BRPI0410972A - método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia - Google Patents
método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemiaInfo
- Publication number
- BRPI0410972A BRPI0410972A BRPI0410972-4A BRPI0410972A BRPI0410972A BR PI0410972 A BRPI0410972 A BR PI0410972A BR PI0410972 A BRPI0410972 A BR PI0410972A BR PI0410972 A BRPI0410972 A BR PI0410972A
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- extending
- shelf life
- treating hyperglycemia
- peptide
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 201000001421 hyperglycemia Diseases 0.000 title 1
- 108010088406 Glucagon-Like Peptides Proteins 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Abstract
"MéTODO PARA AUMENTAR A VIDA DE ARMAZENAGEM DE UMA COMPOSIçãO FARMACêUTICA, COMPOSIçãO FARMACêUTICA, E, MéTODO PARA TRATAMENTO DE HIPERGLICEMIA". Método para aumentar a vida de armazenagem de uma composição farmacêutica para administração parenteral compreendendo um peptídeo semelhante a glucagon que é preparado a partir de um produto de peptídeo que tem sido submetido ao tratamento em um pH acima de pH neutro.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200300819 | 2003-06-03 | ||
DKPA200300819 | 2003-06-03 | ||
DKPA200400075 | 2004-01-19 | ||
DKPA200400075 | 2004-01-19 | ||
PCT/DK2004/000380 WO2004105781A2 (en) | 2003-06-03 | 2004-06-03 | Stabilized pharmaceutical peptide compositions |
Publications (4)
Publication Number | Publication Date |
---|---|
BRPI0410972A true BRPI0410972A (pt) | 2006-07-04 |
BRPI0410972B1 BRPI0410972B1 (pt) | 2018-01-30 |
BRPI0410972B8 BRPI0410972B8 (pt) | 2018-12-04 |
BRPI0410972C1 BRPI0410972C1 (pt) | 2021-05-25 |
Family
ID=36645905
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0410972A BRPI0410972C1 (pt) | 2003-06-03 | 2004-06-03 | método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia |
Country Status (8)
Country | Link |
---|---|
US (2) | US7632806B2 (pt) |
EP (1) | EP2292254A3 (pt) |
JP (1) | JP4936884B2 (pt) |
KR (1) | KR101308912B1 (pt) |
CN (1) | CN102940879B (pt) |
AT (1) | ATE541582T1 (pt) |
BR (1) | BRPI0410972C1 (pt) |
ES (1) | ES2380437T3 (pt) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7635463B2 (en) | 2002-02-27 | 2009-12-22 | Pharmain Corporation | Compositions for delivery of therapeutics and other materials |
WO2003072143A1 (en) * | 2002-02-27 | 2003-09-04 | Pharmain, Ltd. | Compositions for delivery of therapeutics and other materials, and methods of making and using the same |
US7731947B2 (en) | 2003-11-17 | 2010-06-08 | Intarcia Therapeutics, Inc. | Composition and dosage form comprising an interferon particle formulation and suspending vehicle |
JP2007524592A (ja) * | 2003-06-03 | 2007-08-30 | ノボ・ノルデイスク・エー/エス | 安定化された薬学的ペプチド組成物 |
WO2005112977A2 (en) * | 2004-04-23 | 2005-12-01 | Pharmain, Ltd. | Compositions for treatment with glucagon-like peptide, and methods of making and using the same |
US11246913B2 (en) | 2005-02-03 | 2022-02-15 | Intarcia Therapeutics, Inc. | Suspension formulation comprising an insulinotropic peptide |
