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NO20072393L - P13-kinase gamma hemmere for behandling av anemi - Google Patents

P13-kinase gamma hemmere for behandling av anemi

Info

Publication number
NO20072393L
NO20072393L NO20072393A NO20072393A NO20072393L NO 20072393 L NO20072393 L NO 20072393L NO 20072393 A NO20072393 A NO 20072393A NO 20072393 A NO20072393 A NO 20072393A NO 20072393 L NO20072393 L NO 20072393L
Authority
NO
Norway
Prior art keywords
anemia
treatment
kinase
inhibitors
gamma inhibitors
Prior art date
Application number
NO20072393A
Other languages
English (en)
Inventor
Christian Rommel
Reinhard Wetzker
Angelika Mueller
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of NO20072393L publication Critical patent/NO20072393L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Den foreliggende oppfinnelsen vedrører anvendelse av selektive P13-kinase ?-hemmere for fremstillingen av et medikament for behandling av lidelser på grunn av erytrocyttsvikt. Mer spesifikt angår oppfinnelsen bruken av selektive P13-kinase ?-hemmere, for eksempel substituerte azolidinonvinylkondenserte benzenderivater med formel I hvor A, X, Yl, Y2, X, N, R1 og R2 er som detaljert beskrevet i den etterfølgende beskrivelsen for behandlingen av en anemi, inklusive hemolytisk anemi, aplastisk anemi og ren rødcelleanemi.
NO20072393A 2004-10-12 2007-05-09 P13-kinase gamma hemmere for behandling av anemi NO20072393L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04104997 2004-10-12
PCT/EP2005/055156 WO2006040318A2 (en) 2004-10-12 2005-10-11 Pi3 kinase gamma inhibitors for the treatment of anaemia

Publications (1)

Publication Number Publication Date
NO20072393L true NO20072393L (no) 2007-05-09

Family

ID=34929693

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072393A NO20072393L (no) 2004-10-12 2007-05-09 P13-kinase gamma hemmere for behandling av anemi

Country Status (14)

Country Link
US (1) US20090042773A1 (no)
EP (1) EP1807075A2 (no)
JP (1) JP2008515955A (no)
KR (1) KR20070073857A (no)
CN (1) CN101056633A (no)
AU (1) AU2005293556A1 (no)
BR (1) BRPI0517416A (no)
CA (1) CA2580480A1 (no)
EA (1) EA200700848A1 (no)
IL (1) IL182110A0 (no)
MX (1) MX2007004302A (no)
NO (1) NO20072393L (no)
WO (1) WO2006040318A2 (no)
ZA (1) ZA200702435B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101052640B (zh) * 2004-09-03 2011-05-11 默克雪兰诺有限公司 吡啶亚甲基唑烷酮类及其作为磷酸肌醇抑制剂的用途
US20090215818A1 (en) * 2006-07-24 2009-08-27 Smithkline Beecham Corporation Thiozolidinedione derivatives as pi3 kinase inhibitors
AU2008282728B2 (en) 2007-08-02 2012-04-19 Amgen Inc. Pl3 kinase modulators and methods of use
WO2009085230A1 (en) 2007-12-19 2009-07-09 Amgen Inc. Inhibitors of pi3 kinase
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
WO2010027002A1 (ja) * 2008-09-05 2010-03-11 塩野義製薬株式会社 Ｐｉ３ｋ阻害活性を有する縮環モルホリン誘導体
WO2010110380A1 (ja) * 2009-03-27 2010-09-30 興和株式会社 縮合ピペリジン化合物及びこれを含有する医薬
EP2440556A1 (en) * 2009-06-10 2012-04-18 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatidylinositol 3-kinase
UY33199A (es) * 2010-01-26 2011-08-31 Boehringer Ingelheim Int 5-alquinil-pirimidinas.
US8609672B2 (en) 2010-08-27 2013-12-17 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
CN102584809B (zh) * 2011-01-14 2014-12-24 湘北威尔曼制药股份有限公司 胺基噻唑烷酮化合物及其制备方法与在制备抗肿瘤药物中的应用
WO2012145617A2 (en) * 2011-04-22 2012-10-26 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors
CA2853454C (en) 2011-11-04 2020-01-21 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors
IN2014CN04174A (no) * 2011-12-22 2015-09-04 Novartis Ag
CA2945212A1 (en) 2014-04-24 2015-10-29 Novartis Ag Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
PT3134396T (pt) 2014-04-24 2019-12-16 Novartis Ag Derivados de amino piridina como inibidores da fosfatidilinositol 3-quinase
CN106458966B (zh) 2014-04-24 2019-05-07 诺华股份有限公司 作为磷脂酰肌醇3-激酶抑制剂的吡嗪衍生物
KR20210003160A (ko) 2018-04-18 2021-01-11 콘스텔레이션 파마슈티칼스, 인크. 메틸 변형 효소 조절제, 이의 조성물 및 용도
EP3797108B1 (en) 2018-05-21 2022-07-20 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
JPWO2022163843A1 (no) * 2021-02-01 2022-08-04

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW518219B (en) * 1996-04-26 2003-01-21 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
BR0312650A (pt) * 2002-07-10 2005-05-03 Applied Research Systems Derivados de benzeno fundido azolidinona-vinila
WO2004047760A2 (en) * 2002-11-22 2004-06-10 Smithkline Beecham Corporation Novel chemical compounds

Also Published As

Publication number Publication date
BRPI0517416A (pt) 2008-10-07
IL182110A0 (en) 2007-07-24
KR20070073857A (ko) 2007-07-10
JP2008515955A (ja) 2008-05-15
EA200700848A1 (ru) 2007-10-26
CN101056633A (zh) 2007-10-17
US20090042773A1 (en) 2009-02-12
CA2580480A1 (en) 2006-04-20
ZA200702435B (en) 2008-06-25
WO2006040318A2 (en) 2006-04-20
MX2007004302A (es) 2007-06-07
WO2006040318A3 (en) 2006-08-10
AU2005293556A1 (en) 2006-04-20
EP1807075A2 (en) 2007-07-18

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