAO to promote flow of QI, relieving diarrhea with astringents.For Deficiency and coldness of spleen and stomach, incessant chronic diarrhea, abdominal distention, lack of appetite vomiting.Modern pharmacological research shows there is sedative-hypnotic effect, antibacterial action, and antitumor action, reduces glutamate pyruvate transaminase effect.

As a kind of special compound Chinese medicinal preparation product, the composition of compound preparation and the dosage of Chinese crude drug are two essence marrow of traditional Chinese medical science prescription.In many cases, even the prescription that same medicine forms, because the consumption of each ingredients is different, its medication effect is also different.Therefore selecting the proportioning of specific raw material and definite stock yard is the key of Chinese medicine health-care preparation.In traditional theory of Chinese medical science, have the principles of formulating prescriptions of " dose plus-minus ", according to this principle, can work out new drug, on the basis of an existing drug prescription, even if do not change the ingredients of prescription, the consumption of some drugs in writing out a prescription by adjustment, also can make the function of medicine or effect change.

Below by concrete pharmacology and clinical experiment data, to the safe and sound Traditional Chinese medicine capsule compound preparation of gout in treatment acute alcoholism and the application in treatment ventilation medicine further instruction in addition.

One, pharmacological experiment study:

(1) acute alcoholism is comparatively common in clinical emergency, main manifestations is for nauseating, vomiting, hypomnesis, absent minded, fine movement ability is impaired and emotional instability, and severe patient can cause death because of ethanol extra-inhibitory central nervous system.The compound Chinese medicinal preparation of this research just has relieving alcohol intoxication, this experiment adopts " the safe and sound capsule of gout (formula of embodiment 5 is exclusively used in drunk) " of development voluntarily to carry out prophylactic treatment chmice acute alcoholism, to evaluate this buccal tablet, capsule to the prevention of acute alcoholism, therapeutic effect.

1 material and method

1.1 material

" the safe and sound capsule of gout " (formula of embodiment 5 is exclusively used in drunk) divests capsule shells, uses mortar porphyrize, makes 50% suspension solution for standby with 0.5% CMC-Na solution; Ethanol is " Lao Bai Fenyang wine " (lot number is 20120211121) that SHANXI XINGHUACUN FEN WINE FACTORY CO. LTD produces, containing 53% ethanol.40 of kunming mices, body weight (20 ± 2) g ，You Tianyin Test Animal Centre provides.

1.2 method

40 of kunming mices, fasting 12h, freely drinks water.Be divided at random matched group, experimental group, 20 every group.Experimental group gives " the safe and sound capsule of gout " solution gavage, and administration volume is 40 ml/kg body weight, and matched group gives isometric normal saline gavage, and dosage is 10g/kg body weight.After administration 1h, all mices carry out ethanol gavage, and while giving wine 0.2 ml/10 g, righting reflex loss rate is 100 %, and righting reflex recovery rate is 85 %.Observe immediately righting reflex loss size of animal, record righting reflex loss incubation period the time of righting reflex loss (after the ethanol gavage to) and persistent period (disappearing to the time of recovering from righting transmitting).Data analysis measurement data group difference is checked with t, and enumeration data two sample rates relatively adopt the check of the definite probabilistic method of Fisher, and the P <0.05 of take has statistical significance as difference.

2 results

While giving mice to wine 0.2 ml/10g, righting reflex loss rate is 100%, and righting reflex recovery rate is 85%, gavage is given after 53% ethanol (0.2ml/10g), 10 min, the whole drunk stupors of control group mice, muscular flaccidity, absent corneal reflex, righting reflex loss, after wherein having 14 mice lethargy 1～2h, in succession revive, recover righting reflex, have 6 mices to die off after lethargy 1～2 h, postmortem stomach, lung no abnormality seen, get rid of because of dead due to gavage operation.Experimental mice is after Isodose ethanol gavage, and the drunk shape disease such as righting reflex loss and recovery righting reflex persistent period obviously shorten (P<0.05); Animal dead number all obviously lacks and matched group (P<0.05) (in Table 1).

Table 1 " the safe and sound capsule of gout " is on the impact of acute alcoholism mice righting reflex time and death toll (x ± s)

Before giving mouse gavaging ethanol, gavage is given " the safe and sound capsule of gout " solution, the incubation period of mice righting reflex loss, righting reflex persistent period obviously shorten, with matched group comparing difference remarkable (P <0.05), experimental group is compared with matched group, animal dead number all obviously reduces (P<0.05), and prompting " the safe and sound capsule of gout " has certain preventive and therapeutic action to chmice acute alcoholism.Its mechanism of action may with the effect of lowering containing the alcohol dehydrogenase acid activity playing a major role in the Anti-ethanol metabolism such as Radix Puerariae Semen Hoveniae (Fructus Hoveniae) in side, be conducive to ethanol catabolism in vivo, reduce Ethanol concentration in rat blood, thereby reduce the inhibition of ethanol to central nervous system.This experiment is disposable " the safe and sound capsule of the gout " observation to acute alcoholism prevention and therapeutic effect of taking in a large number.

(2) pharmacological evaluation of the safe and sound capsule for treating gout of gout:

L material

1.1 50 of animal Kunming mouses, male, body weight (20～25) g; All purchased from experimental animal feeding center, Tianjin; Feedstuff is the full nutrition piece material that Nat'l Pharmaceutical & Biological Products Control Institute produces.

1.2 medicines and the safe and sound capsule of reagent gout: self-control.The suspendible medicinal liquid that is configured to contain crude drug 6 g/L and 3 g/L with 0.5% sodium carboxymethyl cellulose (CMC-Na) is before use for animal gastric infusion.Benzbromarone sheet: German He Man is large, and pharmaceutical factory is commercially available, lot number: 0100839, Chinese import drugs registration certificate number: 20000142, the suspendible medicinal liquid that is configured to 1.25 g/L with 0.5% sodium carboxymethyl cellulose (CMC-Na) is before use for animal gastric infusion.Uric acid: Sigma EC 200 720-7, are made into the suspension of 1.25g/100ml before use with sterile purified water.Uric acid detectable: Sysmex, lot number: ZG4002.

2 experimental techniques

The foundation of 2.1 hyperuricemia models selects lumbar injection uric acid suspension according to the dosage disposable celiac injection of 0.25g/kg body weight, makes hyperuricemia model, adopts the concentration of testing uric acid kit measurement serum uric acid.

2.2 remove the effects of Mouse Blood uric acid is divided into 5 groups each 10 at random by 50 mices, i.e. blank group, model group, benzbromarone group, the safe and sound capsule high and low dose of gout group, 10 every group.Blank group and model group all gavage 0.9% sodium chloride solution 0.4 mL, other groups gavage respectively benzbromarone suspension 0.03g/kg, safe and sound difference 20 g/kg of gout and 10 g/kg and, every day is respectively at 8:00 and 18:00 administration 1 time, continuous 7 d, except blank group, other 4 groups equal 30min lumbar injection uric acid suspensions after most end single administration, to make hyperuricemia model, after modeling 30, each group of 60 and 120 min is all plucked eyeball and is got blood, centrifugalize serum, by the amount of testing uric acid kit measurement uric acid in serum.

2.4 statistical method acquired results represent with (x ± s), carry out variance analysis check.

3 results

The safe and sound capsule of gout the results are shown in Table 2 to the impact of mice serum uric acid level.

The safe and sound capsule of table 2 gout is on the impact of hyperuricemia Mouse Blood uric acid level (x ± s, n=10)

With model group comparison, * P<0.05,

Known from table l, after modeling, the safe and sound capsule in high dose group of 90 min gout serum uric acid concentration is starkly lower than model group (P<0.05), and the safe and sound capsule of prompting gout can significantly reduce the content of uric acid in mice serum; The safe and sound capsule small dose group of gout mice serum uric acid concentration also has to a certain degree reduction, and positive drug benzbromarone can significantly reduce the concentration of mice serum uric acid.

