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EA200700848A1 - Ингибиторы pi3-гамма-киназы для лечения анемии - Google Patents

Ингибиторы pi3-гамма-киназы для лечения анемии

Info

Publication number
EA200700848A1
EA200700848A1 EA200700848A EA200700848A EA200700848A1 EA 200700848 A1 EA200700848 A1 EA 200700848A1 EA 200700848 A EA200700848 A EA 200700848A EA 200700848 A EA200700848 A EA 200700848A EA 200700848 A1 EA200700848 A1 EA 200700848A1
Authority
EA
Eurasian Patent Office
Prior art keywords
anemia
treatment
kinase inhibitors
gamma kinase
selective
Prior art date
Application number
EA200700848A
Other languages
English (en)
Inventor
Райнхард Ветцкер
Ангелика Мюллер
Кристиан Роммель
Original Assignee
Апплайд Резеч Системз Арс Холдинг Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Апплайд Резеч Системз Арс Холдинг Н. В. filed Critical Апплайд Резеч Системз Арс Холдинг Н. В.
Publication of EA200700848A1 publication Critical patent/EA200700848A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение связано с применением селективных ингибиторов PI3-гамма-киназы в производстве лекарственного средства для лечения расстройств, связанных с дефицитом эритроцитов. В частности, настоящее изобретение связано с применением селективных ингибиторов PI3-гамма-киназы, например, замещенных азолидинон-винил-конденсированных бензольных производных формулы (I)в которой А, X, Y, Y, Z, n, Rи Rимеют значения, подробно описанные в описании заявки, для лечения анемии, включая гемолитическую анемию, апластическую анемию и чисто эритроцитарную анемию.
EA200700848A 2004-10-12 2005-10-11 Ингибиторы pi3-гамма-киназы для лечения анемии EA200700848A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04104997 2004-10-12
PCT/EP2005/055156 WO2006040318A2 (en) 2004-10-12 2005-10-11 Pi3 kinase gamma inhibitors for the treatment of anaemia

Publications (1)

Publication Number Publication Date
EA200700848A1 true EA200700848A1 (ru) 2007-10-26

Family

ID=34929693

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700848A EA200700848A1 (ru) 2004-10-12 2005-10-11 Ингибиторы pi3-гамма-киназы для лечения анемии

Country Status (14)

Country Link
US (1) US20090042773A1 (ru)
EP (1) EP1807075A2 (ru)
JP (1) JP2008515955A (ru)
KR (1) KR20070073857A (ru)
CN (1) CN101056633A (ru)
AU (1) AU2005293556A1 (ru)
BR (1) BRPI0517416A (ru)
CA (1) CA2580480A1 (ru)
EA (1) EA200700848A1 (ru)
IL (1) IL182110A0 (ru)
MX (1) MX2007004302A (ru)
NO (1) NO20072393L (ru)
WO (1) WO2006040318A2 (ru)
ZA (1) ZA200702435B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1786812B1 (en) * 2004-09-03 2011-11-09 Merck Serono SA Pyridine methylene azolidinones and their use as phosphoinositide inhibitors
JP2009544723A (ja) * 2006-07-24 2009-12-17 スミスクライン・ビーチャム・コーポレイション Ｐｉ３キナーゼ阻害剤としてのチオゾリジンジオン誘導体
EP2183232B1 (en) 2007-08-02 2013-03-06 Amgen, Inc Pi3 kinase modulators and methods of use
PE20091268A1 (es) 2007-12-19 2009-09-19 Amgen Inc Derivados heterociclicos como inhibidores de pi3 quinasa
US8268834B2 (en) 2008-03-19 2012-09-18 Novartis Ag Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
EP2341052A4 (en) * 2008-09-05 2011-10-12 Shionogi & Co RING-CONDENSED MORPHOLINE DERIVATIVITY WITH PI3K-INHIBITING EFFECT
US8604030B2 (en) 2009-03-27 2013-12-10 Kowa Company, Ltd. Fused piperidine compound and pharmaceutical containing same
EP2440556A1 (en) * 2009-06-10 2012-04-18 Vertex Pharmaceuticals Incorporated Inhibitors of phosphatidylinositol 3-kinase
UY33199A (es) * 2010-01-26 2011-08-31 Boehringer Ingelheim Int 5-alquinil-pirimidinas.
WO2012027495A1 (en) 2010-08-27 2012-03-01 University Of The Pacific Piperazinylpyrimidine analogues as protein kinase inhibitors
CN102584809B (zh) * 2011-01-14 2014-12-24 湘北威尔曼制药股份有限公司 胺基噻唑烷酮化合物及其制备方法与在制备抗肿瘤药物中的应用
EP2699569B1 (en) * 2011-04-22 2017-08-30 Jasco Pharmaceuticals, LLC Aminopyrimidine kinase inhibitors
BR112014010563B1 (pt) 2011-11-04 2021-01-12 Jasco Pharmaceuticals, LLC compostos inibidores da aminopirimidina quinase
CR20200286A (es) * 2011-12-22 2020-09-23 Novartis Ag DERIVADOS DE DIHIDRO-BENZO-OXAZINA Y DIHIDRO-PIRIDO-OXAZINA (Divisional 2014-0294)
CA2945069A1 (en) 2014-04-24 2015-10-29 Novartis Ag Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
US10004732B2 (en) 2014-04-24 2018-06-26 Novartis Ag Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
ES2667424T3 (es) 2014-04-24 2018-05-10 Novartis Ag Derivados de pirazina como inhibidores de fosfatidil-inositol-3-quinasa
TWI828677B (zh) 2018-04-18 2024-01-11 美商星座製藥公司 甲基修飾酵素之調節劑、其組成物及用途
US11919912B2 (en) 2018-05-21 2024-03-05 Constellation Pharmaceuticals, Inc. Modulators of methyl modifying enzymes, compositions and uses thereof
JPWO2022163843A1 (ru) * 2021-02-01 2022-08-04

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI240627B (en) * 1996-04-26 2005-10-01 Chugai Pharmaceutical Co Ltd Erythropoietin solution preparation
EA011807B1 (ru) * 2002-07-10 2009-06-30 Лаборатуар Сероно Са Азолидинонвинильные производные конденсированного бензола
CA2507256A1 (en) * 2002-11-22 2004-06-10 Smithkline Beecham Corporation Thiazolidine compounds in the treatment of anemic conditions

Also Published As

Publication number Publication date
AU2005293556A1 (en) 2006-04-20
MX2007004302A (es) 2007-06-07
KR20070073857A (ko) 2007-07-10
NO20072393L (no) 2007-05-09
BRPI0517416A (pt) 2008-10-07
CA2580480A1 (en) 2006-04-20
WO2006040318A3 (en) 2006-08-10
US20090042773A1 (en) 2009-02-12
EP1807075A2 (en) 2007-07-18
IL182110A0 (en) 2007-07-24
JP2008515955A (ja) 2008-05-15
ZA200702435B (en) 2008-06-25
CN101056633A (zh) 2007-10-17
WO2006040318A2 (en) 2006-04-20

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