BRPI0822069A2 - Extraro de cardo leiteiro, método para preparação, e uso. - Google Patents

Extraro de cardo leiteiro, método para preparação, e uso.

Info

Publication number: BRPI0822069A2
Authority: BR; Brazil
Prior art keywords: preparation; milk thistle; thistle extract; extract; milk
Prior art date: 2007-12-23

Application number

BRPI0822069-7A

Other languages

English (en)

Inventor

Astrid Nagell

Jaime Xiol Aguirre

Santiago Rull Procus

Original Assignee

Euromed Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-23

Filing date

2008-12-23

Publication date

2015-06-23

2008-12-23 Application filed by Euromed Sa filed Critical Euromed Sa

2015-06-23 Publication of BRPI0822069A2 publication Critical patent/BRPI0822069A2/pt

2019-10-08 Publication of BRPI0822069B1 publication Critical patent/BRPI0822069B1/pt

2021-05-25 Publication of BRPI0822069B8 publication Critical patent/BRPI0822069B8/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Natural Medicines & Medicinal Plants (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Botany (AREA)
Microbiology (AREA)
Mycology (AREA)
Medical Informatics (AREA)
Biotechnology (AREA)
Alternative & Traditional Medicine (AREA)
Virology (AREA)
Gastroenterology & Hepatology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BRPI0822069A 2007-12-23 2008-12-23 método para preparação de um extrato de fruta de cardo leiteiro BRPI0822069B8 (pt)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
DE102007063115		2007-12-23
DE102007063115.6		2007-12-23
DE102008039271.5		2008-08-23
DE102008039271A DE102008039271A1 (de)	2007-12-23	2008-08-23	Neuer Mariendistelextrakt, Verfahren zur Herstellung und Verwendung
PCT/DE2008/002117 WO2009080006A2 (de)	2007-12-23	2008-12-23	Neuer mariendistelextrakt, verfahren zur herstellung und verwendung

Publications (3)

Publication Number	Publication Date
BRPI0822069A2 true BRPI0822069A2 (pt)	2015-06-23
BRPI0822069B1 BRPI0822069B1 (pt)	2019-10-08
BRPI0822069B8 BRPI0822069B8 (pt)	2021-05-25

Family

ID=40690102

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0822069A BRPI0822069B8 (pt)	2007-12-23	2008-12-23	método para preparação de um extrato de fruta de cardo leiteiro

Country Status (20)

Country	Link
US (1)	US20110027396A1 (pt)
EP (2)	EP2567703A3 (pt)
JP (2)	JP5442632B2 (pt)
KR (2)	KR101541938B1 (pt)
CN (2)	CN104189043A (pt)
AU (1)	AU2008340922B2 (pt)
BR (1)	BRPI0822069B8 (pt)
CA (2)	CA2709947C (pt)
CY (1)	CY1115081T1 (pt)
DE (1)	DE102008039271A1 (pt)
DK (1)	DK2222320T3 (pt)
ES (1)	ES2438003T3 (pt)
HK (1)	HK1203352A1 (pt)
HR (1)	HRP20131165T1 (pt)
MX (1)	MX2010006982A (pt)
PL (1)	PL2222320T3 (pt)
PT (1)	PT2222320E (pt)
RU (1)	RU2489161C2 (pt)
SI (1)	SI2222320T1 (pt)
WO (1)	WO2009080006A2 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK2430017T3 (en) *	2009-05-14	2016-10-03	Madaus Gmbh	PROCESS FOR THE PREPARATION OF AMORPHOUS silibinin.
CN102225085B (zh) *	2011-06-20	2012-09-05	黑龙江大学	一种从水飞蓟秸秆中提取水飞蓟总黄酮的方法
KR101316806B1 (ko) *	2011-08-02	2013-10-10	(주)이뮤노텍	글루타치온과 실리마린을 유효성분으로 함유하는 항산화 및 간보호용 조성물
KR101655396B1 (ko) *	2013-08-06	2016-09-08	에스케이바이오랜드 주식회사	수용성 밀크씨슬 추출물 및 이의 제조방법
JP2015113332A (ja) *	2013-12-16	2015-06-22	花王株式会社	生薬粉体
CN104744447B (zh) *	2013-12-31	2017-12-26	天士力制药集团股份有限公司	水飞蓟宾迷迭香酸酯及其制备方法和用途
CN104651037A (zh) *	2014-01-17	2015-05-27	吴长军	一种亚临界流体萃取水飞蓟籽仁中油脂和蛋白的方法
CN105622594B (zh) *	2016-03-17	2019-05-17	江苏中兴药业有限公司	一种高纯度水飞蓟素的制备方法
ES2706008B8 (es) *	2017-09-22	2021-07-12	Euromed S A	Procedimiento para la preparacion de una composicion a partir del cardo mariano y composicion obtenida
KR102242002B1 (ko)	2019-02-21	2021-04-19	주식회사 노바케이메드	동충하초균사체로 고상발효된 홍삼 추출물을 유효성분으로 함유하는 지방간 질환 예방 또는 치료용 조성물
CN111518090B (zh) *	2020-05-12	2021-08-10	沈阳药科大学	黄烷黄酮衍生物及其制备方法和用途
KR102669644B1 (ko) *	2023-06-27	2024-05-27	한국자연한방 주식회사	실리마린 생체이용률이 증대된 밀크씨슬 추출물을 포함하는 지방간 개선, 예방 또는 치료용 조성물

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1767666C3 (de)	1968-06-01	1986-07-31	Dr. Madaus & Co, 5000 Koeln	Pharmazeutische Zubereitung gegen Lebererkrankungen
DE1923982C3 (de)	1969-05-10	1978-07-13	Hoechst Ag, 6000 Frankfurt	Flammfestmachen von Polyurethanschaumstoffen
DE2020407A1 (de)	1970-04-27	1971-11-11	Bernhard Dr Janiak	Technisches Verfahren zur Isolierung von Silimarin
FR2181188A5 (en) *	1972-04-20	1973-11-30	Dott Inverni Della Beffa	Polyhydroxyphenylchromones - by solvent extn of non-defatted fruit of Silybum marianum
US4061765A (en) *	1973-01-19	1977-12-06	Dr. Madaus & Co.	Polyhydroxyphenylchromanone salts and therapeutic composition
DD112261A1 (pt) *	1974-06-18	1975-04-05
DE2914330A1 (de) *	1979-04-09	1980-10-30	Madaus & Co Dr	Verfahren zur gewinnung von silymarin aus pflanzen
CH646695A5 (en) *	1980-10-06	1984-12-14	Madaus & Co Dr	Method of obtaining silymarin from plants
DE3225688A1 (de) *	1982-07-09	1984-01-12	Suschnik Matthias Dr	Verfahren zur gewinnung von silymarin aus silybum marianum
IT1241673B (it)	1989-10-09	1994-01-27	Istituto Biochimico Italiano	Complessi di inclusione di silibinina con ciclodestrina, loro preparazione e composizioni farmaceutiche che li contengono.
DE19501266A1 (de)	1995-01-18	1996-07-25	Madaus Ag	Verfahren zur Herstellung von Flavano-Lignan-Zubereitungen mit verbesserter Freisetzung und Resorbierbarkeit danach erhältliche Zubereitungen und deren Verwendung zur Herstellung von Arzneimitteln
KR0161349B1 (ko)	1995-01-20	1998-11-16	무라따 야스따까	압전 자기 조성물
RU2102999C1 (ru) *	1996-07-10	1998-01-27	Куркин Владимир Александрович	Способ получения экстракта расторопши пятнистой
DE19744459A1 (de) *	1997-10-08	1999-04-15	Schwabe Willmar Gmbh & Co	Flavonolignan-Zubereitungen, insbesondere Silymarin-Zubereitungen
IN192343B (pt) *	2000-05-26	2004-04-10	Ranbaxy Lab Ltd
CZ292832B6 (cs) *	2001-08-30	2003-12-17	Ivax Pharmaceuticals S.R.O.	Způsob přípravy silymarinu se zvýšenou rozpustností
JP2003135023A (ja)	2001-10-30	2003-05-13	Os Kogyo Kk	健康食品
US7238373B2 (en) *	2003-04-04	2007-07-03	Nutritox Llc	Nutritional supplement