Two, clinical practice situation

The safe and sound capsule of gout of the present invention is developed by the precious biotechnology of nine father-in-law research center, Tianjin, in Hebei, Tianjin painting out-patient department, has carried out clinical trial for many years, and concrete condition is as follows:

1. pre-preventing drunkenness:

120 people take " the safe and sound capsule of gout " 5 for 30～60 minutes before drinking, drinking amount is to increase by 50～100% under common state, 98 people keep clearheaded, effectively (not thirsty 111 people after drinking wherein, 19 people blush and alleviate or not red, and 14 application on human skin prurituss, symptom of erythema disappear, the 12 people distension transference cure of having a stomachache, 5 people's palpitating speeds manifest disappearance); 11 people's vomitings, unconsciousness, invalid (wherein 11 people's drinking amounts exceed original amount more than 3 times), pre-preventing drunkenness effective percentage is 90.8%.

Zhu, man, 46, cadre, often has dinner party dinner party, on average drinks for 4～5 times weekly, readme drink Chinese liquor 100ml will cause erythra, rubescent from head to foot, palpitating speed, dizzy, midnight is thirsty hard to bear, and uric acid level, at 370 μ mol/L, worries that gout occurs in uric acid rising, come to go to a doctor, require to take " the safe and sound capsule of gout "." the safe and sound capsule of gout " 5 taken in each dinner party for first 30～60 minutes, drinks in 200ml left and right, erythra do not occur again, blushes and alleviates, and heart beating is normal, clearheaded, after half a year, detects, and uric acid level is at 210 μ mol/L.

2. treat drunk being drunk overnight:

Physical data: 28 examples are the alcoholic that disposable excessive consumption of alcohol causes consciousness changing, male 22 examples, female's 6 examples; At 24～58 years old age, 28 examples all have excessive excessive drinking history, and the drunk Zhi Lai shortest time 1h of institute appears in drinking amount 300～800mL, and the longest 18h is divided into excitation periods 18 example by the clinical manifestation of acute alcoholism by stages, ataxia phases 14 example.Previously without special medical history, and get rid of other nerves, mental sickness.All patients are all with symptoms such as multi-lingual, vomiting in various degree, stomachache, dizziness, headaches, breathing, in vomitus, have alcohol smell.

Therapeutic Method: patient after coming institute medical immediately oral " the safe and sound capsule of gout (formula of embodiment 5 is exclusively used in drunk) " 4～8 open, content is poured out, warm water takes, observation ward lies up.　

Therapeutic outcome: excitation period and ataxia phase patient is generally clear-headed at 25～40min, patient realizes recovery gradually after above-mentioned treatment, breathes and recovers normal, after 1h, completely clear-headed, can walk steadily, and 28 routine patients all cure.According to drunk degree, use various dose, 6～8 of serious use.

3. treat gout:

1 data and method

The routine patient of 1.1 physical data 44 is my outpatient service in March, 2008～2012 this out-patient in year March.Patient, is male, oldest 69 years old, minimum 35 years old, 53.4 years old mean age, has the longest 10 years of gout history, the shortest 7 months.44 routine uric acid are all higher than normal value, and gout is invaded the first metatarsophalangeal joints 39 examples, ankle joint 3 examples, knee joint 2 examples.Merge hyperglycemia 6 examples, hyperlipidemia 28 examples, hypertension 8 examples.

1. 1.2 inclusion criterias meet the gout diagnostic criteria that Americanism damp disease association proposes in 1977; 2. meet the diagnostic criteria of gout in < < traditional Chinese medical science disease Standardization of diagnosis and curative effect > > in 1999 simultaneously; 7. 30～70 years old age.

1.3 Therapeutic Method: the concentrated pill of writing out a prescription and making by the present invention, every day 2 times, each 6g.30 days courses for the treatment of.Diabetes oral antidiabetic drug, hypertension enalapril meleate.Diet is nursed the suitable light and light food of diet, avoids being rich in the food of purine, as animal liver, kidney, brain, fish and shrimp, Eriocheir sinensis, beans etc.The pungent greasy product of fasting, avoid tobacco and wine.Every day great quantity of water drinking, in order to urate excretion.Take base-forming food, with alkalized urine more

2 results

2.1 efficacy assessment standards are according to < < new Chinese medicine treatment gout guideline of clinical investigations > > efficacy assessment standard, clinical cure: symptom disappears completely, joint function recovery is normal, and main physico-chemical examination index is normal; Effective: cardinal symptom disappears, and function of joint is recovered substantially, main physico-chemical examination index normal; Effective: cardinal symptom disappears substantially, main function of joint and main physical and chemical index make moderate progress; Invalid: with before treatment, compare each side and be all not improved.

