CN100496596C - Improved Chinese medicinal paste for arthralgia and its preparation - Google Patents
Improved Chinese medicinal paste for arthralgia and its preparation Download PDFInfo
- Publication number
- CN100496596C CN100496596C CNB2004100233116A CN200410023311A CN100496596C CN 100496596 C CN100496596 C CN 100496596C CN B2004100233116 A CNB2004100233116 A CN B2004100233116A CN 200410023311 A CN200410023311 A CN 200410023311A CN 100496596 C CN100496596 C CN 100496596C
- Authority
- CN
- China
- Prior art keywords
- powder
- chinese medicinal
- radix aconiti
- treatment
- rhizoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000001976 improved effect Effects 0.000 title abstract description 7
- 208000006820 Arthralgia Diseases 0.000 title description 22
- 238000002360 preparation method Methods 0.000 title description 5
- 239000003814 drug Substances 0.000 claims abstract description 40
- 239000000843 powder Substances 0.000 claims description 17
- 239000002689 soil Substances 0.000 claims description 15
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 13
- 239000006071 cream Substances 0.000 claims description 11
- 241001057584 Myrrha Species 0.000 claims description 10
- 229940079593 drug Drugs 0.000 claims description 9
- 210000000582 semen Anatomy 0.000 claims description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
- 241000717739 Boswellia sacra Species 0.000 claims description 8
- 239000004863 Frankincense Substances 0.000 claims description 8
- 241000237636 Pheretima Species 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 2
- 239000000284 extract Substances 0.000 claims description 2
- 239000000706 filtrate Substances 0.000 claims description 2
- 238000012856 packing Methods 0.000 claims description 2
- 239000007788 liquid Substances 0.000 claims 1
- 201000003068 rheumatic fever Diseases 0.000 abstract description 11
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract description 8
- 239000000463 material Substances 0.000 abstract description 3
- 241001671653 Aconitum carmichaelii Species 0.000 abstract 1
- 240000007311 Commiphora myrrha Species 0.000 abstract 1
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract 1
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract 1
- 244000273928 Zingiber officinale Species 0.000 abstract 1
- 235000006886 Zingiber officinale Nutrition 0.000 abstract 1
- 206010003246 arthritis Diseases 0.000 abstract 1
- 235000008397 ginger Nutrition 0.000 abstract 1
- 229910052602 gypsum Inorganic materials 0.000 abstract 1
- 239000010440 gypsum Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 39
- 208000002193 Pain Diseases 0.000 description 18
- 230000006870 function Effects 0.000 description 16
- 230000006872 improvement Effects 0.000 description 12
- 210000004369 blood Anatomy 0.000 description 9
- 239000008280 blood Substances 0.000 description 9
- 238000010438 heat treatment Methods 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 230000001737 promoting effect Effects 0.000 description 8
- 210000000952 spleen Anatomy 0.000 description 8
- 230000008961 swelling Effects 0.000 description 8
- 210000004185 liver Anatomy 0.000 description 7
- 230000001225 therapeutic effect Effects 0.000 description 7
- 238000002560 therapeutic procedure Methods 0.000 description 7
- 201000008482 osteoarthritis Diseases 0.000 description 6
- 208000024891 symptom Diseases 0.000 description 6
- 230000008859 change Effects 0.000 description 5
- 230000001105 regulatory effect Effects 0.000 description 5
- 208000008454 Hyperhidrosis Diseases 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 238000000554 physical therapy Methods 0.000 description 4
- 238000011160 research Methods 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- 206010005963 Bone formation increased Diseases 0.000 description 3
- 206010015150 Erythema Diseases 0.000 description 3
- 206010020880 Hypertrophy Diseases 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 3
- 208000013219 diaphoresis Diseases 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 210000001624 hip Anatomy 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 230000001617 migratory effect Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 231100000925 very toxic Toxicity 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 206010015226 Erythema nodosum Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 231100000321 erythema Toxicity 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000000622 irritating effect Effects 0.000 description 2
- 210000000629 knee joint Anatomy 0.000 description 2
- 210000000265 leukocyte Anatomy 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 231100000614 poison Toxicity 0.000 description 2
- 230000001047 pyretic effect Effects 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 108010048734 sclerotin Proteins 0.000 description 2
- 238000004062 sedimentation Methods 0.000 description 2
- 210000003932 urinary bladder Anatomy 0.000 description 2
- 230000000283 vasomotion Effects 0.000 description 2
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010018873 Haemoconcentration Diseases 0.000 description 1
- 206010019468 Hemiplegia Diseases 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- 206010027336 Menstruation delayed Diseases 0.000 description 1
- 201000002481 Myositis Diseases 0.000 description 1
- 241000475481 Nebula Species 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 206010061372 Streptococcal infection Diseases 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 210000003423 ankle Anatomy 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001166 anti-perspirative effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003213 antiperspirant Substances 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 229940124584 antitussives Drugs 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- 239000001175 calcium sulphate Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 238000003759 clinical diagnosis Methods 0.000 description 1
- 230000007012 clinical effect Effects 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000008034 disappearance Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 210000001513 elbow Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 210000003414 extremity Anatomy 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 238000001794 hormone therapy Methods 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 229960003444 immunosuppressant agent Drugs 0.000 description 1
- 230000001861 immunosuppressant effect Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 229960000905 indomethacin Drugs 0.000 description 1
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000009916 joint effect Effects 0.000 description 1
- 230000008407 joint function Effects 0.000 description 1
- 208000018934 joint symptom Diseases 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 208000030208 low-grade fever Diseases 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000002398 materia medica Substances 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 239000003415 peat Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002688 persistence Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 210000002832 shoulder Anatomy 0.000 description 1
- 239000010802 sludge Substances 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000004218 vascular function Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
An improved Chinese medicine in the form of paste for treating rheumatoid arthritis, rheumatic arthritis and bony arthritis is prepared from 13 Chinese-medicinal materials including gypsum, Sichuan aconite root, ginger, myrrh, etc.
Description
[technical field]
The present invention relates to a kind of improvement Chinese medicinal paste and preparation method for the treatment of arthromyodynia, belong to the field of Chinese medicines.
[background technology]
The alleged arthromyodynia of the traditional Chinese medical science, similar in appearance to the autoimmune disease of modern medicine, the rheumatism category is such as rheumatoid arthritis, rheumatic arthritis, osteoarthritis, rheumatic fever, rheumatic myositis etc., wherein with rheumatoid arthritis, rheumatic arthritis, osteoarthritis for seeing more.Western medical treatment is general to adopt analgesic, antiinflammatory, analgesic, such as ibuprofen, and indometacin etc., severe patient adopts immunosuppressant and hormone therapy, but side effect is big, and the state of an illness is easily repeatedly.The conventional medicament treatment is easy to generate drug resistance, is difficult to prove effective.Aspect physiotherapy, panoramic physical therapy and physical therapy method, such as electric therapeutic instrument, the spectrogrph ubiquity and is worth costliness, and complicated operation uses and owes convenient, needs problems such as prolonged application.Though the tradition mud therapy is effective to the treatment arthromyodynia, can not be at etiological treatment, effect is still not ideal enough.The tradition mud therapy is to be the physiotherapy of principle with warm mechanical stimulus, is about to the method that all kinds of mud class materials heating are coated in the certain position treatment of human body arthromyodynia, and is general many with mud, mud coal, peat, artificial mud etc.Wherein mainly contain a large amount of mineral, biology, Organic substance, inorganic matter etc., have warm, machinery, chemistry, the antibiotic physical action that waits is so be applicable to the treatment of arthromyodynia.But will add warm sludge class material and problem such as clean hygiene not in advance because mud therapy exists, moderns come into disuse more, so traditional mud therapy utmost point is waited to improve.The inventor since nineteen eighty-three so far, last 21 years, research has been carried out in traditional mud therapy treatment to be improved, on No. 7, " Chinese digests magazine " the 6th volume special issue, delivered one piece and be entitled as the paper of " mud cream is processed treatment gastric abscess 108 examples " in October, 1998, announced first with hakuzen soil (stir-fry) 20g, Gypsum Fibrosum (ripe) 180g two flavor adds the water furnishing processs cream and spreads in the district of cave, soon solidifies heating; About temperature 50 degree, each 30～50min, 2 times/day, 10 is a course of treatment, continuous 2 courses of treatment, therapeutic outcome shows that this medicine has the good curing effect to stomachache, feeling of fullness.The inventor utilizes hakuzen soil, Gypsum Fibrosum preparata to mix the principle of heating with water again later on, adds relevant Chinese crude drug, the arthromyodynia patient is contrasted treatment observe, in the hope of obtaining the good efficacy to arthromyodynia.
[summary of the invention]
In order to improve the research of mud cream to arthromyodynia, the inventor is on the basis of former Chinese medicinal paste, according to clinical needs, add medicine, mud cream treatment arthromyodynia is improved, and, found a kind of improvement Chinese medicinal paste for the treatment of arthromyodynia that better curative effect is arranged finally by clinical checking repeatedly.
The object of the invention provides a kind of to the more efficiently improvement Chinese medicinal paste of treatment arthromyodynia compositions.Another object of the present invention provides this improvement Chinese medicinal paste preparation of compositions method.
Medicament selection hakuzen soil of the present invention (stir-fry), Gypsum Fibrosum (ripe) makes up, be because Gypsum Fibrosum preparata is a half-H 2 O calcium sulphate, add water and can solidify heat release that temperature can reach about 43 ℃-50 ℃, its clinical effect is: (1) can make tissue temperature raise, the blood of heating, blood circulation promoting increases the joint peripheral blood flow, increase joint nutrition, thereby quicken the recovery of function of joint; (2) skin of heating makes dermalaxia, opening of the pores, the Transdermal absorption of beneficial drug; (3) medicine of heating promotes medicine dissolution, improves the haemoconcentration of topical remedy, by the skin surface administration, makes medicine enter human circulation and produces whole body or local therapeutic effects, thereby set up the diathermanous drug-supplying system of the percutaneous that meets on the modern medicine meaning.Hakuzen soil is a parian ware base soil, and Compendium of Materia Medica is said: " function wins wet spleen invigorating for hakuzen soil, the hot temperature of abnormal smells from the patient." soil can win and wet, also can spleen invigorating, two medicines make up, and have dispelling cold by warming the meridian, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling, the function of relaxing muscles and tendons and activating QI and blood in the collateral is so be applicable to the treatment of arthromyodynia.Medicament selection Radix Aconiti of the present invention, Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Rhizoma Pinelliae, Rhizoma Zingiberis Recens makes up, and is because of Radix Aconiti suffering, hardship, big heat, very toxic, GUIXIN liver, spleen, kidney channel.Effect: dispelling cold by warming the meridian, expelling wind and removing dampness, the meridian dredging, sharp joint.Radix Aconiti Kusnezoffii is hot and big hot, and the toxicity efficacy of a drug is stronger with Radix Aconiti is identical for very toxic function.Rhizoma Arisaematis hardship, Xin Wen, poisonous return liver, spleen, lung meridian.Effect: drying dampness to eliminate phlegm, dispersing swelling and dissipating binds, stopping nausea and vomiting by lowering the adverse flow of QI.Rhizoma Zingiberis Recens is hot, GUIXIN, lung, spleen, stomach warp, effect: relieving the exterior syndrome by diaphoresis, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing.Rhizoma Zingiberis Recens can also be separated the poison of Rhizoma Arisaematis, the Rhizoma Pinelliae.This five kinds of Chinese medicine combination has dispelling cold by warming the meridian, and the function of expelling wind and removing dampness collateral dredging is applicable to the treatment of arthromyodynia.
In order to reach better therapeutic, medicine of the present invention has also added Semen Strychni, Herba Ephedrae, Olibanum, Myrrha makes up, and selects Semen Strychni to be because Semen Strychni hardship, cold, very toxic, return the liver spleen channel, the function removing obstruction in the collateral to relieve pain, contained soil rather the central nervous system is had excited strong effect; Herba Ephedrae suffering, little bitter temperature are returned lung, urinary bladder channel.Effect: relieving the exterior syndrome by diaphoresis, antiasthmatic-antitussive, inducing diuresis to remove edema, the modern pharmacological research ephedrine has the effect of stimulating central nervous system function, with the Semen Strychni combination, has the effect of regulating function of nervous system.Selecting Olibanum, is because of the Olibanum hardship, Xin Wen, GUIXIN, liver, spleen channel, effect: promoting blood circulation and stopping pain, detumescence and promoting granulation; Selecting Myrrha, is because the Myrrha hardship is flat, GUIXIN, liver, spleen channel.Effect: the blood and relieving pain that looses, detumescence and promoting granulation.Myrrha has local irritant effect, when can be used for angiasthenia with excited vasomotion.This two flavors medicine combination has the function of blood circulation promoting and blood stasis dispelling, has the effect of regulating vascular function.This four Chinese medicine combination, blood circulation promoting and blood stasis dispelling, removing obstruction in the collateral to relieve pain has the effect of regulating the nervus vasculairs function.
In order to reach better therapeutic, medicine of the present invention is also selected Pheretima, and Periostracum Serpentis makes up, and selects Pheretima, is because Pheretima is salty-cold, returns liver, lung, and urinary bladder channel, effect: endogenous wind stopping heat clearing away collateral dredging, relieving asthma diuresis.Can be used for arthralgia, hemiplegia.Periostracum Serpentis is sweet, and is salty, flat, returns Liver Channel, effect: expelling wind for relieving convulsion, and antipruritic, nebula removing.This two flavors medicine combination effect: dispelling wind and removing obstruction in the collateral.
The consumption of drug component of the present invention is also repeatedly groped, is summed up and draw through the inventor, and each amounts of components all has curative effect preferably to different arthromyodynias.
Medicine of the present invention is made up of following bulk drugs: fry hakuzen soil 20g, Gypsum Fibrosum Preparatum 180g, Radix Aconiti 3g, Radix Aconiti Kusnezoffii 3g, Rhizoma Arisaematis 3g, Rhizoma Pinelliae 3g, Rhizoma Zingiberis Recens 3g, Herba Ephedrae 3g, Olibanum 3g, Myrrha 3g, Pheretima 3g, Periostracum Serpentis 3g and living Semen Strychni 3g.
The preparation method of medicine of the present invention, it may further comprise the steps: 1. will fry hakuzen soil 20g, Gypsum Fibrosum Preparatum 180g, 126～180 ℃ of calcine temperature are ground into fine powder altogether after the merging, cross 100 mesh sieves, make mud cream powder, the hermetic container of packing into is standby: 2. take by weighing Radix Aconiti by following weight proportion, Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Rhizoma Pinelliae, Rhizoma Zingiberis Recens, Herba Ephedrae, Olibanum, Myrrha, Pheretima, Periostracum Serpentis and living each 3g of Semen Strychni, the pure one-tenth of powder fine powder, cross 100 mesh sieves, leave and take 1/10th, surplus medicine decocts with water 2 times, each amount of water was not to have powder 5cm degree of being, boiled 30 minutes, and merged twice decoction, filter to get filtrate, concentrate, extract concentrated solution with 1/10th medicated powder of being left and taken, dry under 45 ℃～50 ℃, be ground into fine powder, cross 100 mesh sieves, make pharmaceutically active component of the present invention; C, the boiled water furnishing mud paste of when using the mud cream powder of described weight proportion being heated, sharing is on preprepared plastic sheeting, then that medicine activity component of the present invention is very thin and be spread in equably on the mud cream surface, promptly make the Chinese medicinal paste of improvement of the present invention.
The beneficial effect of medicine of the present invention:
1, the present invention selects hakuzen soil, Gypsum Fibrosum preparata makes up with the Chinese medicine of relevant treatment arthromyodynia, utilize hakuzen soil, Gypsum Fibrosum preparata to add the principle of the solid heat release of water-setting, make it in to the pars affecta skin heating, medicine is heated, the Transdermal absorption of medicine is convenient in favourable dissolving with medicine, promotes the blood circulation of affected part.
2, the present invention selects Radix Aconiti for use, Radix Aconiti Kusnezoffii, Rhizoma Arisaematis, Rhizoma Pinelliae, the combination of Rhizoma Zingiberis Recens five kinds of Chinese medicine, the product of all big hot Da Xin, with hakuzen soil, Gypsum Fibrosum preparata makes up the external application affected part or is correlated with and locates through the cave, the relieving the exterior syndrome by diaphoresis effect of slight sweating is arranged, and " control wind and control blood earlier, the blood sector-style is from going out thereby played traditional Chinese medical science what is called." and " cold effect of from antiperspirant, flowing." Rhizoma Pinelliae and the reverse thinking combination that Radix Aconiti, Radix Aconiti Kusnezoffii make up genus violation eighteen imcompatible pairs combination principle, be used to treat the reaction of arthromyodynia no side effects outward, can promote to treat the curative effect of arthromyodynia on the contrary each other.
3, the present invention selects Herba Ephedrae for use, Semen Strychni, and Olibanum, the combination of Myrrha four medicines has the effect of regulating the nervus vasculairs function.Myrrha has local irritant effect, and it has the angiokinetic effect of promotion when vasomotion is unable.
4, the present invention selects Pheretima and Periostracum Serpentis combination for use, does not see same combination report in the past, and this combination has similar hormone-like effect according to modern pharmacological research, can replace hormone to use, and has the effect of regulating immunologic function, helps the therapeutic effect to arthromyodynia.
[specific embodiment]
Further set forth beneficial effect of the present invention below by improvement Chinese medicinal paste treatment arthromyodynia 120 routine clinical observation test examples.
1, physical data
This is organized 120 routine arthromyodynia patients and all belongs to clinic case, wherein male 57 examples, women 63 examples, age reckling 12 years old, the maximum 65 years old.The shortest person of the course of disease 3 days, elder 15 years.Chinese medical discrimination typing: migratory arthralgia person's 20 examples, arthralgia aggravated by cold person's 49 examples, damp arthralgia person 45 examples, pyretic arthralgia person 6 examples.Through Western medicine diagnose rheumatoid arthritis 35 examples, rheumatic arthritis 35 examples, osteoarthritis 50 examples.
2, Western medicine diagnose standard
2.1 rheumatic arthritis diagnostic criteria: before (1) is sick the hemolytic streptococcal infection history is arranged more; (2) symptom: four big joint (wrist, elbow, shoulder, ankle, knee joint, hip) migration are scurried pain or are swollen and ache; (3) the sign joint of getting involved is red, and is swollen, burning pain or swelling, and movable function is limited, and part patient can have low grade fever concurrently, erythema nodosum or erythema iris, heart change etc.; (4) lab testing, ESR increases piece more, and ASO (+) is (1:600U); (5) the rarely seen soft tissue swelling of X line, no sclerotin change; (6) deformity is not stayed in prognosis.
2.2 rheumatoid arthritis diagnostic criteria: (1) based on little joint, mostly be multiple and swell and ache or little joint symmetry swells and ache (more than 6 weeks), morning deadlock.(2) sign: the arthroncus of getting involved, tenderness, movable function is limited, and is lopsided or tetanic, and some cases can have subcutaneous nodule.(3) lab testing, RF (+), ESR speeds more.(4) X ray examination: the emphasis joint of getting involved has typical rheumatoid arthritis X line finding.(5) by stages: 1. early stage: swell and ache in the joint and limitation of activity though get involved mostly extremely, and the X line only shows soft tissue swelling and osteoporosis.2. mid-term: the part function of joint activity of getting involved is obviously limited; X-ray film shows that the joint space narrows down and corrosion in various degree.3. late period: various deformities appear in the majority joint of getting involved, and fiber is tetanic, movable difficulty.X-ray film shows the joint heavy damage, dislocation or fusion.
2.3 the diagnostic criteria of bone rheumatic arthritis: this organizes 50 examples (1), takes the photograph sheet through the X line and confirms that a place or many places are lip sample hypertrophy and change 35 examples, the bony spur shape changes 15 examples.(2) all have and ache, twinge, heavy, numbness, a series of clinical symptoms such as unable, even limitation of activity be can't take care of oneself.