2008
- 2008-08-23 DE DE102008039271A patent/DE102008039271A1/de not_active Withdrawn
- 2008-12-23 WO PCT/DE2008/002117 patent/WO2009080006A2/de active Application Filing
- 2008-12-23 EP EP12195762A patent/EP2567703A3/de not_active Withdrawn
- 2008-12-23 DK DK08865199.7T patent/DK2222320T3/da active
- 2008-12-23 CA CA2709947A patent/CA2709947C/en active Active
- 2008-12-23 CN CN201410378585.0A patent/CN104189043A/zh active Pending
- 2008-12-23 BR BRPI0822069A patent/BRPI0822069B8/pt active IP Right Grant
- 2008-12-23 US US12/810,178 patent/US20110027396A1/en not_active Abandoned
- 2008-12-23 KR KR1020107015846A patent/KR101541938B1/ko active Active
- 2008-12-23 MX MX2010006982A patent/MX2010006982A/es active IP Right Grant
- 2008-12-23 PT PT88651997T patent/PT2222320E/pt unknown
- 2008-12-23 CN CN2008801254794A patent/CN101925360A/zh active Pending
- 2008-12-23 HR HRP20131165AT patent/HRP20131165T1/hr unknown
- 2008-12-23 AU AU2008340922A patent/AU2008340922B2/en active Active
- 2008-12-23 RU RU2010130855/15A patent/RU2489161C2/ru active
- 2008-12-23 KR KR1020157006607A patent/KR101607445B1/ko active Active
- 2008-12-23 EP EP08865199.7A patent/EP2222320B1/de active Active
- 2008-12-23 CA CA2922846A patent/CA2922846A1/en not_active Abandoned
- 2008-12-23 PL PL08865199T patent/PL2222320T3/pl unknown
- 2008-12-23 SI SI200831118T patent/SI2222320T1/sl unknown
- 2008-12-23 JP JP2010538335A patent/JP5442632B2/ja active Active
- 2008-12-23 ES ES08865199.7T patent/ES2438003T3/es active Active
2011
- 2011-01-26 HK HK15103460.8A patent/HK1203352A1/xx unknown
2013
- 2013-12-13 CY CY20131101145T patent/CY1115081T1/el unknown
- 2013-12-18 JP JP2013260758A patent/JP2014074051A/ja active Pending

Also Published As

Publication number	Publication date
RU2010130855A (ru)	2012-01-27
WO2009080006A2 (de)	2009-07-02
DK2222320T3 (da)	2013-12-16
MX2010006982A (es)	2010-12-06
BRPI0822069B8 (pt)	2021-05-25
CA2709947C (en)	2016-05-17
BRPI0822069B1 (pt)	2019-10-08
DE102008039271A1 (de)	2009-06-25
HK1203352A1 (en)	2015-10-30
PT2222320E (pt)	2013-12-23
WO2009080006A3 (de)	2009-10-08
EP2222320B1 (de)	2013-09-18
AU2008340922A1 (en)	2009-07-02
EP2567703A2 (de)	2013-03-13
RU2489161C2 (ru)	2013-08-10
AU2008340922B2 (en)	2012-07-19
JP5442632B2 (ja)	2014-03-12
CA2709947A1 (en)	2009-07-02
CN104189043A (zh)	2014-12-10
KR20150038663A (ko)	2015-04-08
SI2222320T1 (sl)	2014-01-31
KR20100126272A (ko)	2010-12-01
EP2567703A3 (de)	2013-03-20
EP2222320A2 (de)	2010-09-01
HRP20131165T1 (hr)	2014-01-03
PL2222320T3 (pl)	2014-02-28
CY1115081T1 (el)	2016-12-14
JP2014074051A (ja)	2014-04-24
CA2922846A1 (en)	2009-07-02
JP2011507812A (ja)	2011-03-10
KR101541938B1 (ko)	2015-08-04
US20110027396A1 (en)	2011-02-03
KR101607445B1 (ko)	2016-03-29
CN101925360A (zh)	2010-12-22
ES2438003T3 (es)	2014-01-15

Publication	Publication Date	Title
BRPI0822069A2 (pt)	2015-06-23	Extraro de cardo leiteiro, método para preparação, e uso.
BRPI1010775A2 (pt)	2016-03-22	composição, método para preparar uma composição, e, uso de uma composição.
MX325514B (es)	2014-11-21	Metodo para elaborar cetales y acetales.
BRPI0925314A2 (pt)	2015-07-21	Sistema e método para preparar uma quantidade predeterminada de bebida, cápsula, e, uso de uma cápsula.
BRPI0925331A2 (pt)	2015-07-21	"sistema e método para preparar uma quantidade predeterminada de bebida, cápsula, e, uso de uma cápsula."
BRPI0813237A2 (pt)	2014-12-23	Composto, método para preparar o composto, composição, medicamento, e, uso do composto.
BRPI0819127A2 (pt)	2015-05-05	Método para cimentar.
BRPI0905910A2 (pt)	2015-06-23	Método para fabricar materiais mesoporosos, materiais assim produzidos e uso de materiais mesoporosos.
BRPI0910399A2 (pt)	2015-10-06	aparelho para preparar alimento.
BRPI0816318A2 (pt)	2015-03-24	Dispositivo de liberação transdérmica, e, método para preparar o mesmo
BRPI1007266A2 (pt)	2016-02-10	aparelhos e métodos para separação, e para separação e transferência de pastilha.
BRPI1008740A2 (pt)	2015-09-01	Proteínas pesticidas e métodos para seu uso.
BRPI0819085A2 (pt)	2015-04-22	Sistema para uso com produção de hidrocarbonetos, e, método associado com produção de hidrocarbonetos
BRPI0914918A2 (pt)	2015-10-20	forma de dosagem farmacêutica, e, método para preparar uma forma de dosagem sólida.
BRPI0808032A2 (pt)	2014-06-17	Processos para preparar hidroxipivalinaldeído e para preparar neopentil glicol.
BRPI1014700A2 (pt)	2016-04-12	composição de revestimento e método para a fabricação e uso da mesma.
BRPI0816349A2 (pt)	2018-07-31	sistema, sistema para uso em um poço, e método
BRPI0823030A2 (pt)	2015-07-28	Sistema de elevador, e, método para fazer um sistema de elevador.
BRPI0920446A2 (pt)	2015-12-22	método para fabricar um extrato de fruta da família solanaceae, e, extrato de fruta
BRPI1014035A2 (pt)	2016-04-12	método para contracepção.
BRPI0718974A2 (pt)	2014-02-25	Copolímero, e, método para preparar um copolímero
BRPI0818483A2 (pt)	2015-04-14	Método para preparar uma composição farmacêutica, composição farmacêutica, e, uso da mesma.
BRPI0812096A2 (pt)	2014-11-25	Máquina para pegar e armazenar preendedores de trilho de uma linha férrea, e método.
BRPI0808813A2 (pt)	2016-08-02	método para a preparação de compostos de borracha, e, uso de compostos
BRPI1010617A2 (pt)	2016-03-15	uso de uma composição, composição, uso não médico da composição, e, método para preprar uma composição.

Legal Events

Date	Code	Title	Description
2017-03-01	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2017-07-04	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-07-31	B07E	Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
2018-10-09	B06T	Formal requirements before examination [chapter 6.20 patent gazette]
2019-04-16	B06A	Patent application procedure suspended [chapter 6.1 patent gazette]
2019-08-20	B09A	Decision: intention to grant [chapter 9.1 patent gazette]
2019-10-08	B16A	Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]	Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS. (CO) 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/10/2019, OBSERVADAS AS CONDICOES LEGAIS
2021-05-25	B16C	Correction of notification of the grant [chapter 16.3 patent gazette]	Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 23/12/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF
2025-06-17	B25A	Requested transfer of rights approved	Owner name: MADAUS GMBH (DE)