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BR9915986A - Estabilização de macrolìdios - Google Patents

Estabilização de macrolìdios

Info

Publication number
BR9915986A
BR9915986A BR9915986-4A BR9915986A BR9915986A BR 9915986 A BR9915986 A BR 9915986A BR 9915986 A BR9915986 A BR 9915986A BR 9915986 A BR9915986 A BR 9915986A
Authority
BR
Brazil
Prior art keywords
stabilization
macro
macrolydes
crystalline form
relates
Prior art date
Application number
BR9915986-4A
Other languages
English (en)
Inventor
Francois Navarro
Samuel Petit
Guy Stone
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314797&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9915986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR9915986A publication Critical patent/BR9915986A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Steroid Compounds (AREA)

Abstract

Patente de Invenção: <B>"ESTABILIZAçãO DE MACROLìDIOS"<D>. A invenção refere-se à estabilização de macrolídios de polieno e a um particular macrolídio obtido na forma cristalina.
BR9915986-4A 1998-12-07 1999-12-06 Estabilização de macrolìdios BR9915986A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9826882.4A GB9826882D0 (en) 1998-12-07 1998-12-07 Organic compounds
GBGB9904934.8A GB9904934D0 (en) 1998-12-07 1999-03-04 Organic compounds
PCT/EP1999/009521 WO2000033878A2 (en) 1998-12-07 1999-12-06 Stabilization of macrolides

Publications (1)

Publication Number Publication Date
BR9915986A true BR9915986A (pt) 2001-09-04

Family

ID=26314797

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915986-4A BR9915986A (pt) 1998-12-07 1999-12-06 Estabilização de macrolìdios

Country Status (38)

Country Link
US (5) US6605613B2 (pt)
EP (4) EP2279751A3 (pt)
JP (3) JP3805625B2 (pt)
KR (2) KR100695834B1 (pt)
CN (2) CN1876657B (pt)
AR (3) AR026102A1 (pt)
AT (1) ATE365051T1 (pt)
AU (1) AU759219B2 (pt)
BE (1) BE1012869A3 (pt)
BR (1) BR9915986A (pt)
CA (3) CA2351580C (pt)
CO (1) CO4980847A1 (pt)
CY (1) CY1106870T1 (pt)
CZ (2) CZ303006B6 (pt)
DE (1) DE69936352T3 (pt)
DK (1) DK1137439T4 (pt)
ES (1) ES2288033T5 (pt)
FR (1) FR2786771B1 (pt)
GB (2) GB9826882D0 (pt)
HK (1) HK1038889B (pt)
HU (2) HU228939B1 (pt)
ID (1) ID29250A (pt)
IL (1) IL143092A0 (pt)
IT (1) IT1319701B1 (pt)
MY (2) MY127579A (pt)
NO (2) NO332698B1 (pt)
NZ (2) NZ511936A (pt)
PE (1) PE20001333A1 (pt)
PL (2) PL196627B1 (pt)
PT (1) PT1137439E (pt)
RU (1) RU2243769C2 (pt)
SG (1) SG151072A1 (pt)
SI (1) SI1137439T2 (pt)
SK (2) SK286688B6 (pt)
TR (2) TR200201428T2 (pt)
TW (2) TWI270550B (pt)
WO (1) WO2000033878A2 (pt)
ZA (1) ZA200104360B (pt)

Families Citing this family (35)

