CN101703708B - Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof - Google Patents
Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof Download PDFInfo
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Abstract
The invention provides a Chinese medicinal preparation for treating rheumatoid arthritis and gout, which is prepared from 60 raw material medicaments, such as pubescent angelica root, incised notopterygium rhizome, ephedra, cassia twig and the like. The preparation comprises oral preparation and externally applied preparation. The preparation method comprises the following steps: preparing water extract from raw material medicaments; preparing the oral preparation and spray preparation from the water extract; preparing extraction powder from the water extract, and preparing granules, pills, electuary, tablets or capsules from the extraction powder; or preparing raw powder from the raw material medicaments, and preparing granules, pills, electuary, tablets, capsules and externally applied ointment from the raw powder; or preparing medicinal liquor by infusing the raw material medicaments. The preparation mainly treats syndrome of damp-heat stagnation in the rheumatoid arthritis and gout, also treats syndrome of damp-heat waist invasion in lumbar hyperosteogency and endoretention of damp heat in lumbar disc herniation and the like, and has obvious curative effect on traumatic injury and rheumatoid arthritis. The Chinese medicinal preparation is prepared by adopting pure Chinese medicaments, has convenient use, safety and reliability, has no toxic or side effect on liver, kidney, lung, stomach and spleen, and can be used for long time.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation and preparation method thereof, concrete is a kind of Chinese medicine preparation for the treatment of rheumatoid arthritis, gout and preparation method thereof.
Background technology
Rheumatoid arthritis be a kind of be the chronic systemic autoimmune disease of feature with the joint synovitis disease.It mainly shows as the multiple repeated relapsing arthritis of symmetry, the easiest the getting involved in the little joint of brothers.Early stage or acute onset joint is red more, and is swollen, heat, pain and moving obstacle; Can cause destruction of joint late period, stiff, deformity and afunction, and bone and skeletal muscle atrophy are arranged.In the whole course of disease, can be with heating, anemia loses weight, and pathological changes such as vasculitis and subcutaneous nodule also can be involved a plurality of organs of whole body.Primary disease is commonly encountered diseases, frequently-occurring disease, the serious health Jiankang of endangering people.The traditional Chinese medical science thinks that rheumatoid arthritis belongs to Chinese medicine " arthromyodynia " category.The acute attack stage is to contain or retention of damp-heat in the interior in the wind heat, belongs to " pyretic arthralgia ", " severe and migratory arthralgia " scope; Be that cold-damp is gone into network late period, and deficiency of the liver and kindey belongs to " rheumatism involving the bone " category.Be plain body yang blood and qi deficiency, the invasion and attack of taking advantage of a weak point in opponent's defence of the damp and hot heresy of wind and cold cause the resistance of QI and blood numbness and fall ill.
Modern medicine thinks that gout is because the purine biosynthetic metabolism increases, and uric acid produces too much or because of uric acid in the bad hyperamization of urate excretion raises, the repeated relapsing inflammatory diseases that causes.The right red and swollen heat pain of primary minimum joint soldier of falling ill at present can not be walked, and is very painful.The traditional Chinese medical science thinks that gout belongs to Chinese medicine " arthromyodynia " category, and is in close relations with arthralgia aggravated by cold, migratory arthralgia.Its cause of disease is outside intrusions such as wind, cold, wet, heat, endogenous cause of ill and positive QI-insufficiency, and work and rest is improper, and body constitution void is thanks to relevant, and main pathogenesis is the damp and hot passages through which vital energy circulates of being detained, and QI-blood circulation is unsmooth, kidney qi loss, performance has void that reality is arranged, based on excess syndrome.
Summary of the invention
The objective of the invention is to for overcoming the deficiencies in the prior art the treatment rheumatoid arthritis that propose a kind of stable curative effect, has no side effect, Chinese medicine preparation of gout and preparation method thereof.
