CN102920969A - Traditional Chinese medicine compound preparation for treating vasculitis, ischialgia and spondylitis, and preparation method thereof - Google Patents
Traditional Chinese medicine compound preparation for treating vasculitis, ischialgia and spondylitis, and preparation method thereof Download PDFInfo
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- CN102920969A CN102920969A CN2012104810530A CN201210481053A CN102920969A CN 102920969 A CN102920969 A CN 102920969A CN 2012104810530 A CN2012104810530 A CN 2012104810530A CN 201210481053 A CN201210481053 A CN 201210481053A CN 102920969 A CN102920969 A CN 102920969A
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Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a traditional Chinese medicine compound preparation for treating vasculitis, ischialgia and spondylitis, and a preparation method thereof. The traditional Chinese medicine compound preparation is characterized in that the traditional Chinese medicine compound preparation is a cataplasma or gelata, which comprises the following 14 Chinese medicinal plants taken as main effective components: angelica, cinnamon, Chinese herbaceous peony, asarum, akebiaquinata, kudzuvine root, honey-fried licorice root, fructus evodiae, nutgrass galingale rhizome, galanga, suberect spatholobus stem, achyranthis root, radix dipsaci and jujube. The traditional Chinese medicine compound preparation is mainly used for treating thromboangiitis obliterans, ischialgia, hypertrophic myelitis, scapulohumeral periarthritis, rheumatism and ostealgia, chilblain, infantile hydrocele of tunica vaginalis, migraine, scleredema of newborn, hernia and the like, which are caused by deficiency of blood, insufficiency of Yang spirit and coldness invaded meridians.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparation that is prepared from as main active component take several kinds of Chinese medicinal materials and preparation method thereof.Relate in particular to the cataplasma made take Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Achyranthis Bidentatae, Radix Dipsaci and 14 kinds of Chinese crude drugs of Fructus Jujubae as main active component and gel and preparation method thereof.
Background technology
The thromboangiitis obliterans disease claims again B.gerger sick, and the multiple male adults of being born in has severe to have a liking for cigarette history more.Typical clinical manifestation is intermittent claudication, rest pain and migration superficial thrombophlebitis.This disease is mainly invaded limbs, especially lower limb in, vein and the skin superficial vein of small artery and companion thereof row, involved vessels presents the nonsuppurative inflammation of blood vessel wall holostrome, thrombosis is arranged in the tube chamber, it is narrow so that entirely shut that tube chamber presents carrying out property, cause limb ischemia and produce pain, ulcer and the gangrene of healing can occur to be difficult in the severe patient acra.May cause permanent disfunction or limbs to be lost, in addition dead.
At present, China mainly adopts Chinese medicine theory and method to treat to the treatment of thromboangiitis obliterans.Ancient Times in China medical science is attributed to vasculitis " necrosis " category.In Huangdi's Internal Classics, namely put down in writing relevant for primary disease.It is the most effective with the apply ointment or plaster method of black plaster of external treatment that Traditional Chinese Medicine is treated this disease.
Wherein the most representative person surely belongs to traditional recipe " vascular SHENGFU GAO ", and the party has condensed Ancient Times in China well-known doctor's wisdom, carries out compatibility for the disease type of vasculitis disease, basically can repair inflammation, embodies the theory of the traditional Chinese medical science " treatment of disease must aim at its pathogenesis ".But the party's side effect is large, and is not portable, and flavour of a drug have very strong zest, and along with the development of modern science, the application clinically of this type of ointment is fewer and feweri.
Sciatica refers to the pain of sciatic nerve path and distribution thereof, i.e. the pain in the outside and the foot outside behind buttocks thigh rear side, shank.If pain is shown effect repeatedly, the atrophy of Ipsilateral lower limb muscles with the passing of time can occur, or occur walking lamely.Sciatica belongs to again the category of lumbago and skelalgia, and it is by due to the outstanding compressing of the lumbar vertebra sciatic nerve that part is arranged.The onset cause of disease of sciatica has a lot, modal prolapse of lumbar intervertebral disc, be everlasting firmly, bend over or the inducement such as aggravating activities under, acute or subacute onset.Minority is chronic onset.Pain is often radiated to a side buttocks, thigh Hou ， popliteal nest, the shank outside and foot from waist, is and burns sample or cutting pains, and pain can be aggravated when cough reached firmly, and night more very.China treats clinically at present this disease and mainly adopts operation and Drug therapy, and operation risk is large, and accident is many; Medicine is western medicine especially, can not effect a permanent cure, and only can take stopgap measures, and the probability of recurrence is very high, so these two kinds of methods all can not fundamentally be cured.
China's Traditional Chinese Medicine is thought: sciatica is because " waist lower limb cold type of pain is walked to alter up and down, bends and stretches inconvenience, meets overcast and rainy cold climate and increases the weight of, or accompany lower extremity swelling and distension; White and thin fur or white greasy, floating and tense pulse or heavy.Have and dampen history in the waist, the twinge of waist lower limb, the sore spot tenderness, by twinge diffuse, hypnalgia very can not pitching, changes one's position unfavorable; Purplish tongue is dark or ecchymosis is arranged, and arteries and veins is unsmooth." traditional Chinese medical science is thought simultaneously, if " dispelling cold by warming the meridian is searched the wind analgesic therapy with Chinese crude drug; The anxious pain relieving of gentle muscular atonia, warm cold expelling is evil, promoting diuresis to eliminate damp pathogen; QI invigorating is to help promoting the flow of QI-blood by warming the meridian; Wind-expelling pain-stopping." can fundamentally cure this disease.
Spondylitic symptom is the chronic inflammation back pain in early days, and characteristics are that invisible outbreak, pain surpass three months, improve after the rest postemphasis, motion, and patient often has the stiff situation of daystart, even wakes up because of stiff pain at midnight.Usually the position of morbidity is at sacroiliac joint the earliest, pain can emit to buttocks and thigh rear side, sometimes can be to large leg outer side or front side, usually can not arrive below the knee, along with the progress of disease, inflammation is carried out to lumbar vertebra, thoracic vertebra gradually, can affect cervical vertebra at last, the range of activity variation of vertebra, the initial stage is that the palintrope lateral bending is limited, and is antecurvature also limited during late period.Spondylitis is broadly divided into 3 classes:
1. ankylosing spondylitis.The youngster morbidity is many, generally is no more than 30 years old, and the male is more than the women.
2. do not break up SpA.Do not obtain the spondylitis of clarifying a diagnosis, namely do not have the classical symptom of ankylosing spondylitis.
3. hyperplastic spondylitis.Be mainly in the old people, belong to metabolic disease, have the ring sample to change.
Treating clinically at present spondylitic main method is exercise therapy and operative treatment.The exercise therapy time is very long and effect is slowly not obvious; The risk of operative therapy is high, and malpractice is many.
China's traditional medicine thinks, ankylosing spondylitis belongs to " BI-syndrome involved the kidney ", " flaccidity syndrome and arthralgia syndrome " " rheumatism involving the bone ", " governor vessel is sick " of the traditional Chinese medical science.The cause of disease is take " suffer from a deficiency of the kidney and superintend and direct sky " " being invaded by exogenous pathogen " " governor vessels of congestion retardance meridians " as main.One of rheumatism involving the bone belongs to one of " five body constituents numbness " first appeared in Huangdi's Internal Classics." Plain Questions-air pocket opinion " said: " accumulated cold staying in the body, Rong Wei does not occupy, volume meat contracting muscle, the rib elbow must not be stretched, and interior is rheumatism involving the bone, is outward meciless, life is said deficiency ".Because cold-damp is attacked outward in brief, damp and hot contamination, traumatic injury, obstruction of collaterals by blood stasis, QI-blood circulation is not smooth, or natural endowment is not enough, and deficiency of kidney-essence is due to the mistake of bone arteries and veins is supported.According to this theory, use compound Chinese medicinal preparation, can fundamentally treat spondylitis.
The present invention aims to provide a kind of Traditional Chinese medical theory and Chinese medicine method for making utilized, in conjunction with the modern Chinese medicine production technology, and the compound Chinese medicinal preparation of making as main active component take several kinds of Chinese medicinal materials; Its function is mainly dispelling cold by warming the meridian with curing mainly, nourishing blood and promoting blood circulation, and the expelling pathogenic factors from muscles pain relieving is invigorated blood circulation.Being mainly used in clinically treating thromboangiitis obliterans, sciatica, hypertrophic spondylitis, scapulohumeral periarthritis, rheumatic ostalgia, chilblain, testis in children hydrocele of tunica vaginalis, migraine, neonatal scleredema, hernia etc. belongs to blood deficiency, YANG QI deficiency, coldly invades person due to the passages through which vital energy circulates.
Summary of the invention
The object of the present invention is to provide a kind of compound Chinese medicinal preparation that is prepared from as main active component take several kinds of Chinese medicinal materials and preparation method thereof.Relate in particular to bar cloth cream or gel compound Chinese medicinal preparation and the preparation method made as main active component take Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Achyranthis Bidentatae, Radix Dipsaci and 14 kinds of Chinese crude drugs of Fructus Jujubae.
The present invention also comprises the adjuvant commonly used that pharmaceutical preparation is required except main active component is Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Achyranthis Bidentatae, Radix Dipsaci and 14 kinds of Chinese crude drugs of Fructus Jujubae.The needed backing of cataplasma, lid lining, substrate.Its mesostroma mainly is comprised of sticker, excipient, wetting agent and Percutaneous absorption enhancer.The needed substrate of gel, antiseptic, cosolvent, emulsifying agent, antioxidant, thickening agent, dermal osmosis accelerator.
Content of the present invention is made Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Achyranthis Bidentatae, Radix Dipsaci and 14 kinds of Chinese crude drugs of Fructus Jujubae the compound medicinal formulation except comprising, also comprises the production technology of using common drug pharmaceutical adjunct useful in preparing drug formulations.
The objective of the invention is to be finished by following technical proposals.
A kind of spondylitic compound Chinese medicinal preparation of vasculitis sciatica for the treatment of is characterized in that mainly being comprised of by weight (part) the following traditional Chinese medicines material:
Radix Angelicae Sinensis 6-24 part
Cortex Cinnamomi 4-18 part
Radix Paeoniae 4-18 part
Herba Asari 1-6 part
Caulis Akebiae 3-12 part
Radix Puerariae 7-30 part
Radix Glycyrrhizae Preparata 3-12 part
Fructus Evodiae 4-18 part
Rhizoma Cyperi 4-18 part
Rhizoma Alpiniae Officinarum 3-12 part
Caulis Spatholobi 4-18 part
Radix Achyranthis Bidentatae 3-12 part
Radix Dipsaci 4-18 part
Fructus Jujubae 1-4 part
Add the required adjuvant commonly used of appropriate amount of drug preparation: backing, lid lining, substrate, make cataplasma; Perhaps add the required adjuvant commonly used of appropriate amount of drug preparation: substrate, antiseptic, cosolvent, emulsifying agent, antioxidant, thickening agent, dermal osmosis accelerator, make gel.
The present invention preferably fills a prescription and mainly is comprised of by weight (part) the following traditional Chinese medicines material:
12 parts of Radix Angelicae Sinensis
9 parts of Cortex Cinnamomis
9 parts of Radix Paeoniaes
3 parts of Herba Asaris
6 parts of Caulis Akebiaes
15 parts of Radix Puerariaes
6 parts of Radix Glycyrrhizae Preparatas
9 parts of Fructus Evodiaes
9 parts of Rhizoma Cyperis
6 parts of Rhizoma Alpiniae Officinarum
9 parts of Caulis Spatholobis
6 parts of Radix Achyranthis Bidentataes
9 parts of Radix Dipsaci
2 parts in Fructus Jujubae
Add the required adjuvant commonly used of appropriate amount of drug preparation: backing, lid lining, substrate, make cataplasma; Perhaps add the required adjuvant commonly used of appropriate amount of drug preparation: substrate, antiseptic, cosolvent, emulsifying agent, antioxidant, thickening agent, dermal osmosis accelerator, make gel.
Production technology of the present invention:
1. the production technology of cataplasma
1) takes by weighing above-mentioned 14 flavor Chinese crude drugs in the recipe quantity ratio, clean respectively, pulverize, sieve;
2) with above-mentioned 14 flavor Chinese crude drug fine powder sterilizations;
3) get Radix Angelicae Sinensis, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Dipsaci fine powder after the sterilization, extracted 2 hours the concentrated extractum that to get of extracting solution with 90 ℃ of 80% ethanol;
4) get Cortex Cinnamomi, Radix Achyranthis Bidentatae, Fructus Jujubae fine powder after the sterilization, after ultrasonic 30 minutes, 100 ℃ of water extractions 3 hours, the concentrated extractum that to get of extracting solution;
5) with 3) and 4) in extractum fully mix after, join in the substrate, fully stir, mix homogeneously gets ointment;
6) ointment is evenly coated on the backing, thickness 1-3mm adds a cover the lid lining, and cutting gets finished product.
Required pharmaceutic adjuvant in the production technology of the present invention refers to backing, lid lining, substrate.
Backing refers to non-woven fabrics.
Lid lining refers to a kind of in separate paper, plastic sheeting, aluminium foil one polyethylene composite film, the hard gauze.
Substrate mainly is comprised of sticker, excipient, wetting agent and Percutaneous absorption enhancer.
Sticker refers to one or more in polyisobutylene, polyvinyl acetate, polysiloxane-based, polyacrylic, sodium alginate, tragacanth, corn starch, gelatin, arabic gum, methylcellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, Polyethylene Glycol, the polyvinyl acetate.
Excipient refers to one or more in micropowder silica gel, calcium carbonate, Kaolin, kieselguhr, kaolin, titanium dioxide, the zinc oxide.
Wetting agent refers to one or more in glycerol, Polyethylene Glycol, sorbitol, the propylene glycol.
Percutaneous absorption enhancer mainly refers to one or more in azone, propylene glycol, Borneolum Syntheticum and the Oleum menthae.
2. the production technology of gel
1) takes by weighing above-mentioned 14 flavor Chinese crude drugs in the recipe quantity ratio, clean respectively, pulverize, sieve;
2) with above-mentioned 14 flavor Chinese crude drug fine powder sterilizations;
3) get Radix Angelicae Sinensis, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Dipsaci fine powder after the sterilization, extracted 2 hours the concentrated extractum that to get of extracting solution with 90 ℃ of 80% ethanol;
4) get Cortex Cinnamomi, Radix Achyranthis Bidentatae, Fructus Jujubae fine powder after the sterilization, after ultrasonic 30 minutes, 100 ℃ of water extractions 3 hours, the concentrated extractum that to get of extracting solution;
5) with 3) and 4) in extractum fully mix after, join in the substrate, fully stir, add successively pH adjusting agent, wetting agent, antiseptic, antioxidant, Percutaneous absorption enhancer, mix homogeneously gets ointment;
6) with the ointment embedding, get finished product.
Required pharmaceutic adjuvant refers in the production technology of the present invention: substrate, pH adjusting agent, wetting agent, antiseptic, antioxidant Percutaneous absorption enhancer.
Substrate refers to one or more in carbomer, alginate, tragacanth, gelatin, chitin, acrylic polyester, polyvinyl alcohol, carbopol, liquid paraffin, polyoxyethylene, fatty oil, the colloid silicon.
PH adjusting agent refers to a kind of in anhydrous citric acid, the sodium bicarbonate.
Wetting agent refers to one or more in water, glycerol, propylene glycol, the sorbitol.
Antiseptic refers to one or more in sodium benzoate, potassium sorbate, hydroxybenzoate, hydroxyl phenylacetic acid ester, hydroxy benzoic propionate, the hydroxy benzenes butyrate.
Antioxidant refers to a kind of in sodium sulfite, the vitamin C.
Percutaneous absorption enhancer refers to one or more in Mentholum, azone, carbitol, oleic acid, propylene glycol, the eucalyptus oil.
Side of the present invention separates as follows:
We's card is weak by nutrient blood, and cold accumulating in meridian is due to blood is unfavorable.Element body blood deficiency and passages through which vital energy circulates catch cold, and the cold-evil stagnates, and blood is unfavorable, and yang-energy can not reach in limb end, and nutrient blood can not fill blood vessels, then are brothers' cold, thready pulse being about to disappear of fainting.It is that fingers and palms are not warm to wrist, ankle that these brothers faint cold, faints contrary different with extremity.Control and work as dispelling cold by warming the meridian, nourishing blood and promoting blood circulation.We remove Rhizoma Zingiberis Recens with guizhi decoction, and times Fructus Jujubae adds Radix Angelicae Sinensis, Medulla Tetrapanacis, Herba Asari composition.The sweet temperature of Radix Angelicae Sinensis nourishes blood and blood in the side; The hot temperature of Cortex Cinnamomi, dispelling cold by warming the meridian, warm promoting blood circulation is monarch drug.The Herba Asari dispelling cold by warming the meridian helps Ramulus Cinnamomi temperature promoting blood circulation; The Radix Paeoniae Alba is nourished blood and seeks, and helps Radix Angelicae Sinensis tonification nutrient blood, is ministerial drug altogether.The Caulis Akebiae qualcomm meridian is with smooth blood; Fructus Jujubae, Radix Glycyrrhizae, replenishing QI to invigorate the spleen nourishes blood, and is adjuvant drug altogether.Reuse Fructus Jujubae, both be fated return, Radix Paeoniae to be to mend nutrient blood, anti-Cortex Cinnamomi, the dry strong serious offense of Herba Asari injure cloudy blood again.Radix Glycyrrhizae has concurrently transfers the property of medicine and for making medicine.Full side plays dispelling cold by warming the meridian, the effect of nourishing blood and promoting blood circulation altogether.
We's compatibility characteristics are warming YANG and cold expelling and usefulness, nourish blood and double the executing of promoting blood circulation, and are warm and not dry, tonify without causing stagnation.
Control waist, thigh, lower limb, sufficient pain and belong to blood deficiency cold coagulation person, can drink the product of blood circulation promoting and blood stasis dispelling such as adding Radix Dipsaci, Radix Achyranthis Bidentatae, Caulis Spatholobi, Fructus Chaenomelis; If add the Fructus Evodiae Rhizoma Zingiberis Recens, can demonstrate,prove chronic interior-cold in the side of effecting a permanent cure again, have diseases caused by retention of fluid vomiting person concurrently; If with the abdominal pain in menstruation of controlling women's blood deficiency cold coagulation, reach man's colic of cold type, testis dragging pain, the few abdomen cold type of pain of traction, cold extremities stringy pulse person, can drink regulating QI to relieve pain such as adding the Radix Linderae, Fructus Foeniculi, Rhizoma Alpiniae Officinarum, Rhizoma Cyperi; If the limb kibe due to the blood deficiency cold coagulation, the person no matter the initial stage does not burst or burst all can use by we's plus-minus.
Clinical application range of the present invention:
1) male: the lumbago knee joint is soft, lower limb are heavy, a series of subhealth symptoms such as spiritlessness and weakness, tinnitus dizziness, urine urgency-frequency, sexual impotence, premature ejaculation, prostatitis, sexual hypofunction.
2) women: soreness of waist lumbago, trick are ice-cold, dysmenorrhea, leukorrhagia, menoxenia, endocrine disturbance, climacteric wait a series of subhealth symptom in advance.
3) person in middle and old age: the aching and tired pain of articular muscle, be afraid of cold, neck is takeed on aching and tired stiff, the lumbago soreness of waist, abdominal part cold type of pain, the empty easy catching a cold of body etc.
In a word, the present invention is mainly used in treating thromboangiitis obliterans, sciatica, hypertrophic spondylitis, scapulohumeral periarthritis, rheumatic ostalgia, chilblain, testis in children hydrocele of tunica vaginalis, migraine, neonatal scleredema, hernia etc. and belongs to blood deficiency, YANG QI deficiency cold is invaded person due to the passages through which vital energy circulates.
Use pharmaceutical preparation of the present invention, through 27 routine Patients With Thromboangitis Obliterans clinical treatments are added up its clinical cure 8 examples, produce effects 12 examples, effective 5 examples, invalid 2 examples, total effective rate 92.6%; Through its clinical cure 7 examples, produce effects 10 examples, effective 3 examples, invalid 1 example, total effective rate 95.2% are added up in 21 routine sciatica patient clinical treatments; Through 25 routine spondylitic's clinical treatments are added up its clinical cure 8 examples, produce effects 9 examples, effective 6 examples, invalid 2 examples, total effective rate 92.0%; Illustrate that the present invention has higher curative effect aspect treatment thromboangiitis obliterans, sciatica and the spondylitis disease, each sick treated effect of planting all is higher than 92%.At 3 kinds of sick totally 73 routine patient clinical treatment viewing durations of planting, all do not find obvious untoward reaction after patient's medication, show that toxic and side effects of the present invention is low, safe and effective.
Excellent characteristics of the present invention are:
1, the prescription of innovation.
Be prescription with Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Achyranthis Bidentatae, Radix Dipsaci and 14 kinds of Chinese crude drugs of Fructus Jujubae first, make the compound medicine of innovation.
2, the production technology of innovation.
First Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Achyranthis Bidentatae, Radix Dipsaci and 14 kinds of Chinese crude drugs of Fructus Jujubae are made cataplasma and gel.
3, strengthened curative effect of medication.
The present invention has used advanced modern Chinese medicine preparation technology, add suitable substrate and Percutaneous absorption enhancer and made cataplasma or gel, so that drug loading increases greatly, the sticker and the wetting agent that have added simultaneously rational proportion, so that product good biocompatibility of the present invention, moisture retention and good permeability have strengthened curative effect of medication.
4, clinical application range is extensive.
The present invention is first with Radix Angelicae Sinensis, Cortex Cinnamomi, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Achyranthis Bidentatae, 14 kinds of Chinese crude drugs of Radix Dipsaci and Fructus Jujubae are made compound Chinese medicinal preparation, and 14 kinds of Chinese crude drug the monarch and his subjects make medicine clearly demarcated, effect is complemented each other, given full play to the compound recipe advantage of China's Chinese medicine, can be used for clinically treating thromboangiitis obliterans, sciatica, hypertrophic spondylitis, scapulohumeral periarthritis, rheumatic ostalgia, chilblain, the testis in children hydrocele of tunica vaginalis, migraine, neonatal scleredema, hernias etc. belong to blood deficiency, YANG QI deficiency cold is invaded person due to the passages through which vital energy circulates.Have wide range of applications.
The specific embodiment
Embodiment 1,
Take by weighing respectively Radix Angelicae Sinensis 12g, Cortex Cinnamomi 9g, Radix Paeoniae 9g, Herba Asari 3g, Caulis Akebiae 6g, Radix Puerariae 15g, Radix Glycyrrhizae Preparata 6g, Fructus Evodiae 9g, Rhizoma Cyperi 9g, Rhizoma Alpiniae Officinarum 6g, Caulis Spatholobi 9g, Radix Achyranthis Bidentatae 6g, Radix Dipsaci 9g and Fructus Jujubae 2g totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 1. cataplasmas of production technology of the present invention " described step, make cataplasma.
Embodiment 2,
Take by weighing respectively Radix Angelicae Sinensis 1200g, Cortex Cinnamomi 900g, Radix Paeoniae 900g, Herba Asari 300g, Caulis Akebiae 600g, Radix Puerariae 1500g, Radix Glycyrrhizae Preparata 600g, Fructus Evodiae 900g, Rhizoma Cyperi 900g, Rhizoma Alpiniae Officinarum 600g, Caulis Spatholobi 900g, Radix Achyranthis Bidentatae 600g, Radix Dipsaci 900g and Fructus Jujubae 200g totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 1. cataplasmas of production technology of the present invention " described step, make cataplasma.
Embodiment 3,
Take by weighing respectively Radix Angelicae Sinensis 12kg, Cortex Cinnamomi 9kg, Radix Paeoniae 9kg, Herba Asari 3kg, Caulis Akebiae 6kg, Radix Puerariae 15kg, Radix Glycyrrhizae Preparata 6kg, Fructus Evodiae 9kg, Rhizoma Cyperi 9kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 9kg, Radix Achyranthis Bidentatae 6kg, Radix Dipsaci 9kg and Fructus Jujubae 2kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 1. cataplasmas of production technology of the present invention " described step, make cataplasma.
Embodiment 4,
Take by weighing respectively Radix Angelicae Sinensis 6kg, Cortex Cinnamomi 9kg, Radix Paeoniae 5kg, Herba Asari 3kg, Caulis Akebiae 6kg, Radix Puerariae 30kg, Radix Glycyrrhizae Preparata 6kg, Fructus Evodiae 9kg, Rhizoma Cyperi 6kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 9kg, Radix Achyranthis Bidentatae 4kg, Radix Dipsaci 9kg and Fructus Jujubae 1kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 1. cataplasmas of production technology of the present invention " described step, make cataplasma.
Embodiment 5,
Take by weighing respectively Radix Angelicae Sinensis 24kg, Cortex Cinnamomi 9kg, Radix Paeoniae 9kg, Herba Asari 6kg, Caulis Akebiae 6kg, Radix Puerariae 8kg, Radix Glycyrrhizae Preparata 12kg, Fructus Evodiae 9kg, Rhizoma Cyperi 9kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 9kg, Radix Achyranthis Bidentatae 6kg, Radix Dipsaci 18kg and Fructus Jujubae 2kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 1. cataplasmas of production technology of the present invention " described step, make cataplasma.
Embodiment 6,
Take by weighing respectively Radix Angelicae Sinensis 12kg, Cortex Cinnamomi 18kg, Radix Paeoniae 18kg, Herba Asari 6kg, Caulis Akebiae 12kg, Radix Puerariae 15kg, Radix Glycyrrhizae Preparata 12kg, Fructus Evodiae 9kg, Rhizoma Cyperi 18kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 18kg, Radix Achyranthis Bidentatae 12kg, Radix Dipsaci 9kg and Fructus Jujubae 4kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 1. cataplasmas of production technology of the present invention " described step, make cataplasma.
Embodiment 7,
Take by weighing respectively Radix Angelicae Sinensis 12g, Cortex Cinnamomi 9g, Radix Paeoniae 9g, Herba Asari 3g, Caulis Akebiae 6g, Radix Puerariae 15g, Radix Glycyrrhizae Preparata 6g, Fructus Evodiae 9g, Rhizoma Cyperi 9g, Rhizoma Alpiniae Officinarum 6g, Caulis Spatholobi 9g, Radix Achyranthis Bidentatae 6g, Radix Dipsaci 9g and Fructus Jujubae 2g totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 2. gels of production technology of the present invention " described step, make gel.
Embodiment 8,
Take by weighing respectively Radix Angelicae Sinensis 1200g, Cortex Cinnamomi 900g, Radix Paeoniae 900g, Herba Asari 300g, Caulis Akebiae 600g, Radix Puerariae 1500g, Radix Glycyrrhizae Preparata 600g, Fructus Evodiae 900g, Rhizoma Cyperi 900g, Rhizoma Alpiniae Officinarum 600g, Caulis Spatholobi 900g, Radix Achyranthis Bidentatae 600g, Radix Dipsaci 900g and Fructus Jujubae 200g totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 2. gels of production technology of the present invention " described step, make gel.
Embodiment 9,
Take by weighing respectively Radix Angelicae Sinensis 12kg, Cortex Cinnamomi 9kg, Radix Paeoniae 9kg, Herba Asari 3kg, Caulis Akebiae 6kg, Radix Puerariae 15kg, Radix Glycyrrhizae Preparata 6kg, Fructus Evodiae 9kg, Rhizoma Cyperi 9kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 9kg, Radix Achyranthis Bidentatae 6kg, Radix Dipsaci 9kg and Fructus Jujubae 2kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 2. gels of production technology of the present invention " described step, make gel.
Embodiment 10,
Take by weighing respectively Radix Angelicae Sinensis 6kg, Cortex Cinnamomi 9kg, Radix Paeoniae 5kg, Herba Asari 3kg, Caulis Akebiae 6kg, Radix Puerariae 30kg, Radix Glycyrrhizae Preparata 6kg, Fructus Evodiae 9kg, Rhizoma Cyperi 6kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 9kg, Radix Achyranthis Bidentatae 4kg, Radix Dipsaci 9kg and Fructus Jujubae 1kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 2. gels of production technology of the present invention " described step, make gel.
Embodiment 11,
Take by weighing respectively Radix Angelicae Sinensis 24kg, Cortex Cinnamomi 9kg, Radix Paeoniae 9kg, Herba Asari 6kg, Caulis Akebiae 6kg, Radix Puerariae 8kg, Radix Glycyrrhizae Preparata 12kg, Fructus Evodiae 9kg, Rhizoma Cyperi 9kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 9kg, Radix Achyranthis Bidentatae 6kg, Radix Dipsaci 18kg and Fructus Jujubae 2kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 2. gels of production technology of the present invention " described step, make gel.
Embodiment 12,
Take by weighing respectively Radix Angelicae Sinensis 12kg, Cortex Cinnamomi 18kg, Radix Paeoniae 18kg, Herba Asari 6kg, Caulis Akebiae 12kg, Radix Puerariae 15kg, Radix Glycyrrhizae Preparata 12kg, Fructus Evodiae 9kg, Rhizoma Cyperi 18kg, Rhizoma Alpiniae Officinarum 6kg, Caulis Spatholobi 18kg, Radix Achyranthis Bidentatae 12kg, Radix Dipsaci 9kg and Fructus Jujubae 4kg totally 14 kinds of Chinese crude drugs by inventory, according to aforementioned " production technologies of 2. gels of production technology of the present invention " described step, make gel.
