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BR112022022409A2 - 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2 - Google Patents

6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2

Info

Publication number
BR112022022409A2
BR112022022409A2 BR112022022409A BR112022022409A BR112022022409A2 BR 112022022409 A2 BR112022022409 A2 BR 112022022409A2 BR 112022022409 A BR112022022409 A BR 112022022409A BR 112022022409 A BR112022022409 A BR 112022022409A BR 112022022409 A2 BR112022022409 A2 BR 112022022409A2
Authority
BR
Brazil
Prior art keywords
heteroaryloxy
azabenzimidazoles
benzimidazoles
jak2 inhibitors
jak2
Prior art date
Application number
BR112022022409A
Other languages
English (en)
Inventor
E Masse Craig
R Greenwood Jeremy
Mondal Sayan
Xu Jiayi
Ghanakota Phani
Michelle Mcrobb Fiona
Boyles Nicholas
Original Assignee
Ajax Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajax Therapeutics Inc filed Critical Ajax Therapeutics Inc
Publication of BR112022022409A2 publication Critical patent/BR112022022409A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

6-HETEROARILÓXI BENZIMIDAZÓIS E AZABENZIMIDAZÓIS COMO INIBIDORES DE JAK2. A presente invenção refere-se a compostos de 6-heteroarilóxi benzimi-dazol e azabenzimidazol e composições destes que são úteis para inibir JAK2.
BR112022022409A 2020-05-06 2021-05-05 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2 BR112022022409A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063020645P 2020-05-06 2020-05-06
US202063087717P 2020-10-05 2020-10-05
US202063130254P 2020-12-23 2020-12-23
PCT/US2021/030926 WO2021226261A1 (en) 2020-05-06 2021-05-05 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors

Publications (1)

Publication Number Publication Date
BR112022022409A2 true BR112022022409A2 (pt) 2023-02-07

Family

ID=76076558

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022022409A BR112022022409A2 (pt) 2020-05-06 2021-05-05 6-heteroarilóxi benzimidazóis e azabenzimidazóis como inibidores de jak2

Country Status (9)

Country Link
US (2) US11691963B2 (pt)
EP (1) EP4146639A1 (pt)
JP (1) JP2023525047A (pt)
CN (1) CN115996917A (pt)
AU (1) AU2021267373A1 (pt)
BR (1) BR112022022409A2 (pt)
CA (1) CA3181537A1 (pt)
TW (1) TW202204350A (pt)
WO (1) WO2021226261A1 (pt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3181537A1 (en) 2020-05-06 2021-11-11 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
US12043632B2 (en) 2020-12-23 2024-07-23 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
WO2023009708A1 (en) * 2021-07-29 2023-02-02 Ajax Therapeutics, Inc. Heteroaryloxy triazolo- and imidazo-azines as jak2 inhibitors
WO2023009709A1 (en) * 2021-07-29 2023-02-02 Ajax Therapeutics, Inc. Pyrazolo piperazines as jak2 inhibitors
WO2023009712A1 (en) * 2021-07-29 2023-02-02 Ajax Therapeutics, Inc. Heteroaryloxy thiazolo azines as jak2 inhibitors
JP2024540292A (ja) * 2021-11-09 2024-10-31 エイジャックス セラピューティクス， インコーポレイテッド Ｊａｋ２阻害剤としての６－ヘテロアリールオキシベンゾイミダゾール及びアザベンゾイミダゾール
WO2023086320A1 (en) * 2021-11-09 2023-05-19 Ajax Therapeutics, Inc. Forms and compositions of inhibitors of jak2
WO2024116528A1 (ja) * 2022-11-28 2024-06-06 ユニマテック株式会社 含フッ素ピリドン化合物およびその製造方法
CN116003407B (zh) * 2022-12-27 2025-04-01 株洲千金药业股份有限公司 一种大规模生产唑吡坦的合成方法
WO2024196989A1 (en) * 2023-03-20 2024-09-26 University Of Central Florida Research Foundation, Inc. Anti-malarial therapy
WO2024229295A1 (en) 2023-05-03 2024-11-07 Ajax Therapeutics, Inc. Forms and compositions of a jak2 inhibitor

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