3, tcm diagnosis standard:
3.1 migratory arthralgia, the arthralgia aggravated by cold migration is indefinite, involves the joint, many places, and the companion feels sick, heating, white and thin fur, floating pulse;
3.2 arthralgia aggravated by cold, localized pain, the pain gesture is acute, and meeting trembles with fear then weighs, the joint joint stuffiness, tongue fur is white, stringy and tense pulse;
3.3 damp arthralgia, aching is weighing, and numbness of the skin is meciless, and limbs are heavy, accompanies nose heave pain as wrapping up in white and greasy fur, soft pulse;
3.4 pyretic arthralgia, the arthralgia redness, inconvenient activity, the heat that occurs together is thirsty, dry and yellowish fur, slippery and rapid pulse.
4, Therapeutic Method:
Medicament active composition of the present invention is sprinkling upon on the mud cream face that is mixed up thinly equably external application affected part or relevant with pathological changes in the district of cave then, each 30～50 minutes, every day 1～2 time, 30 days 1 courses of treatment.
5, efficacy assessment standard:
5.1 rheumatic arthritis curative effect judging standard: 1. cure: the arthralgia of getting involved disappears, and joint function recovery is normal, check ESR, and ASO, three indexs of leukocyte recover normal, erythema nodosum, erythema iris disappears; 2. produce effects: the joint of getting involved is clearly better or disappears, ESR, and ASO, leukocyte do not recover normally, or have recovered normal, but arthralgia disappears as yet; 3. effective: through treatment the get involved arthralgia or the improvement of swelling and ache; 4. invalid: through treating more than the course of treatment, the joint symptom of getting involved does not have improvement.
5.2 rheumatoid arthrosis curative effect judging standard: 1. control in the recent period, the arthralgia of getting involved after treatment disappears, and function of joint is improved.Or recovering normal, RF, ESR recover normal, follow up a case by regular visits to not recurrence more than 3 months; 2. produce effects: the arthralgia of getting involved is clearly better or disappears, ESR, and the RF titre reduces or has recovered normal, but arthralgia disappears as yet; 3. effective: after treatment, the get involved arthralgia or the improvement of swelling and ache; 4. invalid: through treating more than 1-3 courses of treatment, the arthralgia of getting involved does not have improvement.
5.3 osteoarthritis curative effect judging standard: 1. cure: clinical symptom disappearance such as pain, numbness, functional rehabilitation is normal, and the X line is taken the photograph the sheet check, and hyperosteogeny obviously absorbs and is normal, follows up a case by regular visits to 3 years not recidivists; 2. effective: clinical symptoms such as pain, numbness disappear substantially or improve, and function is recovered normal substantially or improved, and the X line is taken the photograph the sheet check, and hyperosteogeny absorbs and dwindles to some extent; 3. invalid: treatment back symptom, the X line is taken the photograph sheet does not have change.
6, therapeutic outcome: add up curative effect through 1-3 courses of treatment.Rheumatic arthritis is totally 35 examples: cure 18 examples, account for 51.43%, produce effects 7 examples account for 20%, and effective 8 examples account for 21.4%, and invalid 2 examples account for 5.7%, and total 92.86; Rheumatoid arthritis is totally 35 examples: control 15 examples in the recent period, account for 42.86%, produce effects 5 examples account for 14.28%, effective 7 examples, and invalid 8 examples account for 21.43%, total effective rate 77.14%; Hyperosteogeny 50 examples: cure example and account for 70%, produce effects 10 examples account for 20%, and effective 2 examples account for 4%, and invalid 3 examples account for 6%, total effective rate 94%.
7, model case 1: the village so-and-so, the woman, 30 years old, whole body joint migration pain 1 year, based on double knee joint pain, the heating of local mild swelling, the Changes in weather aggravation, body of the tongue is light red, white and thin fur, pulse condition are carefully slow.Lab testing: erythrocyte sedimentation rate 45mm/h, anti-" 0 " 1:800U, X-ray film: soft tissue swelling is seen in the joint of getting involved, no sclerotin change.Clinical diagnosis is a rheumatic arthritis, and card belongs to migratory arthralgia, control when the expelling wind and removing dampness collateral dredging be main, assistant is with blood circulation promoting and blood stasis dispelling.Acupoint selection: inside and outside Xiyan, after treating 1 course of treatment with the improvement Chinese medicinal paste.The clinical symptoms complete obiteration, joint motion is normal, check: erythrocyte sedimentation rate 12mm/h, anti-" 0 " reduces to 1:400U.