1 course for the treatment of of the 2.2 equal Chinese medicines for oral administration of this group of therapeutic outcome case all cases, by above-mentioned efficacy assessment standard, result clinical cure 31 examples, effective 10 examples, effective 3 examples.9 routine times of defecation increase (every day 2 times), and all the other do not find obvious adverse reaction.

Before treatment, blood uric acid is (590.1 ± 97.9) μ mol/L, after treatment, blood uric acid is (318.4 ± 101.3) μ mol/L, treating the transference cures such as front and back Level of Serum Uric Acid t checks (P < 0.05), and Level of Serum Uric Acid obviously declines, redness and swelling of joints burning pain or alleviating is 5 days.

Hypertension 6 examples are at the just inactive oral depressor of the 10-12d that takes medicine, and blood pressure is normal; Diabetes 7 examples are at the 7-10 days that takes medicine, fasting glucose 6.4-6.9mmol/L, post-prandial glycemia 8.7～9.2mmol/L.Hyperlipidemia patient, when finish a course for the treatment of, observes hyperlipemic patients blood lipids index: before treatment and treat 4 weeks serum cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C) and low density lipoprotein, LDL (LDL-C) have significant change afterwards.

Blood lipids index change list before and after 28 routine high fat of blood human therapies

Time	TG(mmol/L)	TC(mmol/L)	LDL-CH(mmol/L)	HDL-CH(mmol/L)
					Before treatment	1.89±0.81	6.39±0.68	3.8±1.31	1.49±0.41
After treatment	1.55±0.43	5.11±0.52	2.60±0.58	1.88±0.33

Typical cases

Wang, man, 48 years old.Without inducement, before 5 years, there is finger, toes arthralgia in patient.Patient often has dinner party, again and again drinks, and fish and shrimp seafood is without cease, in addition weariness from a tiring journey, is affected by the cold, and time sense finger, toes swell and ache.Often in drink or tired, catch cold after, pain exacerbates, swelling and ache in left sufficient thumb inner side, take hypnalgia as acute.Examination in hospital is " ventilation ", takes in this year western medicine result not good.Before 1 week again because wine causes this onste, local red and swollen heat pain, function limitation.Have a medical check-up: swelling and ache in left hallux inner side, swells and ache unbearably, and hypnalgia play very.Blood uric acid 718umol/L, bitter taste, yellow and greasy fur, wiry and frequent pulse, right two have tophus tuberosity.Patient takes the concentrated pill of making by we, every day 2 times, and each 6g, after 3 days, pain relief, swelling and ache of toes subtracts clearly, continues to take after 1 month the above transference cure of patient, blood uric acid 433umol/L, advise it to continue to strengthen, take half a year, follow up a case by regular visits to 1 year, not recurrence.

Zhao, man, 57 years old, cadre.The big body of shape is rich, and body weight exceedes 90kg.First visit on May 11 in 2011.Because right metatarsophalangeal joints swells and ache repeatedly to show effect, within 1 year, increase the weight of 2d, from taking indometacin, do not take effect and go to a doctor.Examine and see: metatarsophalangeal joints swelling, tenderness is obvious, local red and swollen.3d heavy drinking food meat once before being admitted to hospital.Each outbreak all with smoke, drink, eat meat and suffer from cold relevant, without family history.Right foot the first metatarsophalangeal joints is red, swollen, hot, and pain can not be touched.Auxiliary examination C reactive protein (CRP) 512mg/L, erythrocyte sedimentation rate (ESR) 40mm/h, blood uric acid (UA) 490mol/L.Western medicine diagnose is gouty arthritis, and tcm diagnosis is arthromyodynia (damp heat downward flowing type).Before 2 years, found that blood fat was high during health check-up, blood biochemical investigation triglyceride is up to 18.85mmol/l.Patient takes the concentrated pill of making by we, every day 2 times, and each 6g, after 4d, pain relief, swelling and ache of toes alleviates, above transference cure after January, check UA, CRP, ESR all declines than before, and triglyceride is reduced to 12.64mmol/l; Adhere to taking 3 months, UA, CRP, ESR is normally.Check triglyceride is reduced to 7.56mmol/l, advises it to adhere to keeping on a diet, strengthen taking exercise.

Liao, man, 57 years old.Body is strong usually, happiness food meat or fish, on November 6th, 2010, before two days, there is right hallux metatarsophalangeal joints pain, redness, hypnalgia very, aching as needle stabbing, oral allopurinol and the indometacin state of an illness are without improvement, and private prosecution has diet risk factor: before 3 days, drank Chinese liquor 200ml, eat Eriocheir sinensis.Examine and see: right hallux metatarsophalangeal joints red and swollen heat pain, joint motion is limited, and part has no tophus, with heating (37.5 ℃ of body temperature) weak asthenia, thirst with desire to drink, dimly red tongue, thick, yellow and greasy fur, wiry and frequent pulse.Fasting glucose 9.8mmol/L, 2 hours blood glucose 17.9mmol/L after the meal, routine urinalysis: glucose in urine (++) routine urianlysis is normal, blood uric acid 728 μ mol/L, erythrocyte sedimentation rate: 40mm/ hour.Patient takes the concentrated pill of making by the present invention, every day 2 times, each 6g, after 3 days, conscious arthralgia obviously alleviates, and after 7 days, redness obviously disappears, and takes medicine after 10 days, all diseases disappear, month medical treatment check blood uric acid 376 μ mol/L of following the service, fasting glucose 6.1mmol/L, after the meal 2 hours blood glucose 9.4mmol/L, glucose in urine stable disease, patient takes after three months by we, and body weight is without alleviating, and xerostomia symptom is alleviated to some extent.All diseases fade, and curative effect is obvious.Advise it to adhere to taking, after 1 year, each index is all down to normal value.Advise it to keep on a diet, and effectively control blood glucose.Follow up a case by regular visits to not recurrence in a year.

Compound Chinese medicinal preparation is observed in this research, when treatment metabolic arthritis disease, hepatic and renal function does not occur abnormal.Prompting said preparation is without obvious toxic-side effects, and the property of medicine is gentle, is conducive to long-term taking.The author also sees that compliance and toleration that patient takes medicine are good in part is followed up a case by regular visits to patient, year attack times declines to some extent and is combined diabetes, hyperlipidemia, the even positive effect of vascular hypertension, and the control symptom that the acute gouty arthritis patient for outbreak repeatedly that can yet be regarded as can long-term taking reduces the Chinese medicine preparation of the safety of outbreak.

The specific embodiment

Below in conjunction with embodiment, the present invention is described, the scheme of embodiment described here, do not limit the present invention, one of skill in the art can make improvements and change according to spirit of the present invention, these described improvement and variation all should be considered as within the scope of the invention, and scope of the present invention and essence are limited by claim.The Pachyrhizua angulatus of using in embodiment: the ratio of weight and number of bavin Pueraria lobota is 0.5-1:2, other Chinese crude drug used is all on sale.Part that the present invention mentions can be gram or kilogram, according to the actual needs of producing, selected.

Embodiment 1(part)

Flos Lonicerae 10, Radix Puerariae (Pachyrhizua angulatus and Chai Ge) 10, Rhizoma Smilacis Glabrae 15, Semen Coicis 15, Poria 10, Semen Hoveniae (Fructus Hoveniae) 15, Radix Notoginseng 5, Zaocys 10, Rhizoma Curcumae Longae 10, Fructus Phyllanthi 5, Fructus Amomi 10, Semen Myristicae 10, Radix Panacis Quinquefolii 10, Ganoderma 10, Fructus Schisandrae Chinensis 10, FRUCTUS TERMINALIAE IMMATURUS 10.

Preparation method:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Ophidia black snake powder to be broken into fine powder;

(2) select Flos Lonicerae, Rhizoma Smilacis Glabrae, Chai Ge, Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Fructus Schisandrae Chinensis, Ganoderma and Rhizoma Curcumae Longae to be ground into respectively coarse powder, use respectively 50% (w/w) ethanol extraction 2 times of 5 times of amounts of medical material weight; Each 1 hour, filter, merging filtrate, filtrate is condensed into proportion 1.2(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Zaocys fine powder, dry, pulverize into fine powder, mix, sieve, with water pill, cold drying, polishing, dries in the shade.

Embodiment 2(part)

Flos Lonicerae 20, Radix Puerariae (Pachyrhizua angulatus and Chai Ge) 20, Rhizoma Smilacis Glabrae 15, Semen Coicis 30, Poria 30, Semen Hoveniae (Fructus Hoveniae) 40, Radix Notoginseng 10, Zaocys 20, Rhizoma Curcumae Longae 20, Fructus Phyllanthi 15, Fructus Amomi 10, Semen Myristicae 10, Radix Panacis Quinquefolii 20, Ganoderma 20, Fructus Schisandrae Chinensis 15, FRUCTUS TERMINALIAE IMMATURUS 15.

Preparation method:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Ophidia black snake powder to be broken into fine powder;

(2) select Flos Lonicerae, Rhizoma Smilacis Glabrae, Semen Hoveniae (Fructus Hoveniae), Chai Ge, FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Fructus Schisandrae Chinensis, Ganoderma and Rhizoma Curcumae Longae to be ground into respectively coarse powder, use respectively 40% (w/w) ethanol extraction 3 times of 8 times of amounts of medical material weight; Each 1 hour, filter, merging filtrate, filtrate is condensed into proportion 1.35(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Zaocys fine powder, dry, be ground into fine powder, mix, sieve, then mix and (slowly add medicated powder with the PEG-4000 of 415g melting state (100 ℃ of left and right), constantly stir), when temperature is down to 80 ℃ of left and right, adopt the heavy 40mg single head of ball or bull pill dripping machine to splash into (liquid paraffin or silicone oil) in coolant, collect the drop pill in coolant.Through wiping, airing, selects drop pill, bottling.

Embodiment 3(part)

Flos Lonicerae 15, Radix Puerariae (Pachyrhizua angulatus 5 and Chai Ge 10) 15, Rhizoma Smilacis Glabrae 15, Semen Coicis 25, Poria 25, Semen Hoveniae (Fructus Hoveniae) 40, Radix Notoginseng 10, Zaocys 15, Rhizoma Curcumae Longae 15, Fructus Phyllanthi 15, Fructus Amomi 10, Semen Myristicae 10, Radix Panacis Quinquefolii 20, Ganoderma 20, Fructus Schisandrae Chinensis 5-15, FRUCTUS TERMINALIAE IMMATURUS 15.

Preparation method:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Ophidia black snake powder to be broken into fine powder;

(2) select Flos Lonicerae, Rhizoma Smilacis Glabrae, Chai Ge, Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Fructus Schisandrae Chinensis, Ganoderma and Rhizoma Curcumae Longae to be ground into respectively coarse powder, use respectively 30% (w/w) ethanol extraction 3 times of 10 times of amounts of medical material weight; Each 2 hours, filter, merging filtrate, filtrate is condensed into proportion 1.2(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Zaocys fine powder, dry, pulverize into fine powder, mix, sieve, then mix homogeneously with starch 300g, with starch slurry (get starch 220g water and make starch slurry) granule processed, sieve, dry, encapsulated.