Technical scheme of the present invention is, a kind of Chinese medicine preparation for the treatment of rheumatoid arthritis, gout, and it is the medicament of being made by following weight parts proportion raw material medical material:
Radix Angelicae Pubescentis 6-60 Rhizoma Et Radix Notopterygii 6-60 Herba Ephedrae 3-30 Ramulus Cinnamomi 3-30
Radix Puerariae 3-60 Radix Saposhnikoviae 6-60 Radix Clematidis 6-60 Radix Gentianae Macrophyllae 6-60
Semen Coicis 6-120 Radix Angelicae Sinensis 6-60 Radix Rehmanniae 6-60 Radix Astragali 6-120
Radix Salviae Miltiorrhizae 6-60 Radix Notoginseng 6-60 Radix Achyranthis Bidentatae 6-60 Radix Paeoniae 6-60
Os Sus domestica 6-60 Caulis Spatholobi 6-120 Caulis Lonicerae 6-90 Caulis Piperis Kadsurae 6-60
Caulis Trachelospermi 6-60 Caulis Erycibes 6-30 Radix Tripterygii Wilfordii 6-30 Caulis Sinomenii 6-60
Celastrus orbiculatus Thunb. 6-60 fevervine 6-120 Cortex erythrinae 6-60 Herba Aristolochiae Mollissimae 6-60
Zaocys 3-30 Agkistrodon 3-30 Pheretima 6-60 Formica fusca 6-90
Rhizoma Dioscoreae Nipponicae 6-60 Cortex Eucommiae 6-30 Herba Taxilli 6-30 Ramulus Mori 6-60
Ramulus Pini 6-60 Lignum Pini Nodi 6-60 Radix Stephaniae Tetrandrae 6-60 Radix Rubiae 6-60
Herba Siegesbeckiae 6-60 Rhizoma Smilacis Glabrae 6-120 Rhizoma Dioscoreae Septemlobae 6-120 melon network 6-30
Cortex Phellodendri 6-60 Rhizoma Anemarrhenae 6-60 Semen Sinapis Albae 6-30 Rhizoma Corydalis 6-60
Rhizoma Atractylodis 6-60 Fructus Chaenomelis 6-60 Herba Begoniae Yunnanensis 6-90 Herba Leonuri 6-90
Herba Artemisiae Annuae 6-60 Nidus Vespae 1-15 Rhizoma Cibotii 6-60 Fructus Liquidambaris 6-30
Cortex schizophragmatis integrifolii radicis 6-30 Rhizoma Polygoni Cuspidati 6-30 Rhizoma Homalomenae 6-60 Radix Glycyrrhizae 6-60.
Described medicament is oral agents and external agent, and oral agents is oral liquid, granule, ball type, powder, capsule, electuary, medicated wine and tablet, and the external agent is outer liniment, external-applied ointment, medicated wine and spray.
A kind of preparation method for the treatment of the Chinese medicine preparation of rheumatoid arthritis, gout, form by following steps:
(1) crude drug being made as according to a conventional method water content is 10% aqueous extract,
(2) aqueous extract of using step (1) to make according to a conventional method is made as oral liquid,
(3) aqueous extract of using step (1) to obtain according to a conventional method is made as spray,
(4) aqueous extract of using step (1) to make according to a conventional method is made as externally applied liniment,
(5) the aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, extracting screen underflow is an extract drugs powder;
(6) the extract drugs powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or the capsule in the oral agents.
A kind of preparation method for the treatment of the Chinese medicine preparation of rheumatoid arthritis, gout, fecula powder and preparation thereof are made by following steps:
(1) crude drug is sieved dedust soil, pulverizes,
(2) cross at least 200 mesh sieves, extracting screen underflow,
(3) sterilization, the pulvis of making a living,
(4) the fecula powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or the capsule in the oral agents,
(5) the fecula powder of using step (3) to make according to a conventional method is made as external-applied ointment.
A kind of preparation method for the treatment of the Chinese medicine preparation of rheumatoid arthritis, gout, medicated wine is made by following steps:
(1) with the described crude drug sieve of claim 1 dedust soil, pulverize, put into container,
(2) Chinese liquor made from grain is to going into container, the submergence crude drug, and sealed container,
(3) after infusion 3-6 month, remove medicinal residues, be medicated wine.
