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ATE440840T1 - Quinuclidin-derivate bindend an muscarin-m3- rezeptoren - Google Patents

Quinuclidin-derivate bindend an muscarin-m3- rezeptoren

Info

Publication number
ATE440840T1
ATE440840T1 AT04730519T AT04730519T ATE440840T1 AT E440840 T1 ATE440840 T1 AT E440840T1 AT 04730519 T AT04730519 T AT 04730519T AT 04730519 T AT04730519 T AT 04730519T AT E440840 T1 ATE440840 T1 AT E440840T1
Authority
AT
Austria
Prior art keywords
muscarine
receptors
quinuclidine derivatives
derivatives binding
binding
Prior art date
Application number
AT04730519T
Other languages
English (en)
Inventor
Stephen Paul Collingwood
Brian Cox
Urs Baettig
Gurdip Bhalay
Nicholas James Devereux
Original Assignee
Novartis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33420896&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE440840(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0324887A external-priority patent/GB0324887D0/en
Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh
Application granted granted Critical
Publication of ATE440840T1 publication Critical patent/ATE440840T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04730519T 2003-05-02 2004-04-30 Quinuclidin-derivate bindend an muscarin-m3- rezeptoren ATE440840T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0310232 2003-05-02
GB0324887A GB0324887D0 (en) 2003-10-24 2003-10-24 Organic compounds
PCT/EP2004/004605 WO2004096800A2 (en) 2003-05-02 2004-04-30 Quinuclidine derivatives binding to mucarinic m3 receptors

Publications (1)

Publication Number Publication Date
ATE440840T1 true ATE440840T1 (de) 2009-09-15

Family

ID=33420896

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04730519T ATE440840T1 (de) 2003-05-02 2004-04-30 Quinuclidin-derivate bindend an muscarin-m3- rezeptoren

Country Status (31)

Country Link
US (2) US20070060563A1 (de)
EP (1) EP1631569B1 (de)
JP (1) JP4416786B2 (de)
KR (1) KR100896544B1 (de)
AR (1) AR044134A1 (de)
AT (1) ATE440840T1 (de)
AU (1) AU2004234069B2 (de)
BR (1) BRPI0410238A (de)
CA (1) CA2523436C (de)
CL (1) CL2004000918A1 (de)
CO (1) CO5700782A2 (de)
CY (1) CY1109655T1 (de)
DE (1) DE602004022805D1 (de)
DK (1) DK1631569T3 (de)
EC (1) ECSP056134A (de)
ES (1) ES2331185T3 (de)
HR (1) HRP20050933A2 (de)
IL (1) IL171591A (de)
IS (1) IS2746B (de)
MA (1) MA27775A1 (de)
MX (1) MXPA05011739A (de)
MY (1) MY142652A (de)
NO (1) NO20055688L (de)
NZ (1) NZ542995A (de)
PE (1) PE20050465A1 (de)
PL (1) PL1631569T3 (de)
PT (1) PT1631569E (de)
RU (1) RU2363700C2 (de)
SI (1) SI1631569T1 (de)
TW (1) TWI340139B (de)
WO (1) WO2004096800A2 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2239546B1 (es) * 2004-03-15 2006-12-01 Almirall Prodesfarma, S.A. Nuevos esteres de quinuclidina cuaternizados.
GB0410712D0 (en) 2004-05-13 2004-06-16 Novartis Ag Organic compounds
GB0424284D0 (en) 2004-11-02 2004-12-01 Novartis Ag Organic compounds
GB0428416D0 (en) * 2004-12-24 2005-02-02 Novartis Ag Organic compounds
GB0601951D0 (en) 2006-01-31 2006-03-15 Novartis Ag Organic compounds
EP1900737A1 (de) * 2006-08-31 2008-03-19 Novartis AG Polymorph von (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromid
EP1894568A1 (de) * 2006-08-31 2008-03-05 Novartis AG Pharmazeutische Zusammensetzungen zur Behandlung von entzündlichen oder obstruktiven Atemwegserkrankungen
TW200825084A (en) * 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
JP4604129B2 (ja) * 2006-12-19 2010-12-22 アストラゼネカ・アクチエボラーグ ムスカリン受容体アンタゴニストとしてのキヌクリジノール誘導体
EP1950196A1 (de) * 2007-01-29 2008-07-30 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur Herstellung von Ammoniumhexafluorophosphaten
PT2197841E (pt) 2007-09-07 2012-01-02 Theravance Inc Compostos contendo guanidina úteis como antagonistas do receptor muscarínico
WO2009079392A1 (en) 2007-12-14 2009-06-25 Theravance, Inc. Amidine-containing compounds useful as muscarinic receptor antagonists
PT2231642E (pt) 2008-01-11 2014-03-12 Novartis Ag Pirimidinas como inibidores de quinase
NZ589091A (en) 2008-05-13 2011-07-29 Astrazeneca Ab Quinuclidine derivatives as muscarinic m3 receptor antagonists
GB0808709D0 (en) * 2008-05-13 2008-06-18 Astrazeneca Ab New combination 295
CN102088976B (zh) * 2008-05-13 2012-12-26 阿斯利康(瑞典)有限公司 包含毒蕈碱性受体拮抗剂和β2-肾上腺素受体激动剂的药物产品
US20090326004A1 (en) 2008-06-03 2009-12-31 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
GB0811100D0 (en) * 2008-06-17 2008-07-23 Astrazeneca Ab New combination
WO2009153536A1 (en) * 2008-06-17 2009-12-23 Argenta Discovery Limited 1-aza-bicyclo [2.2.2] octane derivatives useful as muscarinic receptor antagonists
BR112012032332A2 (pt) * 2010-06-22 2016-11-08 Chiesi Farma Spa composto, uso de um composto, composição farmacêutica, combinação de um composto e dispositivo
UY33597A (es) 2010-09-09 2012-04-30 Irm Llc Compuestos y composiciones como inhibidores de la trk
WO2012034095A1 (en) 2010-09-09 2012-03-15 Irm Llc Compounds and compositions as trk inhibitors
WO2012116217A1 (en) 2011-02-25 2012-08-30 Irm Llc Compounds and compositions as trk inhibitors
JP2011195593A (ja) * 2011-06-30 2011-10-06 Astrazeneca Ab ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
CA2862008A1 (en) * 2011-12-30 2013-07-04 Chiesi Farmaceutici S.P.A. Quinuclidine esters of 1-azaheterocyclylacetic acid as antimuscarinic agents, process for their preparation and medicinal compositions thereof
CN104470515B (zh) * 2012-05-03 2016-12-07 圣路易斯药学院 用于增加神经营养肽的组合物和方法
TWI647227B (zh) * 2013-02-28 2019-01-11 日商安斯泰來製藥股份有限公司 ２－醯胺噻唑衍生物或其鹽
CZ306791B6 (cs) 2013-10-29 2017-07-12 Zentiva, K.S. Průmyslově využitelný způsob přípravy aklidinium bromidu o vysoké čistotě
PT108370B (pt) * 2015-03-30 2018-10-25 Hovione Farm S A Processo de preparação de brometo de aclidínio
PL3111978T3 (pl) 2015-07-03 2022-01-24 Novartis Ag Inhalator przystosowany do odczytu informacji przechowywanych w środkach przechowywania danych pojemnika

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1219606A (en) * 1968-07-15 1971-01-20 Rech S Et D Applic Scient Soge Quinuclidinol derivatives and preparation thereof
DK534178A (da) * 1977-12-16 1979-06-17 Interx Research Corp Anticholinerge midler med sektrtionshaemmende virkning
IT1230881B (it) * 1989-06-20 1991-11-08 Angeli Inst Spa Derivati del r(-) 3-chinuclidinolo
ES2165768B1 (es) * 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
EP1302458A4 (de) * 2000-07-11 2005-10-19 Banyu Pharma Co Ltd Esterderivate
EE05404B1 (et) * 2000-12-28 2011-04-15 Almirall Prodesfarma Ag Kinuklidiini derivaat, selle saamine ja kasutamine ravimi valmistamiseks, mis on ette n„htud respiratoorsete, kuseelundite v?i mao-soolte haiguste ravimiseks, ning seda sisaldav ravimkompositsioon
RS52522B (sr) * 2001-12-20 2013-04-30 Chiesi Farmaceutici S.P.A. Derivati 1-alkil-1-azoniabiciklo/2.2.2./oktan karbamata i njihova upotreba kao antagonista muskarinskih receptora
GB0424284D0 (en) * 2004-11-02 2004-12-01 Novartis Ag Organic compounds
EP1900737A1 (de) * 2006-08-31 2008-03-19 Novartis AG Polymorph von (R)-3-(2-hydroxy-2,2-diphenyl-acetoxy)-1-(isoxazol-3-ylcarbamoyl-methyl)-1-azonia-bicyclo-[2.2.2]octane bromid

Also Published As

Publication number Publication date
HRP20050933A2 (en) 2006-12-31
PL1631569T3 (pl) 2010-02-26
PT1631569E (pt) 2009-11-26
NO20055688D0 (no) 2005-12-01
KR100896544B1 (ko) 2009-05-07
AR044134A1 (es) 2005-08-24
CA2523436C (en) 2011-11-01
BRPI0410238A (pt) 2006-05-16
EP1631569A2 (de) 2006-03-08
EP1631569B1 (de) 2009-08-26
MA27775A1 (fr) 2006-02-01
WO2004096800A3 (en) 2005-01-06
TW200505920A (en) 2005-02-16
HK1087704A1 (en) 2006-10-20
US8168654B2 (en) 2012-05-01
NZ542995A (en) 2009-02-28
PE20050465A1 (es) 2005-07-18
AU2004234069A1 (en) 2004-11-11
TWI340139B (en) 2011-04-11
MY142652A (en) 2010-12-15
JP2006525267A (ja) 2006-11-09
CO5700782A2 (es) 2006-11-30
IL171591A (en) 2010-11-30
SI1631569T1 (sl) 2010-01-29
DK1631569T3 (da) 2009-11-23
ES2331185T3 (es) 2009-12-23
IS8158A (is) 2005-11-30
US20100041887A1 (en) 2010-02-18
MXPA05011739A (es) 2006-01-26
ECSP056134A (es) 2006-04-19
DE602004022805D1 (de) 2009-10-08
AU2004234069B2 (en) 2008-02-21
CY1109655T1 (el) 2014-08-13
JP4416786B2 (ja) 2010-02-17
CL2004000918A1 (es) 2005-02-11
IS2746B (is) 2011-08-15
WO2004096800A2 (en) 2004-11-11
CA2523436A1 (en) 2004-11-11
KR20060015572A (ko) 2006-02-17
RU2363700C2 (ru) 2009-08-10
RU2005137360A (ru) 2006-07-27
NO20055688L (no) 2006-01-09
US20070060563A1 (en) 2007-03-15

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