CN105943860A - Medicine preparation for treating diabetes mellitus and preparation method thereof - Google Patents
Medicine preparation for treating diabetes mellitus and preparation method thereof Download PDFInfo
- Publication number
- CN105943860A CN105943860A CN201610451605.1A CN201610451605A CN105943860A CN 105943860 A CN105943860 A CN 105943860A CN 201610451605 A CN201610451605 A CN 201610451605A CN 105943860 A CN105943860 A CN 105943860A
- Authority
- CN
- China
- Prior art keywords
- parts
- rhizoma
- extract
- pharmaceutical preparation
- processed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 46
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 36
- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- 229940079593 drug Drugs 0.000 title claims description 24
- 241000218176 Corydalis Species 0.000 claims abstract description 33
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims abstract description 31
- 241000628997 Flos Species 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 80
- 239000000284 extract Substances 0.000 claims description 40
- 239000012567 medical material Substances 0.000 claims description 38
- 238000010992 reflux Methods 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 26
- 239000008187 granular material Substances 0.000 claims description 25
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 20
- 239000008517 radix Trichosanthis Substances 0.000 claims description 20
- 239000000203 mixture Substances 0.000 claims description 11
- 238000001035 drying Methods 0.000 claims description 10
- 239000000706 filtrate Substances 0.000 claims description 10
- 229920000609 methyl cellulose Polymers 0.000 claims description 10
- 239000001923 methylcellulose Substances 0.000 claims description 10
- 239000007779 soft material Substances 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 235000008216 herbs Nutrition 0.000 claims description 9
- 229930006000 Sucrose Natural products 0.000 claims description 8
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 8
- 239000005720 sucrose Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 235000000346 sugar Nutrition 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 4
- 239000007924 injection Substances 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- 240000000111 Saccharum officinarum Species 0.000 claims 2
- 235000007201 Saccharum officinarum Nutrition 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006196 drop Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- -1 tincture Substances 0.000 claims 1
- 229940098465 tincture Drugs 0.000 claims 1
- 210000004369 blood Anatomy 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 17
- 208000024891 symptom Diseases 0.000 abstract description 8
- 230000006870 function Effects 0.000 abstract description 3
- 208000002193 Pain Diseases 0.000 abstract description 2
- 230000017531 blood circulation Effects 0.000 abstract description 2
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 241000512991 Epipactis mairei Species 0.000 abstract 1
- 244000303040 Glycyrrhiza glabra Species 0.000 abstract 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 abstract 1
- 235000017443 Hedysarum boreale Nutrition 0.000 abstract 1
- 235000007858 Hedysarum occidentale Nutrition 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 241000608233 Orchis italica Species 0.000 abstract 1
- 241001522129 Pinellia Species 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 210000004204 blood vessel Anatomy 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 210000003734 kidney Anatomy 0.000 abstract 1
- 230000002936 tranquilizing effect Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 15
- 239000008103 glucose Substances 0.000 description 15
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 14
- 238000012360 testing method Methods 0.000 description 9
- 230000037396 body weight Effects 0.000 description 8
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 8
- 102000004877 Insulin Human genes 0.000 description 7
- 108090001061 Insulin Proteins 0.000 description 7
- 229940125396 insulin Drugs 0.000 description 7
- 235000010981 methylcellulose Nutrition 0.000 description 7
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 description 6
- 239000013641 positive control Substances 0.000 description 6
- 235000012054 meals Nutrition 0.000 description 5
- 239000003651 drinking water Substances 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 235000001727 glucose Nutrition 0.000 description 4
- 229960003105 metformin Drugs 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- 206010019280 Heart failures Diseases 0.000 description 3
- 230000036528 appetite Effects 0.000 description 3
- 235000019789 appetite Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000036541 health Effects 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 241000208340 Araliaceae Species 0.000 description 2
- 208000008960 Diabetic foot Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 210000001367 artery Anatomy 0.000 description 2
- 238000010241 blood sampling Methods 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 210000002216 heart Anatomy 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 230000003907 kidney function Effects 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 230000003908 liver function Effects 0.000 description 2
- 229960004329 metformin hydrochloride Drugs 0.000 description 2
- OETHQSJEHLVLGH-UHFFFAOYSA-N metformin hydrochloride Chemical compound Cl.CN(C)C(=N)N=C(N)N OETHQSJEHLVLGH-UHFFFAOYSA-N 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 208000010125 myocardial infarction Diseases 0.000 description 2
- 230000000291 postprandial effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 230000035922 thirst Effects 0.000 description 2
- 210000003462 vein Anatomy 0.000 description 2
- 241001061264 Astragalus Species 0.000 description 1
- 206010061666 Autonomic neuropathy Diseases 0.000 description 1
- 208000031648 Body Weight Changes Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 206010007559 Cardiac failure congestive Diseases 0.000 description 1
- 206010007572 Cardiac hypertrophy Diseases 0.000 description 1
- 208000006029 Cardiomegaly Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 241000288570 Chionochloa conspicua Species 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010018429 Glucose tolerance impaired Diseases 0.000 description 1
- 102000017011 Glycated Hemoglobin A Human genes 0.000 description 1
- 108010014663 Glycated Hemoglobin A Proteins 0.000 description 1
- 206010020710 Hyperphagia Diseases 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 244000018795 Prunus mume Species 0.000 description 1
- 235000011158 Prunus mume Nutrition 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 230000002547 anomalous effect Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000002785 anti-thrombosis Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 235000006533 astragalus Nutrition 0.000 description 1
- 230000003143 atherosclerotic effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000004579 body weight change Effects 0.000 description 1
- 230000003683 cardiac damage Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 208000029078 coronary artery disease Diseases 0.000 description 1
- 210000004351 coronary vessel Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 230000002526 effect on cardiovascular system Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 150000002304 glucoses Chemical class 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 210000000087 hemolymph Anatomy 0.000 description 1
- 230000002218 hypoglycaemic effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000003914 insulin secretion Effects 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000003680 myocardial damage Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000022530 polyphagia Diseases 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 208000037921 secondary disease Diseases 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- PJANXHGTPQOBST-UHFFFAOYSA-N stilbene Chemical compound C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 description 1
- 235000021286 stilbenes Nutrition 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 210000004233 talus Anatomy 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
- A61K36/8888—Pinellia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a medicine preparation for treating diabetes mellitus and a preparation method thereof. The medicine preparation is prepared from the following traditional Chinese medicinal materials in parts by weight: 6-15 parts of rhizoma corydalis, 10-30 parts of cortex moutan, 5-14 parts of flos albiziae, 10-32 parts of fructus arctii, 4-11 parts of ginger processed pinellia, 10-24 parts of radices trichosanthis, 6-16 parts of herba centellae, 5-11 parts of orchis italica, 3-10 parts of coptis chinensis, 7-13 parts of fructus mume, 8-14 parts of licorice root and 3-9 parts of epipactis mairei. The medicine preparation is prepared from compatible medicinal materials, accords with traditional Chinese medicine and modern medicine theories, is used for balancing yin and yang, and has the effects of soothing blood vessels, protecting musculus cardiacus, relieving pain, diminishing inflammation, tonifying qi, nourishing blood, tranquilizing, tonifying kidneys and nourishing yin, so that medicinal efficacy and functions can be comprehensive, symptoms and root causes can be treated, and the medicinal materials are matched to achieve the aim of improving blood circulation.
Description
Technical field
The invention belongs to medical treatment field, relate to a kind of for treating preparations for diabetes and preparation method thereof.
Background technology
Diabetes have become the third-largest killer of the mankind, and whole world diabetics is 2.85 hundred million at present, and China's diabetics is about
92400000, pre-diabetic 1.48 hundred million, the significant damage brought to the mankind in view of diabetes, and World Health Organization (WHO) is referred to as
For " disaster of 21 century ".Its harm the most perhaps will not allow patient do to fear, but the complication in later stage be very serious and
Make diabetics the most worried, such as cardiovascular diseases, diabetic foot, to add up according to latest data, the diabetics of China is
1.14 hundred million are occupied first place in the world, and wherein the prevalence of diabetic foot has reached the 4% of the total number of patients of diabetes, more than 450
Ten thousand people.
Diabetic cardiopathy is the one of the main reasons that diabetics is lethal, especially in type 2 diabetes mellitus patient.Extensively
The diabetic cardiopathy of justice includes coronary atherosclerotic heart disease (coronary heart disease), Diabetic myocardial infarction and diabetes
Cardiovascular autonomic neuropathy etc..Diabetic cardiopathy normal onset compared with ND compares early, diabetics companion's hat
Cardiopathia often shows as painless myocardial infarction, and infarct size is bigger, and wall-through infarction is many, and the many ratios of the state of an illness are more serious, prognosis ratio
Poor, case fatality rate is higher；Such as coronarography and clinical coronary artery pathological changes of getting rid of, the heart that diabetics appearance is serious
Restrain not normal cardiac hypertrophy pulmonary venous pleonaemia and congestive heart failure, especially refractory heart failure.
The traditional Chinese medical science is the traditional medicine of China, has played, in the historical development of China, the effect that can not be substituted.In recent years, the traditional Chinese medical science
Also important, unique, irreplaceable effect is played in the field for the treatment of diabetes.National drug management board is the most
There are Chinese patent medicine preparation and the some Chinese Patent Medicines preparation of the treatment diabetes included, such as diabetes pill, ginseng, astragalus diabetes capsule, ginseng stilbene fall
Sugar granule, Jiangtangwan pill, Xiao Ke Lin sheet, YUQUAN WAN etc..
Up to now, the myocardial damage caused for diabetes there is no specific short at present, and first clinical treatment is to control DM,
Then treat mainly for cardiac damage, arrhythmia, heart failure and antithrombotic.And due to some patients in early days
And non-evident sympton, and all there is certain limitation in above-mentioned Therapeutic Method, can not stop effectively and timely it development.
Western medicine medication is expensive and has dependency, and Chinese medicine does not reaches again significantly on therapeutic effect, drops hypoglycemic purpose immediately,
Although Chinese medicine preparation also has much, but it is little to play effective effect.Therefore, in clinical practice in the urgent need to
Searching can effectively prevent and treat newtype drug and the approach of diabetic cardiopathy, improves the treatment with substantial diabetic cardiopathy further
Strategy.
There is provided at present a kind of definite effect, aobvious particularly important of the little Chinese medicine preparation of side reaction.
Summary of the invention
For the defect of prior art, the present invention be directed to treat at present the present situation of diabetes, it is provided that a kind for the treatment of and prevention is imitated
The best pharmaceutical preparation, and have no side effect.
Specifically, the present invention is realized in.
Inventor provides a kind of prescriptions of Chinese medicine treating preparations for diabetes according to drug matching experience, including following Chinese medicine:
Rhizoma Corydalis, Cortex Moutan, Flos Albiziae, Fructus Arctii, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Trichosanthis, Herba Centellae, Herba Orchidis Latifoliae, Rhizoma Coptidis, Fructus Mume, sweet
Purple careless, little is with a smile.
Each raw material dosage of prescription all has preferable curative effect, described formula and weight portion in the weight portion scope of the present invention: Rhizoma Corydalis 6-15
Part, Cortex Moutan 10-30 part, Flos Albiziae 5-14 part, Fructus Arctii 10-32 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-11 part, Radix Trichosanthis 10-24 part,
Herba Centellae 6-16 part, Herba Orchidis Latifoliae 5-11 part, Rhizoma Coptidis 3-10 part, Fructus Mume 7-13 part, Radix Glycyrrhizae 8-14 part, little purple have a smile on one's face 3-9
Part.
