BRPI0517416A - inibidores de pi3 quinase gama para o tratamento de anemia - Google Patents
inibidores de pi3 quinase gama para o tratamento de anemiaInfo
- Publication number
- BRPI0517416A BRPI0517416A BRPI0517416-3A BRPI0517416A BRPI0517416A BR PI0517416 A BRPI0517416 A BR PI0517416A BR PI0517416 A BRPI0517416 A BR PI0517416A BR PI0517416 A BRPI0517416 A BR PI0517416A
- Authority
- BR
- Brazil
- Prior art keywords
- anemia
- treatment
- gamma
- kinase inhibitors
- selective
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
INIBIDORES DE PI3 QUINASE GAMA PARA O TRATAMENTO DE ANEMIA. A presente invenção refere-se ao uso de inibidores de PI3 Quinase gama seletivos para a produção de medicamento para o tratamento de distúrbios relacionados com deficiência de eritrócitos. Especificamente, a presente invenção refere-se ao uso de inibidores de PI3 Quinase gama seletivos, por exemplo, derivados benzênicos fundidos com azolidinona-vinila substituidas para o tratamento de anemia, incluindo anemia hemolitica, anemia aplásica e anemia eritrocítica pura. em que A, X, Y~ 1~, Y~ 2~, Z, n, e R são descritos em detalhes na descrição.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104997 | 2004-10-12 | ||
| PCT/EP2005/055156 WO2006040318A2 (en) | 2004-10-12 | 2005-10-11 | Pi3 kinase gamma inhibitors for the treatment of anaemia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0517416A true BRPI0517416A (pt) | 2008-10-07 |
Family
ID=34929693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0517416-3A BRPI0517416A (pt) | 2004-10-12 | 2005-10-11 | inibidores de pi3 quinase gama para o tratamento de anemia |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090042773A1 (pt) |
| EP (1) | EP1807075A2 (pt) |
| JP (1) | JP2008515955A (pt) |
| KR (1) | KR20070073857A (pt) |
| CN (1) | CN101056633A (pt) |
| AU (1) | AU2005293556A1 (pt) |
| BR (1) | BRPI0517416A (pt) |
| CA (1) | CA2580480A1 (pt) |
| EA (1) | EA200700848A1 (pt) |
| IL (1) | IL182110A0 (pt) |
| MX (1) | MX2007004302A (pt) |
| NO (1) | NO20072393L (pt) |
| WO (1) | WO2006040318A2 (pt) |
| ZA (1) | ZA200702435B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2007002604A (es) * | 2004-09-03 | 2007-04-25 | Applied Research Systems | Azolidinonas de piridina metileno y uso de las mismas. |
| WO2008014219A2 (en) * | 2006-07-24 | 2008-01-31 | Smithkline Beecham Corporation | Thiozolidinedione derivatives as p13 kinase inhibitors |
| EP2183232B1 (en) | 2007-08-02 | 2013-03-06 | Amgen, Inc | Pi3 kinase modulators and methods of use |
| CA2710194C (en) | 2007-12-19 | 2014-04-22 | Amgen Inc. | Inhibitors of p13 kinase |
| US8268834B2 (en) | 2008-03-19 | 2012-09-18 | Novartis Ag | Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme |
| EP2341052A4 (en) * | 2008-09-05 | 2011-10-12 | Shionogi & Co | RING-CONDENSED MORPHOLINE DERIVATIVITY WITH PI3K-INHIBITING EFFECT |
| US8604030B2 (en) | 2009-03-27 | 2013-12-10 | Kowa Company, Ltd. | Fused piperidine compound and pharmaceutical containing same |
| EP2440556A1 (en) * | 2009-06-10 | 2012-04-18 | Vertex Pharmaceuticals Incorporated | Inhibitors of phosphatidylinositol 3-kinase |
| US8633183B2 (en) * | 2010-01-26 | 2014-01-21 | Boehringer Ingelheim International Gmbh | 5-alkynyl-pyrimidines |
| US8609672B2 (en) | 2010-08-27 | 2013-12-17 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
| CN102584809B (zh) * | 2011-01-14 | 2014-12-24 | 湘北威尔曼制药股份有限公司 | 胺基噻唑烷酮化合物及其制备方法与在制备抗肿瘤药物中的应用 |
| AU2012245344B2 (en) * | 2011-04-22 | 2017-11-09 | Jasco Pharmaceuticals, LLC | Aminopyrimidine kinase inhibitors |
| JP6215832B2 (ja) | 2011-11-04 | 2017-10-18 | ジャスコ ファーマスーティカルズ エルエルシーＪａｓｃｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， ＬＬＣ | アミノピリミジンキナーゼ阻害剤 |
| MA37142B1 (fr) * | 2011-12-22 | 2019-07-31 | Novartis Ag | Dérivés de dihydro-benzo-oxazine et de dihydro-pyrido-oxazine |
| EA032075B1 (ru) | 2014-04-24 | 2019-04-30 | Новартис Аг | Производные аминопиразина в качестве ингибиторов фосфатидилинозитол-3-киназы |
| KR20160141856A (ko) | 2014-04-24 | 2016-12-09 | 노파르티스 아게 | 포스파티딜이노시톨 3-키나제 억제제로서의 피라진 유도체 |
| CN106458980A (zh) | 2014-04-24 | 2017-02-22 | 诺华股份有限公司 | 作为磷脂酰肌醇3‑激酶抑制剂的氨基吡啶衍生物 |
| PL3781561T3 (pl) | 2018-04-18 | 2024-07-22 | Constellation Pharmaceuticals, Inc. | Modulatory enzymów modyfikujących grupę metylową, kompozycje i ich zastosowania |
| CA3100977A1 (en) | 2018-05-21 | 2019-11-28 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| WO2022163843A1 (ja) * | 2021-02-01 | 2022-08-04 | 国立大学法人徳島大学 | Ｐｉｍ２阻害剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI240627B (en) * | 1996-04-26 | 2005-10-01 | Chugai Pharmaceutical Co Ltd | Erythropoietin solution preparation |
| WO2004007491A1 (en) * | 2002-07-10 | 2004-01-22 | Applied Research Systems Ars Holding N.V. | Azolidinone-vinyl fused-benzene derivatives |
| CN100579978C (zh) * | 2002-11-22 | 2010-01-13 | 史密丝克莱恩比彻姆公司 | 化合物 |
-
2005
- 2005-10-11 JP JP2007536166A patent/JP2008515955A/ja active Pending
- 2005-10-11 BR BRPI0517416-3A patent/BRPI0517416A/pt not_active IP Right Cessation
- 2005-10-11 CN CNA200580038804XA patent/CN101056633A/zh active Pending
- 2005-10-11 EA EA200700848A patent/EA200700848A1/ru unknown
- 2005-10-11 MX MX2007004302A patent/MX2007004302A/es not_active Application Discontinuation
- 2005-10-11 AU AU2005293556A patent/AU2005293556A1/en not_active Abandoned
- 2005-10-11 CA CA002580480A patent/CA2580480A1/en not_active Abandoned
- 2005-10-11 US US11/664,969 patent/US20090042773A1/en not_active Abandoned
- 2005-10-11 KR KR1020077010007A patent/KR20070073857A/ko not_active Withdrawn
- 2005-10-11 EP EP05801722A patent/EP1807075A2/en not_active Withdrawn
- 2005-10-11 WO PCT/EP2005/055156 patent/WO2006040318A2/en active Application Filing
- 2005-10-11 ZA ZA200702435A patent/ZA200702435B/en unknown
-
2007
- 2007-03-22 IL IL182110A patent/IL182110A0/en unknown
- 2007-05-09 NO NO20072393A patent/NO20072393L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| MX2007004302A (es) | 2007-06-07 |
| CN101056633A (zh) | 2007-10-17 |
| IL182110A0 (en) | 2007-07-24 |
| WO2006040318A2 (en) | 2006-04-20 |
| WO2006040318A3 (en) | 2006-08-10 |
| US20090042773A1 (en) | 2009-02-12 |
| EA200700848A1 (ru) | 2007-10-26 |
| EP1807075A2 (en) | 2007-07-18 |
| NO20072393L (no) | 2007-05-09 |
| ZA200702435B (en) | 2008-06-25 |
| KR20070073857A (ko) | 2007-07-10 |
| AU2005293556A1 (en) | 2006-04-20 |
| JP2008515955A (ja) | 2008-05-15 |
| CA2580480A1 (en) | 2006-04-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: LABORATOIRES SERONO S.A. (CH) Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |