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BRPI0410238A - compostos orgánicos - Google Patents

compostos orgánicos

Info

Publication number
BRPI0410238A
BRPI0410238A BRPI0410238-0A BRPI0410238A BRPI0410238A BR PI0410238 A BRPI0410238 A BR PI0410238A BR PI0410238 A BRPI0410238 A BR PI0410238A BR PI0410238 A BRPI0410238 A BR PI0410238A
Authority
BR
Brazil
Prior art keywords
compounds
organic compounds
muscarinic
meanings
mediated
Prior art date
Application number
BRPI0410238-0A
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Brian Cox
Urs Baettig
Gurdip Bhalay
Nicholas James Devereux
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33420896&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0410238(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0324887A external-priority patent/GB0324887D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BRPI0410238A publication Critical patent/BRPI0410238A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

"COMPOSTOS ORGáNICOS". A presente invenção refere-se a compostos da fórmula (I), em forma de sal ou zwitteriónicaem que, R¬ 1¬, R¬ 2¬, R¬ 3¬ e R¬ 4¬ têm os significados como indicado na especificação, são úteis para tratar condições que são mediadas pelo receptor M3 muscarínico. As composições farmacêuticas que contêm os compostos e um processo para preparar os compostos são da mesma forma descritos.
BRPI0410238-0A 2003-05-02 2004-04-30 compostos orgánicos BRPI0410238A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0310232 2003-05-02
GB0324887A GB0324887D0 (en) 2003-10-24 2003-10-24 Organic compounds
PCT/EP2004/004605 WO2004096800A2 (en) 2003-05-02 2004-04-30 Quinuclidine derivatives binding to mucarinic m3 receptors

Publications (1)

Publication Number Publication Date
BRPI0410238A true BRPI0410238A (pt) 2006-05-16

Family

ID=33420896

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0410238-0A BRPI0410238A (pt) 2003-05-02 2004-04-30 compostos orgánicos

Country Status (32)

Country Link
US (2) US20070060563A1 (pt)
EP (1) EP1631569B1 (pt)
JP (1) JP4416786B2 (pt)
KR (1) KR100896544B1 (pt)
AR (1) AR044134A1 (pt)
AT (1) ATE440840T1 (pt)
AU (1) AU2004234069B2 (pt)
BR (1) BRPI0410238A (pt)
CA (1) CA2523436C (pt)
CL (1) CL2004000918A1 (pt)
CO (1) CO5700782A2 (pt)
CY (1) CY1109655T1 (pt)
DE (1) DE602004022805D1 (pt)
DK (1) DK1631569T3 (pt)
EC (1) ECSP056134A (pt)
ES (1) ES2331185T3 (pt)
HK (1) HK1087704A1 (pt)
HR (1) HRP20050933A2 (pt)
IL (1) IL171591A (pt)
IS (1) IS2746B (pt)
MA (1) MA27775A1 (pt)
MX (1) MXPA05011739A (pt)
MY (1) MY142652A (pt)
NO (1) NO20055688L (pt)
NZ (1) NZ542995A (pt)
PE (1) PE20050465A1 (pt)
PL (1) PL1631569T3 (pt)
PT (1) PT1631569E (pt)
RU (1) RU2363700C2 (pt)
SI (1) SI1631569T1 (pt)
TW (1) TWI340139B (pt)
WO (1) WO2004096800A2 (pt)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2239546B1 (es) * 2004-03-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos esteres de quinuclidina cuaternizados.
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0428416D0 (en) * 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP1894568A1 (en) * 2006-08-31 2008-03-05 Novartis AG Pharmaceutical compositions for the treatment of inflammatory or obstructive airway diseases
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
EP2121137B1 (en) * 2006-12-19 2012-04-25 AstraZeneca AB Quinuclidinol derivatives as muscarinic receptor antagonists
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
DK2197841T3 (da) 2007-09-07 2012-02-06 Theravance Inc Guanidinholdige forbindelser anvendelige som muscariniske receptorantagonister
WO2009079392A1 (en) 2007-12-14 2009-06-25 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
GB0808709D0 (en) * 2008-05-13 2008-06-18 Astrazeneca Ab New combination 295
AU2009247021B2 (en) * 2008-05-13 2012-06-07 Astrazeneca Ab Pharmaceutical product comprising a muscarinic receptor antagonist and a beta2-adrenoceptor agonist
BRPI0822693A2 (pt) 2008-05-13 2015-07-07 Astrazeneca Ab Derivados de quinuclidina como antagonistas do receptor muscarínico m3
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
WO2009153536A1 (en) * 2008-06-17 2009-12-23 Argenta Discovery Limited 1-aza-bicyclo [2.2.2] octane derivatives useful as muscarinic receptor antagonists
GB0811100D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination
KR20130087405A (ko) * 2010-06-22 2013-08-06 키에시 파르마슈티시 엣스. 피. 에이. 알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
KR20140014184A (ko) 2011-02-25 2014-02-05 아이알엠 엘엘씨 Trk 억제제로서의 화합물 및 조성물
JP2011195593A (ja) * 2011-06-30 2011-10-06 Astrazeneca Ab ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
EP2797910B1 (en) * 2011-12-30 2015-09-16 Chiesi Farmaceutici S.p.A. Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof
WO2013166413A2 (en) * 2012-05-03 2013-11-07 Saint Louis College Of Pharmacy Compositions and methods for increasing neurotrophic peptides
TWI647227B (zh) * 2013-02-28 2019-01-11 日商安斯泰來製藥股份有限公司 ２－醯胺噻唑衍生物或其鹽
CZ306791B6 (cs) 2013-10-29 2017-07-12 Zentiva, K.S. Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
PL3111978T3 (pl) 2015-07-03 2022-01-24 Novartis Ag Inhalator przystosowany do odczytu informacji przechowywanych w środkach przechowywania danych pojemnika

