BRPI0716762A2 - melhorias da cultura celular - Google Patents
melhorias da cultura celularInfo
- Publication number
- BRPI0716762A2 BRPI0716762A2 BRPI0716762-8A2A BRPI0716762A BRPI0716762A2 BR PI0716762 A2 BRPI0716762 A2 BR PI0716762A2 BR PI0716762 A BRPI0716762 A BR PI0716762A BR PI0716762 A2 BRPI0716762 A2 BR PI0716762A2
- Authority
- BR
- Brazil
- Prior art keywords
- cell culture
- culture improvements
- cell
- culture
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0037—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0031—Serum-free culture media
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
- C12N2500/24—Iron; Fe chelators; Transferrin
- C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/38—Vitamins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/50—Soluble polymers, e.g. polyethyleneglycol [PEG]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/60—Buffer, e.g. pH regulation, osmotic pressure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/74—Undefined extracts from fungi, e.g. yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/76—Undefined extracts from plants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/33—Insulin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84515806P | 2006-09-13 | 2006-09-13 | |
US87637406P | 2006-12-21 | 2006-12-21 | |
PCT/US2007/020027 WO2008033517A2 (en) | 2006-09-13 | 2007-09-13 | Cell culture improvements |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0716762A2 true BRPI0716762A2 (pt) | 2013-09-24 |
Family
ID=39184386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0716762-8A2A BRPI0716762A2 (pt) | 2006-09-13 | 2007-09-13 | melhorias da cultura celular |
Country Status (17)
Country | Link |
---|---|
US (11) | US8093045B2 (pt) |
EP (4) | EP2532737A3 (pt) |
JP (3) | JP5878682B2 (pt) |
KR (2) | KR20090074040A (pt) |
CN (6) | CN103276033A (pt) |
AU (1) | AU2007294731B2 (pt) |
BR (1) | BRPI0716762A2 (pt) |
CA (5) | CA2663442A1 (pt) |
IL (1) | IL197444A0 (pt) |
MX (4) | MX2009002748A (pt) |
MY (4) | MY185887A (pt) |
NO (1) | NO20091439L (pt) |
NZ (2) | NZ597334A (pt) |
RU (2) | RU2518289C2 (pt) |
SG (3) | SG10201510384UA (pt) |
TW (4) | TWI548747B (pt) |
WO (1) | WO2008033517A2 (pt) |
Families Citing this family (146)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
CN103275221B (zh) * | 1996-02-09 | 2016-08-17 | 艾伯维生物技术有限公司 | 结合人TNFα的人抗体 |
NZ563452A (en) * | 2002-07-19 | 2010-04-30 | Abbott Biotech Ltd | Treatment of TNFalpha related disorders |
US20090280065A1 (en) * | 2006-04-10 | 2009-11-12 | Willian Mary K | Uses and Compositions for Treatment of Psoriasis |
US20040033228A1 (en) | 2002-08-16 | 2004-02-19 | Hans-Juergen Krause | Formulation of human antibodies for treating TNF-alpha associated disorders |
MY150740A (en) * | 2002-10-24 | 2014-02-28 | Abbvie Biotechnology Ltd | Low dose methods for treating disorders in which tnf? activity is detrimental |
TWI556829B (zh) | 2004-04-09 | 2016-11-11 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
WO2006041970A2 (en) * | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
EP2500037A3 (en) | 2005-05-16 | 2012-10-24 | Abbott Biotechnology Ltd | Use of TNF alpha inhibitor for treatment of erosive polyarthritis |
EP1948235B1 (en) * | 2005-11-01 | 2013-08-28 | AbbVie Biotechnology Ltd | Methods for determining efficacy of adalimumab in subjects having ankylosing spondylitis using ctx-ii and mmp3 as biomarkers |
EP2738178A1 (en) | 2006-04-05 | 2014-06-04 | AbbVie Biotechnology Ltd | Antibody purification |
US20080118496A1 (en) * | 2006-04-10 | 2008-05-22 | Medich John R | Uses and compositions for treatment of juvenile rheumatoid arthritis |
WO2007120656A2 (en) * | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of rheumatoid arthritis |
WO2007120626A2 (en) | 2006-04-10 | 2007-10-25 | Abbott Biotechnology Ltd. | Uses and compositions for treatment of ankylosing spondylitis |
US9605064B2 (en) * | 2006-04-10 | 2017-03-28 | Abbvie Biotechnology Ltd | Methods and compositions for treatment of skin disorders |
US20090317399A1 (en) * | 2006-04-10 | 2009-12-24 | Pollack Paul F | Uses and compositions for treatment of CROHN'S disease |
EP2666472A3 (en) | 2006-04-10 | 2014-04-02 | Abbott Biotechnology Ltd | Uses and compositions for treatment of psoriatic arthritis |
US20080131374A1 (en) * | 2006-04-19 | 2008-06-05 | Medich John R | Uses and compositions for treatment of rheumatoid arthritis |
US20080311043A1 (en) * | 2006-06-08 | 2008-12-18 | Hoffman Rebecca S | Uses and compositions for treatment of psoriatic arthritis |
US20100021451A1 (en) * | 2006-06-08 | 2010-01-28 | Wong Robert L | Uses and compositions for treatment of ankylosing spondylitis |
WO2008005315A2 (en) | 2006-06-30 | 2008-01-10 | Abbott Biotechnology Ltd. | Automatic injection device |
RU2518289C2 (ru) | 2006-09-13 | 2014-06-10 | Эббви Инк, | Способ получения антитела или его фрагмента с подпиткой (варианты) |
BRPI0717335A2 (pt) | 2006-10-27 | 2013-12-10 | Abbott Biotech Ltd | Anticorpos anti-htnfalfa cristalinos |
EP2137655B1 (en) * | 2007-04-16 | 2012-07-11 | Momenta Pharmaceuticals, Inc. | Defined glycoprotein products and related methods |
US20110137012A1 (en) * | 2007-04-26 | 2011-06-09 | Chugai Seiyaku Kabushiki Kaisha | Cell culture method using amino acid-enriched medium |
US8092998B2 (en) * | 2007-05-31 | 2012-01-10 | Abbott Laboratories | Biomarkers predictive of the responsiveness to TNFα inhibitors in autoimmune disorders |
EP2171451A4 (en) | 2007-06-11 | 2011-12-07 | Abbott Biotech Ltd | METHOD FOR TREATING JUVENILIAN IDIOPATHIC ARTHRITIS |
KR102055873B1 (ko) | 2007-07-09 | 2019-12-13 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
CA2693771A1 (en) * | 2007-07-13 | 2009-01-22 | Abbott Biotechnology Ltd. | Methods and compositions for pulmonary administration of a tnf.alpha. inhibitor |
SG183709A1 (en) | 2007-08-08 | 2012-09-27 | Abbott Lab | Compositions and methods for crystallizing antibodies |
US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
US8883146B2 (en) | 2007-11-30 | 2014-11-11 | Abbvie Inc. | Protein formulations and methods of making same |