Model case 2: Ao so-and-so, woman, 47 years old, nineteen ninety-five first visit on March 2.Frequent waist distending pain, heavy discomfort, aggravation when meeting overcast and rainy wet weather and overworking.Waist persistence distending pain occurs in nearly one month and accompanied right lower extremity pain, light red tongue, tongue is white, stringy and tense pulse.X ray examination: L3-L4 vertebral body has lip sample hypertrophy, and L5 has the bony spur hypertrophy.Improved the Chinese medicinal paste external application affected part and the right side obviously place of pain that has a pain in the leg, one day 2 times, 30 days 1 courses of treatment.Through 2 course of therapy, the pain complete obiteration, functional rehabilitation is normal, follows up a case by regular visits to not recurrence.
8, sum up: 120 routine arthromyodynias are observed from using Chinese medicinal paste of the present invention, the rheumatic arthritis cure rate reaches 51.43%, total effective rate reaches 92.86%, the recent control rate of rheumatoid arthritis reaches 42.86%, total effective rate reaches 77.14%, and the osteoarthritis cure rate reaches 70%, and total effective rate reaches 94%, show Chinese medicinal paste good effect of the present invention, be fit to the treatment of arthromyodynia.
Claims (2)
1, a kind of Chinese medicinal paste for the treatment of arthromyodynia is characterized in that the crude drug for preparing this Chinese medicinal paste consists of: fry hakuzen soil 20g, Gypsum Fibrosum Preparatum 180g, Radix Aconiti 3g, Radix Aconiti Kusnezoffii 3g, Rhizoma Arisaematis 3g, Rhizoma Pinelliae 3g, Rhizoma Zingiberis Recens 3g, Herba Ephedrae 3g, Olibanum 3g, Myrrha 3g, Pheretima 3g, Periostracum Serpentis 3g and living Semen Strychni 3g.
2, a kind of method for preparing the Chinese medicinal paste of the described treatment arthromyodynia of claim 1,, it is characterized in that: comprise the steps: 1. will fry hakuzen soil 20g, Gypsum Fibrosum Preparatum 180g, 126～180 ℃ of calcine temperature are ground into fine powder altogether after the merging, cross 100 mesh sieves, make mud cream powder, the hermetic container of packing into is standby: 2. be equipped with than taking by weighing Radix Aconiti, Radix Aconiti Kusnezoffii by following weight, Rhizoma Arisaematis, Rhizoma Pinelliae, Rhizoma Zingiberis Recens, Herba Ephedrae, Olibanum, Myrrha, Pheretima, Periostracum Serpentis and living each 3g of Semen Strychni, the pure one-tenth of powder fine powder, cross 100 mesh sieves, leave and take 1/10th, surplus medicine decocts with water 2 times, and each amount of water was not to have powder 5cm degree of being, boiled 30 minutes, merge decocting liquid twice, filter to get filtrate, concentrate, extract concentrated solution with 1/10th medicated powder of being left and taken, dry under 45～50 ℃, the pure one-tenth of powder fine powder is crossed 100 mesh sieves, make active component: the boiled water furnishing mud paste of when 3. using mud cream powder being heated, sharing is spread in active component on the mud cream surface on preprepared plastic sheeting then, promptly makes described Chinese medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100233116A CN100496596C (en) | 2004-06-15 | 2004-06-15 | Improved Chinese medicinal paste for arthralgia and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100233116A CN100496596C (en) | 2004-06-15 | 2004-06-15 | Improved Chinese medicinal paste for arthralgia and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1582961A CN1582961A (en) | 2005-02-23 |
| CN100496596C true CN100496596C (en) | 2009-06-10 |
Family
ID=34600776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100233116A Expired - Fee Related CN100496596C (en) | 2004-06-15 | 2004-06-15 | Improved Chinese medicinal paste for arthralgia and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN100496596C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028930A (en) * | 2010-12-01 | 2011-04-27 | 黎永明 | Medicated wine |