For having reached optimum effect, to described formula and weight portion be: Rhizoma Corydalis 10.5 parts, Cortex Moutan 20 parts, Flos Albiziae 9.5 parts,
Fructus Arctii 21 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7.5 parts, Radix Trichosanthis 17 parts, Herba Centellae 11 parts, Herba Orchidis Latifoliae 8 parts, Rhizoma Coptidis 6.5 parts, crow
10 parts of prunus mume (sieb.) sieb.et zucc., 11 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6 parts.
Or:
Rhizoma Corydalis 11 parts, Cortex Moutan 21 parts, Flos Albiziae 10 parts, Fructus Arctii 21.5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8.5 parts, Radix Trichosanthis 17.5 parts,
Herba Centellae 11.5 parts, Herba Orchidis Latifoliae 8.5 parts, Rhizoma Coptidis 7 parts, Fructus Mume 10.5 parts, 11.5 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6.5 parts.
The function of each taste Chinese crude drug used in the pharmaceutical preparation of the treatment diabetes of the present invention is as follows:
Rhizoma Corydalis: bitter in the mouth, warm in nature, GUIXIN, spleen, liver, lung meridian.
Effect: have promoting blood circulation to remove blood stasis, the function of promoting the circulation of QI pain relieving.
Clinical practice: utilize the effect of corydalis tuber analgesic dissipating blood stasis clinically, is usually used in treating hepatocarcinoma, cancer of pancreas, pulmonary carcinoma etc..
Flos Albiziae: sweet in the mouth, property is put down.
Gui Jing: GUIXIN, Liver Channel.
Function cures mainly: resolving stagnation for tranquilization.For irritability, melancholy insomnia.
Fructus Arctii: acrid in the mouth, cold in nature.
Gui Jing: attach to the lung and stomach meridians.
Function cures mainly: dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.For anemopyretic cold, cough with copious phlegm, measles, rubella,
Laryngopharynx swelling and pain, mumps erysipelas, carbuncle sore tumefacting virus.
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): acrid in the mouth, temperature；Poisonous.
Gui Jing: return spleen, stomach, lung meridian.
Function cures mainly: drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.For abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm,
Syncope due to accumulation of phlegm is had a headache, and vomits regurgitation, and breast gastral cavity painful abdominal mass is vexed, globus hystericus；Raw with external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI.
Radix Trichosanthis: sweet in the mouth, micro-hardship, is slightly cold.
Gui Jing: attach to the lung and stomach meridians.
Function cures mainly: clearing away heat and promoting production of body fluid, detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat quenches one's thirst, sore swollen toxin.
Rhizoma Coptidis: bitter in the mouth, cold in nature.
Gui Jing: GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.
Function cures mainly: heat clearing and damp drying, eliminating fire and detoxication.For damp and hot feeling of fullness, vomit acid regurgitation, dysentery, jaundice, unconsciousness due to high fever,
Hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion, and toothache is quenched one's thirst, carbuncle furuncle；External treatment eczema, eczema, auditory meatus
Suppurate.It is burning hot that Rhizoma Coptidis (processed with wine) is apt to the clear part of the body cavity above the diaphragm housing the heart and lungs.Fructus Mume
Radix Glycyrrhizae: sweet in the mouth, property is put down.
Gui Jing: enter spleen, stomach, the heart, lung meridian.
Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain.
Little purple is had a smile on one's face: sweet in the mouth, and property is put down.
Function cures mainly: promoting flow of QI and blood；Heat-clearing and toxic substances removing.Main cough due to lung-heat；Stagnation of QI chest pain；Vomit and diarrhoea；Painful and swollen testis；Rheumatism waist
Bitterly；Traumatic injury；Sore and toxic
Herba Centellae: bitter in the mouth, cold in nature.
Gui Jing: return liver,spleen,kidney warp.
Function cures mainly: clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, sand Stranguria stranguria with blood, carbuncle sore tumefacting virus,
Injury from falling down.
Herba Orchidis Latifoliae: sweet in the mouth, property is put down.
Function cures mainly: heart tonifying, and the kidney invigorating is promoted the production of body fluid, and quenches the thirst, strengthening the spleen and stomach.
Irritated thirsty, anorexia, menoxenia.Asthenia anemia, dizzy, dim eyesight.Herba Orchidis Latifoliae, Radix seu Herba Spiranthis Lanceae, Rhizoma Polygonati,
Each 3 money of Radix Polygoni Multiflori, are decocted in water for oral dose.
Fructus Litseae: acrid in the mouth, warm in nature.
Gui Jing: return spleen, stomach, kidney, bladder warp.
Effect: warming spleen and stomach for dispelling cold, promoting the circulation of QI to relieve pain, for cold syndrome of the stomach vomiting, coldness and pain in the epigastrium, colic of cold type suffers from abdominal pain, stagnancy of cold-damp,
Turbid urine.
Cortex Moutan: bitter in the mouth, pungent, cold in nature.
Gui Jing: GUIXIN, liver, kidney channel.
Effect: clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling.Thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, night fever abating at dawn, lossless
Hectic fever due to YIN-deficiency, amenorrhea dysmenorrhea, fall and flutter the pain of injury, carbuncle sore tumefacting virus.
Above material medicine is extracted is prepared as pharmaceutically acceptable preparation.Pharmaceutical dosage form of the present invention selected from granule,
In capsule, tablet, injection, tincture, suppository, pill, syrup, mixture, powder, lotion, membrane, drop pill
One.More preferably granule.
The preparation method of pharmaceutical preparation of the present invention is:
(1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 6-15 part, Cortex Moutan 10-30 part,
Flos Albiziae 5-14 part, Fructus Arctii 10-32 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-11 part, Radix Trichosanthis 10-24 part, Herba Centellae 6-16 part, red door
Blue 5-11 part, Rhizoma Coptidis 3-10 part, Fructus Mume 7-13 part, Radix Glycyrrhizae 8-14 part, little purple have a smile on one's face 3-9 part.
(2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract,
Twice, each 10-15 times of medical material weight, extract 1-2 hour every time, extracting solution cools, filters, merges；
(3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 8-12 times of medical material weight, extract 1-2 little every time
Time, extracting solution concentrating under reduced pressure, it is 65-75% that concentrated solution adds ethanol to containing alcohol weight, filters；
(4) (2) and (3) gained filtrate is merged, be condensed into extractum, cold drying, pulverize, add methyl
Cellulose 7-19 part, sucrose 500-1200 part, after mix homogeneously, add appropriate 70-80% ethanol, make soft material, pelletize, wave
Remove ethanol, 80 DEG C of spray drying, make granule, weight per package is 10g.
Preferably, the present invention provides the preparation method of a kind of granule, comprises the steps:
(1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 11 parts, Cortex Moutan 21 parts, Herba Albiziae
Spend 10 parts, Fructus Arctii 21.5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8.5 parts, Radix Trichosanthis 17.5 parts, Herba Centellae 11.5 parts, Herba Orchidis Latifoliae 8.5 parts,
Rhizoma Coptidis 7 parts, Fructus Mume 10.5 parts, 11.5 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6.5 parts.
(2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract,
Twice, each 12 times of medical material weight, extract 2 hours every time, extracting solution cools, filters, merges；
(3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 10 times of medical material weight, extract 1.5 little every time
Time, extracting solution concentrating under reduced pressure, it is 70% that concentrated solution adds ethanol to containing alcohol weight, filters；
(4) (2) and (3) gained filtrate is merged, be condensed into extractum, cold drying, pulverize, add methyl
Cellulose 14 parts, sucrose 800 parts, after mix homogeneously, add appropriate 70% ethanol, make soft material, pelletize, fling to ethanol, 80C
Being spray-dried, make granule, weight per package is 10g.
It is highly preferred that
(1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 10.5 parts, Cortex Moutan 20 parts, Herba Albiziae
Spend 9.5 parts, Fructus Arctii 21 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7.5 parts, Radix Trichosanthis 17 parts, Herba Centellae 11 parts, Herba Orchidis Latifoliae 8 parts, Rhizoma Coptidis
6.5 parts, Fructus Mume 10 parts, 11 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6 parts.
(2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, two
Secondary, each 12 times of medical material weight, extract 2 hours every time, extracting solution cools, filters, merges；
(3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 10 times of medical material weight, extract 1.5 little every time
Time, extracting solution concentrating under reduced pressure, it is 70% that concentrated solution adds ethanol to containing alcohol weight, filters；
(4) (2) and (3) gained filtrate is merged, be condensed into extractum, cold drying, pulverize, add Methyl cellulose
Element 13 parts, sucrose 850 parts, after mix homogeneously, add appropriate 70% ethanol, make soft material, pelletize, fling to ethanol, 80C sprays
Mist is dried, and makes granule, and weight per package is 10g.
Above preparation preparation diabetes in application, especially preparation treatment type 2 diabetes mellitus in application.
The present invention is that pure raw material of Chinese medicine medicine is made, scientific and reasonable, in zoology test, it is possible to significantly reduce the content of blood glucose,
Side effect is less, and the Granular pesticide preparation method of the present invention is simple, it is easy to operation, is suitable for industrial mass production.
Specific embodiment
The detailed description of the invention of the following stated, the only present invention, protection scope of the present invention is not limited thereto, any familiar
Those skilled in the art in the technical scope that the invention discloses, the change that can readily occur in or replacement, all should contain
Within protection scope of the present invention.
Embodiment 1: a kind of granule for treating diabetes, containing the Chinese crude drug of following weight portion:
Rhizoma Corydalis 6 grams, Cortex Moutan 10 grams, Flos Albiziae 5 grams, Fructus Arctii 10 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4 grams, Radix Trichosanthis 10 grams, accumulated snow
Grass 6 grams, Herba Orchidis Latifoliae 5 grams, Rhizoma Coptidis 3 grams, Fructus Mume 7 grams, 8 grams of Radix Glycyrrhizae, little purple have a smile on one's face 3 grams.Preparation method include with
Lower step:
(1) above-mentioned weight portion Chinese crude drug is taken；
(2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, two
Secondary, each 10-15 times of medical material weight, extract 1-2 hour every time, extracting solution cools, filters, merges；
(3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 8 times of medical material weight, extract 1 hour every time, carry
Taking liquid concentrating under reduced pressure, it is 65% that concentrated solution adds ethanol to containing alcohol weight, filters；
(4) (2) and (3) gained filtrate is merged, be condensed into extractum, cold drying, pulverize, add methylcellulose 7
Part, sucrose 500 parts, after mix homogeneously, add appropriate 70% ethanol, make soft material, pelletize, fling to ethanol, 80 DEG C of spray dried
Dry, make granule, weight per package is 10g.