WO2006083761A2 (en) | 2005-02-03 | 2006-08-10 | Alza Corporation | Solvent/polymer solutions as suspension vehicles |
KR101529318B1 (ko) | 2005-12-19 | 2015-06-16 | 파마인 코포레이션 | 치료제를 전달하기 위한 소수성 코어 담체 조성물, 이조성물의 제조 방법 및 그 조성물의 이용 방법 |
DK2020990T3 (da) | 2006-05-30 | 2010-12-13 | Intarcia Therapeutics Inc | Strømningsmodulator med en indre kanal til et todelt osmotisk fremføringssystem |
KR101200728B1 (ko) | 2006-08-09 | 2012-11-13 | 인타르시아 세라퓨틱스 인코포레이티드 | 삼투성 전달 시스템 및 피스톤 조립체 |
KR100746658B1 (ko) | 2007-04-23 | 2007-08-06 | 성균관대학교산학협력단 | 소수성 담즙산이 접합된 엑센딘-4 유도체, 이의 제조방법및 이를 포함하는 약학 조성물 |
ES2402172T3 (es) | 2007-04-23 | 2013-04-29 | Intarcia Therapeutics, Inc | Formulación en suspensión de péptidos insulinotrópicos y usos de los mismos |
US7960336B2 (en) | 2007-08-03 | 2011-06-14 | Pharmain Corporation | Composition for long-acting peptide analogs |
US8563527B2 (en) * | 2007-08-20 | 2013-10-22 | Pharmain Corporation | Oligonucleotide core carrier compositions for delivery of nucleic acid-containing therapeutic agents, methods of making and using the same |
US20090176892A1 (en) * | 2008-01-09 | 2009-07-09 | Pharmain Corporation | Soluble Hydrophobic Core Carrier Compositions for Delivery of Therapeutic Agents, Methods of Making and Using the Same |
DK2240155T3 (da) | 2008-02-13 | 2012-09-17 | Intarcia Therapeutics Inc | Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler |
US20110034385A1 (en) * | 2008-04-07 | 2011-02-10 | National Institute Of Immunology | Compositions Useful for the Treatment of Diabetes and Other Chronic Disorder |
RU2753280C2 (ru) | 2009-09-28 | 2021-08-12 | Интарсия Терапьютикс, Инк. | Быстрое достижение и/или прекращение существенной стабильной доставки лекарственного средства |
US9445992B2 (en) | 2009-11-25 | 2016-09-20 | Arisgen Sa | Mucosal delivery compositions comprising a peptide complexed with a crown compound and/or a counter ion |
RU2557301C2 (ru) * | 2010-05-17 | 2015-07-20 | Бетта Фармасьютикалз Ко.,Лтд | Новые аналоги глюкагон-подобного пептида, композиция и способ применения |
US8636711B2 (en) * | 2010-06-14 | 2014-01-28 | Legacy Emanuel Hospital & Health Center | Stabilized glucagon solutions and uses therefor |
US20120208755A1 (en) | 2011-02-16 | 2012-08-16 | Intarcia Therapeutics, Inc. | Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers |
EP2526971A1 (en) | 2011-05-25 | 2012-11-28 | ArisGen SA | Mucosal delivery of drugs |
US9546205B2 (en) | 2012-09-17 | 2017-01-17 | Imperial Innovations Limited | Peptide analogues of glucagon and GLP1 |
UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
HK1211231A1 (en) | 2012-12-21 | 2016-05-20 | Sanofi | Exendin-4 derivatives |
MY180276A (en) * | 2013-06-28 | 2020-11-26 | Amgen Inc | Stable liquid formulation of amg 416 (velcalcetide) |
EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重glp-1/升糖素受體促效劑 |
WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
TW201609795A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 作為雙重glp-1/gip受體促效劑的艾塞那肽-4(exendin-4)胜肽類似物 |
TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自exendin-4之雙重glp-1/升糖素受體促效劑 |
TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽-4(Exendin-4)之肽類雙重GLP-1/升糖素受體促效劑 |
TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重glp-1/昇糖素受體激動劑之艾塞那肽-4衍生物 |
US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
KR20170021313A (ko) * | 2014-06-25 | 2017-02-27 | 글락소스미스클라인 엘엘씨 | 제약 조성물 |
US9889085B1 (en) | 2014-09-30 | 2018-02-13 | Intarcia Therapeutics, Inc. | Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c |
KR102650751B1 (ko) | 2015-06-03 | 2024-03-22 | 인타르시아 세라퓨틱스 인코포레이티드 | 임플란트 배치 및 제거 시스템들 |
AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重glp-1/升糖素受體促效劑之新毒蜥外泌肽(exendin-4)衍生物 |
TWI814219B (zh) | 2016-05-16 | 2023-09-01 | 美商因塔希亞治療公司 | 升糖素受體選擇性多肽和彼之使用方法 |
USD840030S1 (en) | 2016-06-02 | 2019-02-05 | Intarcia Therapeutics, Inc. | Implant placement guide |
USD860451S1 (en) | 2016-06-02 | 2019-09-17 | Intarcia Therapeutics, Inc. | Implant removal tool |
US10835580B2 (en) | 2017-01-03 | 2020-11-17 | Intarcia Therapeutics, Inc. | Methods comprising continuous administration of a GLP-1 receptor agonist and co-administration of a drug |
KR102568413B1 (ko) | 2017-06-15 | 2023-08-21 | 한국전자통신연구원 | 이온 빔 치료장치 |
EP4360651A3 (en) | 2017-08-24 | 2024-07-17 | Novo Nordisk A/S | Glp-1 compositions and uses thereof |
CN110551203B (zh) * | 2019-09-25 | 2023-02-10 | 成都奥达生物科技有限公司 | 一种艾塞那肽类似物 |
CA3165355A1 (en) | 2020-02-18 | 2021-07-22 | Tommy SANDER | Pharmaceutical formulations |
WO2021219710A1 (en) * | 2020-04-29 | 2021-11-04 | Novo Nordisk A/S | Solid compositions comprising a glp-1 agonist and histidine |
EP4281039A2 (en) | 2021-01-25 | 2023-11-29 | Mylan Ireland Limited | Pharmaceutical glp peptide compositions and methods of preparation thereof |
CN118307645A (zh) * | 2021-05-28 | 2024-07-09 | 广东众生睿创生物科技有限公司 | 多肽的制备及其应用 |
Family Cites Families (76)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4468346A (en) | 1983-10-27 | 1984-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Monoclonal antibodies to porcine immunoglobulins |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
JP2818176B2 (ja) | 1987-05-14 | 1998-10-30 | コモンウェルス・サイエンティフィック・アンド・インダストリアル・リサーチ・オーガナイゼーション | ホエー蛋白フラクション |
JPH03505401A (ja) | 1988-06-27 | 1991-11-28 | ジェネックス・コーポレーション | 組換えタンパク質の培養培地への熱放出 |
EP0431679B1 (en) | 1989-12-05 | 1994-10-19 | Merck & Co. Inc. | Method of stabilizing recombinant hepatitis B virus surface proteins from yeast |
DE4002066A1 (de) | 1990-01-25 | 1991-08-01 | Basf Ag | Verfahren zur abtrennung von riboflavin aus fermentationssuspensionen |
US5272135A (en) * | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
SE9101381D0 (sv) | 1991-05-07 | 1991-05-07 | Tomas Moks | Peptide hormone solution |
US5206219A (en) | 1991-11-25 | 1993-04-27 | Applied Analytical Industries, Inc. | Oral compositions of proteinaceous medicaments |
ATE147619T1 (de) | 1992-05-13 | 1997-02-15 | Sandoz Ag | Opthalmische zusammensetzungen enthaltend ein cyclosporin |
