CL2009000647A1 - Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. - Google Patents
Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto.Info
- Publication number
- CL2009000647A1 CL2009000647A1 CL2009000647A CL2009000647A CL2009000647A1 CL 2009000647 A1 CL2009000647 A1 CL 2009000647A1 CL 2009000647 A CL2009000647 A CL 2009000647A CL 2009000647 A CL2009000647 A CL 2009000647A CL 2009000647 A1 CL2009000647 A1 CL 2009000647A1
- Authority
- CL
- Chile
- Prior art keywords
- antibody
- treating
- liver cancer
- preventing liver
- agent
- Prior art date
Links
- 201000007270 liver cancer Diseases 0.000 title abstract 4
- 208000014018 liver neoplasm Diseases 0.000 title abstract 4
- 239000002246 antineoplastic agent Substances 0.000 title abstract 2
- 239000003795 chemical substances by application Substances 0.000 title abstract 2
- 229940127089 cytotoxic agent Drugs 0.000 title abstract 2
- 230000000694 effects Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Composición farmacéutica para tratar o prevenir cáncer hepático que comprende una combinación de un agente quimioterapéutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; método para tratar o prevenir un cáncer hepático de un sujeto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008098309 | 2008-04-04 | ||
| PCT/JP2008/002690 WO2009041062A1 (ja) | 2007-09-28 | 2008-09-26 | 血漿中動態が改善されたグリピカン3抗体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2009000647A1 true CL2009000647A1 (es) | 2010-06-04 |
Family
ID=41135076
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2009000647A CL2009000647A1 (es) | 2008-04-04 | 2009-03-18 | Composicion farmaceutica para tratar o prevenir cancer hepatico que comprende una combinacion de un agente quimioterapeutico y un anticuerpo anti-glipicano 3; agente para atenuar un efecto secundario que comprende dicho anticuerpo; metodo para tratar o prevenir un cancer hepatico de un sujeto. |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20110104157A1 (es) |
| EP (1) | EP2275135A4 (es) |
| JP (2) | JP5306327B2 (es) |
| KR (1) | KR101612139B1 (es) |
| CN (1) | CN102046200B (es) |
| AR (1) | AR071003A1 (es) |
| AU (1) | AU2009233301B2 (es) |
| BR (1) | BRPI0911147A2 (es) |
| CA (1) | CA2720359A1 (es) |
| CL (1) | CL2009000647A1 (es) |
| CO (1) | CO6300964A2 (es) |
| CR (1) | CR11769A (es) |
| EC (1) | ECSP10010589A (es) |
| IL (1) | IL208451A0 (es) |
| MA (1) | MA32360B1 (es) |
| MX (1) | MX2010010954A (es) |
| NZ (1) | NZ588913A (es) |
| PE (1) | PE20091655A1 (es) |
| RU (1) | RU2523897C2 (es) |
| SG (1) | SG189754A1 (es) |
| TW (1) | TWI468175B (es) |
| UA (1) | UA103614C2 (es) |
| WO (1) | WO2009122667A1 (es) |
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| CN102702353A (zh) * | 2004-07-09 | 2012-10-03 | 中外制药株式会社 | 抗-磷脂酰肌醇蛋白聚糖3抗体 |
| AU2005297772B2 (en) * | 2004-10-26 | 2011-06-23 | Chugai Seiyaku Kabushiki Kaisha | Anti-glypican 3 antibody having modified sugar chain |
| US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
| CN101809162B (zh) * | 2007-09-28 | 2013-06-05 | 中外制药株式会社 | 血浆中动力学被改善的磷脂酰肌醇蛋白聚糖3抗体 |
| SG11201407972RA (en) | 2012-06-01 | 2015-01-29 | Us Health | High-affinity monoclonal antibodies to glypican-3 and use thereof |
| EP3557260B1 (en) | 2012-12-21 | 2022-05-18 | Chugai Seiyaku Kabushiki Kaisha | Gpc3-targeting drug which is administered to patient responsive to gpc3-targeting drug therapy |
| TWI693073B (zh) * | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對gpc3標的治療劑療法為有效之患者投與的gpc3標的治療劑 |
| US11760807B2 (en) | 2014-05-08 | 2023-09-19 | Chugai Seiyaku Kabushiki Kaisha | GPC3-targeting drug which is administered to patient responsive to GPC3-targeting drug therapy |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| RU2683020C2 (ru) * | 2014-11-11 | 2019-03-26 | Петр Иванович Никитин | Субстанция и способ для модуляции активности агента в организме |
| US10688083B2 (en) | 2015-06-30 | 2020-06-23 | Eiger Group International, Inc. | Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions |
| WO2017002934A1 (ja) | 2015-07-01 | 2017-01-05 | 中外製薬株式会社 | Gpc3標的治療剤が有効である患者に投与されるgpc3標的治療剤 |
| EP3333192B1 (en) * | 2015-08-03 | 2021-05-19 | Cafa Therapeutics Limited | Antibody against glypican-3 and application thereof |
| WO2017159699A1 (en) | 2016-03-15 | 2017-09-21 | Chugai Seiyaku Kabushiki Kaisha | Methods of treating cancers using pd-1 axis binding antagonists and anti-gpc3 antibodies |
| JP7382922B2 (ja) | 2017-09-20 | 2023-11-17 | 中外製薬株式会社 | Pd-1系結合アンタゴニストおよびgpc3標的化剤を使用する併用療法のための投与レジメン |
| JPWO2020017479A1 (ja) * | 2018-07-17 | 2021-08-02 | ノイルイミューン・バイオテック株式会社 | 抗gpc3一本鎖抗体を含むcar |
| KR102154683B1 (ko) * | 2019-11-08 | 2020-09-11 | 주식회사 압타머사이언스 | 글리피칸-3 특이적 변형 압타머 및 이의 용도 |
| CA3176125A1 (en) * | 2020-03-18 | 2021-09-23 | Eutilex Co., Ltd. | Gpc3 car- t cells secreting il-18 and methods of making and using the same |
| JP2023518930A (ja) * | 2020-03-18 | 2023-05-09 | ユーティレックス カンパニー リミテッド | Gpc3 car-t細胞組成物、並びにそれを作製する方法及び使用する方法 |
| US20240301085A1 (en) * | 2021-02-10 | 2024-09-12 | Simcere Zaiming Pharmaceutical Co., Ltd. | Humanized gpc3 antibody and application thereof |
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2009
- 2009-03-18 CL CL2009000647A patent/CL2009000647A1/es unknown
- 2009-03-19 JP JP2010505322A patent/JP5306327B2/ja not_active Expired - Fee Related
- 2009-03-19 CN CN200980119069.3A patent/CN102046200B/zh not_active Expired - Fee Related
- 2009-03-19 UA UAA201013035A patent/UA103614C2/uk unknown
- 2009-03-19 MX MX2010010954A patent/MX2010010954A/es active IP Right Grant
- 2009-03-19 RU RU2010145177/15A patent/RU2523897C2/ru not_active IP Right Cessation
- 2009-03-19 SG SG2013025549A patent/SG189754A1/en unknown
- 2009-03-19 PE PE2009000413A patent/PE20091655A1/es not_active Application Discontinuation
- 2009-03-19 NZ NZ588913A patent/NZ588913A/xx not_active IP Right Cessation
- 2009-03-19 AR ARP090100996A patent/AR071003A1/es unknown
- 2009-03-19 TW TW98108942A patent/TWI468175B/zh not_active IP Right Cessation
- 2009-03-19 KR KR1020107024691A patent/KR101612139B1/ko not_active Expired - Fee Related
- 2009-03-19 AU AU2009233301A patent/AU2009233301B2/en not_active Ceased
- 2009-03-19 EP EP09727052A patent/EP2275135A4/en not_active Withdrawn
- 2009-03-19 CA CA2720359A patent/CA2720359A1/en not_active Abandoned
- 2009-03-19 US US12/936,367 patent/US20110104157A1/en not_active Abandoned
- 2009-03-19 BR BRPI0911147A patent/BRPI0911147A2/pt not_active IP Right Cessation
- 2009-03-19 WO PCT/JP2009/001249 patent/WO2009122667A1/ja not_active Ceased
-
2010
- 2010-10-03 IL IL208451A patent/IL208451A0/en unknown
- 2010-10-27 CO CO10133385A patent/CO6300964A2/es active IP Right Grant
- 2010-11-01 CR CR11769A patent/CR11769A/es unknown
- 2010-11-03 MA MA33323A patent/MA32360B1/fr unknown
- 2010-11-04 EC EC2010010589A patent/ECSP10010589A/es unknown
- 2010-12-28 JP JP2010291590A patent/JP5506654B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| MA32360B1 (fr) | 2011-06-01 |
| KR20100132060A (ko) | 2010-12-16 |
| TW200950804A (en) | 2009-12-16 |
| AU2009233301B2 (en) | 2014-01-23 |
| IL208451A0 (en) | 2010-12-30 |
| EP2275135A1 (en) | 2011-01-19 |
| ECSP10010589A (es) | 2010-12-30 |
| NZ588913A (en) | 2012-10-26 |
| CR11769A (es) | 2011-03-30 |
| KR101612139B1 (ko) | 2016-04-12 |
| CO6300964A2 (es) | 2011-07-21 |
| AR071003A1 (es) | 2010-05-19 |
| CN102046200B (zh) | 2015-03-25 |
| MX2010010954A (es) | 2011-03-24 |
| AU2009233301A1 (en) | 2009-10-08 |
| TWI468175B (zh) | 2015-01-11 |
| BRPI0911147A2 (pt) | 2019-09-24 |
| RU2010145177A (ru) | 2012-05-20 |
| RU2523897C2 (ru) | 2014-07-27 |
| JPWO2009122667A1 (ja) | 2011-07-28 |
| US20110104157A1 (en) | 2011-05-05 |
| JP5506654B2 (ja) | 2014-05-28 |
| JP5306327B2 (ja) | 2013-10-02 |
| EP2275135A4 (en) | 2013-03-06 |
| CN102046200A (zh) | 2011-05-04 |
| WO2009122667A1 (ja) | 2009-10-08 |
| JP2011068682A (ja) | 2011-04-07 |
| CA2720359A1 (en) | 2009-10-08 |
| UA103614C2 (uk) | 2013-11-11 |
| HK1151734A1 (en) | 2012-02-10 |
| PE20091655A1 (es) | 2009-11-04 |
| SG189754A1 (en) | 2013-05-31 |
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