Chinese medicine thinks that the damp and hot criminal's waist in rheumatoid arthritis, the goat is demonstrate,proved its cause of disease and mostly is plain body yang blood and qi deficiency, and the invasion and attack of taking advantage of a weak point in opponent's defence of the damp and hot heresy of wind and cold cause the resistance of QI and blood numbness and fall ill.In treatment, be its common method of treatment with " a surname logical ", the cold person's using warming therapy of ancestor, heat syndrome should be treated with clearing away heat therapy, treatment of deficiency-syndrome by reinforcement's principle makes qi and blood circulation, the Wei Fuchang of battalion, arthralgia pain can be gradually to healing.In prescription of the present invention, Radix Angelicae Pubescentis, Rhizoma Et Radix Notopterygii, Herba Ephedrae, Ramulus Cinnamomi, Radix Puerariae, Radix Saposhnikoviae, Radix Clematidis, Radix Gentianae Macrophyllae, Semen Coicis, Radix Angelicae Sinensis, the Radix Rehmanniae, the Radix Astragali, Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Achyranthis Bidentatae, Radix Paeoniae, Os Sus domestica, Caulis Spatholobi, Caulis Lonicerae, Caulis Piperis Kadsurae, Caulis Trachelospermi, Caulis Erycibes, Radix Tripterygii Wilfordii, Caulis Sinomenii, Celastrus orbiculatus Thunb., fevervine, Cortex erythrinae, Herba Aristolochiae Mollissimae, Zaocys, Agkistrodon, Pheretima, Formica fusca, Rhizoma Dioscoreae Nipponicae, the Cortex Eucommiae, Herba Taxilli are monarch drug, with wind-damp dispelling, the meridian dredging, fill blood; Ramulus Mori, Ramulus Pini, Lignum Pini Nodi, Radix Stephaniae Tetrandrae, Radix Rubiae, Herba Siegesbeckiae, Rhizoma Smilacis Glabrae, Rhizoma Dioscoreae Septemlobae, Retinervus Luffae Fructus, Cortex Phellodendri, the Rhizoma Anemarrhenae are ministerial drug, with dispelling wind and removing obstruction in the collateral, clearing away heat-damp and promoting diuresis; Radix Salviae Miltiorrhizae, Radix Notoginseng, Radix Achyranthis Bidentatae, Fructus Liquidambaris are auxilliary, with wind-damp dispelling, the meridian dredging, invigorate blood circulation, blood stasis dispelling, pain relieving; Radix Glycyrrhizae detoxifcation coordinating the actions of various ingredients in a prescription.The present invention mainly identifies and corrects according to Chinese medicine and executes the principle of controlling, the tame chief of the many doctors of collection, extensively adopt the strange medicine wonderful recipe in the rich Yunnan various nationalities of receipts area, based on pathogenetic understanding and the Therapeutic Principle of Chinese medicine to rheumatoid arthritis, gout, reference is the pharmacological research achievement at all times, the natural Chinese medicine of screening expelling wind and removing dampness, heat clearing and blood stasis dispersing, reducing swelling and alleviating pain by the theory of Chinese medical science prescription, forms through the clinical practice summary of diagnosis and treatment case for a long time.Medicine of the present invention is mainly expelling wind and removing dampness, heat clearing and blood stasis dispersing, and reducing swelling and alleviating pain is also paid attention to blood-enriching qi-invigorating.Chinese medicine is thought, qi as the commander of blood, blood circulation depending on qi flow.Control wind and control blood earlier, the blood sector-style is from going out.Pathogen usually intruding into collateral in protracted disease, through ruton, wind, wet, heat, the stasis of blood are all removed; The QI and blood row, meridians are unobstructed, and the muscles and bones blood vessels are strong, and rheumatism is dispelled, and swells and ache to disappear, and is sick from removing.Strengthening vital QI to eliminate pathogenic factors, immunity strengthens, rheumatoid arthritis, gout recovery from illness.Medicine of the present invention is by the principle organic assembling of the monarch in the Chinese medicine, and all medicine synergism all have curative effect preferably, treating both the principal and secondary aspects of a disease to rheumatoid arthritis, gout.The present invention cures mainly the syndrome of accumulated dampness-heat in rheumatoid arthritis and the gout, and the double damp and hot criminal's waist card in the lumbar vertebra hyperosteogeny disease, the retention of damp-heat in the interior card in the prolapse of lumbar intervertebral disc etc. controlled all have obvious curative effects to traumatic injury and rheumatic arthritis.The present invention adopts pure Chinese medicine to make, and is esy to use, safe and reliable, liver, kidney, lung, stomach, spleen are all had no side effect, but life-time service.
The each 10-30ml of oral liquid of the present invention, day obeys oral 3 times, or chip select agent, granule, pill, powder, capsule, electuary etc. are wherein a kind of, each 3-10 gram, day obeys 3 times, various dosage forms can be used alternatingly, and extract powder and with each dosage form medicine and fecula powder and identical with each dosage form survival dose of its preparation of its preparation.Treating 30 days is a course of treatment, light disease 1-3 course of treatment, serious symptom 3-9 the course of treatment.
Taboo: 1, age of sucking, anemia of pregnant woman, unmarried teenager are avoided usefulness.2, the heart, liver, renal insufficiency, hematopathy, the careful usefulness of granulocytopenia person or forbidding.
Attention: 1, menstrual phase is stopped using.2, this medicine should not mix use with other medicines.3, under instructing, the doctor uses.
Clinical trial data of the present invention:
1, rheumatoid arthritis
Adopt medicine of the present invention to follow the tracks of the treatment rheumatoid and lose disease 100 examples, wherein, women's 79 examples, male's 21 examples, age 20-45 year.
Diagnosis: patient's first disease in several weeks or several months shows as fatigue, discomfort, poor appetite loses weight, whole body muscular soreness, and low grade fever is arranged, joint single-shot symmetry swells and ache around occurring subsequently, based on little joint, mostly be multiple arthroncus or little joint symmetry swells and ache, burning pain and dysfunction appear rapidly that multi-joint is red, swollen, in 20% above patient's polyarthritis Acute onset, and General Symptoms is heavier.The joint appearance of getting involved after the patient rises morning or after stopping action in a period of time is stiff, limitation of activity, serious appearance joint deformity.
Lab testing: the most anemias of patient, platelet count is higher, and erythrocyte sedimentation rate is fast, and serum immune globulin and rheumatoid factor positive reaction appear in the case of Serological testing 70%, and serum immune globulin increases.The emphasis joint of getting involved has typical rheumatoid arthritis X line finding.43 routine early stage patients are got involved, and swell and ache in the joint and limitation of activity, but the X line only shows soft tissue swelling and sclerotin coloured glaze pine.36 example patients in the mid-term function of joint activities of partly getting involved are obviously limited, and the X line shows that the joint space narrows down or bone erosion in various degree.Various deformities appear in the 21 routine patients with terminal majorities joint of getting involved, or tetanic, movable difficulty, and X-ray film shows joint heavy damage, dislocation or fusion.
Therapeutic Method: medicine is an oral agents, select in powder, tablet, pill, capsule, electuary, the oral liquid any, oral 3 times of every day, each 6-10 gram, 10 days is a course of treatment, and common 3-5 course of treatment is effective, and pertinacious disease needs 6-9 the course of treatment, the medicine of various dosage forms can be used alternatingly, and can add medicated wine every day 1-2 time.Also can adopt medicated wine, spray to wipe or spray outward outward, or powder is soaked the affected part, also available external application medical ointment when needing.
Therapeutic effect: after 3-5 the course of treatment of taking medicine, the produce effects patient that clinical symptoms disappears substantially is 39 examples, obvious effective rate 39%.Patient's 47 examples that clinical symptoms has part to reduce, effective percentage 47%, after 6-9 the course of treatment, the still unalterable patient of symptom is 14 examples, inefficiency 14%.In therapeutic process, do not see obvious adverse effect and toxic and side effects, do not have to find to have the phenomenon of liver, kidney, lung, spleen, stomach upset.
2, gout
Adopt medicine of the present invention to follow the tracks of treatment gout 100 examples, wherein, male's 87 examples, women's 23 examples, age 35-80 year.
Clinical symptoms: the right red and swollen heat pain of following primary minimum joint soldier, tenderness can not land, and lies awake all night, part of touching is scorching hot, coolly then relax, it is hot thirsty to occur together, vexed uneasiness, yellow urine, red tongue, yellow and greasy fur, slippery and rapid pulse.
Lab testing: blood uric acid 620-790 μ mol/L.Differential diagnosis in tcm belongs to eating and drinking without temperance, damp and hot interior giving birth to, and damp invasion of lower energizer, with the passing of time the venation stasis of blood stagnates.
Therapeutic Method: medicine is an oral agents, selects in powder, tablet, pill, capsule, electuary, the oral liquid any, oral 3 times of every day, each 6-10 gram, 10 days is a course of treatment, 3-5 the course of treatment is effective usually, pertinacious disease needs 6-9 the course of treatment, and the medicine of various dosage forms can be used alternatingly.Available outer liniment is wiped the red and swollen heat pain place.Also can adopt medicated wine, spray to wipe or spray outward outward, or powder is soaked the affected part.
Therapeutic effect: after taking medicine 3 days, symptom begins to alleviate or disappear.Take medicine after 1-5 the course of treatment, the healing patient of clinical symptoms complete obiteration is 61 people, cure rate 61%.The produce effects patient that clinical symptoms disappears substantially is 25 people, obvious effective rate 25%.Clinical symptoms has minimizing in various degree, and after 5 courses of treatment, effective patient that symptom still can not complete obiteration is 10 people, and effective percentage is 10%.After 5 courses of treatment, the invalid patient that symptom can not alleviate or disappear is 4 people, inefficiency 4%.In therapeutic process, do not have to find to have the phenomenon of liver, kidney, lung, spleen, stomach upset, do not see obvious adverse effect and toxic and side effects.
3, prolapse of lumbar intervertebral disc
Adopt medicine of the present invention to follow the tracks of treatment prolapse of lumbar intervertebral disc 100 examples, wherein, male's 73 examples, women's 27 examples in age 40-80 year, are taken the photograph sheet through hospital and are diagnosed as patients with lumbar disc herniation 37 examples, protrusion of lumbar intervertebral disc disease patient 39 examples, lumbar degenerative pathological changes patient 24 examples.