US6284727B1 (en) | 1993-04-07 | 2001-09-04 | Scios, Inc. | Prolonged delivery of peptides |
GB9320782D0 (en) | 1993-10-08 | 1993-12-01 | Univ Leeds Innovations Ltd | Stabilising of proteins on solution |
JPH09505290A (ja) | 1993-11-19 | 1997-05-27 | ジー.ディー.サール アンド カンパニー | N‐[N‐[5‐[4‐(アミノイミノメチル)フェニル]‐1‐オキソペンチル]‐L‐α‐アスパルチル]‐L‐フェニルアラニンまたはそのエステル並びにそれらの医薬的に許容される塩類の経皮的組成物 |
US5705483A (en) | 1993-12-09 | 1998-01-06 | Eli Lilly And Company | Glucagon-like insulinotropic peptides, compositions and methods |
WO1995022560A1 (en) | 1994-02-22 | 1995-08-24 | The Syntex-Synergen Neuroscience Joint Venture | Pharmaceutical formulations of cntf |
US5652216A (en) | 1994-05-26 | 1997-07-29 | Novo Nordisk A/S | Pharmaceutical preparation |
DE69532492T2 (de) | 1994-08-31 | 2004-12-02 | Mitsubishi Pharma Corp. | Verfahren zur Reinigung von rekombinantem menschlichem Serumalbumin |
US5512549A (en) | 1994-10-18 | 1996-04-30 | Eli Lilly And Company | Glucagon-like insulinotropic peptide analogs, compositions, and methods of use |
JPH10511365A (ja) | 1994-12-23 | 1998-11-04 | ノボ ノルディスク アクティーゼルスカブ | 遅延性glp−1組成物 |
US5834428A (en) * | 1995-04-14 | 1998-11-10 | 1149336 Ontario Inc. | Glucagon-like peptide-2 and its therapeutic use |
US6184201B1 (en) * | 1995-04-14 | 2001-02-06 | Nps Allelix Corp. | Intestinotrophic glucagon-like peptide-2 analogs |
EP0828753B1 (en) | 1995-06-02 | 2003-03-26 | Novozymes A/S | Al/Fe-TREATMENT OF A PROTEIN SOLUTION, FOLLOWED BY MEMBRANE CONCENTRATION |
US5631347A (en) | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
ES2283025T3 (es) | 1996-08-30 | 2007-10-16 | Novo Nordisk A/S | Derivados de glp-1.1. |
US6268343B1 (en) * | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
RU2180218C2 (ru) | 1997-01-20 | 2002-03-10 | Джапэн Энерджи Корпорейшн | Способ стабилизации гирудина и/или вариантов гирудина, лиофилизированная фармацевтическая композиция, полученная с применением данного способа |
CA2236519C (en) * | 1997-05-02 | 2011-09-13 | 1149336 Ontario Inc. | Methods of enhancing functioning of the large intestine |
DE69738333T2 (de) | 1997-10-01 | 2008-11-27 | Novadel Pharma Inc. | Nichtpolares Spray zur bukkalen Verabreichung |
ATE237636T1 (de) | 1997-10-24 | 2003-05-15 | Genentech Inc | Reinigung von molekülen |
AU1617399A (en) * | 1997-12-05 | 1999-06-28 | Eli Lilly And Company | Glp-1 formulations |
US6380357B2 (en) | 1997-12-16 | 2002-04-30 | Eli Lilly And Company | Glucagon-like peptide-1 crystals |
JP2002504527A (ja) | 1998-02-27 | 2002-02-12 | ノボ ノルディスク アクティーゼルスカブ | 部分的に組織化したミセル様凝集物を形成する25%を越えるヘリックス成分を有するglp−2誘導体 |
JP2002504518A (ja) | 1998-02-27 | 2002-02-12 | ノボ ノルディスク アクティーゼルスカブ | 部分的に構造化されたミセルー様凝集体を形成する、25%を超えるヘリックス−含有率を有するglp−1誘導体 |
AU3247799A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | Glp-1 derivatives of glp-1 and exendin with protracted profile of action |
AU2610899A (en) | 1998-02-27 | 1999-09-15 | Novo Nordisk A/S | N-terminally modified glp-1 derivatives |
EP1060191B1 (en) | 1998-02-27 | 2010-04-28 | Novo Nordisk A/S | Derivatives of glp-1 analogs |