Claims (2)
1. treat the spondylitic compound Chinese medicinal preparation of vasculitis sciatica for one kind, it is characterized in that mainly being formed by weight by the following traditional Chinese medicines material:
Radix Angelicae Sinensis 6-24 part
Cortex Cinnamomi 4-18 part
Radix Paeoniae 4-18 part
Herba Asari 1-6 part
Caulis Akebiae 3-12 part
Radix Puerariae 7-30 part
Radix Glycyrrhizae Preparata 3-12 part
Fructus Evodiae 4-18 part
Rhizoma Cyperi 4-18 part
Rhizoma Alpiniae Officinarum 3-12 part
Caulis Spatholobi 4-18 part
Radix Achyranthis Bidentatae 3-12 part
Radix Dipsaci 4-18 part
Fructus Jujubae 1-4 part
Add the required adjuvant commonly used of appropriate amount of drug preparation, backing, lid lining, substrate are made cataplasma; Perhaps add the required adjuvant commonly used of appropriate amount of drug preparation, substrate, antiseptic, cosolvent, emulsifying agent, antioxidant, thickening agent, dermal osmosis accelerator are made gel; Its preparation method is:
The production technology of A, cataplasma
1) takes by weighing above-mentioned 14 flavor Chinese crude drugs in the recipe quantity ratio, clean respectively, pulverize, sieve;
2) with above-mentioned 14 flavor Chinese crude drug fine powder sterilizations;
3) get Radix Angelicae Sinensis, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Dipsaci fine powder after the sterilization, extracted 2 hours the concentrated extractum that to get of extracting solution with 90 ℃ of 80% ethanol;
4) get Cortex Cinnamomi, Radix Achyranthis Bidentatae, Fructus Jujubae fine powder after the sterilization, after ultrasonic 30 minutes, 100 ℃ of water extractions 3 hours, the concentrated extractum that to get of extracting solution;
5) with 3) and 4) in extractum fully mix after, join in the substrate, fully stir, mix homogeneously gets ointment;
6) ointment is evenly coated on the backing, thickness 1-3mm adds a cover the lid lining, and cutting gets finished product;
The production technology of B, gel
1) takes by weighing above-mentioned 14 flavor Chinese crude drugs in the recipe quantity ratio, clean respectively, pulverize, sieve;
2) with above-mentioned 14 flavor Chinese crude drug fine powder sterilizations;
3) get Radix Angelicae Sinensis, Radix Paeoniae, Herba Asari, Caulis Akebiae, Radix Puerariae, Radix Glycyrrhizae Preparata, Fructus Evodiae, Rhizoma Cyperi, Rhizoma Alpiniae Officinarum, Caulis Spatholobi, Radix Dipsaci fine powder after the sterilization, extracted 2 hours the concentrated extractum that to get of extracting solution with 90 ℃ of 80% ethanol;
4) get Cortex Cinnamomi, Radix Achyranthis Bidentatae, Fructus Jujubae fine powder after the sterilization, after ultrasonic 30 minutes, 100 ℃ of water extractions 3 hours, the concentrated extractum that to get of extracting solution;
5) with 3) and 4) in extractum fully mix after, join in the substrate, fully stir, add successively pH adjusting agent, wetting agent, antiseptic, antioxidant, Percutaneous absorption enhancer, mix homogeneously gets ointment;
6) with the ointment embedding, get finished product.
2. compound Chinese medicinal preparation according to claim 1 is characterized in that: mainly be comprised of by weight the following traditional Chinese medicines material:
12 parts of Radix Angelicae Sinensis
9 parts of Cortex Cinnamomis
9 parts of Radix Paeoniaes
3 parts of Herba Asaris
6 parts of Caulis Akebiaes
15 parts of Radix Puerariaes
6 parts of Radix Glycyrrhizae Preparatas
9 parts of Fructus Evodiaes
9 parts of Rhizoma Cyperis
6 parts of Rhizoma Alpiniae Officinarum
9 parts of Caulis Spatholobis
6 parts of Radix Achyranthis Bidentataes
9 parts of Radix Dipsaci
2 parts in Fructus Jujubae
Add the required adjuvant commonly used of appropriate amount of drug preparation, backing, lid lining, substrate are made cataplasma; Perhaps add the required adjuvant commonly used of appropriate amount of drug preparation, substrate, antiseptic, cosolvent, emulsifying agent, antioxidant, thickening agent, dermal osmosis accelerator are made gel.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561172A (en) * | 2015-11-10 | 2016-05-11 | 张强 | Traditional Chinese medicine composition for treating infantile hernia |
| CN116370358A (en) * | 2023-03-16 | 2023-07-04 | 北京中医药大学 | Hand cream for warming hands and preparation method thereof |
| WO2024103378A1 (en) * | 2022-11-18 | 2024-05-23 | 谢丞威 | Chinese herbal medicine external formulation for treating muscle soreness and preparation method therefor |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874835A (en) * | 2009-11-19 | 2010-11-03 | 律北平 | Oral Chinese medicinal formula for treating thromboangitis obliterans |
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- 2012-11-23 CN CN2012104810530A patent/CN102920969A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101874835A (en) * | 2009-11-19 | 2010-11-03 | 律北平 | Oral Chinese medicinal formula for treating thromboangitis obliterans |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105561172A (en) * | 2015-11-10 | 2016-05-11 | 张强 | Traditional Chinese medicine composition for treating infantile hernia |
| WO2024103378A1 (en) * | 2022-11-18 | 2024-05-23 | 谢丞威 | Chinese herbal medicine external formulation for treating muscle soreness and preparation method therefor |
| CN116370358A (en) * | 2023-03-16 | 2023-07-04 | 北京中医药大学 | Hand cream for warming hands and preparation method thereof |
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Application publication date: 20130213 |