Clinical symptoms: waist acid is expanded and is had a pain, and sore spot is with burning sensation, and movable back pain can alleviate, and whole body is stranded heavy, greasy taste in the mouth bitter taste, turbid urine yellow skin, red tongue, yellowish fur, slippery and rapid pulse or moisten number.The differential diagnosis in tcm genus is damp and hot criminal's waist card.
Therapeutic Method: medicine be in powder, tablet, pill, capsule, electuary, the oral liquid any, oral 3 times of every day, each 3-10 gram, 10 days is an outer course of treatment, and common 1-3 course of treatment is effective, and pertinacious disease needs 3-5 the course of treatment, also can various dosage forms can be used alternatingly, can add medicated wine every day 1-2 time.Also can adopt medicated wine, spray to wipe or spray outward also available external application medical ointment when needing outward.
Take medicine after 3 courses of treatment, the healing patient that clinical symptoms disappears substantially is 68 people, obvious effective rate 68%.That clinical symptoms partly disappears is 28 people, effective percentage 28%, and wherein 5 routine brain atrophy patients' PD is controlled.The unaltered invalid patient of symptom is 4 people after 5 courses of treatment, inefficiency 4%.After 5 courses of treatment, do not have discovery that the phenomenon of liver, kidney, lung, spleen, stomach, discomfort is arranged, do not have toxic and side effects.
4, lumbar vertebra hyperosteogeny disease
Adopt medicine of the present invention to follow the tracks of treatment lumbar vertebra hyperosteogeny 100 examples, wherein, male's 56 examples, women's 44 examples, are taken the photograph sheet through hospital and are diagnosed as lumbar vertebra hyperosteogeny at age 40-80 year
Therapeutic Method: medicine be in powder, tablet, pill, capsule, electuary, the oral liquid any, oral 3 times of every day, each 3-10 gram, 10 days is an outer course of treatment, common 1-3 course of treatment is effective, and pertinacious disease needs 3-5 the course of treatment, also can various dosage forms can be used alternatingly, can add medicated wine every day 1-2 time, each 10-20 milliliter.Also can adopt medicated wine, spray to wipe or spray outward also available external application medical ointment when needing outward.
Take medicine after 3 courses of treatment, the healing patient that clinical symptoms disappears substantially is 58 people, obvious effective rate 58%.That clinical symptoms partly disappears is 38 people, effective percentage after 38%, 5 course of treatment the unaltered invalid patient of symptom be 4 people, inefficiency 4%.After 5 courses of treatment, do not have discovery that the phenomenon of liver, kidney, lung, spleen, stomach, discomfort is arranged, do not have toxic and side effects.
5, traumatic injury
Adopt medicine of the present invention to follow the tracks of fracture, muscles and bones fracture, new and old cutter, gunshot wound that the treatment traumatic injury causes, various patient with sympotoms 100 examples such as that wound causes is hemorrhage, blood stasis, wherein, male's 79 examples, women's 21 examples, age 10-80 year.On inspection, film making diagnosis, open fracture 21 examples wherein, closed fracture, bone splits, new and old cutter, gunshot wound, various symptom 37 examples such as that wound causes is hemorrhage, blood stasis, this two classes patient mainly is that vehicle accident and industrial injury cause; Athlete's 16 examples of fracturing; Muscle tendon and soft tissue injury's 26 examples.
Clinical symptoms: the swelling of fresh bone injury, blood stasis is with pain, limitation of activity; The old bone injury, limb functional recover is poor, and numb limbs and tense tendons is unable, and is not obedient; Sick and wounded injury swelling such as that muscle tendon and soft tissue injury and wound cause is hemorrhage, blood stasis, blood stasis, pain, limb function is poor, and numb limbs and tense tendons is unable.
Therapeutic Method: any is adopted in oral liquid, granule, pill, powder, capsule, electuary, the tablet in before the operation of fresh bone injury and operation back, oral 3 times of every day, each 6-10 gram, 30 days is a course of treatment, common 1-4 course of treatment is effective, and pertinacious disease needs 5-8 the course of treatment, and various dosage forms can be used alternatingly.The old bone injury adopts in oral liquid, granule, ball type, powder, ball, capsule, electuary, the tablet any, oral 3 times of every day, each 6-10 gram, 30 days is a course of treatment, usually 1-4 the course of treatment effective, pertinacious disease need 5-8 the course of treatment, various dosage forms can be used alternatingly.Can add medicated wine every day 1-2 time, each 10-20 milliliter.Also can adopt medicated wine, spray to wipe or spray outward outward, or powder is soaked the affected part, also available external application medical ointment when needing.
Therapeutic effect: after 3-5 the course of treatment of taking medicine, the produce effects patient that clinical symptoms disappears substantially is 39 examples, obvious effective rate 39%.Patient's 47 examples that clinical symptoms has part to reduce, effective percentage 47%, after 6-9 the course of treatment, the still unalterable patient of symptom is 14 examples, inefficiency 14%.In therapeutic process, do not see obvious adverse effect and toxic and side effects, do not have to find to have the phenomenon of liver, kidney, lung, spleen, stomach upset.
6, rheumatic arthritis
Adopt medicine of the present invention to follow the tracks of treatment rheumatic arthritis 100 examples, wherein, male's 87 examples, women's 23 examples, age 35-80 year.
Clinical symptoms: joint congestion and swelling pain during outbreak, day cold easy recurrence.
Differential diagnosis in tcm belongs to eating and drinking without temperance, damp and hot interior giving birth to, and damp invasion of lower energizer, with the passing of time the venation stasis of blood stagnates.
Adopt in oral liquid, granule, pill, powder, capsule, electuary, the tablet any, oral 3 times of every day, each 6-10 gram, 30 days is a course of treatment, common 1-4 course of treatment is effective, and pertinacious disease needs 5-8 the course of treatment, and various dosage forms can be used alternatingly, serious symptom can add medicated wine every day 1-2 time, each 10-20 milliliter.Also can adopt medicated wine, spray to wipe or spray outward outward, or powder is soaked the affected part, also available external application medical ointment when needing.
Therapeutic effect: after taking medicine 3 days, symptom begins to alleviate or disappear.Take medicine after 1-5 the course of treatment, the healing patient of clinical symptoms complete obiteration is 55 people, cure rate 55%.The produce effects patient that clinical symptoms disappears substantially is 25 people, obvious effective rate 25%.Clinical symptoms has minimizing in various degree, and after 5 courses of treatment, effective patient that symptom still can not complete obiteration is 12 people, and effective percentage is 12%.After 5 courses of treatment, the invalid patient that symptom can not alleviate or disappear is 8 people, inefficiency 8%.In therapeutic process, do not have to find to have the phenomenon of liver, kidney, lung, spleen, stomach upset, do not see obvious adverse effect and toxic and side effects.
The specific embodiment
Table 1
| Sequence number | The Chinese medicine title | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
| 1 | Radix Angelicae Pubescentis 6-60 (g) | 6 | 50 | 60 | 30 | 20 |
| 2 | Rhizoma Et Radix Notopterygii 6-60 | 60 | 20 | 6 | 40 | 50 |
| 3 | Herba Ephedrae 3-30 | 30 | 3 | 25 | 10 | 8 |
| 4 | Ramulus Cinnamomi 3-30 | 8 | 30 | 3 | 10 | 20 |
| 5 | Radix Puerariae 3-60 | 10 | 3 | 60 | 50 | 25 |
| 6 | Radix Saposhnikoviae 6-60 | 50 | 60 | 6 | 10 | 40 |
| 7 | Radix Clematidis 6-60 | 20 | 10 | 50 | 60 | 6 |
| 8 | Radix Gentianae Macrophyllae 6-60 | 30 | 60 | 20 | 6 | 50 |
| 9 | Semen Coicis 6-120 | 120 | 6 | 20 | 100 | 80 |
| 10 | Radix Angelicae Sinensis 6-60 | 6 | 60 | 50 | 12 | 20 |
| 11 | Radix Rehmanniae 6-60 | 60 | 20 | 6 | 50 | 20 |
| 12 | Radix Astragali 6-120 | 6 | 120 | 100 | 20 | 80 |
| 13 | Radix Salviae Miltiorrhizae 6-60 | 60 | 20 | 6 | 50 | 30 |
| 14 | Radix Notoginseng 6-60 | 10 | 40 | 60 | 6 | 20 |
| 15 | Radix Achyranthis Bidentatae 6-60 | 50 | 20 | 6 | 60 | 30 |
| 16 | Radix Paeoniae 6-60 | 20 | 50 | 60 | 10 | 6 |
| 17 | Os Sus domestica 6-60 | 30 | 20 | 6 | 50 | 60 |
| 18 | Caulis Spatholobi 6-120 | 100 | 30 | 80 | 6 | 120 |
| 19 | Caulis Lonicerae 6-90 | 10 | 70 | 30 | 90 | 6 |
| 20 | Caulis Piperis Kadsurae 6-60 | 40 | 20 | 6 | 10 | 60 |
| 21 | Caulis Trachelospermi 6-60 | 30 | 6 | 60 | 40 | 10 |
| 22 | Caulis Erycibes 6-30 | 15 | 30 | 6 | 10 | 20 |
| 23 | Radix Tripterygii Wilfordii 6-30 | 6 | 10 | 20 | 25 | 30 |
| 24 | Caulis Sinomenii 6-60 | 60 | 50 | 6 | 10 | 20 |
| 25 | Celastrus orbiculatus Thunb. 6-60 | 6 | 10 | 60 | 50 | 20 |
| 26 | Fevervine 6-120 | 20 | 100 | 6 | 80 | 120 |
| 27 | Cortex erythrinae 6-60 | 60 | 10 | 50 | 30 | 6 |
| 28 | Herba Aristolochiae Mollissimae 6-60 | 6 | 50 | 20 | 10 | 60 |
| 29 | Zaocys 3-30 | 30 | 3 | 10 | 20 | 8 |
| 30 | Agkistrodon 3-30 | 10 | 30 | 8 | 3 | 20 |
| 31 | Pheretima 6-60 | 20 | 10 | 60 | 50 | 6 |
| 32 | Formica fusca 6-90 | 90 | 20 | 70 | 6 | 50 |
| 33 | Rhizoma Dioscoreae Nipponicae 6-60 | 6 | 60 | 30 | 50 | 10 |
| 34 | Cortex Eucommiae 6-30 | 30 | 6 | 15 | 8 | 20 |
| 35 | Herba Taxilli 6-30 | 30 | 20 | 10 | 25 | 6 |
| 36 | Ramulus Mori 6-60 | 10 | 40 | 6 | 20 | 60 |
| 37 | Ramulus Pini 6-60 | 40 | 20 | 60 | 6 | 10 |
| 38 | Lignum Pini Nodi 6-60 | 6 | 10 | 20 | 60 | 40 |
| 39 | Radix Stephaniae Tetrandrae 6-60 | 20 | 60 | 40 | 10 | 6 |
| 40 | Radix Rubiae 6-60 | 60 | 6 | 10 | 20 | 40 |
| 41 | Herba Siegesbeckiae 6-60 | 10 | 40 | 6 | 60 | 20 |
| 42 | Rhizoma Smilacis Glabrae 6-120 | 120 | 20 | 100 | 6 | 40 |
| 43 | Rhizoma Dioscoreae Septemlobae 6-120 | 6 | 100 | 20 | 120 | 60 |
| 44 | Retinervus Luffae Fructus 6-30 | 25 | 10 | 20 | 6 | 30 |
| 45 | Cortex Phellodendri 6-60 | 6 | 40 | 20 | 6 | 60 |
| 46 | Rhizoma Anemarrhenae 6-60 | 20 | 10 | 40 | 60 | 6 |
| 47 | Semen Sinapis Albae 6-30 | 15 | 20 | 10 | 6 | 30 |
| 48 | Rhizoma Corydalis 6-60 | 50 | 60 | 30 | 6 | 10 |
| 49 | Rhizoma Atractylodis 6-60 | 20 | 6 | 10 | 40 | 60 |
| 50 | Fructus Chaenomelis 6-60 | 50 | 60 | 40 | 20 | 6 |
| 51 | Herba Begoniae Yunnanensis 6-90 | 10 | 6 | 30 | 90 | 60 |
| 52 | Herba Leonuri 6-90 | 30 | 60 | 90 | 6 | 10 |
| 53 | Herba Artemisiae Annuae 6-60 | 20 | 10 | 6 | 50 | 60 |
| 54 | Nidus Vespae 1-15 | 1 | 10 | 15 | 8 | 5 |
| 55 | Rhizoma Cibotii 6-60 | 60 | 6 | 10 | 30 | 50 |
| 56 | Fructus Liquidambaris 6-30 | 30 | 6 | 20 | 15 | 10 |
| 57 | Cortex schizophragmatis integrifolii radicis 6-30 | 10 | 30 | 6 | 20 | 20 |
| 58 | Rhizoma Polygoni Cuspidati 6-30 | 20 | 15 | 30 | 10 | 6 |
| 59 | Rhizoma Homalomenae 6-60 | 6 | 40 | 10 | 60 | 40 |
| 60 | Radix Glycyrrhizae 6-60 | 60 | 30 | 50 | 6 | 10 |
1, form by following steps with the preparation method of the Chinese medicine preparation of medicine aqueous extract preparation treatment rheumatoid arthritis, gout:
(1) the dry product crude drug of table 1 being made as according to a conventional method water content is 10% medicine aqueous extract,
(2) the medicine aqueous extract of using step (1) to make according to a conventional method is made as oral liquid, packing,
(3) aqueous extract of using step (1) to obtain according to a conventional method is made as spray,
(4) the medicine aqueous extract of using step (1) to make according to a conventional method is made as externally applied liniment, packing,
(5) the medicine aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, extracting screen underflow is an extract drugs powder, packing, every bag of 5-10 gram,
(6) the extract drugs powder of using step (4) to make according to a conventional method is made as tablet, granule, pill, electuary or the capsule in the oral agents.Every contains medicine extraction powder 0.2-1 gram, contains medicine in every bag of granule and extract powder 2-10 gram; Electuary, pill contains extraction powder 2-10 gram, capsule, every 0.2-1 gram for every bag.
