CN102631496B - Traditional Chinese medicine composition capable of improving immunity and resisting fatigue - Google Patents

Abstract

The invention relates to a health product composition for improving human body immunity and anti-fatigue. The effective components of the composition are composed of ginseng, saffron, hippocampus and spirulina. The invention has the effects of enhancing the body's immune ability and anti-fatigue, strengthening the body and relaxing tendons and activating collaterals, with remarkable curative effect and mild effect.

Description

Traditional Chinese medicine composition for improving immunity and anti-fatigue

technical field

The invention relates to a traditional Chinese medicine composition which has the functions of synergistically improving human immunity, anti-fatigue and relaxing tendons and activating collaterals.

technical background

With the continuous development of social economy and the improvement of people's living standards, people's control over their health is gradually increasing. In today's world, each of us is vulnerable to many external threats to our health, including air pollution, video Pollution, environmental pollution, work pressure, economic pressure, bacteria and viruses, improper diet and so on. Furthermore, due to urban work and changes in the rhythm of life, it is easy to cause chronic fatigue, that is, a sub-health state. All these unhealthy factors usually cause people to be unable to concentrate, memory decline, frequent slackening, and premature aging. Therefore, it is very important to improve self-immunity and enhance the ability to resist various adverse health factors.

At present, there are many kinds of health care products on the market for enhancing the body's immunity, but the effects are uneven.

Contents of the invention

The technical problem to be solved by the present invention is: the purpose of the present invention is to provide a traditional Chinese medicine composition that enhances the immunity of the body, resists fatigue and relaxes tendons and activates collaterals. With ginseng, saffron, hippocampus and spirulina as the main Chinese medicinal materials, through mutual synergistic effect, it is expected to improve disease resistance, enhance immune effect, relieve physical fatigue and relax tendons and activate collaterals.

In order to solve the above-mentioned technical problems, the present invention provides a health product composition that synergistically improves human immunity, anti-fatigue, and relaxes tendons and collaterals. The health product composition for body immunity, anti-fatigue and function of relaxing tendons and activating collaterals is characterized in that the composition contains ginseng, saffron, hippocampus and spirulina. The effective components are calculated by weight: 4-65 parts of ginseng, 2-55 parts of saffron, 5-60 parts of hippocampus, and 5-65 parts of spirulina. Preferably, 8-50 parts of ginseng, 4-40 parts of saffron, 7-45 parts of hippocampus, and 7-50 parts of spirulina.

Preferably, the weight ratio of each component is: 65 parts of ginseng, 55 parts of saffron, 60 parts of hippocampus, and 65 parts of spirulina.

Preferably, the weight ratio of each component is: 4 parts of ginseng, 2 parts of saffron, 5 parts of hippocampus, and 5 parts of spirulina.

Preferably, the weight ratio of each component is: 8 parts of ginseng, 4 parts of saffron, 7 parts of hippocampus, and 7 parts of spirulina.

Preferably, the weight ratio of each component is: 50 parts of ginseng, 40 parts of saffron, 45 parts of hippocampus, and 50 parts of spirulina.

The medicinal and health-care properties of each component that the present invention adopts are:

Ginseng: The ginseng involved in the present invention refers to the general name of a kind of perennial herb of the genus Panax of the Araliaceae Panax family of Umbelliferae, including red ginseng, white ginseng, American ginseng (American ginseng), bar ginseng, Codonopsis ginseng and heterophylla wait. The ginseng in the present invention includes ginseng extract after processing and refining, ginseng fine powder after grinding and crushing or various forms during the growth process of ginseng. Has sweet and slightly bitter, warm in nature, enters the spleen and lung meridians, greatly invigorates vital energy, solidifies and promotes fluid production, and calms the nerves. Treatment of fatigue, fatigue, lack of appetite, lassitude, nausea and vomiting, slippery stool, cough and shortness of breath, spontaneous sweating, palpitations, forgetfulness, dizziness and headache, impotence, frequent urination, thirst, metrorrhagia in women, chronic shock in children , and long-term deficiency, all symptoms of insufficient qi, blood and body fluid.