Embodiment 2: a kind of granule for treating diabetes, containing the Chinese crude drug of following weight portion:
Rhizoma Corydalis 15 grams, Cortex Moutan 30 grams, Flos Albiziae 14 grams, Fructus Arctii 32 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 11 grams, Radix Trichosanthis 24 grams,
Herba Centellae 16 grams, Herba Orchidis Latifoliae 11 grams, Rhizoma Coptidis 10 grams, Fructus Mume 13 grams, 14 grams of Radix Glycyrrhizae, little purple have a smile on one's face 9 grams.Preparation side
Method comprises the following steps:
(1) above-mentioned weight portion Chinese crude drug is taken；
(2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, two
Secondary, each 15 times of medical material weight, extract 2 hours every time, extracting solution cools, filters, merges；
(3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 12 times of medical material weight, extract 2 hours every time, carry
Taking liquid concentrating under reduced pressure, it is 75% that concentrated solution adds ethanol to containing alcohol weight, filters；
(4) (2) and (3) gained filtrate is merged, be condensed into extractum, cold drying, pulverize, add methylcellulose 19
Part, sucrose 1200 parts, after mix homogeneously, add appropriate 80% ethanol, make soft material, pelletize, fling to ethanol, 80 DEG C of sprayings
Being dried, make granule, weight per package is 10g.
Embodiment 3: a kind of granule for treating diabetes, containing the Chinese crude drug of following weight portion:
Rhizoma Corydalis 10.5 grams, Cortex Moutan 20 grams, Flos Albiziae 9.5 grams, Fructus Arctii 21 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7.5 grams, Radix Trichosanthis 17 grams,
Herba Centellae 11 grams, Herba Orchidis Latifoliae 8 grams, Rhizoma Coptidis 6.5 grams, Fructus Mume 10 grams, 11 grams of Radix Glycyrrhizae, little purple have a smile on one's face 6 grams.Preparation side
Method comprises the following steps:
(1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 10.5 parts, Cortex Moutan 20 parts, Flos Albiziae
9.5 parts, Fructus Arctii 21 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7.5 parts, Radix Trichosanthis 17 parts, Herba Centellae 11 parts, Herba Orchidis Latifoliae 8 parts, Rhizoma Coptidis 6.5
Part, Fructus Mume 10 parts, 11 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6 parts.
(2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, twice,
Each 12 times of medical material weight, extract 2 hours every time, and extracting solution cools, filters, merges；
(3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 10 times of medical material weight, extract 1.5 hours every time,
Extracting solution concentrating under reduced pressure, it is 70% that concentrated solution adds ethanol to containing alcohol weight, filters；
(4) (2) and (3) gained filtrate is merged, is condensed into extractum, cold drying, pulverizes, add methylcellulose 13 parts,
Sucrose 850 parts, after mix homogeneously, adds appropriate 70% ethanol, makes soft material, pelletizes, and flings to ethanol, and 80C is spray-dried,
Making granule, weight per package is 10g.
Embodiment 4: a kind of granule for treating diabetes, containing the Chinese crude drug of following weight portion:
Rhizoma Corydalis 11 grams, Cortex Moutan 21 grams, Flos Albiziae 10 grams, Fructus Arctii 21.5 grams, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8.5 grams, Radix Trichosanthis 17.5 grams,
Herba Centellae 11.5 grams, Herba Orchidis Latifoliae 8.5 grams, Rhizoma Coptidis 7 grams, Fructus Mume 10.5 grams, 11.5 grams of Radix Glycyrrhizae, little purple have a smile on one's face 6.5 grams.
Preparation method comprises the following steps:
(1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 11 parts, Cortex Moutan 21 parts, Flos Albiziae 10
Part, Fructus Arctii 21.5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8.5 parts, Radix Trichosanthis 17.5 parts, Herba Centellae 11.5 parts, Herba Orchidis Latifoliae 8.5 parts, Rhizoma Coptidis
7 parts, Fructus Mume 10.5 parts, 11.5 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6.5 parts.
(2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, two
Secondary, each 12 times of medical material weight, extract 2 hours every time, extracting solution cools, filters, merges；
(3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 10 times of medical material weight, extract 1.5 hours every time,
Extracting solution concentrating under reduced pressure, it is 70% that concentrated solution adds ethanol to containing alcohol weight, filters；
(4) (2) and (3) gained filtrate is merged, be condensed into extractum, cold drying, pulverize, add methylcellulose 14
Part, sucrose 800 parts, after mix homogeneously, add appropriate 70% ethanol, make soft material, pelletize, fling to ethanol, 80C spray dried
Dry, make granule, weight per package is 10g.
Embodiment 5: pharmaceutical preparation of the present invention is at treatment type 2 diabetes mellitus pharmacodynamics test
Metformin is a line medication for the treatment of type 2 diabetes mellitus, and the present invention is used as treating the positive control test of diabetes.
5.1, rat modeling
SD rat adapt to 1 week after fasting overnight, through lumbar injection streptozotocin 65mg/Kg (0.1mmol/l, PH4.4 citric acid
The solution of 2% (W/V) made by buffer), after 3 days, tail venous blood sampling surveys blood glucose >=16.7mmol/L is modeling success.
5.2, medication and observation index:
The diabetes rat of Cheng Mo is randomly divided into model group, metformin 125mg/Kg group and the A (granule of embodiment 1
10g/kg), B (the granule 10g/kg of embodiment 2), C (the granule 10g/kg of embodiment 3), D (embodiment 4
Granule 10g/kg) often organize 10.Separately take 10 and be only used as controlled trial, adapt to one week, gastric infusion after detection blood glucose, every day one
Secondary, medicine all becomes suspension to be administered with normal saline, drinking-water of the most freely ingesting during experiment, 15 days experimental periods.Giving
Medicine the 7th, 14 days, fasting 2 hours after administration, tail venous blood sampling one-touchultra blood glucose meter measures blood glucose, and detection is big simultaneously
The body weight of Mus.
5.3, statistical procedures:
Statistic software SPSS 16.0 is added up, result such as table 1.
The change of blood glucose after medication respectively organized by table 1
Note:
$p ＜ 0.05 is compared with blank group；$$p ＜ 0.01；
#p ＜ 0.05 is compared with model group；##p ＜ 0.05
@P ＜ 0.05 compared with positive controls.