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US20070032853A1 (en) 2002-03-27 2007-02-08 Hossainy Syed F 40-O-(2-hydroxy)ethyl-rapamycin coated stent
US7452692B2 (en) 2002-02-13 2008-11-18 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Method for extracting a macrolide from biomatter
ZA200406350B (en) 2002-02-13 2006-11-29 Teva Gyogyszergyar Reszveny Tarsasag Method for extracting a macrolide from biomatter
AR040693A1 (es) 2002-07-30 2005-04-13 Wyeth Corp Formulaciones parenterales
ES2229975T1 (es) 2003-03-31 2005-05-01 Teva Gyogyszergyar Reszvenytarsasag Cristalizacion y purificacion de macrolidos.
US20050118344A1 (en) 2003-12-01 2005-06-02 Pacetti Stephen D. Temperature controlled crimping
TW200523266A (en) 2003-07-24 2005-07-16 Biogal Gyogyszergyar Method of purifying macrolides
US9114198B2 (en) * 2003-11-19 2015-08-25 Advanced Cardiovascular Systems, Inc. Biologically beneficial coatings for implantable devices containing fluorinated polymers and methods for fabricating the same
CN1889994A (zh) * 2003-12-10 2007-01-03 艾克若克斯Dds有限公司 伴随透皮或局部药物输送的不希望的效果的治疗方法
US8551512B2 (en) 2004-03-22 2013-10-08 Advanced Cardiovascular Systems, Inc. Polyethylene glycol/poly(butylene terephthalate) copolymer coated devices including EVEROLIMUS
KR20070083839A (ko) * 2004-09-29 2007-08-24 코디스 코포레이션 안정한 무정형 라파마이신 유사 화합물의 약학적 투약 형태
DK1848431T3 (en) 2005-02-09 2016-04-18 Santen Pharmaceutical Co Ltd LIQUID FORMULATIONS FOR TREATMENT OF DISEASES OR CONDITIONS
CA2630786A1 (en) * 2005-12-07 2007-06-14 Wyeth Methods for preparing crystalline rapamycin and for measuring crystallinity of rapamycin compounds using differential scanning calorimetry
US7700614B2 (en) * 2005-12-14 2010-04-20 Abbott Laboratories One pot synthesis of tetrazole derivatives of rapamycin
TW200731967A (en) * 2005-12-20 2007-09-01 Wyeth Corp Control of CCI-779 dosage form stability through control of drug substance impurities
WO2007092620A2 (en) 2006-02-09 2007-08-16 Macusight, Inc. Stable formulations, and methods of their preparation and use
BRPI0709016A2 (pt) 2006-03-23 2011-06-21 Macusight Inc formulações e métodos para doenças ou condições relacionadas com a permeabilidade vascular
JP2013527223A (ja) 2010-06-02 2013-06-27 フレゼニウス・カビ・オンコロジー・リミテッド ラパマイシンエステルの安定な医薬組成物
US20120165260A2 (en) * 2010-06-07 2012-06-28 Telik, Inc. Crystalline ezatiostat hydrochloride ansolvate
JP5985474B2 (ja) * 2010-08-04 2016-09-06 メリル ライフ サイエンシズ ピーブィティ．エルティディ 抗増殖特性を有する新規４２−ｏ−（ヘテロアルコキシアルキル）ラパマイシン化合物の調製プロセス
CA2818225C (en) 2010-11-19 2016-10-25 Biocon Limited Processes for preparation of everolimus and intermediates thereof
WO2012170384A1 (en) 2011-06-06 2012-12-13 Chevron Phillips Chemical Company Lp Use of metallocene compounds for cancer treatment
WO2013022201A1 (en) * 2011-08-11 2013-02-14 Dong-A Pharm. Co., Ltd. Process of preparing a stabilized and solubilized formulation of sirolimus derivatives
US9610385B2 (en) 2013-03-07 2017-04-04 Abbott Cardiovascular Systems Inc. Method of fabricating an implantable medical device comprising a rapamycin derivative
IN2013MU02532A (pt) 2013-07-31 2015-06-26 Sahajanand Medical Technologies Pvt Ltd
CN104721158B (zh) * 2013-12-24 2018-01-30 正大天晴药业集团股份有限公司 一种稳定的依维莫司片剂
CN104892632B (zh) * 2015-06-03 2017-12-26 道中道（菏泽）制药有限公司 一种晶体形式的依维莫司及其制备方法
WO2017018433A1 (ja) 2015-07-28 2017-02-02 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物及びその製造方法
JP6793651B2 (ja) * 2015-08-28 2020-12-02 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物
EP3351245A4 (en) * 2015-09-18 2019-05-22 Nippon Kayaku Kabushiki Kaisha PHARMACEUTICAL COMPOSITION COMPRISING RAPAMYCIN OR A DERIVATIVE THEREOF
WO2017129772A1 (en) 2016-01-29 2017-08-03 Xellia Phamaceuticals Aps Stable pharmaceutical compositions of temsirolimus
JP6855470B2 (ja) 2016-05-27 2021-04-07 日本化薬株式会社 ラパマイシン又はその誘導体を含有する医薬組成物
KR102051806B1 (ko) * 2018-01-12 2019-12-04 주식회사 종근당 에베로리무스를 포함하는 안정화된 약제학적 제제
AU2021242202B2 (en) * 2020-03-27 2024-01-11 Boston Scientific Scimed, Inc. Methods for crystallization of drugs
JP2023028473A (ja) * 2021-08-19 2023-03-03 日本マイクロバイオファーマ株式会社 エベロリムスの製造方法

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JPH04230389A (ja) 1990-07-16 1992-08-19 American Home Prod Corp ラパマイシン誘導体
JP3108192B2 (ja) * 1991-05-07 2000-11-13 アメリカン・ホーム・プロダクツ・コーポレイション 免疫抑制剤、抗炎症剤または抗真菌剤用ラパマイシンの還元生成物
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ES2258763T3 (es) 1992-10-13 2006-09-01 Wyeth Carbamatos de rapamicina.
CN1124276C (zh) 1995-06-09 2003-10-15 诺瓦蒂斯有限公司 雷帕霉素衍生物
BE1009856A5 (fr) * 1995-07-14 1997-10-07 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule.
PT1208847E (pt) * 1996-07-30 2007-07-24 Novartis Ag Composições farmacêuticas para o tratamento da rejeição de transplantes, doenças autoimunes ou inflamatórias compreendendo ciclosporina a e 40-0-(2-hidroxietil)-rapamicina
US6362264B1 (en) * 1996-12-20 2002-03-26 Ck Witco Corporation Stabilizer for food contact and medical grade PVC
AU6041498A (en) 1997-02-04 1998-08-25 Abbott Laboratories Pain reducing parenteral liposome formulation

Also Published As

Publication number Publication date
US7741338B2 (en) 2010-06-22
HU228939B1 (en) 2013-07-29
US20020032213A1 (en) 2002-03-14
EP1137439B1 (en) 2007-06-20
GB9904934D0 (en) 1999-04-28
EP2279751A3 (en) 2011-02-16
NO332698B1 (no) 2012-12-10
ITMI992520A0 (it) 1999-12-02
PL208854B1 (pl) 2011-06-30
SI1137439T1 (sl) 2008-06-30
PT1137439E (pt) 2007-09-25
GB9826882D0 (en) 1999-01-27
IT1319701B1 (it) 2003-10-27
AU759219B2 (en) 2003-04-10
CZ20012001A3 (cs) 2001-09-12
SI1137439T2 (sl) 2012-05-31
NZ511936A (en) 2003-10-31
WO2000033878A2 (en) 2000-06-15
DE69936352T2 (de) 2008-02-14
EP1137439B2 (en) 2011-11-23
HK1038889A1 (en) 2002-04-04
PE20001333A1 (es) 2000-12-12
US7572804B2 (en) 2009-08-11
DE69936352D1 (de) 2007-08-02
MY127579A (en) 2006-12-29
CY1106870T1 (el) 2012-09-26
US20030191148A1 (en) 2003-10-09
KR100695834B1 (ko) 2007-03-19
EP2269651A2 (en) 2011-01-05
PL348333A1 (en) 2002-05-20
HUP0104489A2 (hu) 2002-03-28
EP2269651A3 (en) 2011-03-09
PL196627B1 (pl) 2008-01-31
ATE365051T1 (de) 2007-07-15
KR20060096477A (ko) 2006-09-11
CA2351580C (en) 2012-03-20
US6605613B2 (en) 2003-08-12
ID29250A (id) 2001-08-16
AR026102A1 (es) 2003-01-29
CA2732620C (en) 2013-08-06
AR054444A2 (es) 2007-06-27
JP2005200429A (ja) 2005-07-28