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
DK534178A (da) * 1977-12-16 1979-06-17 Interx Research Corp Anticholinerge midler med sektrtionshaemmende virkning
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
CA2415468A1 (en) * 2000-07-11 2003-01-10 Yoshio Ogino Ester derivatives
EP1353919B1 (en) * 2000-12-28 2006-07-26 Almirall Prodesfarma AG Novel quinuclidine derivatives and medicinal compositions containing the same
ES2425347T3 (es) * 2001-12-20 2013-10-14 Chiesi Farmaceutici S.P.A. Derivados de carbamato de 1-alquil-1-azoniabiciclo[2.2.2]octano y su uso como antagonistas de receptores muscarínicos
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
EP1900737A1 (en) * 2006-08-31 2008-03-19 Novartis AG Polymorph of (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromide

Also Published As

Publication number Publication date
DK1631569T3 (da) 2009-11-23
KR20060015572A (ko) 2006-02-17
EP1631569B1 (en) 2009-08-26
HRP20050933A2 (en) 2006-12-31
TW200505920A (en) 2005-02-16
CA2523436C (en) 2011-11-01
CL2004000918A1 (es) 2005-02-11
AU2004234069A1 (en) 2004-11-11
NZ542995A (en) 2009-02-28
MA27775A1 (fr) 2006-02-01
IL171591A (en) 2010-11-30
PL1631569T3 (pl) 2010-02-26
IS2746B (is) 2011-08-15
ECSP056134A (es) 2006-04-19
NO20055688L (no) 2006-01-09
CO5700782A2 (es) 2006-11-30
AU2004234069B2 (en) 2008-02-21
RU2005137360A (ru) 2006-07-27
TWI340139B (en) 2011-04-11
WO2004096800A2 (en) 2004-11-11
CY1109655T1 (el) 2014-08-13
JP2006525267A (ja) 2006-11-09
NO20055688D0 (no) 2005-12-01
PE20050465A1 (es) 2005-07-18
PT1631569E (pt) 2009-11-26
MXPA05011739A (es) 2006-01-26
DE602004022805D1 (de) 2009-10-08
JP4416786B2 (ja) 2010-02-17
ATE440840T1 (de) 2009-09-15
SI1631569T1 (sl) 2010-01-29
EP1631569A2 (en) 2006-03-08
CA2523436A1 (en) 2004-11-11
KR100896544B1 (ko) 2009-05-07
ES2331185T3 (es) 2009-12-23
IS8158A (is) 2005-11-30
US20100041887A1 (en) 2010-02-18
MY142652A (en) 2010-12-15
WO2004096800A3 (en) 2005-01-06
HK1087704A1 (en) 2006-10-20
US20070060563A1 (en) 2007-03-15
RU2363700C2 (ru) 2009-08-10
AR044134A1 (es) 2005-08-24
US8168654B2 (en) 2012-05-01

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 11A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2308 DE 31/03/2015.