As it can be seen from table 1 matched group is compared with model group, there is significant difference, this method model modeling success be described,
Test each group compared with model group, be respectively provided with significant difference, the therapeutic effect of the granule of embodiments of the invention 3 preparation
Most preferably, and when ground 14 days, compared with positive controls, there is significant difference.
Observe animal two weeks after grouping, at the end of administration, often organize the appetite of Mus, drinking-water, body weights.Body weight change=
Body weight before body weight-administration after medication 14 days；The total of consumption is often organized at the end of medication after appetite, amount of drinking water=beginning medication to 14 day
Amount.
Table 2 body weight, appetite, amount of drinking water information slip
Note:
$p ＜ 0.05 is compared with blank group；$$p ＜ 0.01；
#p ＜ 0.05 is compared with model group；##p ＜ 0.05
@P ＜ 0.05 compared with positive controls.
From table 2, model group has significant difference, positive controls and pharmaceutical preparation group of the present invention with the contrast of blank group
Having significant difference with model control group, and C group of the present invention is substantially better than positive controls, it is poor that the two has statistics
Different P ＜ 0.05, therefore the pharmaceutical preparation of the present invention is suitable for further genralrlization application.
Embodiment 6:
6.1, physical data
My institute accepts 312 patients for medical treatment altogether from March ,-2016 in March, 2012, therefrom selects 300 example patients to enter research, divides at random
For matched group and experimental group, sex between two groups, age, the state of an illness there are no significant difference (P > 0.05).
6.2, diagnostic criteria:
Western medicine diagnose: type 2 diabetes mellitus diagnostic criteria: sick with reference to the diabetes of publication on the Diabetes Care magazine in July, 1997
Because of credit type standard, all diagnostic criterias meeting diabetes, insulin release test result meets the one of following condition and i.e. examines
Break as type 2 diabetes mellitus.
(1) it is that main companion's relative insulin is not enough with insulin resistant；
(2) insulin substantially lacks companion's insulin resistant；
Tcm diagnosis: Chinese medical discrimination diagnostic criteria: deficiency of both QI and YIN or double heat syndrome:
(1) primary symptom: fatigue and weakness, thirst and liking drink, the most hungry polyphagia, frequent micturition；
(2) secondary disease: dysphoria with feverish sensation in the chest palms and soles, spontaneous perspiration or night sweat, breathe hard lazy speech, cardiopalmus, constipation；
(3) tongue arteries and veins: red tongue with a little fluid or corpulent tongue are big, thready pulse or count accurately.
Indispensable 1 of above primary symptom, adds time disease 2, the most diagnosable with reference to tongue arteries and veins.
6.3, therapeutic scheme
Test group: the granule of the embodiment of the present invention 3, each 10g, every day 2 times, takes with meal, 3 weeks courses for the treatment of；
Matched group: blood sugar lowering Tongmai Tablet, one time 3～4,3 times on the one, 3 weeks courses for the treatment of, take with meal.
Forbid during test merging and apply other blood sugar lowering Western medicine, merge Western medicine Uniform provisions as follows:
Moderate state of an illness experimenter: metformin hydrochloride 0.5g 2 times/day, takes with meal；
Severe state of an illness experimenter: metformin hydrochloride 1g 2 times/day, takes with meal.
6.4, diagnosis and curative effect index:
Curative effect index: symptom, sign, fasting glucose, post-prandial glycemia, glycolated hemoglobin, glycated serum protein.
Secondary efficacy index: blood fat, lectin from hemolymph.
Safety indexes: routine blood test, routine urinalysis, just routine, electrocardiogram, liver function, renal function.
Diagnostic result index:
Fasting glucose curative effect obvious effective rate: 7:30 did not took food and measured the concentration of blood glucose before and be decreased obviously morning.
Post-prandial glycemia obvious effective rate: after dining 2 little constantly, measure blood glucose concentration be decreased obviously.
Tcm symptom obvious effective rate: primary symptom shape reduces more than 2, secondary symptom reduces 1 and is significant effective；
Cure rate: return to one's perfect health, within 6 months, call-on back by phone does not recur.
Detailed results is shown in Table 3.
The therapeutic effect of table 3 observation group and matched group compares
Test group is better than matched group to 2 hours blood glucoses after the meal, fasting glucose, the curative effect of tcm symptom, has significant difference.This
Invention treatment by Chinese herbs type 2 diabetes mellitus (deficiency of both QI and YIN hold concurrently heat syndrome) is safely and effectively.
Safety results: extraction matched group and each 50 examples of observation group, does not observes on inspection to the heart, Liver and kidney function, blood
System has anomalous effects and other untoward reaction.Test finds that the observation group target cell sensitivity to insulin is apparently higher than comparison
Group, observation group's antagonism insulin resistant has preferably effect.
6.5, classical clinical case
Case 1: cattle, female 55 years old, Shandong Zibo people, over 2015, my institute checks, suffers from diabetes and takes Western medicine in 5 years always
Treatment, Therapeutic Method mainly takes metformin, and blood glucose raises repeatedly, and patient engenders depression, the phenomenon such as short-tempered,
After get off my institute's treatment in the advice of son, take the Drug therapy of embodiments of the invention 3, persistently taking for 1 course for the treatment of,
Blood glucose is gradually lowered, and mood takes a turn for the better, and continues to take 2 courses for the treatment of, and blood glucose recovers normal substantially, and health body weight substantially increases, and 6
Individual month Effect of follow-up visit by telephone, patient continues to take.
Case 2: Hao, man 47 years old, Pingyi, shandong Province people, suffer from diabetes medical history for a long time, by excessive districts and cities examination in hospital
It is diagnosed as type 2 diabetes mellitus, takes Or Metformin In Treating the treatment of auxiliary injection insulin, start curative effect substantially, but there is medicine
Thing dependency and least, lives agonizing.Patient's private prosecution fatigue and weakness, thirst and liking drink, frequent micturition at night, Patient height
180cm, but body weight only has 56.5 kilograms, and body weight also has the trend gradually alleviated, and comes my institute upon somebody's introduction and checks treatment,
With the granule of the embodiment of the present invention 3,1 course for the treatment of, blood glucose improves significantly, and gradually recovers normal, and 6 months through electricity
Words are paid a return visit, and patient still takes continuing, and body weight increases to 63 kilograms.
Claims (10)
1. one kind for treating the pharmaceutical preparation of diabetes, it is characterised in that includes following Chinese crude drug: Rhizoma Corydalis, Cortex Moutan, Flos Albiziae,
Fructus Arctii, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Trichosanthis, Herba Centellae, Herba Orchidis Latifoliae, Rhizoma Coptidis, Fructus Mume, Radix Glycyrrhizae, little purple are with a smile.
Pharmaceutical preparation the most according to claim 1, it is characterised in that the weight portion of described Chinese crude drug is: Rhizoma Corydalis 6-15 part,
Cortex Moutan 10-30 part, Flos Albiziae 5-14 part, Fructus Arctii 10-32 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-11 part, Radix Trichosanthis 10-24 part, Herba Centellae 6-16
Part, Herba Orchidis Latifoliae 5-11 part, Rhizoma Coptidis 3-10 part, Fructus Mume 7-13 part, Radix Glycyrrhizae 8-14 part, little purple have a smile on one's face 3-9 part.
Pharmaceutical preparation the most according to claim 1, it is characterised in that the weight portion of described Chinese crude drug is: Rhizoma Corydalis 10.5 parts,
Cortex Moutan 20 parts, Flos Albiziae 9.5 parts, Fructus Arctii 21 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7.5 parts, Radix Trichosanthis 17 parts, Herba Centellae 11 parts, Herba Orchidis Latifoliae 8
Part, Rhizoma Coptidis 6.5 parts, Fructus Mume 10 parts, 11 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6 parts.
Pharmaceutical preparation the most according to claim 1, it is characterised in that the weight portion of described Chinese crude drug is: Rhizoma Corydalis 11 parts,
Cortex Moutan 21 parts, Flos Albiziae 10 parts, Fructus Arctii 21.5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8.5 parts, Radix Trichosanthis 17.5 parts, Herba Centellae 11.5 parts,
Herba Orchidis Latifoliae 8.5 parts, Rhizoma Coptidis 7 parts, Fructus Mume 10.5 parts, 11.5 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6.5 parts.
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation is selected from granule, capsule, sheet
One in agent, injection, tincture, suppository, pill, syrup, mixture, powder, lotion, membrane, drop pill.
Pharmaceutical preparation the most according to claim 5, it is characterised in that described pharmaceutical preparation is granule.
7. the method for the pharmaceutical preparation prepared described in claim 1-5, it is characterised in that comprise the following steps:
1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 6-15 part, Cortex Moutan 10-30 part, Flos Albiziae
5-14 part, Fructus Arctii 10-32 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-11 part, Radix Trichosanthis 10-24 part, Herba Centellae 6-16 part, Herba Orchidis Latifoliae 5-11
Part, Rhizoma Coptidis 3-10 part, Fructus Mume 7-13 part, Radix Glycyrrhizae 8-14 part, little purple have a smile on one's face 3-9 part；
2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, twice, often
Secondary 10-15 times of medical material weight, extracts 1-2 hour every time, and extracting solution cools, filters, merges；
3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 8-12 times of medical material weight, extract 1-2 hour every time, carry
Taking liquid concentrating under reduced pressure, it is 65-75% that concentrated solution adds ethanol to containing alcohol weight, filters；
4) by 2 and 3) merging of gained filtrate, it is condensed into extractum, cold drying, pulverizes, add methylcellulose 7-19 part, sugarcane
Sugar 500-1200 part, after mix homogeneously, adds appropriate 70-80% ethanol, makes soft material, pelletizes, flings to ethanol, 80 DEG C of sprayings
Being dried, make granule, weight per package is 10g.
8. the method for the pharmaceutical preparation prepared described in claim 1, it is characterised in that comprise the following steps:
1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 11 parts, Cortex Moutan 21 parts, Flos Albiziae 10 parts,
Fructus Arctii 21.5 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 8.5 parts, Radix Trichosanthis 17.5 parts, Herba Centellae 11.5 parts, Herba Orchidis Latifoliae 8.5 parts, Rhizoma Coptidis 7 parts,
Fructus Mume 10.5 parts, 11.5 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6.5 parts；
2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, twice,
Each 12 times of medical material weight, extract 2 hours every time, and extracting solution cools, filters, merges；
3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 10 times of medical material weight, extract 1.5 hours every time, carry
Taking liquid concentrating under reduced pressure, it is 70% that concentrated solution adds ethanol to containing alcohol weight, filters；
4) by 2) and the merging of (3) gained filtrate, it is condensed into extractum, cold drying, pulverizes, add methylcellulose 14 parts,
Sucrose 800 parts, after mix homogeneously, adds appropriate 70% ethanol, makes soft material, pelletizes, and flings to ethanol, and 80C is spray-dried,
Making granule, weight per package is 10g.
