[go: up one dir, main page]

CH645641A5 - Chinolin- und chinolizincarbonsaeurederivate. - Google Patents

Chinolin- und chinolizincarbonsaeurederivate. Download PDF

Info

Publication number
CH645641A5
CH645641A5 CH614680A CH614680A CH645641A5 CH 645641 A5 CH645641 A5 CH 645641A5 CH 614680 A CH614680 A CH 614680A CH 614680 A CH614680 A CH 614680A CH 645641 A5 CH645641 A5 CH 645641A5
Authority
CH
Switzerland
Prior art keywords
formula
compounds
dihydro
hydrates
mixture
Prior art date
Application number
CH614680A
Other languages
German (de)
English (en)
Inventor
Tsutomo Irikura
Hiroshi Koga
Satoshi Murayama
Original Assignee
Kyorin Seiyaku Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Seiyaku Kk filed Critical Kyorin Seiyaku Kk
Publication of CH645641A5 publication Critical patent/CH645641A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
CH614680A 1979-08-22 1980-08-14 Chinolin- und chinolizincarbonsaeurederivate. CH645641A5 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP10677679A JPS5630964A (en) 1979-08-22 1979-08-22 Novel substituted quinolinecarboxylic acid and its preparation
BE2/58706A BE884824A (fr) 1979-08-22 1980-08-19 Derives de l'acide quinoleine-carboxylique et procede pour leur preparation
BE2059018 1981-02-19

Publications (1)

Publication Number Publication Date
CH645641A5 true CH645641A5 (de) 1984-10-15

Family

ID=27159608

Family Applications (1)

Application Number Title Priority Date Filing Date
CH614680A CH645641A5 (de) 1979-08-22 1980-08-14 Chinolin- und chinolizincarbonsaeurederivate.

Country Status (16)

Country Link
JP (1) JPS5630964A (fr)
AU (1) AU533141B2 (fr)
BE (2) BE884824A (fr)
CA (1) CA1159454A (fr)
CH (1) CH645641A5 (fr)
DE (1) DE3031767C3 (fr)
ES (1) ES8104233A1 (fr)
FR (1) FR2463771A1 (fr)
GB (1) GB2057440B (fr)
HK (1) HK98486A (fr)
HU (1) HU184817B (fr)
IT (1) IT1132392B (fr)
MY (1) MY8700155A (fr)
SE (1) SE440353B (fr)
SG (1) SG71386G (fr)
SU (2) SU978727A3 (fr)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4416884A (en) * 1978-04-12 1983-11-22 Otsuka Pharmaceutical Co., Ltd. Piperazinylbenzoheterocyclic compounds
NO156828C (no) * 1980-11-10 1987-12-02 Otsuka Pharma Co Ltd Analogifremgangsm te for fremstilling av antibakterielt virksomme benzoheterocykliske forbindelser.
JPS57176987A (en) * 1981-04-24 1982-10-30 Otsuka Pharmaceut Co Ltd Pyrrolo(3,2,1-ij)quinoline-5-carboxylic acid derivative
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
JPS58105965A (ja) * 1981-12-15 1983-06-24 Nippon Shinyaku Co Ltd 置換キノリンカルボン酸誘導体
US4472406A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-8-(imidazol-1-yl)-5-methyl-1-oxo-1H,5H-benzo [ij]quinolizine-2-carboxylic acids and derivatives
US4472405A (en) * 1982-11-12 1984-09-18 Riker Laboratories, Inc. Antimicrobial 6,7-dihydro-5,8-dimethyl-9 fluoro-1-oxo-1H, 5H-benzo (ij) quinolizine-2-carboxylic acid and derivatives
JPS59128383A (ja) * 1982-12-29 1984-07-24 Kanebo Ltd 新規キノリンカルボン酸誘導体および該化合物を有効成分とする抗菌剤
JPS59155381A (ja) * 1983-02-22 1984-09-04 Kyorin Pharmaceut Co Ltd ベンゾキノリジンカルボン酸誘導体及びその製造法
DE3308908A1 (de) * 1983-03-12 1984-09-13 Bayer Ag, 5090 Leverkusen Bakterizide mittel
DE3318145A1 (de) * 1983-05-18 1984-11-22 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPS59195842U (ja) * 1983-06-13 1984-12-26 クラリオン株式会社 ラジオ受信機
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids
US4571396A (en) * 1984-04-16 1986-02-18 Warner-Lambert Company Antibacterial agents
GB8412094D0 (en) * 1984-05-11 1984-06-20 Scras Quinoline derivatives
US5468861A (en) * 1984-06-04 1995-11-21 Bayer Aktiengesellschaft 8-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and alkyl esters thereof
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
US4550103A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial 1-oxo-benzoquinolizine-2-carboxylic acids
US4550104A (en) * 1984-07-20 1985-10-29 Warner-Lambert Company Antibacterial thiazolo-quinolines and thiazolo-naphthyridines
JPS61118370A (ja) * 1985-10-30 1986-06-05 Kyorin Pharmaceut Co Ltd キノロンカルボン酸とその製造方法
ZA859283B (en) * 1984-12-06 1987-07-29 Pfizer Substituted dihydroquinolone carboxylic acids and anti-bacterial compositions containing them
JPS61143363A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS61143364A (ja) * 1984-12-17 1986-07-01 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
AU5427286A (en) * 1985-03-08 1986-09-11 Kyorin Pharmaceutical Co. Ltd. 7-(1-pyrrolidinyl)-3-quinolinecarboxylic acid derivatives
ATE77373T1 (de) * 1985-03-21 1992-07-15 Kyorin Seiyaku Kk Verfahren zur herstellung von chinolinsaeurederivaten.
GB8512143D0 (en) * 1985-05-14 1985-06-19 Beecham Group Plc Method of treatment
US4686221A (en) * 1985-10-01 1987-08-11 Kanebo, Ltd. Quinolinecarboxylic acid compounds and antimicrobial agent containing the same
JPS62228063A (ja) * 1985-12-27 1987-10-06 Sankyo Co Ltd キノリンカルボン酸誘導体
JPH0753715B2 (ja) * 1986-02-25 1995-06-07 大塚製薬株式会社 ベンゾヘテロ環化合物
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
JPS62205060A (ja) * 1986-03-04 1987-09-09 Kyorin Pharmaceut Co Ltd ８位置換キノロンカルボン酸誘導体
JPS62215572A (ja) * 1986-03-17 1987-09-22 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体
ZA874696B (en) * 1986-07-03 1988-01-04 F. Hoffmann-La Roche & Co. Aktiengesellschaft Acyl derivatives
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US4851418A (en) * 1987-08-21 1989-07-25 Warner-Lambert Company Naphthyridine antibacterial agents containing an α-amino acid in the side chain of the 7-substituent
JPS6483068A (en) * 1987-09-25 1989-03-28 Otsuka Pharma Co Ltd Production of benzo-heterocyclic compound
JPH01175936A (ja) * 1987-12-28 1989-07-12 Kyorin Pharmaceut Co Ltd ６．８−ジフルオロ−１−（２−フルオロエチル）−１，４−ジヒドロ−７−（４−メチル−１−ピペラジニル）−４−オキソ−３−キノリンカルボン酸を有効成分とする錠剤
JP2526128B2 (ja) * 1988-08-08 1996-08-21 エスエス製薬株式会社 キノロンカルボン酸誘導体
US5185337A (en) * 1989-03-29 1993-02-09 Otsuka Pharmaceutical Co., Ltd. Pyrroloquinoline derivatives and pharmaceutical compositions for antimicrobial use
CA2058424A1 (fr) * 1989-07-21 1991-01-22 Akihiro Shibata Derives d'acide quinoleinecarboxylique
FR2655545B1 (fr) 1989-12-11 1994-06-10 Rhone Poulenc Sante Nouvelle application therapeutique des derives des fluoroquinolones.
FR2656611B1 (fr) * 1990-01-04 1992-05-07 Hoechst France Nouvelles quinolones, leurs sels, utiles comme agents antimicrobiens, procede de preparation et leur application a titre de medicaments et compositions les renfermant.
FR2673426B1 (fr) * 1991-03-01 1993-07-16 Bouchara Sa Nouvelles quinolones, leur procede de preparation et les compositions en refermant.
FR2675144B1 (fr) * 1991-04-10 1995-06-16 Bouchara Sa Nouvelles quinolones difluorees - leur procede de preparation et les compositions pharmaceutiques en renfermant.
US5532239A (en) * 1993-08-02 1996-07-02 Assistance Publique - Hopitaux De Paris Therapeutic application of fluoroquinolone derivatives
US5731440A (en) * 1994-03-01 1998-03-24 Ishihara Sangyo Kaisha Ltd. Intermediates for producing 5,7-dichloro-4-hydroxyquinoline
SE9904108D0 (sv) 1999-11-15 1999-11-15 New Pharma Research Ab Nya föreningar
US7973022B2 (en) 2006-02-17 2011-07-05 Idexx Laboratories, Inc. Fluoroquinolone carboxylic acid salt compositions
US20070197548A1 (en) 2006-02-17 2007-08-23 Murthy Yerramilli V S Fluoroquinolone compositions

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7101049A (fr) * 1970-01-28 1971-07-30
BE793524A (fr) * 1971-12-30 1973-06-29 Riker Laboratories Inc Acides benzoquinolizine-carboxyliques et leurs derives
US4156726A (en) * 1974-12-07 1979-05-29 Fisons Limited 4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds
JPS53141286A (en) * 1977-05-16 1978-12-08 Kyorin Seiyaku Kk Novel substituted quinolinecarboxylic acid
JPS54112877A (en) 1978-02-20 1979-09-04 Sumitomo Chem Co Ltd Preparation of 1-substituted-1,4-dihydro-4-oxo-3-pyridine carboxylic acid derivatives
DE2914258A1 (de) * 1978-04-12 1979-10-25 Otsuka Pharma Co Ltd Piperazinylbenzoheterozyklische verbindungen, verfahren zu deren herstellung und mittel, welche diese enthalten
AU553415B2 (en) * 1983-09-19 1986-07-17 Abbott Japan Co., Ltd. 6-fluoro-1-4-dihydro-4-oxo-7-substituted piperazinyl- quinoline-3-carboxylic acids

Also Published As

Publication number Publication date
IT1132392B (it) 1986-07-02
DE3031767C2 (fr) 1994-04-14
SG71386G (en) 1987-03-27
CA1159454A (fr) 1983-12-27
DE3031767A1 (de) 1981-03-26
AU6112280A (en) 1981-02-26
FR2463771A1 (fr) 1981-02-27
ES494352A0 (es) 1981-04-16
MY8700155A (en) 1987-12-31
HK98486A (en) 1986-12-24
HU184817B (en) 1984-10-29
SU1015827A3 (ru) 1983-04-30
AU533141B2 (en) 1983-11-03
DE3031767C3 (de) 1994-04-14
SU978727A3 (ru) 1982-11-30
IT8024111A0 (it) 1980-08-11
GB2057440A (en) 1981-04-01
BE884824A (fr) 1980-12-16
JPS5630964A (en) 1981-03-28
ES8104233A1 (es) 1981-04-16
BE887574R (fr) 1981-06-15
FR2463771B1 (fr) 1983-04-22
GB2057440B (en) 1983-10-12
SE8005534L (sv) 1981-02-23
SE440353B (sv) 1985-07-29

Similar Documents

Publication Publication Date Title
CH645641A5 (de) Chinolin- und chinolizincarbonsaeurederivate.
EP0113093B1 (fr) Acides 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(alkyl-1-pipérazinyl)-3-quinoléinecarboxyliques, procédé pour leur préparation et des agents antibactériens les contenant
EP0117473B1 (fr) Acides quinolonecarboxyliques, procédé pour leur préparation et compositions antibactériennes les contenant
EP0126355B1 (fr) Acides amino-7 cyclopropyl-1 difluoro-6,8 dihydro-1,4 oxo-4 quinoléinecarboxyliques-3, procédés pour leur préparation et compositions anti-bactériennes les contenant
EP0167763B1 (fr) Acides 7-amino-1-cyclopropyl-6,8-dihalo-1,4-dihydro-4-oxo-3-quinoline carboxyliques, procédé pour leur préparation et agent bactéricide les contenant
EP0078362B1 (fr) Acides 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-pipérazino-quinoléine-3-carboxyliques, procédé pour leur préparation et agents bactéricides les contenant
EP0169993B1 (fr) Acides 7-(3-aryl-1-pipérazinyl)- et 7-(3-cyclohexyl-1-pipérazinyl)-3-quinoline carboxyliques
EP0198192B1 (fr) Acide amino-7(cyclopropyl substitué)-1 dihydro-1,4 oxo-4 quinoléine-carboxyliques-3, procédé pour leur préparation et agents antibactériens contenant ces composés
DE3433924A1 (de) 6-fluoro-1,4-dihydro-4-oxo-7-substituierte piperazinyl-chinolin-3-carbonsaeure-derivate und verfahren zu ihrer herstellung
EP0155587B1 (fr) Acides diamino-1,7 dihydro-1,4 oxo-4(aza)quinoléine-carboxyliques-3, procédé pour leur préparation et leur application dans le traitement de maladies bactériennes
EP0187376B1 (fr) Acides 6,7-disubstitués 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphtyridine-3-carboxyliques
EP0205029A2 (fr) Acides quinoléine carboxyliques à activité bactéricide
EP0113092B1 (fr) Acides 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-(oxoalkyl)-1-pipérazinyl)-3-quinoléinecarboxyliques et leurs dérivés, procédé pour leur préparation et des agents antibactériens les contenant
EP0201829A1 (fr) Acides aryl-1 quinolone-4 carboxyliques-3
DE3601567A1 (de) 7-(azabicycloalkyl)-chinoloncarbonsaeure- und -naphthyridon-carbonsaeure-derivate
EP0166939B1 (fr) Acides 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-pipérazinyl)-3-quinoline carboxyliques, procédé pour leur préparation et agents bactéricides les contenant
EP0191390B1 (fr) Acides 1-cyclopropyl-1,4-dihydro-4-oxo-7-[4-(2-oxo-1,3-dioxol-4-yl-méthyl)-1-pipérazinyl-3-quinoline carboxyliques, leur procédé de préparation et agents bactéricides les contenant
DE3686201T2 (de) Benzo(i,j)chinolizin-2-carbonsaeurederivate, ihre salze und hydrate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung.
DD241258A5 (de) Verfahren zur herstellung 6,7-disubstituierter 1-cyclopropyl-1,4-dihydro-4-oxo-1,8-naphthyridin-3-carbonsaeuren
DD283385A5 (de) Verfahren zur herstellung von derivaten der 7-(1-azetidinyl)-1,4-dihydro-4-oxoquinolein-3-carboxylsaeure
DE19506535A1 (de) 1,6-Naphthyridoncarbonsäurederivate

Legal Events

Date Code Title Description
PL Patent ceased