CN101947284B - Traditional Chinese medicinal composition for treating diabetes and preparation method thereof - Google Patents
Traditional Chinese medicinal composition for treating diabetes and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the field of traditional Chinese medicines and discloses a traditional Chinese medicinal composition for treating diabetes and a preparation method thereof. The traditional Chinese medicinal composition for treating diabetes is prepared from the following raw materials in part by weight: 12 to 30 parts of astragalus, 3 to 5 parts of vine root, 18 to 30 parts of yam, 9 to 15 parts of anemarrhena asphodeloides bunge, 6 to 12 parts of mongolian snakegourd root, 4 to 6 parts of Chinese magnoliavine fruit and 3 to 5 parts of chicken's gizzardskin. The preparation method of the traditional Chinese medicinal composition comprises: leaching the astragalus, vine root and Chinese magnoliavine fruit with ethanol, filtering extract and collecting filtrate; leaching the yam, anemarrhena asphodeloides bunge and mongolian snakegourd root with water, filtering extract, condensing the filtrate, performing alcohol precipitation, filtering and collecting filtrate; and combining filtrate, drying, crushing, and mixing the crushed product with fine chicken's gizzardskin powder. The traditional Chinese medicinal composition for treating diabetes can relieve the symptoms of polydipsia, polyuria, polyphagia, emaciation, fatigue and weakness of diabetes, reduce blood sugar and treat diabetes of deficiency of Qi-Yin syndrome with urine sugar and blood sugar rise, and has remarkable treatment effect.
Description
Technical field
The present invention relates to the field of Chinese medicines, relate to a kind of Chinese medicine composition of treating diabetes and preparation method thereof specifically.
Background technology
Diabetes (diabetes) are regarded as the healthy threat greatly in the whole world; The statistics of IDF and The World Health Organization (WHO) show; The whole world had the people above 2.46 hundred million to suffer from diabetes in 2007; Just have 1 diabetic death per 10 seconds in the world, if do not adopt an important measure, will have the people above 3.80 hundred million to suffer from diabetes to the whole world in 2025.Meanwhile, Chinese diabetes prevalence is also sharply increasing, and has increased by 4～5 times from the eighties to the mid-90 in 20th century, and national diabetes number of patients was 4,000 ten thousand in 2007, and being only second to India becomes global diabetics number second big country.Diabetes are one of whole world diseases of having found in the disease tool destructive power; Its acute and chronic complication; Especially the chronic disease complication is involved a plurality of organs, disables, fatality rate is high, has a strong impact on patient's physical and mental health; And bring white elephant for individual, family and society, be the important Chronic Non-Communicable Diseases of another serious harm people ' s health after cardiovascular and cerebrovascular disease, tumor.
Diabetes are to act on body by various virulence factors such as inherited genetic factors, immunologic function disorders to cause hypoinsulinism, insulin resistant (Insulin Resistance; And a series of metabolism disorder syndromes such as the sugar that causes, protein, fat, power and water Xie Zhi IR) etc.; Be main feature clinically with the hyperglycemia; Performance such as polyuria, polydipsia, polyphagia can appear in model case, become thin, i.e. the multiple acute and chronic complication of " three-many-one-little " symptom, and Chang Bingfa.
The western medical treatment diabetes are hype secretion of insulin and increase its biological activity at present; Reduce the infiltration rate of glucose at enteral; Increase in-vivo tissue to the utilization of glucose and synthesizing of promotion hepatic glycogen; Or the direct injection exogenous insulin etc., it is strong that hypoglycemic activity is fast imitated, and can prevent and treat the acute and chronic complication of diabetes.But the western medical treatment side effect is bigger, and insulin commonly used is easy to generate antibody and impels microangiopathies to take place, and it is relatively poor to improve symptom.
Diabetes spp is in Chinese medicine diabetes category, and head is shown in Huangdi's Internal Classics.The traditional Chinese medical science thinks that factors such as eating and drinking without temperance, disorder of emotion, labor are desired excessively, physical weakness all can cause the generation of diabetes.TCM treatment of diabetes is to be main with organic conception, determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, adopts Therapeutic Principle such as supplementing QI and nourishing YIN, heat clearing and blood circulation promoting, and the adjustment human internal environment improves patient's metabolism status, treatment complication, and non-evident effect.The blood sugar level that many drug controllable system diabetes are arranged clinically, but have defective aspect diabetes " three-many-one-little " symptom improving.
Summary of the invention
The object of the invention provides a kind of Chinese medicine composition of treating diabetes; Said Chinese medicine composition can obviously improve polydipsia, polyuria, polyphagia that diabetes cause, becomes thin, the symptom of fatigue and lack of strength; Blood sugar lowering, the Qi and Yin deficiency diabetes mellitus of treatment glucose in urine and blood sugar increasing.
For realizing the object of the invention, the present invention adopts following technical scheme:
A kind of Chinese medicine composition of treating diabetes is processed by the raw material of following weight portion: Radix Astragali 12-30 part, Radix Puerariae 3-5 part, Rhizoma Dioscoreae 18-30 part, Rhizoma Anemarrhenae 9-15 part, Radix Trichosanthis 6-12 part, Fructus Schisandrae Chinensis 4-6 part, Endothelium Corneum Gigeriae Galli 3-5 part.
Wherein, as preferably, the Chinese medicine composition of said treatment diabetes is processed by the raw material of following weight portion: 20 parts of the Radixs Astragali, 4 parts of Radix Puerariaes, 20 parts of Rhizoma Dioscoreaes, 12 parts of the Rhizoma Anemarrhenaes, 9 parts of Radix Trichosanthis, 5 parts of Fructus Schisandrae Chinensis, 4 parts of Endothelium Corneum Gigeriae Galli.
Chinese medicine composition according to the invention is selected seven flavor Chinese crude drugs such as the Radix Astragali, Radix Puerariae, Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, Radix Trichosanthis, Fructus Schisandrae Chinensis, Endothelium Corneum Gigeriae Galli for use.
Wherein, the Radix Astragali has another name called Radix Astragali, leguminous herbaceous plant, and root has effects such as invigorating QI to consolidate the body surface resistance, diuretic detumescent, expelling pus and toxin by strengthening QI, granulation promoting.Nontoxic, sweet in the mouth, the feeble QI temperature, gas is thin and distinguish the flavor of densely, and the yang invigorating QI invigorating helps temper to rise, and has the effect of two-phase blood sugar regulation, and it is weak to can be used for treating the deficiency of vital energy, and sinking of QI of middle-JIAO, blood deficiency and yellow complexion, interior-heat are quenched one's thirst, diabetes etc.
Radix Puerariae is the dry root of legume pueraria lobata, and is cool in nature, sweet in the mouth, suffering, and expelling pathogenic factors from muscles is delivered, and relieving restlessness is quenched the thirst, and rash antidiarrheal is relieved inflammation or internal heat, all effects of toxin expelling, blood sugar lowering, blood fat reducing, blood pressure lowering, cholesterol reducing.The effect that isoflavonoid Radix Puerariae in the Radix Puerariae have a tangible blood sugar lowering is used to treat hyperglycemia has significant curative effect.
Rhizoma Dioscoreae original name Rhizoma Dioscoreae, herbaceos perennial, tuber is used as medicine.Rhizoma Dioscoreae sweet in the mouth, property are flat, and tonifying the spleen and stomach, lung benefiting kidney cure mainly diseases such as weakness of the spleen and stomach, lassitude, inappetence, the frequent micturition of quenching one's thirst, insufficiency of lung-QI are dry, kidney qi loss.
The Rhizoma Anemarrhenae is liliaceous plant Rhizoma Anemarrhenae rhizome, and is cold in nature, and bitter in the mouth has clearing away heat-fire, nourshing Yin and drynsessmoistening prescription effect, cures mainly diseases such as dysphoria with smothery sensation is quenched one's thirst, lung-heat type cough, hectic fever in the afternoon.
Radix Trichosanthis is the root of cucurbitaceous plant Chinese juniper beach wormwood, sweet, the little hardship of property, is slightly cold, and has clearing away heat-fire, promoting the production of body fluid to quench thirst, and the effect of evacuation of pus detumescence cures mainly the calentura excessive thirst, lung-heat type cough, interior-heat is quenched one's thirst, sore swollen toxin.