Saffron: Saffron (also known as Saffron, Saffron) involved in the present invention is a perennial flower of the genus Saffron in the family Iridaceae. The saffron in the present invention includes ground and pulverized saffron powder, saffron extract obtained through various processes, or other processed forms of saffron. Clinically, saffron is used to treat a variety of chronic diseases in the human body. Through its effects of promoting blood circulation, removing blood stasis, antibacterial and anti-inflammatory effects, it can enhance the body's endurance and enhance the lymphocyte proliferation response, so as to improve the body's cellular immunity and humoral immunity, and play a role in adjusting the body's Qi mechanism. Run, balance the role of Yin and Yang in the human body.

Seahorse: It belongs to the class of fish, the order of sea dragons, and the general name of animals in the genus hippocampus, which belongs to bony fish. Hippocampus is a famous and precious traditional Chinese medicine with high economic value, containing amino acids, proteins, fatty acids, steroids and inorganic elements. It is sweet and warm in nature, enters the liver and kidney meridians, nourishes the kidney and strengthens yang, regulates qi and activates blood circulation, treats impotence, enuresis, dyspnea due to deficiency, dystocia, boils and swollen toxins, and has the functions of strengthening the body, tonifying the kidney and strengthening yang, relaxing tendons and activating collaterals, reducing inflammation and relieving pain, Medicinal functions such as calming the nerves, relieving cough and relieving asthma, are especially effective in treating diseases of the nervous system.

Spirulina: It belongs to a class of lower plants in Cyanophyta, Cyanophyceae, Spirulina, Oscillatoriaceae, and Spirulina, mainly including Spirulina maxima and Spirulina platensis. The spirulina in the present invention contains processed and refined spirulina extract or other processed forms of spirulina. Bitter and salty, cold, enters the spleen, lung, and kidney meridian, antibacterial, anti-radiation, lowers cholesterol, and enhances immunity.

The definition of "synergistic improvement" in the present invention can be understood as the combination of several medicinal materials, the improvement of their drug effect compared to when used alone; the drug effect is more durable; the composition produces unexpected effects in new prevention or health care fields.

Among the components of the present invention, ginseng greatly invigorates the vital energy, relieves fatigue and insufficiency, calms the nerves and improves intelligence. Saffron is sweet in taste and flat in nature, dissipates stagnation and relieves knots, resists fatigue, relieves stagnation and calms the nerves. The hippocampus has the functions of strengthening the body, improving immune function, relaxing tendons and activating collaterals, and calming the nerves. Spirulina can enhance the immune function of the body and improve the effectiveness.

The inventors have found through experiments that the composition of the present invention has a significant synergistic effect on improving human immunity and anti-fatigue pathology, such as the composition of the present invention. The effect of relaxing tendons and activating collaterals. The beneficial effect of the composition of the present invention on certain functions of the human body is incomparable to that of a single dose.

The composition of the present invention can be directly ground into powder or extracted and refined by conventional extraction techniques in the field such as water extraction and alcohol precipitation method or alcohol extraction and water precipitation method as the active ingredient of the therapeutic composition. The active ingredients can be combined with pharmaceutically acceptable carriers or excipients to prepare various pharmaceutical dosage forms, such as multi-granular tablets, granules, capsules, or oral liquids. According to the needs of use, the composition of the present invention can also be processed into sustained-release preparations or immediate-release preparations. The pharmaceutically acceptable carriers or excipients mentioned therein are selected according to different dosage forms. These carriers or excipients to be used can be determined by those of ordinary skill in the pharmaceutical art.

The preparation method of the oral liquid can be, but not limited to, the following one, such as mixing the effective components, adding water to decoct, filtering the decoction to obtain a solution, concentrating the obtained solution to obtain an extract, and then dissolving the obtained extract in The concentration of the extract is 5-10 times of the weight by weight in 95% ethanol aqueous solution, stirred and mixed, and quantitatively distributed to obtain the oral liquid preparation.

The preparation method of the tablet is to sieve the active component mixture, pulverize and fully mix with the commonly used auxiliary agent for preparing the tablet, pass through a 40-80 mesh sieve, and directly press the dry powder into a tablet by tablet pressing.

The preparation process of the capsule preparation can be as follows: sieve the mixture of active components, pulverize and fully mix with the auxiliary agents commonly used in the preparation of tablets, pass through a 40-80 mesh sieve, and pass through granulation, drying, granulation and other processes After filling, polishing and packaging, the finished product is obtained.

The beneficial effects of the present invention are:

The pharmaceutical composition of the present invention has the functions of replenishing qi and consolidating the surface, and improving the immunity of the body. The effect of strengthening the body, the curative effect is remarkable, the effect is mild, and there is no toxic side effect. The medicine has a simple production process and is easy to take, and is an ideal medicine for improving human immunity and anti-fatigue.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT

The following examples illustrate aspects of the invention. They are for illustration only and do not limit the scope of the present invention.

Example 1: Capsules containing ginseng, saffron, hippocampus and spirulina

65 grams of ginseng, 55 grams of saffron, 60 grams of hippocampus, and 65 grams of spirulina.

Soak the above traditional Chinese medicine in water for 40 minutes, the water level is higher than the raw material, the total amount of water added is 8 times of the total medicine amount, after boiling, it is in a low heat boiling state, keep the liquid level higher than the raw material Chinese medicine, decoct for 2 hours, filter to get the filtrate , then add 6 times the water of the total amount of medicine, after boiling, keep the liquid level higher than the height of the raw material traditional Chinese medicine, decoct for 2 hours, filter and merge the filtrate twice, concentrate under reduced pressure (pressure 0.06MPa, temperature 65 ℃) to dry paste, pulverize, through a 300 mesh sieve, add 2% magnesium stearate of total weight, and pack into capsules.

Example 2: Tablets containing ginseng, saffron, hippocampus and spirulina

4 grams of ginseng, 2 grams of saffron, 5 grams of hippocampus, and 5 grams of spirulina.

Dry and pulverize the above-mentioned Chinese herbal medicines into coarse powder, use 50-60% ethanol as a solvent to reflux extract at 60-70°C, after the ethanol is removed from the extract, concentrate at low temperature to form a thick extract, dry, pulverize into fine powder, and sieve , mixed, granulated, compressed into tablets.

Example 3: Capsules containing ginseng, saffron, hippocampus and spirulina

8 grams of ginseng, 4 grams of saffron, 7 grams of hippocampus, and 7 grams of spirulina.

The above-mentioned Chinese medicinal materials are dried and pulverized into fine powder, sieved, mixed evenly, and packed into hard capsule shells to obtain the traditional Chinese medicine composition of the present invention.

Embodiment 4: Oral liquid containing ginseng saffron, hippocampus and spirulina

50 grams of ginseng, 40 grams of saffron, 45 grams of hippocampus, and 50 grams of spirulina.

After mixing the above components, add water to decoct, filter the decoction to obtain a solution, concentrate the obtained solution to obtain an extract, and then dissolve the obtained extract in 5-10 times the weight of the extract to a concentration of 95% by weight ethanol aqueous solution, stirred and mixed, and quantitatively distributed to obtain oral liquid preparations.

Example 5: Tablets containing ginseng, saffron, hippocampus and spirulina

18 grams of ginseng, 10 grams of saffron, 25 grams of hippocampus, 20 grams of spirulina

Dry and pulverize the above-mentioned Chinese herbal medicines into coarse powder, use 50-60% ethanol as a solvent to reflux extract at 60-70°C, after the ethanol is removed from the extract, concentrate at low temperature to form a thick extract, dry, pulverize into fine powder, and sieve , mixed, granulated, compressed into tablets.

Test Example 1: The present invention's impact test on mouse immune function

1. Testing products: the products of embodiment 1, embodiment 2, embodiment 3, embodiment 4 and embodiment 5 are samples.

2. Animals for testing: mice, rats, half male and half male.

3. Inspection basis: Ministry of Health "Technical Specifications for Inspection and Evaluation of Health Food" (2003 Edition)

4. Test items:

4.1 Body weight, thymus/body weight ratio, spleen/body weight ratio

4.2 comA-induced mouse spleen lymphocyte transformation experiment (MTT method)

4.3 Dinitrofluorobenzene-induced delayed hypersensitivity (DTH) in mice

4.4 Detection of antibody-producing cells (Jerne's modified slide method)

4.5 Serum hemolysin test

4.6 Carbon clearance test in mice

4.7 Mouse peritoneal macrophages phagocytosis experiment of chicken red blood cells (drop method)

4.8 NK cell activity assay

5. Test results and judgment

5.1 The test results of body weight, thymus/body weight ratio and spleen/body weight ratio of experimental animals show that under the conditions of this test, the actual samples are 500, 1000, 3000 mg/kg (respectively equivalent to the recommended daily intake per kilogram of body weight for adults) During 5 times, 10 times, 30 times of dosage) dosage, five groups of samples have no obvious influence on the body weight of animal, thymus/body weight ratio, spleen/body weight ratio.

5.2comA-induced mouse spleen lymphocyte transformation experiment (MTT method) showed that under the experimental conditions, there was no statistically significant difference between the optical density difference of each dose group and the solvent control group (P>0.05) . It suggested that the sample did not enhance the proliferation ability of mouse lymphocytes.

5.3 The results of delayed hypersensitivity (DTH) in mice induced by dinitrofluorobenzene showed that under the experimental conditions, the difference in optical density of each dose group was compared with the value of the solvent control group, and there was no statistically significant difference (P >0.05). It is suggested that the sample has the effect of enhancing the delayed allergic reaction induced by dinitrofluorobenzene in mice. The test dose group was positive, suggesting that the sample can enhance the cellular immune function of mice.

5.4 The results of antibody-producing cell detection (Jerne's modified glass slide method) showed that under the test conditions, the number of hemolytic plaques in each dose group was higher than that of the solvent control group, and there was a statistically significant difference between the low and middle dose groups (P< 0.05), suggesting that the sample has the ability to enhance the ability of mice to produce antibody-producing cells.

5.5 The results of the serum hemolysin test showed that under the experimental conditions, there was no statistically significant difference between the half hemolysis value of the mouse serum in each dose group and the value of the solvent control group (P>0.05). It suggested that the sample did not enhance the ability of mice to produce serum hemolysin. The dosage group of one test was positive, suggesting that the sample can enhance the humoral immune function of mice.

5.6 The results of mouse carbon clearance test showed that, under the experimental conditions, there was no statistically significant difference between the phagocytosis plant A of mice in each dose group and the solvent control group (P>0.05). Prompt the function of sample five to enhance the carbon clearance ability.

5.7 The results of mouse peritoneal macrophage phagocytosis chicken erythrocyte experiment (drop method) show that under the test conditions, the mononuclear-macrophage phagocytosis percentage and phagocytosis index of mice in each sample and each dosage group are the same as those of the solvent control group. There was no statistically significant difference (P>0.05). Prompt the role of sample five in enhancing the phagocytic ability of mouse peritoneal macrophages. The test results were all negative, suggesting that the sample did not enhance the phagocytic function of mouse monocyte-macrophages.

5.8 NK cell activity assay results show that under this test condition, the NK cell activity of mice in each dose group is higher than the solvent control group value, and the high dose group has a statistically significant difference (P＜0.05), suggesting that the sample has Enhanced NK cell activity in mice.

Based on the above test results, according to the evaluation standard of immunity-enhancing function of health food, all 5 samples of the prescription of the present invention have the function of enhancing immunity.

Test Example 2: The present invention improves the clinical curative effect of human immune function

Children: immunocompromised, prone to colds, more than twice a month on average, or patients with pneumonia more than twice a year.

Elderly patients: patients suffering from a variety of chronic diseases and diagnosed with lung qi deficiency.

2. Medication method and course of treatment:

The preparations of Examples 1-5 of the present invention were taken orally. Control: saffron single-dose capsule, spirulina single-dose capsule

Adult: 3 cases each time, 3 times a day.

Children under 6 years old: 1 capsule each time, 2-3 times a day.

Children over 6 years old: 2 capsules each time, 2-3 times each time.

All the above patients take one month as a course of treatment, and the treatment takes 1-3 courses of treatment.

3. Observation method:

Conduct blood, urine, and stool routine tests and heart and lung function tests, and observe: fever, aversion to cold, nasal symptoms, pharyngeal symptoms, and general conditions, as well as changes in body temperature, pharyngeal tonsils, tongue and pulse, fingerprints, etc., respectively. Efficacy evaluation.

4. Efficacy evaluation

Table 1 Clinical Observation of Prescriptions of the Invention Improving Human Immune Function

Side effects of the medicine of the present invention: during the period of taking the medicine, a small number of patients have dry mouth and dry stools, and there is no adverse reaction, and the symptoms of drug withdrawal or reduction, taste, and dry stools disappear.

Experimental example 3: the present invention is to the impact test of anti-fatigue of mouse

The formulations of the present invention (Example 1, Example 2, Example 3, Example 4, Example 5) have been tested by the Jiangsu Provincial Center for Disease Control and Prevention on mice's anti-fatigue effects. Ninety mice were randomly divided into six groups, administered by intragastric administration according to the dosage shown in Table 2, once a day, for 10 consecutive days, and the normal control group and model group were given equal volumes of distilled water, both with a volume of 20ml/kg. And on the first day of the test. One hour after the last administration, the animals were placed in a swimming tank at 15±1°C, and the time for observing the mice to sink to the bottom of the water and then float up weakly was defined as the continuous swimming time. The results are shown in Table 2. As can be seen from the results in Table 2, the composition of the present invention can obviously prolong the duration of low temperature swimming in mice.

Table 2. Effect of formulation of the present invention on mouse swimming time

The test results show that the preparation of the invention can significantly prolong the continuous swimming time of mice at low temperature. Show that the present invention has anti-fatigue ability to mice.

Test Example 4: The present invention is used for the clinical treatment test of relaxing muscles and tendons and activating collaterals

The present invention is used for the indications of relaxing muscles and tendons and activating collaterals: tendons, fascia, tendons, bone injuries, lumbago and leg pain, etc., and it is taken when dislocation is reset and recuperated. Through the digestive system, it penetrates into the lesions of the local organs and tissues of the body, produces pharmacological effects, and achieves the effects of promoting blood circulation and removing blood stasis, reducing swelling and pain, relaxing tendons and regulating qi, and reconnecting tendons and bones, thereby treating tendons, fascia, tendons, and bone injuries , lumbago and leg pain and other focus treatment have good curative effect; Utilize the medicament that the embodiment of the present invention 1 and implement 2 to make, through clinical use 158 examples, wherein cervical spondylosis 45 examples, fracture 41 examples, sports sprain 72 examples, all obtained Good effect, the effective rate is 92.7%, the good rate is 77.5%, and all patients have no adverse reactions. Specific examples are as follows:

1. Ms. Xiong, 45 years old, was hit by a bicycle and injured her right thigh and hip. X-ray examination showed that the right femoral intertrochanteric fracture and fascia fell off. The distal end shifted inward and backward, and the local swelling was severe. After 3 courses of treatment with the preparation of Example 1, the patient can get out of bed with crutches and practice walking. After 2 and a half menstrual X-ray examinations, a large amount of bone callus has formed, and the patient can walk without crutches. There was no sequelae in the follow-up observation for 2 years.

2. Mr. Wu, 37 years old, suffered from chest tightness, dizziness, and shortness of breath. He was diagnosed with cervical vertebra 3-6 hyperosteogeny and cervical 3-4 intervertebral disc herniation by cervical CT. After using the preparation of Example 3 for a course of treatment, the symptoms were significantly relieved, relieved after taking 2 months, and continued after 1 month, and the symptoms disappeared, so far no recurrence.

3. Ms. Liu, 27 years old, fell from the balcony while cleaning the window. The symptoms were arm fracture and tendon injury. The patient's left arm could not move. After the fracture block was reset and fixed with plaster, the preparation of Example 2 was used twice a day in the morning and evening. After persisting for 1 month, the patient stopped the treatment and carried out functional exercises. After 2 months, the left arm healed.

4. Mr. Wu, 19 years old, was hit by a classmate when playing basketball, and his knee joint was sprained, and both knees were painful and swollen. After 3 courses of treatment with the prescription preparation of embodiment 4, all symptoms disappeared, and no recurrence was found in follow-up for 1 and a half years.

Claims (5)

1. A health product composition that synergistically improves the immunity of the human body, anti-fatigue effect and relaxing muscles and collaterals, is characterized in that its active ingredients are ginseng, saffron, hippocampus and spirulina, and are composed of raw materials according to the following parts by weight : 8-50 parts of ginseng, 4-40 parts of saffron, 7-45 parts of hippocampus, 7-50 parts of spirulina. 2. The composition according to claim 1, characterized in that said composition is a preparation in oral dosage form. 3. The composition of claim 1 is used in the preparation of health-care medicine for improving immunity. 4. The composition of claim 1 is used in the preparation of anti-fatigue health care medicine. 5. The composition of claim 1 is used in the preparation of a health-care medicine with the function of relaxing tendons and activating collaterals.