| CN102068634B (en) * | 2010-12-27 | 2014-08-06 | 邱天道 | Externally applied ironing moxibustion clay for human body and manufacturing method thereof |
| CN108210682A (en) * | 2018-02-27 | 2018-06-29 | 黄建民 | A kind of promoting blood circulation medicine puree and preparation method for treating Osteoarthritis |
| CN116920071B (en) * | 2023-09-12 | 2023-12-19 | 中国中医科学院中药研究所 | Application of Xiao ban Tang in preparation of preparation for improving abnormal bone metabolism |
-
2004
- 2004-06-15 CN CNB2004100233116A patent/CN100496596C/en not_active Expired - Fee Related
Non-Patent Citations (4)
| Title |
|---|
| 泥膏灸治疗胃脘痛108例. 杨合明，佘清华.华人消化杂志，第6卷第7期. 1998 |
| 泥膏灸治疗胃脘痛108例. 杨合明，佘清华.华人消化杂志，第6卷第7期. 1998 * |
| 泥膏疗法治疗急性胃脘痛32例. 佘清华.湖南中医杂志，第12卷第5期. 1996 |
| 泥膏疗法治疗急性胃脘痛32例. 佘清华.湖南中医杂志，第12卷第5期. 1996 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1582961A (en) | 2005-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101703708B (en) | Chinese medicinal preparation for treating rheumatoid arthritis and gout, and preparation method thereof | |
| CN101366919B (en) | Traditional Chinese medicine ointment for treating rheumatism diseases | |
| CN101537168B (en) | Traditional Chinese medicine composition for treatment of cervical spondylopathy and osteoarticular diseases and preparation method thereof | |
| CN101732579A (en) | Medicinal composition for treating rheumatism and rheumatoid arthritis | |
| CN100496596C (en) | Improved Chinese medicinal paste for arthralgia and its preparation | |
| CN103495126A (en) | Traditional Chinese medicine composition treating rheumatism | |
| CN101199723B (en) | Chinese medicine compound for oral administration for treating lumbar hyperosteogeny | |
| CN102240351B (en) | Traditional Chinese medicine for treating Arthritis, hyperosteogeny, cervical disc herniation and cervical spondylosis | |
| CN101444581A (en) | Externally used Pain-removal plaster for curing arthralgia | |
| CN102205064A (en) | Traditional Chinese medicine (TCM) for treating threatened abortion | |
| CN101732667B (en) | Traditional Chinese medicine for eliminating blood stasis and smoothing collaterals | |
| CN1140274C (en) | Gu'anning ointment for treating hyperosteogeny and its prepn. method | |
| CN102920969A (en) | Traditional Chinese medicine compound preparation for treating vasculitis, ischialgia and spondylitis, and preparation method thereof | |
| CN103599321B (en) | Traditional Chinese medicine composition for treating osteoporosis | |
| CN102579672A (en) | Medicament for treating bone hyperplasia and lumbar disc herniation | |
| CN102058751A (en) | Traditional Chinese medicine for treating chronic infectious arthritis | |
| CN102631563A (en) | Preparation method of ointment for promoting blood circulation, stopping pain and enhancing bone | |
| CN102552443B (en) | Traditional Chinese drug composition for treating rheumatoid arthritis, and preparation method thereof | |
| CN101530522B (en) | Traditional Chinese medicine preparation for treating wind-cold-dampness pain | |
| CN100394925C (en) | Chinese medicinal composition for treating rheumatism rheumatoid arthritis and osteosis | |
| CN102755487A (en) | Traditional Chinese medicine powder for eliminating dampness and invigorating blood circulation | |
| CN1899564B (en) | External use medicine for treating hyperosteogeny and protrusion of intervertebral disc | |
| CN1772245A (en) | Snake medicinal wine for health care massage and its application | |
| CN101590159B (en) | External medicament for treating ankylosing spondylitis and proliferative arthritis and processing method thereof | |
| CN104013732A (en) | Soft capsules for treating rheumatoid diseases |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C17 | Cessation of patent right | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20090610 Termination date: 20100615 |