Fructus Schisandrae Chinensis is the fruit of Magnoliaceae liana Fructus Schisandrae Chinensis, and is warm in nature, sweet in the mouth, acid, have the convergence astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, the effect of kidney calming is used to treat the chronic cough dyspnea due to deficiency, interior-heat is quenched one's thirst, Tianjin wound is thirsty, the diseases such as deficient pulse, incessant chronic diarrhea, palpitation and insomnia of losing heart.
Endothelium Corneum Gigeriae Galli is meant the gizzard inwall of tame chicken, and is cold in nature, and sweet in the mouth has promoting digestion and invigorating the stomach, and the effect of arresting seminal emission is used to treat the food stagnation distension, and the enuresis, diseases such as seminal emission are quenched one's thirst in vomiting regurgitation.
The Chinese medicine composition of treatment diabetes according to the invention can be according to requirement of different patients and pharmaceutically conventional adjuvant, and the different clinical preparation is processed in combination, comprises oral liquid, granule, tablet, pill, powder, capsule and drop pill.
The present invention also provides the method for preparing of the Chinese medicine composition of treatment diabetes according to the invention.
A kind of method for preparing of treating the Chinese medicine composition of diabetes comprises:
Step 1: get Radix Astragali 12-30 part, Radix Puerariae 3-5 part, Fructus Schisandrae Chinensis 4-6 part, ethanol extraction, extracting liquid filtering is collected filtrating;
Step 2: get Rhizoma Dioscoreae 18-30 part, Rhizoma Anemarrhenae 9-15 part, Radix Trichosanthis 6-12 part, extracting in water, extracting liquid filtering, filtrating is concentrated into the clear paste that relative density is 1.10-1.20, adds ethanol and makes and contain alcohol amount and reach 70%-80%, and mixing leaves standstill, and filters, and collects filtrating;
Step 3: combining step 1 and step 2 gained filtrating, drying and crushing promptly gets with the Endothelium Corneum Gigeriae Galli fine powder mixing of 3-5 part.
Wherein, as preferably, the method for preparing of the Chinese medicine composition of treatment diabetes according to the invention comprises:
Step 1: get 20 parts of the Radixs Astragali, 4 parts of Radix Puerariaes, 5 parts of Fructus Schisandrae Chinensis, ethanol extraction, extracting liquid filtering is collected filtrating;
Step 2: get 20 parts of Rhizoma Dioscoreaes, 12 parts of the Rhizoma Anemarrhenaes, 9 parts of Radix Trichosanthis, extracting in water, extracting liquid filtering, filtrating is concentrated into the clear paste that relative density is 1.10-1.20, adds ethanol and makes and contain alcohol amount and reach 70%-80%, and mixing leaves standstill, and filters, and collects filtrating;
Step 3: combining step 1 and step 2 gained filtrating, drying and crushing promptly gets with 4 parts Endothelium Corneum Gigeriae Galli fine powder mixing.
Method for preparing according to the invention, the said backflow ethanol extraction of step 1 is preferably the 70%-80% ethanol with 5-10 times of weight, heating and refluxing extraction 2-4 time, each 1-3 hour.
Method for preparing according to the invention, the said extracting in water of step 2 is preferably the decocting that adds 7-10 times of weight and boils 2-4 time, each 1-3 hour.
Method for preparing according to the invention, step 2 concentrates the filtrating of extracting solution, adds a certain amount of ethanol precipitation, can remove and be insoluble to alcoholic acid composition in the extracting solution.
Method for preparing according to the invention, the said drying and crushing of step 3, be preferably vacuum drying after, be ground into 80-100 order fine powder, or spray drying gets fine powder, wherein, more preferably be that spray drying gets fine powder.
Method for preparing according to the invention, the said Endothelium Corneum Gigeriae Galli fine powder of step 3 is preferably and is ground into 100 purpose fine powders.
The Chinese medicine composition of treatment diabetes according to the invention, determined curative effect, safe in utilization, quality controllable, taking convenience have nourishing kidney-YIN, the function of promoting the production of body fluid to quench thirst.Clinical trial shows; The Chinese medicine composition of method for preparing according to the invention preparation can obviously improve polydipsia, polyuria, polyphagia that diabetes cause, becomes thin, the symptom of fatigue and lack of strength, blood sugar lowering; The Qi and Yin deficiency diabetes mellitus of treatment glucose in urine and blood sugar increasing, evident in efficacy.
The specific embodiment
The embodiment of the invention discloses a kind of Chinese medicine composition of treating diabetes and preparation method thereof.Those skilled in the art can use for reference this paper content, suitably improve technological parameter and can realize.Special needs to be pointed out is that all are similarly replaced and change, for a person skilled in the art, is conspicuous, and they all are regarded as and comprise within the scope of the present invention.Product of the present invention and method; Be described through preferred embodiment; The related personnel obviously can be in not breaking away from content of the present invention, spirit and scope, to product as herein described with method is changed or suitably change and combination, realizes and use technology of the present invention.
In order further to understand the present invention, a kind of Chinese medicine composition of treating diabetes provided by the invention and preparation method thereof is elaborated below in conjunction with embodiment.
Embodiment 1: Chinese medicine composition of treatment diabetes according to the invention and preparation method thereof
The Chinese medicine composition of treatment diabetes according to the invention is processed by the raw material of following weight portion: Radix Astragali 12g, Radix Puerariae 3g, Rhizoma Dioscoreae 18g, Rhizoma Anemarrhenae 9g, Radix Trichosanthis 6g, Fructus Schisandrae Chinensis 4g, Endothelium Corneum Gigeriae Galli 3g.
Method for preparing is:
(1) get the Radix Astragali, Radix Puerariae, the Fructus Schisandrae Chinensis Chinese medicine coarse powder of said weight, extract 2 times with 70% alcohol heating reflux of 5 times of weight, each 1 hour, merge extractive liquid,, filtration, filtrate recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
(2) get Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, the Radix Trichosanthis of said weight, add 7 times of weight decoctings and boil 2 times, each 1 hour; Merge extractive liquid,, filtration, filtrate decompression are concentrated into the clear paste that relative density is 1.10-1.20 (room temperature), cooling; Add ethanol and make and contain alcohol amount and reach 70%, stir, left standstill 12 hours; Filter, filtrate recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
(3) get the merging of (1) and (2) gained filtrating, stir, be ground into 80-100 order fine powder behind the vacuum drying, and be ground into 100 purpose Endothelium Corneum Gigeriae Galli fine powder mixings, promptly get.
Embodiment 2: Chinese medicine composition of treatment diabetes according to the invention and preparation method thereof
The Chinese medicine composition of treatment diabetes according to the invention is processed by the raw material of following weight g: Radix Astragali 30g, Radix Puerariae 5g, Rhizoma Dioscoreae 30g, Rhizoma Anemarrhenae 15g, Radix Trichosanthis 12g, Fructus Schisandrae Chinensis 6g, Endothelium Corneum Gigeriae Galli 5g.
Method for preparing is:
(1) get the Radix Astragali, Radix Puerariae, the Fructus Schisandrae Chinensis Chinese medicine coarse powder of said weight, extract 4 times with 80% alcohol heating reflux of 10 times of weight, each 3 hours, merge extractive liquid,, filtration, filtrate recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
(2) get Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, the Radix Trichosanthis of said weight, add 10 times of weight decoctings and boil 4 times, each 3 hours; Merge extractive liquid,, filtration, filtrate decompression are concentrated into the clear paste that relative density is 1.10-1.20 (room temperature), cooling; Add ethanol and make and contain alcohol amount and reach 80%, stir, left standstill 24 hours; Filter, filtrate recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
(3) get the merging of (1) and (2) gained filtrating, stir, spray drying gets fine powder, and is ground into 100 purpose Endothelium Corneum Gigeriae Galli fine powder mixings, promptly gets.
Embodiment 3: Chinese medicine composition of treatment diabetes according to the invention and preparation method thereof
The Chinese medicine composition of treatment diabetes according to the invention is processed by the raw material of following weight portion: Radix Astragali 20g, Radix Puerariae 4g, Rhizoma Dioscoreae 20g, Rhizoma Anemarrhenae 12g, Radix Trichosanthis 9g, Fructus Schisandrae Chinensis 5g, Endothelium Corneum Gigeriae Galli 4g.
Method for preparing is:
(1) get the Radix Astragali, Radix Puerariae, the Fructus Schisandrae Chinensis Chinese medicine coarse powder of said weight, extract 3 times with 75% alcohol heating reflux of 7 times of weight, each 2 hours, merge extractive liquid,, filtration, filtrate recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
(2) get Rhizoma Dioscoreae, the Rhizoma Anemarrhenae, the Radix Trichosanthis of said weight, add 7 times of weight decoctings and boil 3 times, each 2 hours; Merge extractive liquid,, filtration, filtrate decompression are concentrated into the clear paste that relative density is 1.10-1.20 (room temperature), cooling; Add ethanol and make and contain alcohol amount and reach 75%, stir, left standstill 18 hours; Filter, filtrate recycling ethanol is to there not being the alcohol flavor, and is subsequent use;
(3) get the merging of (1) and (2) gained filtrating, stir, spray drying gets fine powder, and is ground into 100 purpose Endothelium Corneum Gigeriae Galli fine powder mixings, promptly gets.
Embodiment 4: the clinical preparation of the Chinese medicine composition of treatment diabetes according to the invention
The Chinese medicine composition of the said treatment diabetes of embodiment of the invention 1-3 according to the pharmaceutical production technology of routine, adds suitable correctives or sweeting agent, processes oral liquid or granule; Add suitable adjuvant, process oral solid formulations such as tablet, powder, capsule or drop pill.
Embodiment 5: the Chinese medicine composition clinical observation on the therapeutic effect of treatment diabetes according to the invention
Method: 120 routine clinical definite diabeticss are divided into experimental group and matched group at random; Experimental group 60 examples; Matched group 60 examples are taken the Chinese medicine composition of embodiment 3 preparations and commercially available metformin respectively, take continuously 10 days; Observe the clinical efficacy result and see table 1, stop other western medicines in treatment during the treatment.
Diagnostic criteria: with reference to the standard rating curative effect of " the clinical research guideline of the treatment diabetes " defined in " the new Chinese medicine clinical research guideline " of Ministry of Public Health formulation in 1993.Produce effects: treatment back symptom disappears basically, FPG (fasting glucose)＜7.0mmol/L, and P2hPG (2 hours after the meal blood glucose)＜8.3mmol/L or the more preceding decline of blood glucose are more than 30%; Effectively: treatment back symptom is obviously improved FPG＜8.3mmol/L, P2hPG＜10.0mmol/L, or the more preceding decline 10%～29% of blood glucose; Invalid: treatment back symptom does not have obvious improvement, and blood glucose descends and do not reach above-mentioned standard.
The Chinese medicine composition clinical observation on the therapeutic effect of table 1 treatment diabetes according to the invention
Can find out that from table 6 Chinese medicine composition according to the invention has been obtained curative effect preferably clinically; In 60 routine diabeticss, take Chinese medicine composition according to the invention after 5 days, cure 42 examples; Cure rate accounts for 70.0%, 16 examples that take a turn for the better, and obvious effective rate accounts for 26.7%; Total effective rate is 96.7%, invalid 2 examples, and inefficiency accounts for 3.3%.The Chinese medicine composition group of embodiment 1 and embodiment 2 preparations is similar with the Chinese medicine composition group clinical efficacy of embodiment 3 preparations, no difference of science of statistics.