2, form by following steps with the preparation method of the Chinese medicine preparation of medicine fecula preparation treatment rheumatoid arthritis, gout:
(1) with the sieve of the crude drug in the table 1 dedust soil, pulverize,
(2) cross at least 200 mesh sieves, extracting screen underflow,
(3) sterilization is medicine fecula powder, packing, every bag of 5-10 gram.
(4) the medicine fecula powder of using step (3) to make according to a conventional method is made as tablet, granule, pill, electuary or capsule.Every contains medicine extraction powder 0.2-1 gram, contains medicine in every bag of granule and extract powder 2-10 gram; Electuary, pill contains extraction powder 2-10 gram, capsule, every 0.2-1 gram for every bag.
(5) the medicine fecula powder of using step (3) to make according to a conventional method is made as sheet, granule, ball, electuary or the capsule in the oral agents,
(6) the medicine fecula powder of using step (3) to make according to a conventional method is made as external-applied ointment.
3, the medicated wine of treatment rheumatoid arthritis, gout is made by following steps:
(1) with the described crude drug sieve of table 1 dedust soil, pulverize, put into container,
(2) Chinese liquor made from grain is to going into container, the submergence crude drug, and sealed container,
(3) after infusion 3-6 month, remove medicinal residues, be medicated wine.
Claims (5)
1. Chinese medicine preparation for the treatment of rheumatoid arthritis, gout is characterized in that it is the medicament of being made by following weight parts proportion raw material medical material:
2. a kind of Chinese medicine preparation for the treatment of rheumatoid arthritis, gout according to claim 1, it is characterized in that, described medicament is oral agents and external agent, oral agents is oral liquid, tablet, granule, pill, powder, capsule or medicated wine, and the external agent is outer liniment, external-applied ointment, medicated wine and spray.
3. preparation method for the treatment of the Chinese medicine preparation of rheumatoid arthritis, gout is characterized in that being made up of following steps:
(1) crude drug of claim 1 being made as according to a conventional method water content is 10% aqueous extract,
(2) aqueous extract of using step (1) to make according to a conventional method is made as oral liquid,
(3) aqueous extract of using step (1) to obtain according to a conventional method is made as spray,
(4) aqueous extract of using step (1) to make according to a conventional method is made as externally applied liniment,
(5) the aqueous extract drying that step (1) is obtained, pulverizing, mistake at least 200 mesh sieves, extracting screen underflow is an extract drugs powder,
(6) the extract drugs powder that makes with step (5) is made as tablet, granule, pill or the capsule in the oral agents.
4. preparation method for the treatment of the Chinese medicine preparation of rheumatoid arthritis, gout is characterized in that fecula powder and preparation thereof made by following steps:
(1) with the described crude drug sieve of claim 1 dedust soil, pulverize,
(2) cross at least 200 mesh sieves, extracting screen underflow,
(3) sterilization, the pulvis of making a living,
(4) the fecula powder of using step (3) to make according to a conventional method is made as tablet, granule or the capsule in the oral agents,
(5) the fecula powder of using step (3) to make according to a conventional method is made as external-applied ointment.
5. preparation method for the treatment of the Chinese medicine preparation of rheumatoid arthritis, gout is characterized in that medicated wine made by following steps:
(1) with the described crude drug sieve of claim 1 dedust soil, pulverize, put into container,
(2) Chinese liquor made from grain is to going into container, the submergence crude drug, and sealed container,
(3) after infusion 3-6 month, remove medicinal residues, be medicated wine.
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| CN102078543A (en) * | 2011-01-12 | 2011-06-01 | 湖南省药物安全评价研究中心 | Traditional Chinese medicine preparation for treating gout and preparation method thereof |
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2009
- 2009-11-10 CN CN2009100951627A patent/CN101703708B/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078543A (en) * | 2011-01-12 | 2011-06-01 | 湖南省药物安全评价研究中心 | Traditional Chinese medicine preparation for treating gout and preparation method thereof |
| CN102078543B (en) * | 2011-01-12 | 2012-04-25 | 湖南省药物安全评价研究中心 | Traditional Chinese medicine preparation for treating gout and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN101703708A (en) | 2010-05-12 |
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