US8415094B2 (en) * | 2007-12-21 | 2013-04-09 | Jaffar Ali bin M. Abdullah | Protein-free gamete and embryo handling and culture media products |
EP2235059B1 (en) | 2007-12-26 | 2015-02-18 | Xencor, Inc. | Fc variants with altered binding to fcrn |
MX2010007393A (es) * | 2008-01-03 | 2010-11-09 | Abbott Biotech Ltd | Anticipacion de eficacia a largo plazo de un compuesto en el tratamiento de psoriasis. |
DK2250251T3 (en) | 2008-01-09 | 2018-01-22 | Sartorius Stedim Cellca Gmbh | Improved culture medium additive and method of using it |
JP6078217B2 (ja) | 2008-01-15 | 2017-02-08 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | 粉末化されたタンパク質組成物及びその作製方法 |
EP2331700A2 (en) | 2008-08-08 | 2011-06-15 | Biogen Idec MA Inc. | Nutrient monitoring and feedback control for increased bioproduct production |
JP4883067B2 (ja) | 2008-09-29 | 2012-02-22 | 株式会社日立プラントテクノロジー | 培養装置及び培養方法 |
CN102257006A (zh) * | 2008-10-20 | 2011-11-23 | 雅培制药有限公司 | 使用a蛋白亲和层析分离和纯化抗体 |
HUE036415T2 (hu) | 2008-12-30 | 2018-07-30 | Baxalta GmbH | Eljárás sejtnövekedés fokozására alkilamin-n-oxid (AANOx) alkalmazásával |
US8636704B2 (en) | 2009-04-29 | 2014-01-28 | Abbvie Biotechnology Ltd | Automatic injection device |
US11224218B2 (en) * | 2009-05-07 | 2022-01-18 | Hemarina | Heamoglobin and uses thereof |
EP2435556B1 (en) | 2009-05-28 | 2016-05-25 | Boehringer Ingelheim International GmbH | Method for a rational cell culturing process |
US20120135464A1 (en) * | 2009-07-24 | 2012-05-31 | Alexander Alisch | Stirrer system |
CN104059955A (zh) | 2009-08-11 | 2014-09-24 | 弗·哈夫曼-拉罗切有限公司 | 在无谷氨酰胺的细胞培养基中的蛋白质生产 |
NZ627052A (en) | 2009-12-15 | 2015-12-24 | Abbvie Biotechnology Ltd | Improved firing button for automatic injection device |
WO2011127322A1 (en) * | 2010-04-07 | 2011-10-13 | Momenta Pharmaceuticals, Inc. | High mannose glycans |
US20110262965A1 (en) * | 2010-04-23 | 2011-10-27 | Life Technologies Corporation | Cell culture medium comprising small peptides |
SG185014A1 (en) * | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell cultivation process |
PL2575884T3 (pl) | 2010-06-03 | 2018-12-31 | Abbvie Biotechnology Ltd | Zastosowania i kompozycje do leczenia ropni mnogich pach (HS) |
CA2804275A1 (en) * | 2010-07-08 | 2012-01-12 | Baxter International Inc. | Method of producing recombinant adamts13 in cell culture |
EP2611904A2 (en) * | 2010-08-31 | 2013-07-10 | Friesland Brands B.V. | Culture medium for eukaryotic cells |
US8821865B2 (en) | 2010-11-11 | 2014-09-02 | Abbvie Biotechnology Ltd. | High concentration anti-TNFα antibody liquid formulations |
BR112013018905B1 (pt) | 2011-01-24 | 2021-07-13 | Abbvie Biotechnology Ltd | Dispositivos de injeção automática que têm superfícies de pega sobremoldadas. |
WO2012110435A1 (en) * | 2011-02-14 | 2012-08-23 | Basf Se | Bio process additives |
EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
CN103890166A (zh) * | 2011-10-21 | 2014-06-25 | 辉瑞公司 | 添加铁改善细胞培养 |
US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
US20130281355A1 (en) * | 2012-04-24 | 2013-10-24 | Genentech, Inc. | Cell culture compositions and methods for polypeptide production |
EP2844737B1 (en) | 2012-05-02 | 2018-03-21 | Life Technologies Corporation | High yield transient expression in mammalian cells using unique pairing of high density growth and transfection medium and expression enhancers |
US9249182B2 (en) | 2012-05-24 | 2016-02-02 | Abbvie, Inc. | Purification of antibodies using hydrophobic interaction chromatography |
US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
AU2013309506A1 (en) | 2012-09-02 | 2015-03-12 | Abbvie Inc. | Methods to control protein heterogeneity |
AR093460A1 (es) * | 2012-11-14 | 2015-06-10 | Merck Patent Ges Mit Beschränkter Haftung | Medios de cultivo celular |
US10717965B2 (en) | 2013-01-10 | 2020-07-21 | Gloriana Therapeutics, Inc. | Mammalian cell culture-produced neublastin antibodies |
US20150353542A1 (en) * | 2013-01-14 | 2015-12-10 | Amgen Inc. | Methods of using cell-cycle inhibitors to modulate one or more properties of a cell culture |
WO2014143205A1 (en) * | 2013-03-12 | 2014-09-18 | Abbvie Inc. | Human antibodies that bind human tnf-alpha and methods of preparing the same |
WO2014159831A1 (en) | 2013-03-13 | 2014-10-02 | Merck Sharp & Dohme Corp. | Adapted lepidopteran insect cells for the production of recombinant proteins |
US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
US8921526B2 (en) | 2013-03-14 | 2014-12-30 | Abbvie, Inc. | Mutated anti-TNFα antibodies and methods of their use |
EP2970375A1 (en) | 2013-03-14 | 2016-01-20 | AbbVie Inc. | Low acidic species compositions and methods for producing the same using displacement chromatography |
US20140271633A1 (en) * | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Mammalian cell culture performance through surfactant supplementation of feed media |
US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
KR20150129033A (ko) | 2013-03-14 | 2015-11-18 | 애브비 인코포레이티드 | 저 산성 종 조성물 및 이의 제조 및 사용 방법 |
WO2015051293A2 (en) * | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
KR20160068000A (ko) * | 2013-10-14 | 2016-06-14 | 아레스 트레이딩 에스.아. | 포유동물의 고성능 유가식 배양을 위한 신규 배지 |
JP6526025B2 (ja) | 2013-10-16 | 2019-06-05 | オンコバイオロジクス,インコーポレイティド | 抗体安定性を増強する緩衝液製剤 |
US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
JP2017500017A (ja) * | 2013-12-20 | 2017-01-05 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | 生物薬剤フェドバッチ生産能力及び生産物品質を改善するための灌流シード培養の使用 |
EP2923707A1 (en) | 2014-03-28 | 2015-09-30 | Hemarina | Blood substitute with respiratory pigment |
PE20161326A1 (es) | 2014-04-10 | 2016-12-11 | Bayer Healthcare Llc | Formulacion en polvo de medio de compuesto y metodo de preparacion de medio liquido para cultivo celular |
KR101699761B1 (ko) * | 2014-05-23 | 2017-01-25 | 주식회사 비비에이치씨 | 플로로탄닌 분획물을 이용한 중간엽 줄기세포로부터 유도만능 줄기세포를 제조하는 방법 |
FI3926051T3 (fi) | 2014-06-04 | 2024-06-18 | Amgen Inc | Menetelmiä nisäkässoluviljelmien keräämiseksi |
CA2952241A1 (en) * | 2014-06-18 | 2015-12-23 | Medimmune, Llc | Cell culture methods and media comprising n-acetylcysteine |
US20170226552A1 (en) | 2014-07-03 | 2017-08-10 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using cobalt |
WO2016007764A1 (en) | 2014-07-09 | 2016-01-14 | Abbvie Inc. | Methods for modulating the glycosylation profile of recombinant proteins using non-commonly used sugars |
US10435464B1 (en) | 2014-09-05 | 2019-10-08 | Coherus Biosciences, Inc. | Methods for making recombinant proteins |
KR102007930B1 (ko) | 2014-12-31 | 2019-08-06 | 주식회사 엘지화학 | 재조합 당단백질의 글리코실화 조절 방법 |
CN105820246A (zh) * | 2015-01-07 | 2016-08-03 | 上海张江生物技术有限公司 | 一种新型重组抗TNFα嵌合单克隆抗体制备方法及用途 |
WO2016118707A1 (en) | 2015-01-21 | 2016-07-28 | Oncobiologics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
SG11201707857VA (en) | 2015-03-30 | 2017-10-30 | Ajinomoto Kk | Chelated iron-containing culture medium for neural stem cells |
CN106190948B (zh) * | 2015-05-07 | 2020-09-25 | 上海津曼特生物科技有限公司 | 一种cho-s细胞半固体培养基及其配制方法与应用 |
CN105018425B (zh) * | 2015-07-09 | 2018-09-28 | 广州白云山拜迪生物医药有限公司 | 一种无动物来源成分的外周血淋巴细胞培养基 |
EP3322813A1 (en) * | 2015-07-13 | 2018-05-23 | Life Technologies Corporation | System and method for improved transient protein expression in cho cells |
CN105441378A (zh) * | 2015-12-22 | 2016-03-30 | 肇庆大华农生物药品有限公司 | 一种培养Vero细胞用的无血清培养基及其制备方法 |
MX2018009341A (es) | 2016-02-03 | 2019-05-15 | Oncobiologics Inc | Formulaciones tamponadas para una mayor estabilidad de anticuerpos. |
SG11201806335RA (en) * | 2016-02-22 | 2018-09-27 | Agency Science Tech & Res | Cell culture medium |
WO2017195789A1 (ja) * | 2016-05-10 | 2017-11-16 | 興人ライフサイエンス株式会社 | 培地用組成物 |
CN105794772A (zh) * | 2016-05-16 | 2016-07-27 | 天津市中奥天元科技发展有限公司 | 一种无血清细胞冻存液 |
WO2018018613A1 (zh) | 2016-07-29 | 2018-02-01 | 广东东阳光药业有限公司 | 一种提高抗体纯度的细胞培养基和培养方法 |
CN106635974B (zh) * | 2016-10-19 | 2020-10-27 | 浙江译美生物科技有限公司 | 一种人脐带间充质干细胞的分离和培养方法 |
EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
ES2926028T3 (es) | 2016-12-23 | 2022-10-21 | Serum Institute Of India Pvt Ltd | Métodos para potenciar la productividad de anticuerpos en cultivos de células de mamíferos y minimizar la agregación durante los procesos de formulación corriente abajo y las formulaciones de anticuerpos estables obtenidas de los mismos |
CN110520538B (zh) * | 2017-03-31 | 2024-02-20 | 勃林格殷格翰国际公司 | 灌注培养基 |
US10280217B2 (en) | 2017-09-19 | 2019-05-07 | American Air Liquide, Inc. | Cell culture additives and their use for increased bioprotein production from cells |
CN107904200B (zh) * | 2017-10-20 | 2018-10-16 | 通化东宝生物科技有限公司 | 一种表达阿达木单抗的联合培养基及其应用 |
SG11202003833TA (en) * | 2017-11-01 | 2020-05-28 | Chugai Pharmaceutical Co Ltd | Antibody variant and isoform with lowered biological activity |
US20210171901A1 (en) * | 2017-11-16 | 2021-06-10 | Life Technologies Corporation | Streamlined methods for making liquid media |
WO2019106097A1 (en) | 2017-11-30 | 2019-06-06 | F.Hoffmann-La Roche Ag | Process for culturing mammalian cells |
EP3492582A1 (en) * | 2017-12-01 | 2019-06-05 | UCB Biopharma SPRL | Cell culture methods |
AU2019236246B2 (en) * | 2018-03-16 | 2025-06-05 | Genzyme Corporation | Methods for improving cell viability in a production bioreactor |
BR112020019559A2 (pt) | 2018-03-26 | 2021-01-12 | Amgen Inc. | Glicoformas afucosiladas totais de anticorpos produzidos em cultura de células |
AU2019274782A1 (en) * | 2018-05-24 | 2020-12-03 | Ares Trading S.A. | Method for controlling the afucosylation level of a glycoprotein composition |
BR112020025623A2 (pt) * | 2018-07-03 | 2021-03-23 | Bristol-Myers Squibb Company | métodos de produção de proteínas recombinantes |
CN112469814A (zh) * | 2018-07-27 | 2021-03-09 | 味之素株式会社 | 动物细胞的悬浮培养用添加物、悬浮培养用培养基和悬浮培养方法 |
CN109337861B (zh) * | 2018-11-12 | 2021-06-25 | 友康恒业生物科技(北京)有限公司 | 一种支持产物高表达的cho细胞无血清培养基 |
CN114008191A (zh) * | 2018-12-21 | 2022-02-01 | 格洛丽亚娜治疗公司 | 哺乳动物细胞培养物产生的神经胚素抗体 |
JOP20200214A1 (ar) | 2019-09-03 | 2021-03-03 | Serum Institute Of India Pvt Ltd | تركيبات مولدة للمناعة ضد الأمراض المعوية وطرق لتحضيرها |
EP4056678A4 (en) * | 2019-11-05 | 2023-12-06 | Ajinomoto Co., Inc. | PROTEIN PRODUCTION PROCESS |
WO2021112926A1 (en) | 2019-12-06 | 2021-06-10 | Regeneron Pharmaceuticals, Inc. | Anti-vegf protein compositions and methods for producing the same |
CN111233996A (zh) * | 2020-01-20 | 2020-06-05 | 北京交通大学 | 一种将丁酸钠用于促进工程细胞株分泌表达rhIL-24的方法 |
CA3173721A1 (en) * | 2020-03-31 | 2021-10-07 | Cell Exosome Therapeutics Inc. | Method of producing proliferated cells, method of producing cell product, mesenchymal stem cell population and method of producing same, culture supernatant of stem cells and method of producing same, and therapeutic agent |
JP7521738B2 (ja) * | 2020-05-18 | 2024-07-24 | キヤノン株式会社 | 目的細胞の生産方法、目的細胞による生産物の生産方法、および無血清培地 |
CN112592948B (zh) * | 2020-12-16 | 2023-05-09 | 广州汉腾生物科技有限公司 | 动物细胞的灌流培养方法 |
WO2022154762A1 (en) * | 2021-01-18 | 2022-07-21 | Turgut İlaçlari A.Ş. | Method of producing adalimumab |
MX2023012193A (es) * | 2021-04-14 | 2023-10-25 | Genzyme Corp | Metodos de cultivo de perfusion de una celula de mamifero. |
KR102817881B1 (ko) * | 2021-11-17 | 2025-06-10 | 주식회사 웰진 | 저혈청 배지 첨가제 및 이의 용도 |
KR102817880B1 (ko) * | 2021-11-17 | 2025-06-10 | 주식회사 웰진 | 무혈청 세포 배양 배지 조성물 및 이의 용도 |
CN114230669B (zh) * | 2021-12-24 | 2024-01-30 | 天士力生物医药股份有限公司 | 一种双特异性抗体的生产方法 |
KR20240154572A (ko) * | 2022-02-21 | 2024-10-25 | 아지노모토 가부시키가이샤 | 관류 배양 방법 |
WO2024096506A1 (ko) * | 2022-10-31 | 2024-05-10 | 삼성바이오에피스 주식회사 | 고농도 액체 배지 제조 방법 |
CN116064374A (zh) * | 2023-02-27 | 2023-05-05 | 内蒙古奥普赛生物科技有限公司 | 一种即用型无菌mem液体培养基的制备方法及其产品 |
KR20240177497A (ko) * | 2023-06-20 | 2024-12-27 | (주)엑셀세라퓨틱스 | 세포 특성 맞춤형 배지 조성 설계 플랫폼 |
WO2025128951A1 (en) * | 2023-12-14 | 2025-06-19 | Nutrition & Biosciences Usa 1, Llc | Cell culture media containing cellulose derivatives and associated method |
WO2025128949A1 (en) * | 2023-12-14 | 2025-06-19 | Nutrition & Biosciences Usa 1, Llc | Protective effect of polysaccharides on cell cultures containing anti-foam agents |
WO2025128947A1 (en) * | 2023-12-14 | 2025-06-19 | Nutrition & Biosciences Usa 1, Llc | Combinations of polysaccharides and polyether surfactants |
WO2025128955A1 (en) * | 2023-12-14 | 2025-06-19 | Nutrition & Biosciences Usa 1, Llc | Effects of differing viscosity-grade cellulose derivatives on cellular growth |
Family Cites Families (217)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
US5681718A (en) | 1986-03-14 | 1997-10-28 | Celltech Limited | Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US5045468A (en) | 1986-12-12 | 1991-09-03 | Cell Enterprises, Inc. | Protein-free culture medium which promotes hybridoma growth |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
US6048728A (en) | 1988-09-23 | 2000-04-11 | Chiron Corporation | Cell culture medium for enhanced cell growth, culture longevity, and product expression |
WO1990005183A1 (en) | 1988-10-31 | 1990-05-17 | Immunex Corporation | Interleukin-4 receptors |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US6498237B2 (en) | 1989-08-07 | 2002-12-24 | Peptech Limited | Tumor necrosis factor antibodies |
US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
US5110913A (en) | 1990-05-25 | 1992-05-05 | Miles Inc. | Antibody purification method |
WO1991018982A1 (en) | 1990-06-05 | 1991-12-12 | Immunex Corporation | Type ii interleukin-1 receptors |
US5096816A (en) | 1990-06-05 | 1992-03-17 | Cetus Corporation | In vitro management of ammonia's effect on glycosylation of cell products through pH control |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
GB9022543D0 (en) | 1990-10-17 | 1990-11-28 | Wellcome Found | Antibody production |
GB9022545D0 (en) * | 1990-10-17 | 1990-11-28 | Wellcome Found | Culture medium |
US6277969B1 (en) | 1991-03-18 | 2001-08-21 | New York University | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US20040120952A1 (en) | 2000-08-07 | 2004-06-24 | Centocor, Inc | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
EP0610201B2 (en) | 1991-03-18 | 2007-09-26 | New York University | Monoclonal and chimeric antibodies specific for human tumor necrosis factor |
US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
US20070298040A1 (en) | 1991-03-18 | 2007-12-27 | Centocor, Inc. | Methods of treating seronegative arthropathy with anti-TNF antibodies |
US20060246073A1 (en) | 1991-03-18 | 2006-11-02 | Knight David M | Anti-TNF antibodies and peptides of human tumor necrosis factor |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
KR100255717B1 (ko) | 1991-07-15 | 2000-05-01 | 그레이엄 브레레톤 | 항체의 생산방법 |
ES2227513T5 (es) | 1991-10-25 | 2009-04-01 | Immunex Corporation | Citoquina novedosa. |
EP0666312A1 (en) | 1994-02-08 | 1995-08-09 | Wolfgang A. Renner | Process for the improvement of mammalian cell growth |
US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
US5856179A (en) | 1994-03-10 | 1999-01-05 | Genentech, Inc. | Polypeptide production in animal cell culture |
US5741705A (en) | 1995-02-23 | 1998-04-21 | Quest International Flavors & Food Ingredients Company, Division Of Indopco, Inc. | Method for in vitro cell growth of eucaryotic cells using low molecular weight peptides |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
US6656466B1 (en) | 1995-06-06 | 2003-12-02 | Genetech, Inc. | Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition |
US5705364A (en) | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
AU693713B2 (en) | 1995-06-07 | 1998-07-02 | Immunex Corporation | CD40L mutein |
JP4306813B2 (ja) | 1995-09-19 | 2009-08-05 | アスビオファーマ株式会社 | 動物細胞の新規培養方法 |
US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
AR005035A1 (es) | 1995-12-11 | 1999-04-07 | Merck Patent Ges Mit Beschränkter Haftung | Procedimiento para preparar proteinas recombinantes en e. coli, mediante fermentacion con gran concentracion de celulas. |
CA2241174C (en) | 1996-01-11 | 2006-09-12 | Immunex Corporation | Expression augmenting sequence elements (ease) for eukaryotic expression systems |
CN103275221B (zh) | 1996-02-09 | 2016-08-17 | 艾伯维生物技术有限公司 | 结合人TNFα的人抗体 |
ATE222598T1 (de) | 1996-04-19 | 2002-09-15 | Nestle Sa | Menschliche immortalisierte colon- epithelialzellen |
US20040171152A1 (en) * | 1996-10-10 | 2004-09-02 | Invitrogen Corporation | Animal cell culture media comprising non-animal or plant-derived nutrients |
US6103529A (en) | 1996-10-10 | 2000-08-15 | Life Technologies, Inc. | Animal cell culture media comprising peptides derived from rice |
DK1900751T3 (da) | 1996-11-27 | 2010-04-19 | Genentech Inc | Affinitetsoprensning af et polypeptid på Protein A-matrix |
US20020045207A1 (en) | 1997-10-31 | 2002-04-18 | Lynne A. Krummen | Glycoprotein production process |
WO1999032605A1 (en) | 1997-12-19 | 1999-07-01 | Novo Nordisk A/S | Method for producing heterologous proteins in eukaryotic cells on an industrial scale using nucleotide-manipulating agents |
WO1999057246A1 (en) * | 1998-05-01 | 1999-11-11 | Life Technologies, Inc. | Animal cell culture media comprising non-animal or plant-derived nutrients |
CN1810292A (zh) | 1998-05-06 | 2006-08-02 | 基因技术股份有限公司 | 用离子交换层析纯化蛋白质 |
US6528286B1 (en) | 1998-05-29 | 2003-03-04 | Genentech, Inc. | Mammalian cell culture process for producing glycoproteins |
EP1094114B1 (en) * | 1998-07-01 | 2007-01-03 | Takara Bio Inc. | Gene transfer methods |
US6406909B1 (en) | 1998-07-10 | 2002-06-18 | Chugai Seiyaku Kabushiki Kaisha | Serum-free medium for culturing animal cells |
US6210924B1 (en) | 1998-08-11 | 2001-04-03 | Amgen Inc. | Overexpressing cyclin D 1 in a eukaryotic cell line |
US6914128B1 (en) | 1999-03-25 | 2005-07-05 | Abbott Gmbh & Co. Kg | Human antibodies that bind human IL-12 and methods for producing |
US7883704B2 (en) | 1999-03-25 | 2011-02-08 | Abbott Gmbh & Co. Kg | Methods for inhibiting the activity of the P40 subunit of human IL-12 |
AT409379B (de) | 1999-06-02 | 2002-07-25 | Baxter Ag | Medium zur protein- und serumfreien kultivierung von zellen |
US6190523B1 (en) | 1999-07-20 | 2001-02-20 | Basf Corporation | Electrocoat coating composition and process for electrocoating a substrate |
IL148512A0 (en) | 1999-09-27 | 2002-09-12 | Genentech Inc | Methods for making recombinant proteins using apoptosis inhibitors |
CA2386180C (en) | 1999-10-13 | 2010-03-09 | Immunex Corporation | Vectors and methods for recombinant protein expression |
AR026743A1 (es) | 1999-12-09 | 2003-02-26 | Pharmacia Ab | Produccion de peptidos |
EP1254216B1 (en) | 2000-02-08 | 2006-06-07 | Genentech, Inc. | Improved galactosylation of recombinant glycoproteins |
KR20120011898A (ko) | 2000-02-10 | 2012-02-08 | 아보트 러보러터리즈 | 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법 |
AU2001246846A1 (en) * | 2000-04-06 | 2001-10-23 | Chugai Seiyaku Kabushiki Kaisha | Immunoassay of anti-hm1.24 antibody |
US7598055B2 (en) | 2000-06-28 | 2009-10-06 | Glycofi, Inc. | N-acetylglucosaminyltransferase III expression in lower eukaryotes |
EP1175931A1 (en) | 2000-07-25 | 2002-01-30 | Computer Cell Culture Center S.A. | Integration of high cell density bioreactor operation with ultra fast on-line downstream processing |
UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
US20050249735A1 (en) | 2000-08-07 | 2005-11-10 | Centocor, Inc. | Methods of treating ankylosing spondylitis using anti-TNF antibodies and peptides of human tumor necrosis factor |
US20060018907A1 (en) | 2000-08-07 | 2006-01-26 | Centocor, Inc. | Anti-TNF antibodies and peptides of human tumor necrosis factor |
US7288390B2 (en) | 2000-08-07 | 2007-10-30 | Centocor, Inc. | Anti-dual integrin antibodies, compositions, methods and uses |
AU2001294520A1 (en) | 2000-08-21 | 2002-03-04 | Clonex Development, Inc. | Methods and compositions for increasing protein yield from a cell culture |
US6693173B2 (en) | 2000-12-26 | 2004-02-17 | Alpha Therapeutic Corporation | Method to remove citrate and aluminum from proteins |
US20030096414A1 (en) | 2001-03-27 | 2003-05-22 | Invitrogen Corporation | Culture medium for cell growth and transfection |
EP1401870A4 (en) * | 2001-05-24 | 2006-04-19 | Human Genome Sciences | ANTIBODIES AGAINST TUMOR NECROSIS FACTOR DELTA (APRIL) |
EP1714982B1 (en) | 2001-06-05 | 2009-01-21 | Genetics Institute, LLC | Methods for purifying highly anionic proteins |
JP2004532642A (ja) | 2001-06-13 | 2004-10-28 | ジェネンテック・インコーポレーテッド | 動物細胞の培養方法と動物細胞でのポリペプチド産生 |
WO2003011878A2 (en) | 2001-08-03 | 2003-02-13 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
BR0212780A (pt) | 2001-10-02 | 2004-10-13 | Novo Nordisk Healthcare Ag | Métodos para produzir polipeptìdeos em células eucarióticas, para cultivar células eucarióticas e para colher polipeptìdeos produzidos por células eucarióticas |
EP1443961B1 (en) | 2001-10-25 | 2009-05-06 | Genentech, Inc. | Glycoprotein compositions |
US20050069979A1 (en) | 2001-11-28 | 2005-03-31 | Steffen Zeng | Cell culture process |
AU2002356749A1 (en) | 2001-11-28 | 2003-06-10 | Hermann Katinger | Process for the production of polypeptides in mammalian cell cultures |
AU2002359816B2 (en) | 2001-12-21 | 2006-07-13 | Immunex Corporation | Methods for purifying protein |
US20030201229A1 (en) | 2002-02-04 | 2003-10-30 | Martin Siwak | Process for prefiltration of a protein solution |
ATE417858T1 (de) | 2002-02-05 | 2009-01-15 | Genentech Inc | Proteinaufreinigung |
CA2417689C (en) | 2002-03-05 | 2006-05-09 | F. Hoffmann-La Roche Ag | Improved methods for growing mammalian cells in vitro |
AU2003220529B2 (en) | 2002-03-27 | 2006-09-07 | Immunex Corporation | Methods for increasing polypeptide production |
US20030190710A1 (en) | 2002-03-28 | 2003-10-09 | Devries Ruth L. | Control of glycoforms in IgG |
JPWO2003085118A1 (ja) | 2002-04-09 | 2005-08-11 | 協和醗酵工業株式会社 | 抗体組成物の製造方法 |
US20040029229A1 (en) | 2002-05-20 | 2004-02-12 | Reeves Philip J. | High level protein expression system |
ATE359358T1 (de) | 2002-07-15 | 2007-05-15 | Immunex Corp | Verfahren und medien zur kontrolle der sialysierung von proteinen, die von säugetierzellen produziert werden |
US6974681B1 (en) | 2002-08-23 | 2005-12-13 | Immunex Corporation | Cell culture performance with vanadate |
US7067279B1 (en) | 2002-08-23 | 2006-06-27 | Immunex Corporation | Cell culture performance with betaine |
US6924124B1 (en) | 2002-08-23 | 2005-08-02 | Immunex Corporation | Feeding strategies for cell culture |
US7208585B2 (en) | 2002-09-18 | 2007-04-24 | Genencor International, Inc. | Protein purification |
US6890736B1 (en) * | 2002-09-20 | 2005-05-10 | Immunex Corporation | Methods for producing proteins in cultured cells |
US20040071694A1 (en) | 2002-10-14 | 2004-04-15 | Devries Peter J. | Erythropoietin receptor binding antibodies |
CN101044239B (zh) | 2002-12-23 | 2010-12-08 | 布里斯托尔-迈尔斯斯奎布公司 | 用于蛋白质生产的哺乳动物细胞培养方法 |
PL377603A1 (pl) | 2002-12-23 | 2006-02-06 | Bristol-Myers Squibb Company | Poprawa jakości produktu w hodowlach komórek ssaczych do wytwarzania białka |
AU2004215653B2 (en) | 2003-02-28 | 2011-03-17 | Lonza Biologics Plc. | Antibody purification by protein A and ion exchange chromatography |
US20060104968A1 (en) * | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
PT1623019E (pt) | 2003-05-15 | 2010-07-20 | Wyeth Llc | ALIMENTAÃO COM GLUCOSE DE MODO LIMITADO PARA CULTURA DE CéLULAS ANIMAIS |
PL3095793T3 (pl) | 2003-07-28 | 2020-09-07 | Genentech, Inc. | Redukcja wycieku białka A w trakcie chromatografii powinowactwa z białkiem A |
ATE359359T1 (de) * | 2003-08-08 | 2007-05-15 | Cambridge Antibody Tech | Myeloma zellkultur in einem transferrin-freien medium mit niedrigem eisengehalt |
GB2404665B (en) | 2003-08-08 | 2005-07-06 | Cambridge Antibody Tech | Cell culture |
ES2565077T3 (es) | 2003-10-10 | 2016-03-31 | Novo Nordisk Health Care Ag | Método para producción en gran escala de un polipéptido en células eucariotas |
DK1678208T3 (da) | 2003-10-27 | 2013-07-08 | Wyeth Llc | Fjernelse af aggregater med høj molekylvægt under anvendelse af hydroxyapatitchromatografi |
US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
CA2548940A1 (en) | 2003-12-23 | 2005-07-14 | Applied Research Systems Ars Holding N.V. | Process for the production of tumor necrosis factor-binding proteins |
US8084032B2 (en) | 2004-01-21 | 2011-12-27 | Ajinomoto Co., Inc. | Purification method which prevents denaturation of an antibody |
CN1238498C (zh) * | 2004-02-12 | 2006-01-25 | 陈志南 | 动物细胞无血清悬浮培养工艺过程控制参数的方法 |
WO2005087915A2 (en) | 2004-03-08 | 2005-09-22 | Biovest International, Inc. | Use of ethanolamine for enhancing cell growth in membrane systems |
SE0400886D0 (sv) | 2004-04-02 | 2004-04-02 | Amersham Biosciences Ab | Process of purification |
US20060018902A1 (en) | 2004-04-09 | 2006-01-26 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
US20060127950A1 (en) | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
ES2339953T5 (es) | 2004-05-04 | 2020-05-06 | Novo Nordisk Healthcare Ag | Glicoformas de factor VII ligadas a O y método de fabricación |
US20060001890A1 (en) * | 2004-07-02 | 2006-01-05 | Asml Holding N.V. | Spatial light modulator as source module for DUV wavefront sensor |
US7294484B2 (en) | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
HUE027136T2 (en) | 2004-09-30 | 2016-08-29 | Bayer Healthcare Llc | Tools and procedures for the integrated, continuous production of biological molecules |
US20060094104A1 (en) * | 2004-10-29 | 2006-05-04 | Leopold Grillberger | Animal protein-free media for cultivation of cells |
JP2008518597A (ja) | 2004-10-29 | 2008-06-05 | セントカー・インコーポレーテツド | 化学的規定培地組成物 |
JP2006143601A (ja) | 2004-11-16 | 2006-06-08 | Yamato Yakuhin Kk | 血液粘度低下剤 |
US8530192B2 (en) | 2005-02-11 | 2013-09-10 | Novo Nordisk Healthcare Ag | Production of a polypeptide in a serum-free cell culture liquid containing plant protein hydrolysate |
HUE049797T2 (hu) | 2005-03-11 | 2020-10-28 | Wyeth Llc | Gyenge megoszlási kromatográfiás eljárás |
WO2006113743A2 (en) | 2005-04-18 | 2006-10-26 | Massachusetts Institute Of Technology | Compositions and methods for rna interference with sialidase expression and uses thereof |
US7247457B2 (en) | 2005-04-26 | 2007-07-24 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Detection and identification of enteroviruses by semi-nested amplification of the enterovirus VP1 protein |
AU2006255085A1 (en) | 2005-06-03 | 2006-12-14 | Genentech, Inc. | Method of producing antibodies with modified fucosylation level |
WO2006128764A2 (en) | 2005-06-03 | 2006-12-07 | Biovitrum Ab (Publ) | Process for cultivating animal cells comprising the feeding of plant-derived peptones |
BRPI0611901A2 (pt) | 2005-06-14 | 2012-08-28 | Amgen, Inc | composição, liofilizado, kit, e, processo para preparar uma composição |
KR101247836B1 (ko) | 2005-06-17 | 2013-03-28 | 와이어쓰 엘엘씨 | 항 a 베타 항체의 정제 방법 |
PL1917276T3 (pl) | 2005-08-26 | 2018-08-31 | Ares Trading S.A. | Sposób wytwarzania glikozylowanego interferonu beta |
DE102005046225B4 (de) | 2005-09-28 | 2012-01-05 | Cellca Gmbh | Verbessertes Zellkulturmedium |
AR058140A1 (es) | 2005-10-24 | 2008-01-23 | Wyeth Corp | Metodo de produccion proteica utilizando compuestos anti-senescencia |
EP3026109B1 (en) | 2005-12-08 | 2022-03-09 | Amgen Inc. | Improved production of glycoproteins using manganese |
US20070190057A1 (en) | 2006-01-23 | 2007-08-16 | Jian Wu | Methods for modulating mannose content of recombinant proteins |
WO2007136752A2 (en) | 2006-05-19 | 2007-11-29 | Glycofi, Inc. | Erythropoietin compositions |
WO2009017491A1 (en) | 2006-06-14 | 2009-02-05 | Smithkline Beecham Corporation | Methods for purifying antibodies using ceramic hydroxyapatite |
KR101495549B1 (ko) | 2006-07-13 | 2015-02-25 | 와이어쓰 엘엘씨 | 당단백질의 생산 |
BRPI0716597A2 (pt) | 2006-09-08 | 2013-10-08 | Wyeth Corp | Método para o isolamento de um produto; produto preparado pelo método; método para o isolamento de um anticorpo; método para reduzir a turvação de um eluído compreendendo em produto; e método para reduzir a turvação e impurezas de um eluído compreendendo um produto |
US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
RU2518289C2 (ru) | 2006-09-13 | 2014-06-10 | Эббви Инк, | Способ получения антитела или его фрагмента с подпиткой (варианты) |
US10982250B2 (en) | 2006-09-18 | 2021-04-20 | Genentech, Inc. | Methods of protein production |
EP2395077A1 (en) | 2006-11-03 | 2011-12-14 | Wyeth LLC | Glycolysis-inhibiting substances in cell culture |
EP2089424B1 (en) | 2006-12-06 | 2015-07-01 | JCR PHARMACEUTICALS Co., LTD. | Method for production of human erythropoietin |
PT2115126E (pt) | 2007-03-02 | 2015-08-24 | Wyeth Llc | Utilização de cobre e glutamato na cultura de células para a produção de polipeptídeos |
EP2068923A4 (en) | 2007-03-30 | 2010-11-24 | Medimmune Llc | ANTIBODIES HAVING REDUCED DEAMIDATION PROFILES |
WO2008120107A2 (en) | 2007-04-03 | 2008-10-09 | Oxyrane (Uk) Limited | Glycosylation of molecules |
EP2137655B1 (en) | 2007-04-16 | 2012-07-11 | Momenta Pharmaceuticals, Inc. | Defined glycoprotein products and related methods |
TW200902708A (en) | 2007-04-23 | 2009-01-16 | Wyeth Corp | Methods of protein production using anti-senescence compounds |
EP1988101A1 (en) | 2007-05-04 | 2008-11-05 | Novo Nordisk A/S | Improvement of factor VIII polypeptide titers in cell cultures |
WO2008135498A2 (en) | 2007-05-04 | 2008-11-13 | Novo Nordisk A/S | Prevention of protein degradation in mammalian cell cultures |
ES2392701T3 (es) | 2007-05-11 | 2012-12-13 | Amgen Inc. | Medios de alimentación mejorados |
WO2008154014A2 (en) | 2007-06-11 | 2008-12-18 | Amgen Inc. | A method for culturing mammalian cells to improve recombinant protein production |
KR102055873B1 (ko) | 2007-07-09 | 2019-12-13 | 제넨테크, 인크. | 폴리펩티드의 재조합 생산 동안의 디술피드 결합 환원의 방지 |
ES2657055T3 (es) | 2007-08-09 | 2018-03-01 | Wyeth Llc | Uso de perfusión para mejorar la producción de un cultivo de células alimentado por lotes en biorreactores |
SI2215117T2 (en) | 2007-10-30 | 2018-04-30 | Genentech, Inc. | Purification of the antibody by cation exchange chromatography |
US8420081B2 (en) | 2007-11-30 | 2013-04-16 | Abbvie, Inc. | Antibody formulations and methods of making same |
PT2574677T (pt) | 2007-12-27 | 2017-10-19 | Baxalta Inc | Processos para cultura de células |
EP2275431A3 (en) | 2008-01-18 | 2011-05-25 | Bio-Rad Laboratories, Inc. | Enhanced fractionation of phosphorylated and nonphosphorylated biomolecules by apatite chromotography |
JP2011512875A (ja) | 2008-03-11 | 2011-04-28 | ジェネンテック, インコーポレイテッド | 増強されたadcc機能を有する抗体 |
PT2271382E (pt) | 2008-04-15 | 2013-05-07 | Grifols Therapeutics Inc | Ultrafiltração em dois andares/diafiltração |
EP2282773B2 (en) | 2008-05-02 | 2025-03-05 | Seagen Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
EP2331700A2 (en) | 2008-08-08 | 2011-06-15 | Biogen Idec MA Inc. | Nutrient monitoring and feedback control for increased bioproduct production |
AU2008360625C1 (en) | 2008-08-14 | 2017-01-19 | Genentech, Inc. | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
US8084222B2 (en) | 2008-09-26 | 2011-12-27 | Eureka Therapeutics, Inc. | Methods for generating host cells |
WO2010051360A1 (en) | 2008-10-31 | 2010-05-06 | Wyeth Llc | Purification of acidic proteins using ceramic hydroxyapatite chromatography |
CN102245206A (zh) | 2008-12-09 | 2011-11-16 | 弗·哈夫曼-拉罗切有限公司 | 获得无赋形剂抗体溶液的方法 |
JP2012513425A (ja) | 2008-12-22 | 2012-06-14 | エフ.ホフマン−ラ ロシュ アーゲー | 免疫グロブリンの精製 |
WO2010080062A1 (en) | 2009-01-08 | 2010-07-15 | Ge Healthcare Bio-Sciences Ab | Separation method using single polymer phase systems |
JP5728392B2 (ja) | 2009-03-05 | 2015-06-03 | バイオジェン アイデック エムエー インコーポレイティドBiogen Idec Inc. | 免疫グロブリンの精製 |
EP2412817B2 (en) | 2009-03-27 | 2019-06-05 | Asahi Kasei Medical Co., Ltd. | Method for removing viruses in high-concentration monoclonal antibody solution |
US8063189B2 (en) | 2009-04-13 | 2011-11-22 | Bristol-Myers Squibb Company | Protein purification by citrate precipitation |
AU2010240569A1 (en) | 2009-04-20 | 2011-10-20 | Pfizer Inc. | Control of protein glycosylation and compositions and methods relating thereto |
EP2435556B1 (en) | 2009-05-28 | 2016-05-25 | Boehringer Ingelheim International GmbH | Method for a rational cell culturing process |
WO2010141855A1 (en) | 2009-06-05 | 2010-12-09 | Momenta Pharmaceuticals, Inc. | Methods of modulating fucosylation of glycoproteins |
CA3118479A1 (en) | 2009-07-06 | 2011-01-13 | Genentech, Inc. | Method of culturing eukaryotic cells |
JP5540095B2 (ja) | 2009-07-24 | 2014-07-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗体製造の最適化 |
WO2011015926A1 (en) | 2009-08-03 | 2011-02-10 | Avesthagen Limited | A process of fermentation, purification and production of recombinant soluble tumour necrosis factor alfa receptor (tnfr) - human igg fc fusion protein |
AU2010292897B2 (en) | 2009-08-06 | 2016-01-07 | Genentech, Inc. | Method to improve virus removal in protein purification |
WO2011019622A1 (en) | 2009-08-14 | 2011-02-17 | Genentech, Inc. | Cell culture methods to make antibodies with enhanced adcc function |
WO2011024025A1 (en) | 2009-08-28 | 2011-03-03 | Avesthagen Limited | An erythropoietin analogue and a method thereof |
CN102686738A (zh) | 2009-09-01 | 2012-09-19 | 弗·哈夫曼-拉罗切有限公司 | 通过改进的a蛋白洗脱增强的蛋白质纯化 |
US9540426B2 (en) | 2009-10-06 | 2017-01-10 | Bristol-Myers Squibb Company | Mammalian cell culture processes for protein production |
US20120208986A1 (en) | 2009-10-20 | 2012-08-16 | Wenger Marc D | Use of mixed mode chromatography for the capture and purification of basic antibody products |
EP2499973A1 (en) | 2009-11-10 | 2012-09-19 | Hitachi Medical Corporation | Ultrasonic diagnosis device |
US9096879B2 (en) | 2009-11-24 | 2015-08-04 | Biogen Ma Inc. | Method of supplementing culture media to prevent undesirable amino acid substitutions |
WO2011069056A2 (en) | 2009-12-04 | 2011-06-09 | Momenta Pharmaceuticals, Inc. | Antennary fucosylation in glycoproteins from cho cells |
US8277649B2 (en) | 2009-12-14 | 2012-10-02 | General Electric Company | Membranes and associated methods for purification of antibodies |
RU2564569C2 (ru) | 2009-12-18 | 2015-10-10 | Новартис Аг | Промывочный раствор и способ промывки для аффинной хроматографии |
WO2011127322A1 (en) | 2010-04-07 | 2011-10-13 | Momenta Pharmaceuticals, Inc. | High mannose glycans |
SG185014A1 (en) | 2010-04-26 | 2012-11-29 | Novartis Ag | Improved cell cultivation process |
US9428727B2 (en) | 2010-04-26 | 2016-08-30 | Novartis Ag | Cell culture medium |
EP2576580B1 (en) | 2010-05-28 | 2016-09-14 | F.Hoffmann-La Roche Ag | Decreasing lactate level and increasing polypeptide production by downregulating the expression of lactate dehydrogenase and pyruvate dehydrogenase kinase |
SG187198A1 (en) | 2010-08-05 | 2013-03-28 | Amgen Inc | Dipeptides to enhance yield and viability from cell cultures |
WO2012030512A1 (en) | 2010-09-03 | 2012-03-08 | Percivia Llc. | Flow-through protein purification process |
JP5918697B2 (ja) | 2010-10-15 | 2016-05-18 | Jcrファーマ株式会社 | 糖鎖の非還元末端がマンノース残基である糖蛋白質の製造方法 |
EP2450375A1 (en) | 2010-11-09 | 2012-05-09 | Sandoz Gmbh | Cell culture medium and process for protein expression, said medium and process comprising a PAM inhibitor |
US20120149878A1 (en) | 2010-12-08 | 2012-06-14 | Gillespie Ronald | Protein purification |
BR112013012422A2 (pt) | 2010-12-21 | 2016-08-30 | Hoffmann La Roche | "método para produzir uma preparação de anticorpo e anticorpo anti-her2" |
RU2013136908A (ru) | 2011-01-07 | 2015-02-20 | Эббви Инк. | Антитела kil-12/il-23 и их применение |
MX346663B (es) | 2011-03-06 | 2017-03-27 | Merck Serono Sa | Lineas de celulas de bajo nivel de fucosa y usos de las mismas. |
PL2697369T3 (pl) | 2011-03-25 | 2018-12-31 | F.Hoffmann-La Roche Ag | Nowe sposoby oczyszczania białek |
EP2511293A1 (en) | 2011-04-13 | 2012-10-17 | LEK Pharmaceuticals d.d. | A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins |
US9133493B2 (en) | 2011-04-21 | 2015-09-15 | Amgen Inc. | Method for culturing mammalian cells to improve recombinant protein production |
RU2592680C2 (ru) | 2011-04-29 | 2016-07-27 | Биокон Рисерч Лимитед | Способ снижения накопления лактата при культивировании и способ получения антитела |
US20120283419A1 (en) | 2011-05-03 | 2012-11-08 | Avantor Performance Materials, Inc. | Separation of protein monomers from aggregates by solid weak anion exchange support functionalized with amine moieties |
DK2707383T3 (en) | 2011-05-13 | 2018-07-23 | Biogen Ma Inc | PROCEDURES FOR PREVENTION AND REMOVAL OF TRISULPHIDE BINDINGS |
CA2952347A1 (en) | 2011-07-01 | 2013-01-10 | Amgen Inc. | Mammalian cell culture |
WO2013006461A1 (en) | 2011-07-01 | 2013-01-10 | Biogen Idec Ma Inc. | Cholesterol-based media supplementals for cell culture |
US9475858B2 (en) | 2011-07-08 | 2016-10-25 | Momenta Pharmaceuticals, Inc. | Cell culture process |
WO2013013013A2 (en) | 2011-07-21 | 2013-01-24 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for producing modified glycoproteins |
HK1199272A1 (en) | 2011-10-19 | 2015-06-26 | Roche Glycart Ag | Separation method for fucosylated antibodies |
EP2773439A4 (en) | 2011-10-31 | 2015-07-01 | Merck Sharp & Dohme | CHROMATOGRAPHY METHOD FOR RESOLVING HETEROGENIC ANTIBODY AGGREGATES |
-
2007
- 2007-09-13 RU RU2009113613/10A patent/RU2518289C2/ru active
- 2007-09-13 TW TW102127154A patent/TWI548747B/zh not_active IP Right Cessation
- 2007-09-13 KR KR20097007564A patent/KR20090074040A/ko not_active Abandoned
- 2007-09-13 MY MYPI2013003178A patent/MY185887A/en unknown
- 2007-09-13 MY MYPI2013003176A patent/MY185872A/en unknown
- 2007-09-13 MX MX2009002748A patent/MX2009002748A/es active IP Right Grant
- 2007-09-13 TW TW96134338A patent/TWI456062B/zh active
- 2007-09-13 MX MX2012004477A patent/MX345141B/es unknown
- 2007-09-13 EP EP20120171903 patent/EP2532737A3/en not_active Withdrawn
- 2007-09-13 EP EP07838261A patent/EP2064314A4/en not_active Withdrawn
- 2007-09-13 MX MX2017003647A patent/MX353340B/es unknown
- 2007-09-13 CA CA002663442A patent/CA2663442A1/en not_active Abandoned
- 2007-09-13 CN CN2013101680205A patent/CN103276033A/zh active Pending
- 2007-09-13 CN CN201310414770.6A patent/CN103555651A/zh active Pending
- 2007-09-13 KR KR1020147030328A patent/KR20140132017A/ko not_active Ceased
- 2007-09-13 CA CA 2842959 patent/CA2842959A1/en not_active Abandoned
- 2007-09-13 TW TW105116479A patent/TW201708537A/zh unknown
- 2007-09-13 EP EP20120171916 patent/EP2527425A1/en not_active Withdrawn
- 2007-09-13 EP EP20120171921 patent/EP2500413A1/en not_active Withdrawn
- 2007-09-13 MY MYPI20091017A patent/MY161866A/en unknown
- 2007-09-13 SG SG10201510384UA patent/SG10201510384UA/en unknown
- 2007-09-13 WO PCT/US2007/020027 patent/WO2008033517A2/en active Application Filing
- 2007-09-13 CN CN2013101689695A patent/CN103397065A/zh active Pending
- 2007-09-13 CA CA2910619A patent/CA2910619A1/en not_active Abandoned
- 2007-09-13 CN CN201310414890.6A patent/CN103555652A/zh active Pending
- 2007-09-13 SG SG2013049846A patent/SG192441A1/en unknown
- 2007-09-13 TW TW103124010A patent/TW201516149A/zh unknown
- 2007-09-13 SG SG2011065711A patent/SG174804A1/en unknown
- 2007-09-13 BR BRPI0716762-8A2A patent/BRPI0716762A2/pt active Search and Examination
- 2007-09-13 CN CN200780041909XA patent/CN101663390B/zh active Active
- 2007-09-13 MX MX2016013989A patent/MX346523B/es unknown
- 2007-09-13 AU AU2007294731A patent/AU2007294731B2/en active Active
- 2007-09-13 MY MYPI2013003175A patent/MY185040A/en unknown
- 2007-09-13 CA CA 2842966 patent/CA2842966A1/en not_active Abandoned
- 2007-09-13 CN CN2011102942776A patent/CN102337243A/zh active Pending
- 2007-09-13 NZ NZ59733407A patent/NZ597334A/en unknown
- 2007-09-13 CA CA 2842964 patent/CA2842964A1/en not_active Abandoned
- 2007-09-13 JP JP2009528309A patent/JP5878682B2/ja active Active
- 2007-09-13 NZ NZ575328A patent/NZ575328A/en unknown
- 2007-09-13 US US11/901,274 patent/US8093045B2/en active Active
-
2009
- 2009-03-05 IL IL197444A patent/IL197444A0/en unknown
- 2009-04-14 NO NO20091439A patent/NO20091439L/no not_active Application Discontinuation
-
2011
- 2011-11-30 US US13/308,075 patent/US8663945B2/en active Active
-
2013
- 2013-06-04 JP JP2013117841A patent/JP2013230151A/ja not_active Withdrawn
-
2014
- 2014-01-16 US US14/156,829 patent/US20140134674A1/en not_active Abandoned
- 2014-01-16 US US14/157,460 patent/US9234032B2/en active Active
- 2014-03-17 RU RU2014110141/10A patent/RU2014110141A/ru unknown
- 2014-03-26 US US14/226,333 patent/US8906646B2/en active Active
- 2014-06-03 US US14/294,821 patent/US20150125905A1/en not_active Abandoned
- 2014-12-08 US US14/563,993 patent/US9073988B2/en active Active
-
2015
- 2015-04-28 JP JP2015091918A patent/JP2016000030A/ja active Pending
- 2015-10-22 US US14/920,452 patent/US9284371B2/en active Active
-
2016
- 2016-03-14 US US15/069,456 patent/US20160186130A1/en not_active Abandoned
- 2016-06-20 US US15/187,425 patent/US10119118B2/en active Active
-
2018
- 2018-08-30 US US16/118,405 patent/US20190225934A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0716762A2 (pt) | melhorias da cultura celular | |
PL2634242T3 (pl) | Ulepszony sposób hodowli komórek | |
DK3121266T3 (da) | Oligopeptid-frie cellekulturmedier | |
DE602007004421D1 (de) | Zellkulturvorrichtung | |
BRPI0818536A2 (pt) | Linhagem celular cho-k1 | |
EP2005504A4 (en) | ELECTROLYTE | |
BRPI0919919A2 (pt) | transplante celular | |
EP2002009A4 (en) | ANAEROBIC FERMENTATION OF GLYCEROL | |
CL2007002310S1 (es) | Telefono celular. | |
EP2095430A4 (en) | SOLAR CELL | |
BRPI0816956A2 (pt) | Célula de combustível | |
EP2128242A4 (en) | CELL CULTURE MODULE | |
DE112006000958B8 (de) | Brennstoffzelle | |
EP2028264A4 (en) | CELL INCUBATOR | |
DE112007001371B8 (de) | Brennstoffzelle | |
DE112007002407B8 (de) | Brennstoffzelle | |
DE602006012891D1 (de) | Brennstoffzellenseparator | |
BRPI0714209A2 (pt) | Induzidor de morte celular | |
DK2027150T3 (da) | Allo-begrænsede peptid-specifikke t-celler | |
DE602007008627D1 (de) | Zellkulturmedium | |
BRPI0814572A2 (pt) | Célula de lítio | |
DE602006001060D1 (de) | Brennstoffzelle | |
DE112007003333A5 (de) | Fermenter | |
BRPI0813726A2 (pt) | Célula de lítio | |
DE602007007302D1 (de) | Brennstoffzelle |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: ABBVIE INC. (US) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B65X | Notification of requirement for priority examination of patent application | ||
B65Y | Grant of priority examination of the patent application (request complies with dec. 132/06 of 20061117) | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B15W | Others matters related to applications: legal action concerning application | ||
B15N | Others concerning applications: notification of judicial decision | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B11D | Dismissal acc. art. 38, par 2 of ipl - failure to pay fee after grant in time |