TWI270550B (en) 2007-01-11
EP1743657A3 (en) 2007-03-28
DK1137439T3 (da) 2007-09-10
EP2279751A2 (en) 2011-02-02
TR200101416T2 (tr) 2002-01-21
ITMI992520A1 (it) 2001-06-02
CO4980847A1 (es) 2000-11-27
JP5165199B2 (ja) 2013-03-21
NO20012424L (no) 2001-05-16
HUP0104489A3 (en) 2004-05-28
ES2288033T3 (es) 2007-12-16
CA2651609A1 (en) 2000-06-15
DE69936352T3 (de) 2012-05-03
JP2002531527A (ja) 2002-09-24
ZA200104360B (en) 2002-01-16
FR2786771B1 (fr) 2002-12-27
AR048073A2 (es) 2006-03-29
TW200540179A (en) 2005-12-16
CN1876657A (zh) 2006-12-13
HK1038889B (zh) 2008-01-25
JP5043308B2 (ja) 2012-10-10
BE1012869A3 (fr) 2001-04-03
CN1261163C (zh) 2006-06-28
SK287325B6 (sk) 2010-07-07
NO334612B1 (no) 2014-04-22
US7297703B2 (en) 2007-11-20
CA2351580A1 (en) 2000-06-15
AU1657300A (en) 2000-06-26
CN1876657B (zh) 2013-01-09
SK7662001A3 (en) 2001-12-03
JP3805625B2 (ja) 2006-08-02
IL143092A0 (en) 2002-04-21
TR200201428T2 (tr) 2002-12-23
RU2243769C2 (ru) 2005-01-10
CN1374872A (zh) 2002-10-16
FR2786771A1 (fr) 2000-06-09
EP1137439A2 (en) 2001-10-04
JP2006111637A (ja) 2006-04-27
US20090270441A1 (en) 2009-10-29
SG151072A1 (en) 2009-06-29
CZ302210B6 (cs) 2010-12-22
US20050107418A1 (en) 2005-05-19
KR20010101128A (ko) 2001-11-14
ES2288033T5 (es) 2012-04-10
CZ303006B6 (cs) 2012-02-22
TWI248938B (en) 2006-02-11
DK1137439T4 (da) 2012-03-19
NZ527781A (en) 2004-11-26
SK286688B6 (sk) 2009-03-05
EP1743657A2 (en) 2007-01-17
MY120594A (en) 2005-11-30
WO2000033878A3 (en) 2000-11-02
HU230174B1 (hu) 2015-09-28
NO20121113L (no) 2001-05-16
US20080161334A1 (en) 2008-07-03
CA2732620A1 (en) 2000-06-15
NO20012424D0 (no) 2001-05-16
US6852729B2 (en) 2005-02-08

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O E 13 DA LPI.

B12B Appeal against refusal [chapter 12.2 patent gazette]
B15W Others matters related to applications: legal action concerning application

Free format text: INPI-52400.172351/16 ORIGEM: JUIZO DA 031A VARA FEDERAL DO RIO DE JANEIRO PROCESSO NO 0119732-44.2016.4.02.5101 ACAO ORDINARIA DE NULIDADE DA DECISAO ADMINISTRATIVA DE INDEFERIMENTO DO PEDIDO AUTOR: NOVARTIS AG REU: AGENCIA NACIONAL DE VIGILANCIA SANITARIA - ANVISA E INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI