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BRPI0414941A - dispositivo de distribuição de agente ativo acionado osmoticamente proporcionando um perfil de liberação ascendente - Google Patents

dispositivo de distribuição de agente ativo acionado osmoticamente proporcionando um perfil de liberação ascendente

Info

Publication number
BRPI0414941A
BRPI0414941A BRPI0414941-6A BRPI0414941A BRPI0414941A BR PI0414941 A BRPI0414941 A BR PI0414941A BR PI0414941 A BRPI0414941 A BR PI0414941A BR PI0414941 A BRPI0414941 A BR PI0414941A
Authority
BR
Brazil
Prior art keywords
active agent
rate
osmotic pump
controlling membrane
osmotic
Prior art date
Application number
BRPI0414941-6A
Other languages
English (en)
Inventor
Guohua Chen
Rupal A Ayer
Scott Lautenbach
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of BRPI0414941A publication Critical patent/BRPI0414941A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

"DISPOSITIVO DE DISTRIBUIçãO DE AGENTE ATIVO ACIONADO OSMOTICAMENTE PROPORCIONANDO UM PERFIL DE LIBERAçãO ASCENDENTE". Em um aspecto, a presente invenção é dirigida a uma bomba osmótica, que proporciona, automaticamente, uma taxa de liberação ascendente de agente ativo, na medida em que a bomba osmótica funciona em um meio físico de operação, e pode ser projetada para implante dentro de um paciente animal ou humano desejado. Uma bomba osmótica, de acordo com a presente invenção, inclui um reservatório, uma membrana controladora de taxa, uma composição osmótica expansível, uma formulação de agente ativo e um orifício de saída. Uma vez administrada a um meio físico de operação, a água passa pela membrana controladora de taxa e para a composição osmótica, o que faz com que a composição osmótica se expanda e expila a formulação de agente ativo pelo orifício de saída, a uma taxa que é diretamente proporcional à taxa na qual a água passa pela membrana controladora de taxa. Uma bomba osmótica de acordo com a presente invenção permite que o fluxo de água pela membrana controladora de taxa aumente automaticamente, sem a necessidade de manipulação da bomba osmótica, após administração. Na medida em que o fluxo de água pela membrana controladora de taxa aumenta, a taxa na qual a formulação de agente ativo é distribuída da bomba osmótica vai também aumentar proporcionalmente.
BRPI0414941-6A 2003-09-30 2004-09-29 dispositivo de distribuição de agente ativo acionado osmoticamente proporcionando um perfil de liberação ascendente BRPI0414941A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50792003P 2003-09-30 2003-09-30
PCT/US2004/031983 WO2005032524A2 (en) 2003-09-30 2004-09-29 Osmotically driven active agent delivery device providing an ascending release profile

Publications (1)

Publication Number Publication Date
BRPI0414941A true BRPI0414941A (pt) 2006-11-07

Family

ID=34421688

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414941-6A BRPI0414941A (pt) 2003-09-30 2004-09-29 dispositivo de distribuição de agente ativo acionado osmoticamente proporcionando um perfil de liberação ascendente

Country Status (12)

Country Link
US (1) US7241457B2 (pt)
EP (1) EP1682099A2 (pt)
JP (1) JP2007507513A (pt)
KR (1) KR20060097008A (pt)
CN (1) CN1859900A (pt)
AU (1) AU2004277980A1 (pt)
BR (1) BRPI0414941A (pt)
CA (1) CA2538043A1 (pt)
IL (1) IL174294A0 (pt)
MX (1) MXPA06002967A (pt)
WO (1) WO2005032524A2 (pt)
ZA (1) ZA200603420B (pt)

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Also Published As

Publication number Publication date
WO2005032524A2 (en) 2005-04-14
CN1859900A (zh) 2006-11-08
CA2538043A1 (en) 2005-04-14
ZA200603420B (en) 2007-07-25
WO2005032524A3 (en) 2005-05-26
KR20060097008A (ko) 2006-09-13
EP1682099A2 (en) 2006-07-26
MXPA06002967A (es) 2006-06-14
US7241457B2 (en) 2007-07-10
JP2007507513A (ja) 2007-03-29
IL174294A0 (en) 2006-08-01
US20050107772A1 (en) 2005-05-19
AU2004277980A1 (en) 2005-04-14

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Legal Events

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B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A, 6A E 7A ANUIDADE(S)

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2129 DE 25/10/2011.