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SG11201607332UA - Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection - Google Patents

Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection

Info

Publication number
SG11201607332UA
SG11201607332UA SG11201607332UA SG11201607332UA SG11201607332UA SG 11201607332U A SG11201607332U A SG 11201607332UA SG 11201607332U A SG11201607332U A SG 11201607332UA SG 11201607332U A SG11201607332U A SG 11201607332UA SG 11201607332U A SG11201607332U A SG 11201607332UA
Authority
SG
Singapore
Prior art keywords
prophylaxis
hepatitis
novel
treatment
virus infection
Prior art date
Application number
SG11201607332UA
Inventor
Lei Guo
taishan Hu
Buyu Kou
Xianfeng Lin
Hong Shen
Houguang Shi
Shixiang Yan
Weixing Zhang
Zhisen Zhang
Mingwei Zhou
Wei Zhu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11201607332UA publication Critical patent/SG11201607332UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SG11201607332UA 2014-03-07 2015-03-04 Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection SG11201607332UA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CNPCT/CN2014/073068 2014-03-07
CNPCT/CN2014/083027 2014-07-25
CN2015070895 2015-01-16
PCT/EP2015/054454 WO2015132276A1 (en) 2014-03-07 2015-03-04 Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection

Publications (1)

Publication Number Publication Date
SG11201607332UA true SG11201607332UA (en) 2016-10-28

Family

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Family Applications (1)

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SG11201607332UA SG11201607332UA (en) 2014-03-07 2015-03-04 Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection

Country Status (32)

Country Link
US (4) US9233978B2 (en)
EP (1) EP3114128B1 (en)
JP (1) JP6306750B2 (en)
KR (2) KR101933844B1 (en)
CN (3) CN109232613A (en)
AU (1) AU2015226206B2 (en)
BR (1) BR112016020566B1 (en)
CA (1) CA2935811C (en)
CL (1) CL2016002179A1 (en)
CR (1) CR20160337A (en)
DK (1) DK3114128T3 (en)
EA (1) EA030115B9 (en)
ES (1) ES2714110T3 (en)
HK (1) HK1245784A1 (en)
HR (1) HRP20190352T1 (en)
HU (1) HUE041734T2 (en)
IL (1) IL246449B (en)
LT (1) LT3114128T (en)
MA (1) MA39721A (en)
MX (1) MX350439B (en)
MY (1) MY188114A (en)
NZ (1) NZ721520A (en)
PE (1) PE20161338A1 (en)
PH (1) PH12016501631A1 (en)
PL (1) PL3114128T3 (en)
PT (1) PT3114128T (en)
RS (1) RS58384B1 (en)
SG (1) SG11201607332UA (en)
SI (1) SI3114128T1 (en)
TW (2) TWI606050B (en)
UA (1) UA117518C2 (en)
WO (1) WO2015132276A1 (en)

Families Citing this family (190)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2013000744A (en) 2010-07-22 2013-03-07 Gilead Sciences Inc Methods and compounds for treating paramyxoviridae virus infections.
EP3312160B1 (en) 2011-12-21 2020-03-18 Novira Therapeutics Inc. Hepatitis b antiviral agents
JP6505013B2 (en) 2012-08-28 2019-04-24 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Sulfamoyl-arylamides and their use as medicaments for the treatment of hepatitis B
JP6466348B2 (en) 2013-02-28 2019-02-06 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー Sulfamoyl-arylamide and its use as a medicament for treating hepatitis B
EP2981536B1 (en) 2013-04-03 2017-06-14 Janssen Sciences Ireland UC N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
JO3603B1 (en) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc Sulfamoyl pyrolamide derivatives and their use as medicines to treat hepatitis B
US10160743B2 (en) 2013-05-17 2018-12-25 Janssen Sciences Ireland Uc Sulphamoylthiophenamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
EP2997032B1 (en) * 2013-05-17 2018-07-25 F.Hoffmann-La Roche Ag 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
RS57222B1 (en) 2013-07-25 2018-07-31 Janssen Sciences Ireland Uc Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
KR102290189B1 (en) 2013-10-23 2021-08-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
US9573941B2 (en) 2013-11-27 2017-02-21 Sunshine Lake Pharma Co., Ltd. Processes for preparing dihydropyrimidine derivatives and intermediates thereof
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
MX383447B (en) 2014-02-05 2025-03-14 Novira Therapeutics Inc COMBINATION OF A CAPSID ASSEMBLY INHIBITOR AND PEGINTERFERON ALPHA-2A AND ITS USES FOR TREATMENT OF HEPATITIS B VIRUS (HBV) INFECTIONS.
EA035848B1 (en) 2014-02-06 2020-08-20 Янссен Сайенсиз Айрлэнд Юси Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
EP3114128B1 (en) * 2014-03-07 2019-01-02 F. Hoffmann-La Roche AG Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
JP2017512789A (en) 2014-03-28 2017-05-25 サンシャイン・レイク・ファーマ・カンパニー・リミテッドＳｕｎｓｈｉｎｅ Ｌａｋｅ Ｐｈａｒｍａ Ｃｏ．，Ｌｔｄ． Dihydropyrimidine compounds and their application in medicine
BR112016028000B1 (en) * 2014-05-30 2022-05-17 Qilu Pharmaceutical Co., Ltd Loop derivative of dihydropyrimide as an hbv inhibitor
TWI687432B (en) 2014-10-29 2020-03-11 美商基利科學股份有限公司 Methods for treating filoviridae virus infections
CN105859709B (en) 2015-02-07 2018-12-04 广东东阳光药业有限公司 The compound of dihydropyrimidine derivatives and its application in drug
PL3270915T3 (en) 2015-03-16 2020-08-24 F. Hoffmann-La Roche Ag Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
US10442788B2 (en) 2015-04-01 2019-10-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
WO2016183266A1 (en) 2015-05-13 2016-11-17 Enanta Pharmaceuticals, Inc. Ehpatitis b antiviral agents
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
US10179131B2 (en) 2015-07-13 2019-01-15 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US10301255B2 (en) 2015-07-22 2019-05-28 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
SG10202001878WA (en) 2015-09-16 2020-04-29 Gilead Sciences Inc Methods for treating arenaviridae and coronaviridae virus infections
WO2017049140A2 (en) 2015-09-18 2017-03-23 Wake Forest University Health Sciences Angiotensin (1-7) analogs and methods relating thereto
WO2017064156A1 (en) 2015-10-16 2017-04-20 F. Hoffmann-La Roche Ag Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
EP3370759A1 (en) 2015-11-03 2018-09-12 H. Hoffnabb-La Roche Ag Combination therapy of an hbv capsid assembly inhibitor and an interferon
CA2914601A1 (en) * 2015-12-11 2017-06-11 Wake Forest University Health Sciences Angiotensin-(1-7) analogs and methods relating thereto
WO2017108630A1 (en) * 2015-12-21 2017-06-29 F. Hoffmann-La Roche Ag Combination therapy of an hbsag inhibitor and an hbv capsid assembly inhibitor
US10280175B2 (en) 2016-02-02 2019-05-07 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
AR107633A1 (en) 2016-02-19 2018-05-16 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF ACID 4-PHENYL-5-ALCOXICARBONIL-2-TIAZOL-2-IL-1,4-DIHYDROPIRIMIDIN-6-IL- [METHYL] -3-OXO-5,6,8,8A-TETRAHIDRO- 1H-IMIDAZO [1,5A] PIRAZIN-2-IL-CARBOXYL
SG11201806863WA (en) 2016-02-19 2018-09-27 Novartis Ag Tetracyclic pyridone compounds as antivirals
MX384836B (en) 2016-03-07 2025-03-14 Enanta Pharm Inc ANTIVIRAL AGENTS AGAINST HEPATITIS B
CN109640980A (en) 2016-04-15 2019-04-16 诺维拉治疗公司 Combination and method comprising shell assembly inhibitor
DE202016102339U1 (en) * 2016-05-03 2016-06-22 Freund Maschinenfabrik Gmbh & Co. Kg Sliding block for a saw blade in a band saw machine
WO2017198744A1 (en) * 2016-05-20 2017-11-23 F. Hoffmann-La Roche Ag Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases
BR112018075465A2 (en) 2016-06-10 2019-03-19 Enanta Pharmaceuticals, Inc. hepatitis b antiviral agents
WO2017216686A1 (en) 2016-06-16 2017-12-21 Novartis Ag 8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals
WO2017216685A1 (en) 2016-06-16 2017-12-21 Novartis Ag Pentacyclic pyridone compounds as antivirals
JP6991213B2 (en) * 2016-07-29 2022-01-14 グアンジョウ・ルペン・ファーマシューティカル・カンパニー・リミテッド New therapeutic agents for the treatment of HBV infection
JP2019526562A (en) * 2016-08-24 2019-09-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Combination therapy of HBV capsid assembly inhibitor and nucleoside (Thi) analogue
ES2826748T3 (en) 2016-09-02 2021-05-19 Gilead Sciences Inc Derivatives of 4,6-diamino-pyrido [3,2-d] pyrimidine as modulators of Toll-like receptors
AU2017318601B2 (en) 2016-09-02 2020-09-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
WO2018047109A1 (en) 2016-09-09 2018-03-15 Novartis Ag Polycyclic pyridone compounds as antivirals
JP7101663B2 (en) * 2016-09-13 2022-07-15 エフ．ホフマン－ラ ロシュ アーゲー Combination therapy of TLR7 agonist and HBV capsid assembly inhibitor
EP3526323B1 (en) 2016-10-14 2023-03-29 Precision Biosciences, Inc. Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome
WO2018073753A1 (en) 2016-10-18 2018-04-26 Novartis Ag Fused tetracyclic pyridone compounds as antivirals
AU2017353986B2 (en) 2016-11-07 2021-08-19 Arbutus Biopharma Corporation Substituted pyridinone-containing tricyclic compounds, and methods using same
US11166954B2 (en) 2016-11-18 2021-11-09 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Dihydropyrimidine compound and preparation method and use thereof
PL3508483T3 (en) * 2016-11-18 2022-02-07 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Dihydropyrimidine compound and preparation method and use thereof
WO2018133846A1 (en) * 2017-01-23 2018-07-26 上海长森药业有限公司 Cyclothiourea compound and use thereof
AR110768A1 (en) 2017-01-31 2019-05-02 Gilead Sciences Inc CRYSTAL FORMS OF TENOFOVIR ALAFENAMIDA
US10682368B2 (en) 2017-03-14 2020-06-16 Gilead Sciences, Inc. Methods of treating feline coronavirus infections
AU2018238138A1 (en) 2017-03-21 2019-10-17 Arbutus Biopharma Corporation Substituted dihydroindene-4-carboxamides and analogs thereof, and methods using same
JOP20180040A1 (en) 2017-04-20 2019-01-30 Gilead Sciences Inc Pd-1/pd-l1 inhibitors
AR111419A1 (en) 2017-04-27 2019-07-10 Novartis Ag INDAZOL PIRIDONA FUSIONED COMPOUNDS AS ANTIVIRALS
JP2020518578A (en) 2017-05-01 2020-06-25 ギリアード サイエンシーズ， インコーポレイテッド (S)-2-Ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazine-7 -Yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate crystalline form
JP7260488B2 (en) * 2017-06-26 2023-04-18 サンシャイン・レイク・ファーマ・カンパニー・リミテッド Dihydropyrimidine compounds and their use in medicine
AU2018291688B2 (en) 2017-06-27 2022-02-03 Janssen Pharmaceutica Nv Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis B infections
US10675296B2 (en) 2017-07-11 2020-06-09 Gilead Sciences, Inc. Compositions comprising an RNA polymerase inhibitor and cyclodextrin for treating viral infections
SG11202001685TA (en) 2017-08-28 2020-03-30 Enanta Pharm Inc Hepatitis b antiviral agents
WO2019076310A1 (en) * 2017-10-18 2019-04-25 Sunshine Lake Pharma Co., Ltd. Dihydropyrimidine compounds and uses thereof in medicine
AU2018361364B2 (en) 2017-11-02 2020-11-26 Aicuris Gmbh & Co. Kg Novel, highly active amino-thiazole substituted indole-2-carboxamides active against the hepatitis B virus (HBV)
US11236087B2 (en) 2017-11-02 2022-02-01 Aicuris Gmbh & Co. Kg Highly active pyrazolo-piperidine substituted indole-2-carboxamides active against the hepatitis B virus (HBV)
US20210079015A1 (en) 2017-11-17 2021-03-18 Novartis Ag Novel dihydroisoxazole compounds and their use for the treatment of hepatitis b
TW201936192A (en) 2017-12-06 2019-09-16 美商因那塔製藥公司 Hepatitis B antiviral agents
TW201927789A (en) 2017-12-06 2019-07-16 美商因那塔製藥公司 Hepatitis B antiviral agents
CA3084582A1 (en) 2017-12-20 2019-06-27 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein
AU2018392213B2 (en) 2017-12-20 2021-03-04 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3'3' cyclic dinucleotides with phosphonate bond activating the STING adaptor protein
JP2021507906A (en) 2017-12-20 2021-02-25 ノバルティス アーゲー Fusion tricyclic pyrazolo-dihydropyrazinyl-pyridone compound as an antiviral agent
CA3083797A1 (en) * 2017-12-21 2019-06-27 Janssen Sciences Ireland Unlimited Company Isoxazole compounds for the treatment of diseases associated with hbv infections
CN111511739B (en) 2017-12-28 2023-09-15 豪夫迈·罗氏有限公司 Dihydropyrimidinyl thiazoles for the treatment and prophylaxis of hepatitis b virus infections
WO2019143902A2 (en) 2018-01-22 2019-07-25 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
CN118084940A (en) 2018-02-13 2024-05-28 吉利德科学公司 PD-1/PD-L1 inhibitors
JP7050165B2 (en) 2018-02-26 2022-04-07 ギリアード サイエンシーズ， インコーポレイテッド Substituted pyrrolidine compounds as HBV replication inhibitors
WO2019166951A1 (en) 2018-02-28 2019-09-06 Novartis Ag Indole-2-carbonyl compounds and their use for the treatment of hepatitis b
EP3765011A1 (en) 2018-03-14 2021-01-20 Janssen Sciences Ireland Unlimited Company Capsid assembly modulator dosing regimen
US10729688B2 (en) 2018-03-29 2020-08-04 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
EP3774883A1 (en) 2018-04-05 2021-02-17 Gilead Sciences, Inc. Antibodies and fragments thereof that bind hepatitis b virus protein x
TWI833744B (en) 2018-04-06 2024-03-01 捷克科學院有機化學與生物化學研究所 3'3'-cyclic dinucleotides
TW202005654A (en) 2018-04-06 2020-02-01 捷克科學院有機化學與生物化學研究所 2'2'-cyclic dinucleotides
TWI818007B (en) 2018-04-06 2023-10-11 捷克科學院有機化學與生物化學研究所 2'3'-cyclic dinucleotides
TW201945388A (en) 2018-04-12 2019-12-01 美商精密生物科學公司 Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis B virus genome
CN112041311B (en) 2018-04-19 2023-10-03 吉利德科学公司 PD-1/PD-L1 inhibitors
TW202014193A (en) 2018-05-03 2020-04-16 捷克科學院有機化學與生物化學研究所 2’3’-cyclic dinucleotides comprising carbocyclic nucleotide
CN118221646A (en) 2018-07-13 2024-06-21 吉利德科学公司 PD-1/PD-L1 inhibitors
TWI826492B (en) 2018-07-27 2023-12-21 加拿大商愛彼特生物製藥公司 Substituted tetrahydrocyclopenta[c]pyrroles, substituted dihydropyrrolizines, analogues thereof, and methods using same
WO2020028097A1 (en) 2018-08-01 2020-02-06 Gilead Sciences, Inc. Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid
US11053235B2 (en) 2018-08-09 2021-07-06 Janssen Sciences Ireland Unlimited Company Substituted 1,4-dihydropyrimidines for the treatment of HBV infection or HBV-induced diseases
MX2021003253A (en) 2018-09-21 2021-08-11 Enanta Pharm Inc Functionalized heterocycles as antiviral agents.
WO2020086556A1 (en) 2018-10-24 2020-04-30 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
US11071730B2 (en) 2018-10-31 2021-07-27 Gilead Sciences, Inc. Substituted 6-azabenzimidazole compounds
WO2020087107A1 (en) 2018-10-31 2020-05-07 The University Of Sydney Compositions and methods for treating viral infections
IL282535B2 (en) 2018-10-31 2024-05-01 Gilead Sciences Inc Substituted 6-azabenzimidazole compounds as hpk1 inhibitors
UY38437A (en) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg NEW UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PYRAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
UY38439A (en) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg NOVELTY UREA 6,7-DIHYDRO-4H-PYRAZOLE [4,3-C] PYRIDINES ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV)
AR116948A1 (en) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg DERIVATIVES OF UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PYRAZINES ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV)
UY38434A (en) 2018-11-02 2020-05-29 Aicuris Gmbh & Co Kg NEW 6,7-DIHYDRO-4H-PYRAZOLE [1,5-A] PIRAZIN INDOL-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV)
AR116947A1 (en) 2018-11-02 2021-06-30 Aicuris Gmbh & Co Kg DERIVATIVES OF UREA 6,7-DIHIDRO-4H-PIRAZOLO [1,5-A] PIRAZINAS-INDOL-2-CARBOXAMIDAS ACTIVE AGAINST THE VIRUS OF HEPATITIS B (HBV)
EP3873913A1 (en) 2018-11-02 2021-09-08 AiCuris GmbH & Co. KG Novel urea 6,7-dihydro-4h-thiazolo[5,4-c]pyridines active against the hepatitis b virus (hbv)
CA3119973A1 (en) 2018-11-21 2020-05-28 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
TW202415643A (en) 2018-12-12 2024-04-16 加拿大商愛彼特生物製藥公司 Substituted arylmethylureas and heteroarylmethylureas, analogues thereof, and methods using same
TW202035412A (en) * 2018-12-20 2020-10-01 比利時商健生藥品公司 Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis b infections
MA54560A (en) * 2018-12-20 2021-10-27 Janssen Pharmaceutica Nv HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B VIRUS INFECTIONS
WO2020135439A1 (en) * 2018-12-25 2020-07-02 广东东阳光药业有限公司 Deuterated dihydropyrimidine compound and use thereof as drug
KR20210130753A (en) 2019-02-22 2021-11-01 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 Amide derivatives useful for the treatment of HBV infection or HBV-induced disease
US11766447B2 (en) 2019-03-07 2023-09-26 Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. 3′3′-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator
KR102707808B1 (en) 2019-03-07 2024-09-19 인스티튜트 오브 오가닉 케미스트리 앤드 바이오케미스트리 에이에스 씨알 브이.브이.아이. 2'3'-cyclic dinucleotides and prodrugs thereof
CN113574063B (en) 2019-03-07 2025-03-18 捷克共和国有机化学与生物化学研究所 3'3'-Cyclic dinucleotides and prodrugs thereof
CN113614088A (en) 2019-03-25 2021-11-05 豪夫迈·罗氏有限公司 Solid forms of HBV core protein allosteric modifier compounds
CN111825676B (en) * 2019-04-15 2023-10-17 广东东阳光药业股份有限公司 Dihydropyrimidine compounds and application thereof in medicines
TW202104210A (en) 2019-04-17 2021-02-01 美商基利科學股份有限公司 Hiv protease inhibitors
TW202212339A (en) 2019-04-17 2022-04-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
TWI751516B (en) 2019-04-17 2022-01-01 美商基利科學股份有限公司 Solid forms of a toll-like receptor modulator
KR20220002498A (en) 2019-04-30 2022-01-06 아이쿠리스 게엠베하 운트 코. 카게 Novel indolizine-2-carboxamide active against hepatitis B virus (HBV)
CN111848627B (en) * 2019-04-30 2021-10-01 东莞市东阳光新药研发有限公司 Dihydropyrimidine compound and application thereof in medicine
MX2021013105A (en) 2019-04-30 2021-11-17 Aicuris Gmbh & Co Kg Novel oxalyl piperazines active against the hepatitis b virus (hbv).
JP2022531199A (en) 2019-04-30 2022-07-06 アイクリス ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト Novel phenyl and pyridyl urea active against hepatitis B virus (HBV)
MX2021013085A (en) 2019-04-30 2021-11-17 Aicuris Gmbh & Co Kg NEW INDOL-2-CARBOXAMIDES ACTIVE AGAINST HEPATITIS B VIRUS (HBV).
AU2020269897A1 (en) 2019-05-06 2021-10-14 Janssen Sciences Ireland Unlimited Company Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases
CN113825758B (en) * 2019-05-14 2023-08-01 正大天晴药业集团股份有限公司 Crystal forms of anti-HBV tetrahydroisoxazolo [4,3-c ] pyridines
EP3972695A1 (en) 2019-05-23 2022-03-30 Gilead Sciences, Inc. Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors
US11236111B2 (en) 2019-06-03 2022-02-01 Enanta Pharmaceuticals, Inc. Hepatitis B antiviral agents
US11472808B2 (en) 2019-06-04 2022-10-18 Enanta Pharmaceuticals, Inc. Substituted pyrrolo[1,2-c]pyrimidines as hepatitis B antiviral agents
WO2020247561A1 (en) 2019-06-04 2020-12-10 Enanta Pharmaceuticals, Inc, Hepatitis b antiviral agents
EP3980419A1 (en) * 2019-06-06 2022-04-13 F. Hoffmann-La Roche AG Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid
WO2020255016A1 (en) 2019-06-18 2020-12-24 Janssen Sciences Ireland Unlimited Company Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
CA3140702A1 (en) 2019-06-18 2020-12-24 Helen Horton Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators
AU2020301161B2 (en) 2019-06-25 2023-10-26 Gilead Sciences, Inc. FLT3L-Fc fusion proteins and methods of use
US11738019B2 (en) 2019-07-11 2023-08-29 Enanta Pharmaceuticals, Inc. Substituted heterocycles as antiviral agents
US20220257619A1 (en) 2019-07-18 2022-08-18 Gilead Sciences, Inc. Long-acting formulations of tenofovir alafenamide
WO2021018237A1 (en) * 2019-07-31 2021-02-04 Janssen Sciences Ireland Unlimited Company Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases
US20220281865A1 (en) * 2019-07-31 2022-09-08 Janssen Sciences Ireland Unlimited Company Dihydropyrimidine derivatives and uses thereof in the treatment of hbv infection or of hbv-induced diseases
EP4017476A1 (en) 2019-08-19 2022-06-29 Gilead Sciences, Inc. Pharmaceutical formulations of tenofovir alafenamide
WO2021055425A2 (en) 2019-09-17 2021-03-25 Enanta Pharmaceuticals, Inc. Functionalized heterocycles as antiviral agents
TW202126304A (en) 2019-09-20 2021-07-16 瑞士商赫孚孟拉羅股份公司 Method of treating hbv infection using a core protein allosteric modulator
PT4037708T (en) 2019-09-30 2024-11-06 Gilead Sciences Inc Hbv vaccines and methods treating hbv
WO2021078221A1 (en) * 2019-10-24 2021-04-29 广东东阳光药业有限公司 Dihydropyrimidine compound and use thereof in drug
DK4069729T3 (en) 2019-12-06 2025-04-07 Prec Biosciences Inc OPTIMIZED, MODIFIED MEGANUCLEASES WITH SPECIFICITY FOR A RECOGNITION SEQUENCE IN THE HEPATITIS B VIRUS GENOME
KR20220119666A (en) * 2019-12-20 2022-08-30 얀센 파마슈티카 엔.브이. Heteroaryldihydropyrimidine derivatives and methods of treatment of hepatitis B infection
EP4081217A1 (en) 2019-12-24 2022-11-02 F. Hoffmann-La Roche AG Pharmaceutical combination of antiviral agents targeting hbv and/or an immune modulator for treatment of hbv
PT4081305T (en) 2019-12-24 2024-12-04 Gilead Sciences Inc Diacylglycerol kinase modulating compounds
CN114846140A (en) 2019-12-24 2022-08-02 豪夫迈·罗氏有限公司 Pharmaceutical combination of a therapeutic oligonucleotide targeting HBV and a TLR7 agonist for the treatment of HBV
KR20220119616A (en) 2019-12-24 2022-08-30 에프. 호프만-라 로슈 아게 How to treat a viral infection using a TLR7 agonist
JP2023512656A (en) 2020-01-27 2023-03-28 ギリアード サイエンシーズ， インコーポレイテッド Methods for treating SARS CoV-2 infection
JP7554841B2 (en) 2020-03-12 2024-09-20 ギリアード サイエンシーズ， インコーポレイテッド Methods for preparing 1'-cyanonucleosides
US11802125B2 (en) 2020-03-16 2023-10-31 Enanta Pharmaceuticals, Inc. Functionalized heterocyclic compounds as antiviral agents
JP2023518433A (en) 2020-03-20 2023-05-01 ギリアード サイエンシーズ， インコーポレイテッド Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using them
US11701372B2 (en) 2020-04-06 2023-07-18 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carba-nucleoside analogs
IL297595A (en) 2020-04-28 2022-12-01 Hoffmann La Roche Process for the preparation of a chiral piperazine-2-carboxylic acid
WO2021243157A1 (en) 2020-05-29 2021-12-02 Gilead Sciences, Inc. Remdesivir treatment methods
EP4172160A2 (en) 2020-06-24 2023-05-03 Gilead Sciences, Inc. 1'-cyano nucleoside analogs and uses thereof
CN115835910A (en) 2020-07-14 2023-03-21 豪夫迈·罗氏有限公司 Hydrogenated isoquinoline or naphthyridine compounds for the treatment of autoimmune diseases
CA3190794A1 (en) 2020-08-05 2022-02-10 Soren Ottosen Oligonucleotide treatment of hepatitis b patients
PE20230779A1 (en) 2020-08-07 2023-05-09 Gilead Sciences Inc PRODRUGS OF PHOSPHONAMIDE NUCLEOTIDE ANALOGUES AND THEIR PHARMACEUTICAL USE
CR20230100A (en) 2020-08-24 2023-04-28 Gilead Sciences Inc Phospholipid compounds and uses thereof
HRP20240733T1 (en) 2020-08-27 2024-08-30 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
CN111892544A (en) * 2020-08-31 2020-11-06 南通大学 A kind of 3-(aminomethyl)-4-(4-fluorophenyl) piperazine-1-carboxylic acid tert-butyl ester and its synthesis method
WO2022052923A1 (en) * 2020-09-08 2022-03-17 和博医药有限公司 Dihydropyrimidine compound and application thereof
WO2022078479A1 (en) * 2020-10-16 2022-04-21 Janssen Pharmaceuticals, Inc. Combination therapy for treating hepatitis b virus infection
TW202344257A (en) 2020-10-16 2023-11-16 美商基利科學股份有限公司 Phospholipid compounds and uses thereof
TWI815194B (en) 2020-10-22 2023-09-11 美商基利科學股份有限公司 INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE
US20240025905A1 (en) * 2020-11-30 2024-01-25 Sunshine Lake Pharma Co., Ltd. Salts of dihydropyrimidine derivatives, complexes and uses thereof in medicine
CN114621219A (en) * 2020-12-09 2022-06-14 上海维申医药有限公司 Dihydropyrimidine compound, and preparation method and application thereof
CN114853761A (en) * 2021-02-05 2022-08-05 刘沛 Bifunctional derivative containing dihydropyrimidine and application thereof
JP2024505709A (en) * 2021-02-05 2024-02-07 ヘパジーン セラピューティクス（エイチケー）リミティド Phenyldihydropyrimidine compounds and their uses
CN114907355A (en) * 2021-02-09 2022-08-16 上海维申医药有限公司 Dihydropyrimidine compound, preparation method and application thereof
TW202348237A (en) 2021-05-13 2023-12-16 美商基利科學股份有限公司 Combination of a tlr8 modulating compound and anti-hbv sirna therapeutics
US20230000873A1 (en) 2021-05-26 2023-01-05 Gilead Sciences, Inc. Phospholipid formulations of 1'-cyano substituted carba-nucleoside analogs
PE20242071A1 (en) 2021-06-23 2024-10-18 Gilead Sciences Inc DIACYLGLYCEROL KINASE MODULATING COMPOUNDS
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222277A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CN117377671A (en) 2021-06-23 2024-01-09 吉利德科学公司 Diacylglycerol kinase modulating compounds
AU2022328698B2 (en) 2021-08-18 2025-02-20 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
CN114702497B (en) * 2021-12-23 2023-03-21 华南理工大学 Crystal form of dihydropyrimidine derivatives and its preparation method and application in medicine
CN114702498B (en) * 2021-12-23 2022-12-16 华南理工大学 Acid addition salts of dihydropyrimidine derivatives and their application in medicine
KR20240154646A (en) 2022-03-02 2024-10-25 길리애드 사이언시즈, 인코포레이티드 Compounds and methods for treating viral infections
WO2023167944A1 (en) 2022-03-02 2023-09-07 Gilead Sciences, Inc. Compounds and methods for treatment of viral infections
IL315082A (en) 2022-03-03 2024-10-01 Gilead Sciences Inc Antiviral compounds and methods of making and using the same
WO2023168194A1 (en) 2022-03-03 2023-09-07 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
KR20250020476A (en) 2022-06-06 2025-02-11 길리애드 사이언시즈, 인코포레이티드 How to treat viral infections, including SARS-COV-2
WO2024006376A1 (en) 2022-06-29 2024-01-04 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof
US20240043466A1 (en) 2022-06-30 2024-02-08 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof
WO2024173458A1 (en) 2023-02-16 2024-08-22 Gilead Sciences, Inc. Phospholipid compounds and methods of making and using the same
WO2024218026A1 (en) 2023-04-17 2024-10-24 F. Hoffmann-La Roche Ag Process for the preparation of 4-hydroxy-4,5-dihydrothiazole-2-carbonitrile and derivatives thereof
US20250090537A1 (en) 2023-08-31 2025-03-20 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
US20250084088A1 (en) 2023-08-31 2025-03-13 Gilead Sciences, Inc. Antiviral compounds and methods of making and using the same
WO2025054278A1 (en) 2023-09-06 2025-03-13 Gilead Sciences, Inc. Solid forms of a nucleoside analogue and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10012549A1 (en) 2000-03-15 2001-09-20 Bayer Ag New heterocyclic-substituted dihydropyrimidine derivatives useful for treatment of viral infections, especially hepatitis B infections
DE10012824A1 (en) 2000-03-16 2001-09-20 Bayer Ag New 6-hydroxyhydrocarbyl or 6-thiohydrocarbyl-dihydropyrimidine-5-carboxylic acid derivatives, useful for the treatment of viral infections, especially hepatitis B infections
DE10013126A1 (en) * 2000-03-17 2001-09-20 Bayer Ag New 6-aminoalkyl-dihydropyrimidine-5-carboxylate ester derivatives, useful as antiviral agents having strong activity against hepatitis B virus and low cytotoxicity
WO2005085462A1 (en) 2004-02-27 2005-09-15 Dsm Ip Assets B.V. Enzymatic preparation of an enantiomerically enriched beta-2-amino acids
WO2006033995A2 (en) 2004-09-16 2006-03-30 Valeant Research And Development Thiazolidin-4-ones having anti-hepatitis b activity
BRPI0616378A2 (en) 2005-09-22 2011-06-21 Scripps Research Inst indolinone alkoxy-based protein kinase inhibitors and methods for modulating catalytic activity
GB0701366D0 (en) 2007-01-24 2007-03-07 Glaxo Group Ltd Novel pharmaceutical compositions
WO2009067547A1 (en) 2007-11-19 2009-05-28 Takeda Pharmaceutical Company Limited Polo-like kinase inhibitors
PL2098526T3 (en) 2008-02-22 2014-06-30 Neurotune Ag Nitrogen-containing bicyclic compounds active on chronic pain conditions
CA2735177C (en) 2008-08-29 2014-03-25 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Saturated bicyclic heterocyclic derivatives as smo antagonists
WO2010069147A1 (en) 2008-12-17 2010-06-24 张中能 Dihydropyrimidine derivatives, compositions thereof and their use
CN102372706A (en) 2010-08-09 2012-03-14 江苏恒瑞医药股份有限公司 Phthalazinone derivative, its preparation method and application in medicament
AU2013305390C1 (en) * 2012-08-24 2015-12-24 Ruyuan Wei Xiang Technology Co., Ltd. Dihydropyrimidine compounds and their application in pharmaceuticals
EP2997032B1 (en) * 2013-05-17 2018-07-25 F.Hoffmann-La Roche Ag 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CN104650069B (en) * 2013-11-19 2019-04-19 广东东阳光药业有限公司 4- methyl Dihydropyrimidines and its application in drug
EP3114128B1 (en) * 2014-03-07 2019-01-02 F. Hoffmann-La Roche AG Novel 6-fused heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
PL3270915T3 (en) * 2015-03-16 2020-08-24 F. Hoffmann-La Roche Ag Combined treatment with a tlr7 agonist and an hbv capsid assembly inhibitor
EP3370759A1 (en) * 2015-11-03 2018-09-12 H. Hoffnabb-La Roche Ag Combination therapy of an hbv capsid assembly inhibitor and an interferon
AR107633A1 (en) * 2016-02-19 2018-05-16 Hoffmann La Roche PROCEDURE FOR THE PREPARATION OF ACID 4-PHENYL-5-ALCOXICARBONIL-2-TIAZOL-2-IL-1,4-DIHYDROPIRIMIDIN-6-IL- [METHYL] -3-OXO-5,6,8,8A-TETRAHIDRO- 1H-IMIDAZO [1,5A] PIRAZIN-2-IL-CARBOXYL
JP2019526562A (en) * 2016-08-24 2019-09-19 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Combination therapy of HBV capsid assembly inhibitor and nucleoside (Thi) analogue
JP7101663B2 (en) * 2016-09-13 2022-07-15 エフ．ホフマン－ラ ロシュ アーゲー Combination therapy of TLR7 agonist and HBV capsid assembly inhibitor
CN113614088A (en) * 2019-03-25 2021-11-05 豪夫迈·罗氏有限公司 Solid forms of HBV core protein allosteric modifier compounds
TW202126304A (en) * 2019-09-20 2021-07-16 瑞士商赫孚孟拉羅股份公司 Method of treating hbv infection using a core protein allosteric modulator

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IL246449A0 (en) 2016-08-31

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