9. the method for the pharmaceutical preparation prepared described in claim 1, it is characterised in that comprise the following steps:
1) getting it filled material, described medical material contains the raw medicinal herbs of following weight portion: Rhizoma Corydalis 10.5 parts, Cortex Moutan 20 parts, Flos Albiziae 9.5
Part, Fructus Arctii 21 parts, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7.5 parts, Radix Trichosanthis 17 parts, Herba Centellae 11 parts, Herba Orchidis Latifoliae 8 parts, Rhizoma Coptidis 6.5 parts,
Fructus Mume 10 parts, 11 parts of Radix Glycyrrhizae, little purple have a smile on one's face 6 parts；
2) by Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) therein, Fructus Arctii, Rhizoma Corydalis, Cortex Moutan, Herba Centellae 70% alcohol reflux, reflux, extract, twice, often
Secondary 12 times of medical material weight, extract 2 hours every time, and extracting solution cools, filters, merges；
3) medicinal residues add other medical materials, the reflux, extract, that adds water twice, each 10 times of medical material weight, extract 1.5 hours every time, carry
Taking liquid concentrating under reduced pressure, it is 70% that concentrated solution adds ethanol to containing alcohol weight, filters；
4) by 2) and 3) merging of gained filtrate, it is condensed into extractum, cold drying, pulverizes, add methylcellulose 13 parts, sugarcane
Sugar 850 parts, after mix homogeneously, adds appropriate 70% ethanol, makes soft material, pelletizes, and flings to ethanol, and 80C is spray-dried, system
Becoming granule, weight per package is 10g.
Pharmaceutical preparation the most according to claim 1, it is characterised in that described pharmaceutical preparation is in preparation treatment diabetes medicament
Application.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610451605.1A CN105943860A (en) | 2016-06-21 | 2016-06-21 | Medicine preparation for treating diabetes mellitus and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610451605.1A CN105943860A (en) | 2016-06-21 | 2016-06-21 | Medicine preparation for treating diabetes mellitus and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105943860A true CN105943860A (en) | 2016-09-21 |
Family
ID=56907121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610451605.1A Withdrawn CN105943860A (en) | 2016-06-21 | 2016-06-21 | Medicine preparation for treating diabetes mellitus and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105943860A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476557A (en) * | 2021-08-01 | 2021-10-08 | 江苏省中医药研究院 | Traditional Chinese medicine compound composition with effect of treating diabetic cardiac autonomic neuropathy and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357181A (en) * | 2007-08-02 | 2009-02-04 | 天津天士力制药股份有限公司 | Medicine for treating diabetes containing Radix Bupleurum and preparation method thereof |
-
2016
- 2016-06-21 CN CN201610451605.1A patent/CN105943860A/en not_active Withdrawn
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357181A (en) * | 2007-08-02 | 2009-02-04 | 天津天士力制药股份有限公司 | Medicine for treating diabetes containing Radix Bupleurum and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113476557A (en) * | 2021-08-01 | 2021-10-08 | 江苏省中医药研究院 | Traditional Chinese medicine compound composition with effect of treating diabetic cardiac autonomic neuropathy and preparation method thereof |
| CN113476557B (en) * | 2021-08-01 | 2022-03-25 | 江苏省中医药研究院 | Traditional Chinese medicine compound composition with effect of treating diabetic cardiac autonomic neuropathy and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101947284B (en) | Traditional Chinese medicinal composition for treating diabetes and preparation method thereof | |
| CN102205107B (en) | Chinese medicinal preparation for treating duodenal ulcer and preparation method thereof | |
| CN103520572B (en) | A kind of Chinese medicine composition being used for the treatment of atopic dermatitis and preparation method thereof | |
| CN103990081A (en) | Traditional Chinese medicine composition and application thereof in preparation of medicine for treating infant jaundice | |
| CN102188613A (en) | Traditional Chinese medicine preparation for treating diabetes | |
| CN103223111B (en) | Traditional Chinese medicine composition for treating diabetic nephropathy and preparation method thereof | |
| CN101953936B (en) | Traditional Chinese medicine preparation for treating immune thrombocytopenia and preparation method thereof | |
| CN102698077A (en) | Traditional Chinese medicine composition for treating sub-health | |
| CN104206595A (en) | Blood lipid and blood glucose reducing Chinese wolfberry root-bark health care tea and preparation method thereof | |
| CN103705860B (en) | A kind of Chinese medicine composition for the treatment of infant jaundice and preparation method thereof | |
| CN101194982B (en) | A kind of antidepressant traditional Chinese medicine composition and preparation method thereof | |
| CN111358907A (en) | Medicinal and edible traditional Chinese medicine formula granule for treating insomnia and preparation method thereof | |
| CN101757408A (en) | Medicament for treating lupus erythematosus and preparation method thereof | |
| CN104225425A (en) | Chinese herbal preparation for enhancing immunity, improving sleep and preventing cardio-cerebrovascular disease, and preparation method thereof | |
| CN1192789C (en) | 'Shenhuaxiaokecha' tea and preparing method thereof | |
| CN103393938B (en) | Traditional Chinese medicine composition for reducing blood sugar | |
| CN105943860A (en) | Medicine preparation for treating diabetes mellitus and preparation method thereof | |
| CN105169187B (en) | A kind of composition and its application, preparation method and drug, food containing the composition | |
| CN104306847A (en) | Six-ingredient qi-tonifying capsule and preparation process thereof | |
| CN117959394B (en) | Use of Shenqi Tongmai preparation in preparing medicine for preventing and treating diabetic neuropathy | |
| CN107648502A (en) | A kind of pharmaceutical composition for nursing one's health yin-deficiency constitution and its production and use | |
| CN108403803B (en) | A traditional Chinese medicine compound preparation for preventing and treating cardiovascular complications of diabetes | |
| CN1660288A (en) | Capsule of treating gall-stone and cholecystitis, and preparation method | |
| CN106266334A (en) | A kind of Chinese medicine composition treating fat concurrent hyperlipemia and acupuncture and drugs application | |
| CN105664048A (en) | Pharmaceutical composition inhibiting gastric cancer cell proliferation and application thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20160921 |