ATE269103T1 (de) * | 1998-03-13 | 2004-07-15 | Novo Nordisk As | Stabilisierte wässerige glukagonlösungen enthaltend detergenzien |
AU765584B2 (en) | 1998-09-17 | 2003-09-25 | Eli Lilly And Company | Protein formulations |
IL143346A0 (en) | 1998-12-07 | 2002-04-21 | Sod Conseils Rech Applic | Analogues of glp-1 |
ATE307603T1 (de) * | 1998-12-22 | 2005-11-15 | Lilly Co Eli | Lagerstabile flüssige zusammensetzungen von glucagon-ähnlichem peptid-1 |
ES2244416T5 (es) | 1999-01-14 | 2020-01-03 | Amylin Pharmaceuticals Llc | Formulaciones novedosas de agonistas de la exendina y métodos de administración de los mismos |
US6444788B1 (en) | 1999-03-15 | 2002-09-03 | Novo Nordisk A/S | Ion exchange chromatography of GLP-1, analogs and derivatives thereof |
EP1956000B1 (en) | 1999-03-17 | 2016-10-05 | Novo Nordisk A/S | Acylating agents useful for acylating peptides |
CA2369839A1 (en) | 1999-06-25 | 2001-01-04 | Minimed, Inc. | Compositions of insulin and insulin-related peptide for treating diabetes |
US6569832B1 (en) * | 1999-11-12 | 2003-05-27 | Novo Nordisk A/S | Inhibition of beta cell degeneration |
AU777570B2 (en) | 1999-12-16 | 2004-10-21 | Eli Lilly And Company | Polypeptide compositions with improved stability |
US7022674B2 (en) | 1999-12-16 | 2006-04-04 | Eli Lilly And Company | Polypeptide compositions with improved stability |
GB9930882D0 (en) * | 1999-12-30 | 2000-02-23 | Nps Allelix Corp | GLP-2 formulations |
US6734162B2 (en) | 2000-01-24 | 2004-05-11 | Minimed Inc. | Mixed buffer system for stabilizing polypeptide formulations |
EP1396499A3 (en) | 2000-01-27 | 2004-12-29 | Eli Lilly And Company | Process for solubilizing glucagon-like peptide 1 (GLP-1) compounds |
BR0107837A (pt) | 2000-01-27 | 2003-01-14 | Lilly Co Eli | Processo para solubilização de compostos peptìdeo 1 semelhantes a glucagon |
US6844321B2 (en) | 2000-01-31 | 2005-01-18 | Novo Nordisk A/S | Crystallization of a GLP-1 analogue |
WO2001077141A1 (en) | 2000-04-06 | 2001-10-18 | Novo Nordisk A/S | Shock heat treatment of polypeptides |
DZ3388A1 (fr) | 2000-06-16 | 2001-12-27 | Lilly Co Eli | Analogues de peptide 1 du type glucagon |
CN1340549A (zh) * | 2000-08-26 | 2002-03-20 | 徐州万邦生化制药有限公司 | 一种胰高血糖素制备工艺 |
JP4798833B2 (ja) | 2000-10-24 | 2011-10-19 | 一般財団法人化学及血清療法研究所 | 加熱処理工程を含むヒト血清アルブミンの製造方法 |
US7199217B2 (en) * | 2000-12-13 | 2007-04-03 | Eli Lilly And Company | Amidated glucagon-like peptide-1 |
US20020151467A1 (en) | 2000-12-21 | 2002-10-17 | Leung Frank K. | Methods and compositions for oral insulin delivery |
GB2371227A (en) | 2001-01-10 | 2002-07-24 | Grandis Biotech Gmbh | Crystallisation - resistant aqueous growth hormone formulations |
PT1360202E (pt) * | 2001-02-16 | 2008-09-01 | Conjuchem Biotechnologies Inc | Peptídeo do tipo glucagon 2 (glp-2) de longa duração para o tratamento de doenças e distúrbios gastrointestinais |
US6573237B2 (en) * | 2001-03-16 | 2003-06-03 | Eli Lilly And Company | Protein formulations |
DK1412384T3 (da) | 2001-06-28 | 2008-04-28 | Novo Nordisk As | Stabil formulering af modificeret GLP-1 |
CN1335182A (zh) | 2001-08-08 | 2002-02-13 | 华中科技大学 | 胰岛素口腔喷剂及其制备工艺 |
MXPA04001525A (es) | 2001-08-23 | 2004-05-31 | Lilly Co Eli | Analogos de peptido -1 similar al glucagon. |
US7238663B2 (en) | 2001-08-28 | 2007-07-03 | Eli Lilly And Company | Pre-mixes of GLP-1 and basal insulin |
US7179788B2 (en) | 2001-10-19 | 2007-02-20 | Eli Lilly And Company | Biphasic mixtures of GLP-1 and insulin |
JP2005526084A (ja) | 2002-03-15 | 2005-09-02 | ナットイムネ・アクティーゼルスカブ | マンノース結合レクチンを含む医薬組成物 |
WO2003084563A1 (en) | 2002-04-04 | 2003-10-16 | Novo Nordisk A/S | Glp-1 agonist and cardiovascular complications |
US7273921B2 (en) * | 2002-09-25 | 2007-09-25 | Novo Nordisk A/S | Method for producing acylated peptides |
DE60321473D1 (de) | 2002-09-25 | 2008-07-17 | Novo Nordisk As | Aufreinigungsverfahren, das eine mikrofiltration bei erhöhten temperaturen beinhaltet |
WO2004089985A1 (en) | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | Stable pharmaceutical compositions |
US8008255B2 (en) | 2003-05-30 | 2011-08-30 | Amylin Pharmaceuticals, Inc. | Methods and compositions for enhanced transmucosal delivery of peptides and proteins |
CA2527743A1 (en) | 2003-06-03 | 2004-12-09 | Novo Nordisk A/S | Stabilized pharmaceutical peptide compositions |
JP4800959B2 (ja) | 2003-11-13 | 2011-10-26 | ノヴォ ノルディスク アー/エス | 糖尿病及び過食症を治療するためのglp−1ペプチド及び短時間作用型インスリンペプチドを含む、非経口投与用の可溶性医薬組成物 |
US20060287221A1 (en) | 2003-11-13 | 2006-12-21 | Novo Nordisk A/S | Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia |
EP2457580A1 (en) | 2004-08-25 | 2012-05-30 | The UAB Research Foundation | Absorption enhancers for drug administration |
-
2004
- 2004-06-03 KR KR1020127027174A patent/KR101308912B1/ko not_active Expired - Lifetime
- 2004-06-03 EP EP10178212A patent/EP2292254A3/en not_active Withdrawn
- 2004-06-03 BR BRPI0410972A patent/BRPI0410972C1/pt active IP Right Grant
- 2004-06-03 AT AT04735870T patent/ATE541582T1/de active
- 2004-06-03 JP JP2006508132A patent/JP4936884B2/ja not_active Expired - Lifetime
- 2004-06-03 CN CN201210497503.5A patent/CN102940879B/zh not_active Expired - Lifetime
- 2004-06-03 ES ES04735870T patent/ES2380437T3/es not_active Expired - Lifetime
-
2005
- 2005-11-30 US US11/290,634 patent/US7632806B2/en not_active Expired - Lifetime
-
2009
- 2009-11-05 US US12/612,888 patent/US8614181B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
BRPI0410972C1 (pt) | 2021-05-25 |
KR101308912B1 (ko) | 2013-09-23 |
EP2292254A3 (en) | 2011-12-14 |
US20060178304A1 (en) | 2006-08-10 |
US20100056451A1 (en) | 2010-03-04 |
BRPI0410972B8 (pt) | 2018-12-04 |
US7632806B2 (en) | 2009-12-15 |
EP2292254A2 (en) | 2011-03-09 |
ES2380437T3 (es) | 2012-05-11 |
KR20120130264A (ko) | 2012-11-29 |
US8614181B2 (en) | 2013-12-24 |
BRPI0410972B1 (pt) | 2018-01-30 |
ATE541582T1 (de) | 2012-02-15 |
JP2008500262A (ja) | 2008-01-10 |
JP4936884B2 (ja) | 2012-05-23 |
CN102940879A (zh) | 2013-02-27 |
CN102940879B (zh) | 2017-06-06 |
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