[go: up one dir, main page]

BRPI0412308A - métodos para a sìntese estereosseletiva e enriquecimento enantiomérico de ß-aminoácidos - Google Patents

métodos para a sìntese estereosseletiva e enriquecimento enantiomérico de ß-aminoácidos

Info

Publication number
BRPI0412308A
BRPI0412308A BRPI0412308-5A BRPI0412308A BRPI0412308A BR PI0412308 A BRPI0412308 A BR PI0412308A BR PI0412308 A BRPI0412308 A BR PI0412308A BR PI0412308 A BRPI0412308 A BR PI0412308A
Authority
BR
Brazil
Prior art keywords
beta
methods
amino acids
phenylalanine
new
Prior art date
Application number
BRPI0412308-5A
Other languages
English (en)
Inventor
Amit Banerjee
Matthew Chase
Robert A Clayton
Bryan Landis
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of BRPI0412308A publication Critical patent/BRPI0412308A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/22—Tryptophan; Tyrosine; Phenylalanine; 3,4-Dihydroxyphenylalanine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

"MéTODOS PARA A SìNTESE ESTEREOSSELETIVA E ENRIQUECIMENTO ENANTIOMéRICO DE <225>-AMINOáCIDOS". A presente invenção refere-se a métodos para a síntese estereoespecífica e para o enriquecimento enantiomérico de beta-aminoácidos. Uma nova D-beta-aminotransferase, que apresenta estereosseletividade para D-beta-fenilalanina, (ácido D-3-amino-3-fenilpropanóico) , foi purificada a partir de uma nova cepa isolada de Variovorax paradoxus. uma nova L-beta-aminotransferase foi purificada a partir de uma nova cepa isolada de Alcaligenes eutrophus. As D- e L-beta-aminotransferases podem ser utilizadas para facilitar a biossíntese estereosseletiva de beta-D-fenilalanina ou beta-L-fenilalanina, a partir de uma mistura de ácido L-glutâmico ou L-alanina, respectivamente, e ácido 3-ceto-3-fenilpropanóico na presença do cofator piridoxal fosfato.
BRPI0412308-5A 2003-07-10 2004-06-30 métodos para a sìntese estereosseletiva e enriquecimento enantiomérico de ß-aminoácidos BRPI0412308A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US48603203P 2003-07-10 2003-07-10
US49962203P 2003-09-02 2003-09-02
PCT/IB2004/002183 WO2005005633A2 (en) 2003-07-10 2004-06-30 Methods for the stereoselective synthesis and enantiomeric enrichment of b-amino acids

Publications (1)

Publication Number Publication Date
BRPI0412308A true BRPI0412308A (pt) 2006-06-20

Family

ID=34068231

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412308-5A BRPI0412308A (pt) 2003-07-10 2004-06-30 métodos para a sìntese estereosseletiva e enriquecimento enantiomérico de ß-aminoácidos

Country Status (7)

Country Link
US (1) US20050009151A1 (pt)
EP (1) EP1646718A2 (pt)
JP (1) JP2007526751A (pt)
BR (1) BRPI0412308A (pt)
CA (1) CA2529509A1 (pt)
MX (1) MXPA06000367A (pt)
WO (1) WO2005005633A2 (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009165355A (ja) * 2006-04-28 2009-07-30 Ajinomoto Co Inc Ｌ−アミノ酸を生産する微生物及びｌ−アミノ酸の製造法
WO2010081053A2 (en) 2009-01-08 2010-07-15 Codexis, Inc. Transaminase polypeptides
US8921079B2 (en) 2009-06-22 2014-12-30 Codexis, Inc. Transaminase reactions
HUE038434T2 (hu) 2010-06-17 2018-10-29 Codexis Inc Biokatalizátorok és módszerek (S)-3(1-aminoetil)-fenol szintéziséhez
WO2014099730A1 (en) 2012-12-21 2014-06-26 Codexis, Inc. Engineered biocatalysts and methods for synthesizing chiral amines
EP2961844B1 (en) 2013-02-28 2018-09-26 Codexis, Inc. Engineered transaminase polypeptides for industrial biocatalysis
CN106636227B (zh) * 2016-09-22 2020-11-06 精晶药业股份有限公司 一种酶法转化l-丙氨酸制备丙酮酸的方法
US9692784B1 (en) * 2016-10-25 2017-06-27 Fortress Cyber Security, LLC Security appliance
CN111032682B (zh) 2017-06-14 2024-04-12 科德克希思公司 用于工业生物催化的工程化转氨酶多肽
CN107586796B (zh) * 2017-07-20 2021-08-06 暨明医药科技（苏州）有限公司 (r)-2-(1-氨基乙基)-4-氟苯酚的合成方法
JP2023521772A (ja) 2020-04-10 2023-05-25 コデクシス， インコーポレイテッド 操作されたトランスアミナーゼポリペプチド
CN111825563A (zh) * 2020-07-01 2020-10-27 中国科学院福建物质结构研究所 一种β-高谷氨酸的制备方法
CN115851540B (zh) * 2022-12-13 2023-06-06 广州大学 具有耐盐特性的异养硝化好氧反硝化脱氮除磷菌株及应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600692A (en) * 1983-02-10 1986-07-15 Purification Engineering, Inc. Immobilized cells for preparing phenylalanine
US4518692A (en) * 1983-09-01 1985-05-21 Genetics Institute, Inc. Production of L-amino acids by transamination
US4826766A (en) * 1985-09-23 1989-05-02 Genetics Institute, Inc. Production of amino acids using coupled aminotransferases
US5316943A (en) * 1988-06-14 1994-05-31 Kidman Gene E Racemic conversion of using a transaminase
US4950606A (en) * 1989-06-22 1990-08-21 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5169780A (en) * 1989-06-22 1992-12-08 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
US5300437A (en) * 1989-06-22 1994-04-05 Celgene Corporation Enantiomeric enrichment and stereoselective synthesis of chiral amines
JPH08302117A (ja) * 1995-05-08 1996-11-19 Idemitsu Kosan Co Ltd ポリスチレン系樹脂組成物
JP2001523969A (ja) * 1997-05-01 2001-11-27 ジー．ディー．サール アンド カンパニー キラルベータアミノ酸の製造方法および製造装置
US6197558B1 (en) * 1997-05-19 2001-03-06 Nsc Technologies Transaminase biotransformation process
ATE277170T1 (de) * 1999-03-19 2004-10-15 Sumitomo Chemical Co Stereoselektive transaminase, deren kodierende gen und deren verwendungen
DE10160066A1 (de) * 2001-12-06 2003-06-18 Degussa Amidase aus Variovorax

Also Published As

Publication number Publication date
MXPA06000367A (es) 2006-03-28
EP1646718A2 (en) 2006-04-19
WO2005005633A3 (en) 2005-05-12
US20050009151A1 (en) 2005-01-13
CA2529509A1 (en) 2005-01-20
JP2007526751A (ja) 2007-09-20
WO2005005633A2 (en) 2005-01-20

Similar Documents

Publication Publication Date Title
GB2425759A (en) Cover system for a transfer trailer
BRPI0412308A (pt) métodos para a sìntese estereosseletiva e enriquecimento enantiomérico de ß-aminoácidos
BR9803346A (pt) Microorganismos e processo para a preparação fermentativa del-cisteìna, l-cistina, n-acetil-serina ou derivados de tiazoldina.
ES2767898T3 (es) Proceso para la preparación de una amina quiral ópticamente activa
BR9904747A (pt) Microorganismo, e, processo para prodizir ácido l-glutâmico
BR0004832A (pt) Bacéteria pertencendo ao gênero escherichia, e, processo para produzir l-aminoácido
BR0200350A (pt) Bactéria produtora de l-aminoácido pertencente ao gênero escherichia, e, método produzir l-aminoácido
BRPI0414764A (pt) método para purificar ácido succìnico à partir de caldo de fermentação
BR0003943A (pt) Sequências de nucleotìdeo que codificam para o gene thre e processo para a produção enzimática de l-treonina usando bactérias corineforma
BRPI0416546A (pt) produção de ácido 3-hidroxipropiÈnico usando beta-alanina/piruvato aminotransferase
ATE495676T1 (de) Mikroorganismus und verfahren zur herstellung von l-methionin
BR0000897A (pt) Processo para a produção fermentativa de l-aminoácidos usando-se bactéria corineforme
ATE518951T1 (de) Mikroorganismus des genus corynebacterium mit verstärkter l-lysin-produktivität und verfahren zur herstellung von l-lysin damit
BR0212654A (pt) Ativação e expansão de células
RU99121636A (ru) Способ получения l-аминокислот методом ферментации
DE69942821D1 (de) Verfahren zur fermentativen Herstellung von L-Glutaminsäure
BR0303461A (pt) Bactéria que produz l-aminoácido pertencente ao gênero escherichia, e, método para a produção de l-aminoácido
BR9811151A (pt) Cepa bacteriana pertencendo ao gênero corynebacterium, gene codificando amino transferase de glutamina-oxoglutarato, e, processo para produzir ácido l-glutâmico
BR0011283A (pt) Processo para a preparaçâo fermentativa de l-aminoácidos com amplificação do gene zwf
MD2409C2 (ro) Procedeu de cultivare a cianobacteriei Spirulina platensis
BR0009180A (pt) Processo microbiológico para a preparação de pravastatin
BR0104188A (pt) Processo para a preparação fermentativa de l-aminoácidos não proteinogênicos
HUP0101056A2 (hu) Javított eljárás királis aminok enzimszintézissel történő előállítására
ATE442452T1 (de) Verfahren zur herstellung von beta-hydroxy- aminosäuren und dafür geeignetes enzym
WO2003023044A3 (en) Process for the production of l-amino acids using coryneform bacteria

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 4A, 5A, 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.