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CL2021002747A1 - Agentes antivirales para la hepatitis b (solicitud divisional no. 487-2020) - Google Patents

Agentes antivirales para la hepatitis b (solicitud divisional no. 487-2020)

Info

Publication number
CL2021002747A1
CL2021002747A1 CL2021002747A CL2021002747A CL2021002747A1 CL 2021002747 A1 CL2021002747 A1 CL 2021002747A1 CL 2021002747 A CL2021002747 A CL 2021002747A CL 2021002747 A CL2021002747 A CL 2021002747A CL 2021002747 A1 CL2021002747 A1 CL 2021002747A1
Authority
CL
Chile
Prior art keywords
hepatitis
antiviral agents
hbv
present
divisional application
Prior art date
Application number
CL2021002747A
Other languages
English (en)
Inventor
Xuri Gao
Wei Li
Hui Cao
Xiaowen Peng
Yat Sun Or
Yao-Ling Qiu
Jordan Kass
Byung-Chul Suh
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of CL2021002747A1 publication Critical patent/CL2021002747A1/es

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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

La presente invención revela compuestos de la Fórmula (I), o sales, ésteres o promedicamentos farmacéuticos aceptables: que inhiben la(s) proteína(s) codificada(s) por el virus de la hepatitis B (VHB) o interfieren con la función del ciclo de vida del VHB del virus de la hepatitis B y también son útiles como agentes antivirales. La presente invención además relaciona a composiciones farmacéuticas que comprenden el aforementioned compuestos para la administración a un sujeto que sufre de HBV infección. La invención también relaciona a métodos de tratar un HBV infección en un tema por administrar una composición farmacéutica que comprende los compuestos de la presente invención.
CL2021002747A 2017-08-28 2021-10-19 Agentes antivirales para la hepatitis b (solicitud divisional no. 487-2020) CL2021002747A1 (es)

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