Embodiment 4(part)

Flos Lonicerae 10, Radix Puerariae (Pachyrhizua angulatus and Chai Ge) 15, Rhizoma Smilacis Glabrae 10, Semen Coicis 25, Poria 15, Semen Hoveniae (Fructus Hoveniae) 30, Radix Notoginseng 10, Zaocys 20, Rhizoma Curcumae Longae 10, Fructus Phyllanthi 5, Fructus Amomi 10, Semen Myristicae 10, Radix Panacis Quinquefolii 20, Ganoderma 20, Fructus Schisandrae Chinensis 15, FRUCTUS TERMINALIAE IMMATURUS 15.

Preparation method:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Ophidia black snake powder to be broken into fine powder;

(2) select Flos Lonicerae, Rhizoma Smilacis Glabrae, Chai Ge, Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Fructus Schisandrae Chinensis, Ganoderma and Rhizoma Curcumae Longae to be ground into respectively coarse powder, use respectively 50% (w/w) ethanol extraction 3 times of 5 times of amounts of medical material weight; Each 1 hour, filter, merging filtrate, filtrate is condensed into proportion 1.3(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Radix Puerariae, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Zaocys fine powder, dry, pulverize into fine powder, mix, sieve, add 100g sodium carboxymethyl cellulose, 180g sugar, mixes, and with 30% ethanol granule processed, sieves, dry, pack.

Treatment alcoholism, prevent and treat drunk:

Embodiment 5(part)

Radix Puerariae 15(Pachyrhizua angulatus and Chai Ge), Semen Hoveniae (Fructus Hoveniae) 15, Radix Notoginseng 3, Fructus Phyllanthi 6, Fructus Amomi 3, Semen Myristicae 2, Fructus Schisandrae Chinensis 5, FRUCTUS TERMINALIAE IMMATURUS 10.

Preparation method:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Radix Notoginseng powder to be broken into fine powder;

(2) select Semen Hoveniae (Fructus Hoveniae), Chai Ge, FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi and Fructus Schisandrae Chinensis to be ground into respectively coarse powder, with the decocting of 8 times of amounts of medical material weight, boil 2 times respectively; Each 2 hours, filter, merging filtrate, filtrate is condensed into proportion 1.35(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Radix Notoginseng fine powder, dry, pulverize into fine powder, mix, sieve, then mix homogeneously with starch 300g, with starch slurry (get starch 220g water and make starch slurry) granule processed, sieve, dry, encapsulated.

Embodiment 6(part)

Radix Puerariae 20(Pachyrhizua angulatus and Chai Ge), Semen Hoveniae (Fructus Hoveniae) 40, Radix Notoginseng 5, Rhizoma Curcumae Longae 20, Fructus Phyllanthi 15, Fructus Amomi 10, Semen Myristicae 10, Radix Panacis Quinquefolii 10, Fructus Schisandrae Chinensis 5, FRUCTUS TERMINALIAE IMMATURUS 15.

Preparation method:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Radix Notoginseng, Radix Panacis Quinquefolii powder to be broken into fine powder;

(2) select Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Chai Ge, Fructus Phyllanthi, Fructus Schisandrae Chinensis and Rhizoma Curcumae Longae to be ground into respectively coarse powder, use respectively 45% (w/w) ethanol extraction 3 times of 6 times of amounts of medical material weight; Each 2 hours, filter, merging filtrate, filtrate is condensed into proportion 1.35(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Radix Puerariae, Radix Notoginseng, Radix Panacis Quinquefolii fine powder, dry, pulverize into fine powder, mix, starch and cellulose are sieved, and fully mix, polyvinylpyrrolidonesolution solution is mixed with above-mentioned powder, sieve, make wet granular dry in 50-60 ℃, by carboxymethyl starch sodium salt, magnesium stearate and Pulvis Talci sieve in advance, then join tabletting in above-mentioned granule.

Embodiment 7(part)

Radix Puerariae 15(bavin Pueraria lobota and Pachyrhizua angulatus), Semen Hoveniae (Fructus Hoveniae) 30, Radix Notoginseng 10, Rhizoma Curcumae Longae 20, Fructus Phyllanthi 15, Fructus Amomi 10, Semen Myristicae 10, Radix Panacis Quinquefolii 20, Fructus Schisandrae Chinensis 15, FRUCTUS TERMINALIAE IMMATURUS 10.

Preparation method:

(1) select Fructus Amomi, Semen Myristicae, Radix Puerariae, Radix Notoginseng, Radix Panacis Quinquefolii powder to be broken into fine powder;

(2) select Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Fructus Schisandrae Chinensis and Rhizoma Curcumae Longae to be ground into respectively coarse powder, with the decocting of 8 times of amounts of medical material weight, boil 2 times respectively; Each 2 hours, filter, merging filtrate, filtrate is condensed into proportion 1.30(80 ~ 90 ℃) thick paste;

(3) add Fructus Amomi, Semen Myristicae, Radix Puerariae, Radix Notoginseng, Radix Panacis Quinquefolii fine powder, dry, mix, add sodium benzoate appropriate, add again water and be adjusted to total amount, stir through the separated clear liquor that obtains of high speed centrifuge, add latter standing 48 hours of the appropriate stirring of correctives, filter, obtain sepia thick liquid, fill, through 100 ℃ of flowing steam sterilizations, makes oral liquid.

Claims (9)

1. treat a compound Chinese medicinal preparation for alcoholism gout, it is characterized in that it mainly contains the Chinese crude drug of following portions by weight: Radix Puerariae 10-40, Semen Hoveniae (Fructus Hoveniae) 15-40, Radix Notoginseng 3-10, Fructus Phyllanthi 3-15, Fructus Amomi 3-10, Semen Myristicae 1-10, Fructus Schisandrae Chinensis 3-15, FRUCTUS TERMINALIAE IMMATURUS 4-15; Radix Puerariae wherein refers to Pachyrhizua angulatus and Chai Ge, Pachyrhizua angulatus: the ratio of weight and number of bavin Pueraria lobota is 0.5-1:2.

2. compound Chinese medicinal preparation claimed in claim 1, is characterized in that it also contains the Chinese crude drug of following portions by weight: Flos Lonicerae 10-20, Rhizoma Smilacis Glabrae 10-30, Semen Coicis 10-30, Poria 10-30, Zaocys 10-20, Ganoderma 10-20, Radix Panacis Quinquefolii 10-20, Rhizoma Curcumae Longae 10-20.

3. compound Chinese medicinal preparation described in claim 1-2 any one, compound preparation is wherein: solid preparation or liquid preparation.

4. compound Chinese medicinal preparation claimed in claim 3, wherein solid preparation is capsule, tablet, granule or drop pill; Liquid preparation is oral liquid or liniment.

5. the preparation method of compound Chinese medicinal preparation described in claim 2, is characterized in that it is to be undertaken by following step:

(1) select Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Ophidia black snake powder to be broken into fine powder;

(2) select Flos Lonicerae, Chai Ge, Rhizoma Smilacis Glabrae, Semen Hoveniae (Fructus Hoveniae), FRUCTUS TERMINALIAE IMMATURUS, Fructus Phyllanthi, Fructus Schisandrae Chinensis, Ganoderma and Rhizoma Curcumae Longae to be ground into respectively coarse powder, 30～50% (w/w) ethanol of doubly measuring with medical material weight 5-10 respectively or water extraction 2-3 time; Each 1-2 hour, filters, merging filtrate, and filtrate is condensed into and in the time of 80 ~ 90 ℃, surveys proportion is 1.2-1.35 thick paste;

(3) add Fructus Amomi, Semen Myristicae, Pachyrhizua angulatus, Poria, Semen Coicis, Radix Notoginseng, Radix Panacis Quinquefolii and Zaocys fine powder, dry, pulverize into fine powder, mix, add appropriate amount of auxiliary materials to granulate, make solid preparation or liquid preparation.

6. described in claim 1, compound Chinese medicinal preparation is treated alcoholism, is prevented the application in drunk medicine in preparation.

7. the application in the gout medicine that described in claim 3, compound Chinese medicinal preparation causes in preparation treatment acute alcoholism.

8. described in claim 3, compound Chinese medicinal preparation merges the application in high blood cholesterol drug in preparation treatment gout.

9. described in claim 3, compound Chinese medicinal preparation merges the application in hyperglycemia medicine in preparation treatment gout.