Further provide two examples more detailed concrete case below:
Case 1, Ouyang, the woman, 49 years old, readme: since nearly more than 20 days, thirsty suddenly, polyuria, pleasantly sweet in mouthful, urine meaning again and again, many persons one day and night can 20 surplus time, total volume of urine was everlasting more than 2～3L on 1st.Because the polyuria dehydration, always feel excessive thirst, the amount of drinking water and increased frequency, at examination in hospital glucose in urine (++), fasting glucose 10.6mmol/L, 2 hours after the meal 13.6mmol/L are diagnosed as type ii diabetes.Take after glyburide, metformin and the diabetes pill by doctor's advice, glucose in urine changes (+), and blood glucose descends to some extent, but still feels that oropharynx is very thirsty, have no appetite, and fatigue and asthenia, red tongue is dark, indentations at the margin of the tongue, the few Tianjin of white and thin fur, or few tongue, thready and weak pulse.Change the Chinese medicine composition of the clothes embodiment of the invention 1 preparation, serve on 10 days after, dryly alleviate yearningly, sweet taste disappears in mouthful, hypourocrinia, muscle power is recovered to some extent.Continue taking for two weeks, stable disease, glucose in urine is turned out cloudy, fasting glucose 6.0mmol/l, 2 hours after the meal 9.6mmol/L, it is normal that health recovers basically.
Case 2, Lee, man, 60 years old.Before 1 month, often feel thirsty, polydipsia, polyuria, polyphagia feel run-down.The inspection glucose in urine (+++), fasting glucose 11.5mmol/L, 2 hours after the meal 14.4mmol/L are diagnosed as type ii diabetes.After taking diformin tablet, headache, dizzy, hypertension change the Chinese medicine composition that the clothes embodiment of the invention 2 prepares, and after two weeks, headache, dizziness alleviate, and it is normal that blood pressure recovers, and the symptom of polydipsia, polyphagia, polyuria takes a turn for the better to some extent.After taking January, 3 checks, post-prandial glycemia＜7.8mmol/L, fasting glucose＜5.9mmol/L, all rehabilitations of disease.
The explanation of above embodiment just is used for helping to understand method of the present invention and core concept thereof.Should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention, can also carry out some improvement and modification to the present invention, these improvement and modification also fall in the protection domain of claim of the present invention.
Claims (10)
1. a Chinese medicine composition of treating diabetes is processed by the raw material of following weight portion: Radix Astragali 12-30 part, Radix Puerariae 3-5 part, Rhizoma Dioscoreae 18-30 part, Rhizoma Anemarrhenae 9-15 part, Radix Trichosanthis 6-12 part, Fructus Schisandrae Chinensis 4-6 part, Endothelium Corneum Gigeriae Galli 3-5 part; The method for preparing of wherein said Chinese medicine composition comprises:
Step 1: get Radix Astragali 12-30 part, Radix Puerariae 3-5 part, Fructus Schisandrae Chinensis 4-6 part, ethanol extraction, extracting liquid filtering is collected filtrating;
Step 2: get Rhizoma Dioscoreae 18-30 part, Rhizoma Anemarrhenae 9-15 part, Radix Trichosanthis 6-12 part, extracting in water, extracting liquid filtering, filtrating is concentrated into the clear paste that relative density is 1.10-1.20, adds ethanol and makes and contain alcohol amount and reach 70%-80%, and mixing leaves standstill, and filters, and collects filtrating;
Step 3: combining step 1 and step 2 gained filtrating, drying and crushing promptly gets with the Endothelium Corneum Gigeriae Galli fine powder mixing of 3-5 part.
2. Chinese medicine composition according to claim 1 is characterized in that, is processed by the raw material of following weight portion: 20 parts of the Radixs Astragali, 4 parts of Radix Puerariaes, 20 parts of Rhizoma Dioscoreaes, 12 parts of the Rhizoma Anemarrhenaes, 9 parts of Radix Trichosanthis, 5 parts of Fructus Schisandrae Chinensis, 4 parts of Endothelium Corneum Gigeriae Galli; The method for preparing of wherein said Chinese medicine composition comprises:
Step 1: get 20 parts of the Radixs Astragali, 4 parts of Radix Puerariaes, 5 parts of Fructus Schisandrae Chinensis, ethanol extraction, extracting liquid filtering is collected filtrating;
Step 2: get 20 parts of Rhizoma Dioscoreaes, 12 parts of the Rhizoma Anemarrhenaes, 9 parts of Radix Trichosanthis, extracting in water, extracting liquid filtering, filtrating is concentrated into the clear paste that relative density is 1.10-1.20, adds ethanol and makes and contain alcohol amount and reach 70%-80%, and mixing leaves standstill, and filters, and collects filtrating;
Step 3: combining step 1 and step 2 gained filtrating, drying and crushing promptly gets with 4 parts Endothelium Corneum Gigeriae Galli fine powder mixing.
3. the clinical preparation that comprises claim 1 or 2 described Chinese medicine compositions; It is characterized in that; Process by the Chinese medicine composition of said treatment diabetes and pharmaceutically conventional adjuvant combination, comprise oral liquid, granule, tablet, pill, powder, capsule and drop pill.
4. a method for preparing of treating the Chinese medicine composition of diabetes is characterized in that, comprising:
Step 1: get Radix Astragali 12-30 part, Radix Puerariae 3-5 part, Fructus Schisandrae Chinensis 4-6 part, ethanol extraction, extracting liquid filtering is collected filtrating;
Step 2: get Rhizoma Dioscoreae 18-30 part, Rhizoma Anemarrhenae 9-15 part, Radix Trichosanthis 6-12 part, extracting in water, extracting liquid filtering, filtrating is concentrated into the clear paste that relative density is 1.10-1.20, adds ethanol and makes and contain alcohol amount and reach 70%-80%, and mixing leaves standstill, and filters, and collects filtrating;
Step 3: combining step 1 and step 2 gained filtrating, drying and crushing promptly gets with the Endothelium Corneum Gigeriae Galli fine powder mixing of 3-5 part.
5. a method for preparing of treating the Chinese medicine composition of diabetes is characterized in that, comprising:
Step 1: get 20 parts of the Radixs Astragali, 4 parts of Radix Puerariaes, 5 parts of Fructus Schisandrae Chinensis, ethanol extraction, extracting liquid filtering is collected filtrating;
Step 2: get 20 parts of Rhizoma Dioscoreaes, 12 parts of the Rhizoma Anemarrhenaes, 9 parts of Radix Trichosanthis, extracting in water, extracting liquid filtering, filtrating is concentrated into the clear paste that relative density is 1.10-1.20, adds ethanol and makes and contain alcohol amount and reach 70%-80%, and mixing leaves standstill, and filters, and collects filtrating;
Step 3: combining step 1 and step 2 gained filtrating, drying and crushing promptly gets with 4 parts Endothelium Corneum Gigeriae Galli fine powder mixing.
6. according to the Chinese medicine composition of claim 4 or the preparation of 5 described method for preparinies.
7. according to claim 4 or 5 described method for preparinies, it is characterized in that the said ethanol extraction of step 1 is to extract 2-4 time with the 70%-80% alcohol heating reflux of 5-10 times of weight, 1-3 hour at every turn.
8. according to claim 4 or 5 described method for preparinies, it is characterized in that the said extracting in water of step 2 is that the decocting that adds 7-10 times of weight boils 2-4 time, each 1-3 hour.
9. according to claim 4 or 5 described method for preparinies, it is characterized in that the said drying and crushing of step 3 is to be ground into 80-100 order fine powder behind the vacuum drying or spray drying gets fine powder.
10. according to claim 4 or 5 described method for preparinies, it is characterized in that the said Endothelium Corneum Gigeriae Galli fine powder of step 3 is for being ground into 100 purpose fine powders.
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| CN105434807B (en) * | 2016-01-26 | 2017-03-01 | 陕西中医药大学 | The pharmaceutical composition for the treatment of diabetes mellitus encephalopathy and its preparation method and detection method and purposes |
| CN107737280A (en) * | 2017-11-27 | 2018-02-27 | 上海科洋众创空间管理中心（有限合伙） | Traditional Chinese medicine composition for treating diabetes and its preparation method and application |
| CN113769012A (en) * | 2020-06-10 | 2021-12-10 | 王敏 | Preparation method for treating diabetes by embedding lines at special acupoint points |
-
2010
- 2010-09-19 CN CN2010102910696A patent/CN101947284B/en not_active Expired - Fee Related
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