CA2371972A1 - Ent-steroids as selectively active estrogens - Google Patents
Ent-steroids as selectively active estrogens Download PDFInfo
- Publication number
- CA2371972A1 CA2371972A1 CA002371972A CA2371972A CA2371972A1 CA 2371972 A1 CA2371972 A1 CA 2371972A1 CA 002371972 A CA002371972 A CA 002371972A CA 2371972 A CA2371972 A CA 2371972A CA 2371972 A1 CA2371972 A1 CA 2371972A1
- Authority
- CA
- Canada
- Prior art keywords
- ent
- estra
- beta
- alpha
- diol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19917930A DE19917930A1 (de) | 1999-04-15 | 1999-04-15 | Ent-Steroide als selektiv wirksame Estrogene |
| DE19917930.1 | 1999-04-15 | ||
| PCT/EP2000/003470 WO2000063228A1 (en) | 1999-04-15 | 2000-04-17 | Ent-steroids as selectively active estrogens |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2371972A1 true CA2371972A1 (en) | 2000-10-26 |
Family
ID=7905255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002371972A Abandoned CA2371972A1 (en) | 1999-04-15 | 2000-04-17 | Ent-steroids as selectively active estrogens |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1169336B1 (es) |
| JP (1) | JP2002542255A (es) |
| AR (1) | AR023497A1 (es) |
| AT (1) | ATE316978T1 (es) |
| AU (1) | AU4401100A (es) |
| CA (1) | CA2371972A1 (es) |
| CO (1) | CO5180552A1 (es) |
| DE (2) | DE19917930A1 (es) |
| ES (1) | ES2258005T3 (es) |
| PE (1) | PE20010042A1 (es) |
| WO (1) | WO2000063228A1 (es) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6350739B1 (en) | 1999-08-11 | 2002-02-26 | University Of Florida Resarch Foundation, Inc. | Methods of prevention and treatment of ischemic damage |
| US6958327B1 (en) | 1999-11-02 | 2005-10-25 | Schering, Ag | 18 Norsteroids as selectively active estrogens |
| DE50014299D1 (de) * | 1999-11-02 | 2007-06-14 | Bayer Schering Pharma Ag | 18-nor-steroide als selektiv wirksame estrogene |
| DE10039199A1 (de) * | 2000-08-10 | 2002-02-21 | Schering Ag | Kombinationspräparate aus einem ERß selektiven Estrogen und einem SERM oder Antiestrogen |
| GB0020498D0 (en) * | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
| DE10048634A1 (de) * | 2000-09-27 | 2002-04-18 | Jenapharm Gmbh | 19-Nor-17alpha-pregna-1,3,5(10)-trien-17beta-ole mit einem 21, 16alpha-Laktonring |
| CA2427817C (en) | 2000-11-03 | 2009-04-14 | Washington University | Estrone-derivatives having cytoprotective activity |
| US20020132802A1 (en) * | 2000-11-17 | 2002-09-19 | Washington Univeristy | Cytoprotective polycyclic compounds |
| DK1365768T3 (da) * | 2001-02-27 | 2008-08-18 | Bayer Schering Pharma Ag | Anvendelse af ER-beta-selektive antagonister som contraception. |
| DE10151365A1 (de) | 2001-10-17 | 2003-04-30 | Schering Ag | 17-Chlor-D-Homosteroide als selektive Estrogenrezeptorantagonisten |
| DK1390040T3 (da) | 2001-05-18 | 2007-04-23 | Pantarhei Bioscience Bv | Farmaceutisk præparat til anvendelse i hormonerstatningsterapi |
| DE60223795T2 (de) | 2001-05-23 | 2008-11-27 | Pantarhei Bioscience B.V. | Tetrahydroxyliertes Östrogen enthaltendes Arzneistoffverabreichungssystem zur Verwendung in der hormonalen Kontrazeption |
| US7871995B2 (en) | 2001-05-23 | 2011-01-18 | Pantarhei Bioscience B.V. | Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception |
| DE10151363A1 (de) * | 2001-10-17 | 2003-05-08 | Schering Ag | Somatotrope Therapie |
| EP1446128B1 (en) | 2001-11-15 | 2006-12-06 | Pantarhei Bioscience B.V. | Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy |
| EP1358882A1 (en) * | 2002-04-30 | 2003-11-05 | Schering Aktiengesellschaft | Use of estriol sulfamate prodrugs for the treatment of autoimmune diseases |
| EP1511498B1 (en) | 2002-06-11 | 2012-11-21 | Pantarhei Bioscience B.V. | A method of treating human skin and a skin care composition for use in such a method |
| WO2003103684A1 (en) | 2002-06-11 | 2003-12-18 | Pantarhei Bioscience B.V. | Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein |
| SI1526856T1 (sl) | 2002-07-12 | 2008-04-30 | Pantarhei Bioscience Bv | Farmacevtski sestavek, ki obsega estetrolne derivate za uporabo pri zdravljenju raka |
| ATE410170T1 (de) * | 2003-03-27 | 2008-10-15 | Pantarhei Bioscience Bv | Verwendung von estrogenen zur behandlung von männerunfruchtbarkeit |
| DE10317922B4 (de) * | 2003-04-17 | 2009-11-26 | Presearch Gmbh | Verwendung eines Kombinationspräparates aus oralem Kontrazeptivum und Calcium/Vitamin D |
| US8236785B2 (en) | 2007-01-08 | 2012-08-07 | Pantarhei Bioscience B.V. | Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method |
| ES2310968B1 (es) * | 2007-06-25 | 2010-02-08 | Italfarmaco, S.A. | Uso de estriol en bajas dosis. |
| CA2729635A1 (en) * | 2008-07-03 | 2010-01-07 | Ananth Srinivasan | Compounds and processes for production of radiopharmaceuticals |
| BR112014005373B1 (pt) | 2011-09-08 | 2022-04-19 | Sage Therapeutics, Inc | Compostos esteróides neuroativos, composições e usos destes |
| IL280068B1 (en) | 2013-03-13 | 2025-02-01 | Sage Therapeutics Inc | Neuroactivity is modulated at position 24 by hydroxy and alkyl/alkenyl/alkynyl 3beta–hydroxy–cholane and 3beta–hydroxy–chol–5–ene derivatives |
| JP6628745B2 (ja) | 2014-06-18 | 2020-01-15 | セージ セラピューティクス， インコーポレイテッド | オキシステロールおよびその使用方法 |
| CN104926916B (zh) * | 2015-06-05 | 2016-08-24 | 郑祖兰 | 甾体化合物，含其药物组合物及其制备方法和应用 |
| PT3436022T (pt) | 2016-04-01 | 2022-07-04 | Sage Therapeutics Inc | Oxisteróis e métodos de utilização dos mesmos |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| TWI752976B (zh) | 2016-07-07 | 2022-01-21 | 美商賽吉醫療公司 | 氧固醇(oxysterol)及其使用方法 |
| PT3519422T (pt) | 2016-09-30 | 2022-12-05 | Sage Therapeutics Inc | Oxisteróis substituídos em c7 e métodos como moduladores nmda |
| EP4105223A1 (en) | 2016-10-18 | 2022-12-21 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| EP4034618A1 (en) | 2019-09-27 | 2022-08-03 | Basf Se | Process for the purification of phytosterol |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1453212A (fr) * | 1963-06-05 | 1966-06-03 | Roussel Uclaf | Dérivés stéroïdes et procédé de préparation |
| GB1103871A (en) * | 1964-03-11 | 1968-02-21 | Emi Ltd | Improvements relating to magnetic matrix stores |
| FR1509931A (fr) * | 1966-04-29 | 1968-01-19 | Roussel Uclaf | Procédé de préparation de composés cétoniques optiquement actifs et produits enrésultant |
| DD235394A3 (de) * | 1968-08-30 | 1986-05-07 | Barnikol Oettler Kurt | Verfahren zur herstellung von oestradiol-3-methylaether |
| CA942670A (en) * | 1969-07-28 | 1974-02-26 | Richard A. Edgren | Contraceptive compositions |
| ZA81348B (en) * | 1980-01-30 | 1982-02-24 | Akzo Nv | Novel 17-amino-16-hydroxy steroids of the androstane and oestrane series and derivatives thereof,processes for their preparation and pharmaceutical compositions |
| US4330540A (en) * | 1981-01-29 | 1982-05-18 | Akzo N.V. | Ent-16-amino-17-hydroxy-oestra-1,3,5(10)-trienes and derivatives thereof, and pharmaceutical compositions |
| EP0069424B1 (en) * | 1981-07-07 | 1985-05-29 | Akzo N.V. | Process for the selective reduction of a 14, 17-dioxo-8,4-seco-steroid |
| FR2717690B1 (fr) * | 1994-03-24 | 1996-04-26 | Roussel Uclaf | Application de stéroïdes aromatiques 3 substitués par un aminoalcoxy substitué à l'obtention d'un médicament pour contrôler la stérilité, notamment masculine. |
| FR2718138B1 (fr) * | 1994-04-01 | 1996-04-26 | Roussel Uclaf | Nouveaux stéroïdes comportant en position 20 une chaîne aminosubstituée, procédé et intermédiaires de préparation, application comme médicaments et compositions pharmaceutiques les renfermant. |
-
1999
- 1999-04-15 DE DE19917930A patent/DE19917930A1/de not_active Withdrawn
-
2000
- 2000-04-14 AR ARP000101739A patent/AR023497A1/es not_active Application Discontinuation
- 2000-04-14 PE PE2000000346A patent/PE20010042A1/es not_active Application Discontinuation
- 2000-04-14 CO CO00027851A patent/CO5180552A1/es not_active Application Discontinuation
- 2000-04-17 DE DE60025817T patent/DE60025817T2/de not_active Expired - Fee Related
- 2000-04-17 EP EP00925219A patent/EP1169336B1/en not_active Expired - Lifetime
- 2000-04-17 AU AU44011/00A patent/AU4401100A/en not_active Abandoned
- 2000-04-17 WO PCT/EP2000/003470 patent/WO2000063228A1/en active IP Right Grant
- 2000-04-17 JP JP2000612318A patent/JP2002542255A/ja active Pending
- 2000-04-17 ES ES00925219T patent/ES2258005T3/es not_active Expired - Lifetime
- 2000-04-17 AT AT00925219T patent/ATE316978T1/de not_active IP Right Cessation
- 2000-04-17 CA CA002371972A patent/CA2371972A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2258005T3 (es) | 2006-08-16 |
| DE19917930A1 (de) | 2000-10-19 |
| AU4401100A (en) | 2000-11-02 |
| ATE316978T1 (de) | 2006-02-15 |
| CO5180552A1 (es) | 2002-07-30 |
| AR023497A1 (es) | 2002-09-04 |
| DE60025817D1 (de) | 2006-04-13 |
| EP1169336B1 (en) | 2006-02-01 |
| EP1169336A1 (en) | 2002-01-09 |
| WO2000063228A1 (en) | 2000-10-26 |
| DE60025817T2 (de) | 2006-11-02 |
| JP2002542255A (ja) | 2002-12-10 |
| PE20010042A1 (es) | 2001-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |