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BR112021022682A2 - Métodos e composições para prevenir diabetes do tipo 1 - Google Patents

Métodos e composições para prevenir diabetes do tipo 1

Info

Publication number
BR112021022682A2
BR112021022682A2 BR112021022682A BR112021022682A BR112021022682A2 BR 112021022682 A2 BR112021022682 A2 BR 112021022682A2 BR 112021022682 A BR112021022682 A BR 112021022682A BR 112021022682 A BR112021022682 A BR 112021022682A BR 112021022682 A2 BR112021022682 A2 BR 112021022682A2
Authority
BR
Brazil
Prior art keywords
diabetes
compositions
methods
preventing type
preventing
Prior art date
Application number
BR112021022682A
Other languages
English (en)
Inventor
Francisco Leon
S Skyler Jay
C Herold Kevan
Original Assignee
Provention Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provention Bio Inc filed Critical Provention Bio Inc
Publication of BR112021022682A2 publication Critical patent/BR112021022682A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)

Abstract

métodos e composições para prevenir diabetes do tipo 1. é fornecido aqui, em um aspecto, um método para prevenir ou retardar o início de diabetes do tipo 1 clínico (t1d), que compreende: fornecer a um indivíduo não diabético que está em risco de t1d; determinar que o indivíduo não diabético (1) está substancialmente livre de anticorpos contra o transportador de zinco 8 (znt8), (2) é hla-dr4+ e/ou (3) não é hla-dr3+; e administrar uma quantidade profilaticamente eficiente de um anticorpo anti-cd3 ao indivíduo não diabético.
BR112021022682A 2019-05-14 2020-05-14 Métodos e composições para prevenir diabetes do tipo 1 BR112021022682A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962847466P 2019-05-14 2019-05-14
US15/931,685 US11434291B2 (en) 2019-05-14 2020-05-14 Methods and compositions for preventing type 1 diabetes
PCT/US2020/032891 WO2020232247A1 (en) 2019-05-14 2020-05-14 Methods and compositions for preventing type 1 diabetes

Publications (1)

Publication Number Publication Date
BR112021022682A2 true BR112021022682A2 (pt) 2022-02-22

Family

ID=73289320

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021022682A BR112021022682A2 (pt) 2019-05-14 2020-05-14 Métodos e composições para prevenir diabetes do tipo 1

Country Status (7)

Country Link
US (3) US11434291B2 (pt)
JP (3) JP7137696B2 (pt)
KR (2) KR20230031981A (pt)
BR (1) BR112021022682A2 (pt)
IL (2) IL322315A (pt)
JO (1) JOP20210298A1 (pt)
WO (1) WO2020232247A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112021022682A2 (pt) * 2019-05-14 2022-02-22 Provention Bio Inc Métodos e composições para prevenir diabetes do tipo 1
CA3182445A1 (en) 2020-06-11 2021-12-16 Francisco Leon Methods and compositions for preventing type 1 diabetes
EP4164689A4 (en) * 2020-06-11 2024-07-24 Provention Bio, Inc. METHODS AND COMPOSITIONS FOR PREVENTING TYPE 1 DIABETES
KR20240023522A (ko) * 2021-05-24 2024-02-22 프로벤션 바이오, 인코포레이티드 감염 후 자가면역성 당뇨병을 치료하는 방법
KR20240024098A (ko) * 2021-05-24 2024-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병의 치료 방법
AU2022341315A1 (en) * 2021-09-13 2024-05-02 Provention Bio, Inc. Methods and compositions comprising anti-cd3 antibodies and dyrk1a inhibitors for treating diabetes
WO2023230476A1 (en) * 2022-05-24 2023-11-30 Provention Bio, Inc. Methods and compositions for preventing or delaying type 1 diabetes
US20230382993A1 (en) * 2022-05-24 2023-11-30 Provention Bio, Inc. Methods and compositions for preventing or delaying type 1 diabetes

Family Cites Families (509)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303121B1 (en) 1992-07-30 2001-10-16 Advanced Research And Technology Method of using human receptor protein 4-1BB
US20030108548A1 (en) 1993-06-01 2003-06-12 Bluestone Jeffrey A. Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
US6491916B1 (en) 1994-06-01 2002-12-10 Tolerance Therapeutics, Inc. Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7041289B1 (en) 1997-12-05 2006-05-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for treating established spontaneous auto-immune diseases in mammals
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6723538B2 (en) 1999-03-11 2004-04-20 Micromet Ag Bispecific antibody and chemokine receptor constructs
ES2391550T3 (es) 1999-04-15 2012-11-27 Bristol-Myers Squibb Company Inhibidores cíclicos de la proteína tirosina quinasa
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US7527787B2 (en) 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
US7534866B2 (en) 2005-10-19 2009-05-19 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
AUPQ431299A0 (en) 1999-11-26 1999-12-23 Unisearch Limited Method of inducing immune tolerance
JP4078074B2 (ja) 1999-12-10 2008-04-23 ファイザー・プロダクツ・インク ピロロ［２，３−ｄ］ピリミジン化合物
US20020006403A1 (en) 1999-12-14 2002-01-17 Xue-Zhong Yu CD28-specific antibody compositions for use in methods of immunosuppression
DE10001372A1 (de) 2000-01-14 2001-08-02 Deutsches Krebsforsch Anti-CD3-Einzelketten-Antikörper mit humanem Cmu3- und Cmu4- Domänen
CA2396871A1 (en) 2000-01-20 2001-12-20 Ottawa Health Research Institute Immunostimulatory nucleic acids for inducing a th2 immune response
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US7395158B2 (en) 2000-05-30 2008-07-01 Sensys Medical, Inc. Method of screening for disorders of glucose metabolism
PT1297017E (pt) 2000-06-19 2012-09-04 Gen Hospital Corp Composições e métodos de anticorpos monoclonais e policlonais específicos para subpopulações de célula t
CA2412560C (en) 2000-06-26 2008-12-30 Pfizer Products Inc. Pyrrolo[2,3-d]pyrimidine compounds as immunosuppressive agents
WO2002016414A2 (en) 2000-08-22 2002-02-28 Micromet Ag Composition for the elimination of autoreactive b-cells
RU2329263C2 (ru) 2000-11-07 2008-07-20 Новартис Аг Производные имида индолилмалеиновой кислоты как ингибиторы протеинкиназы с
DK1397153T3 (da) 2001-05-23 2008-05-26 Bristol Myers Squibb Co Fremgangsmåde til beskyttelse af allogent ö-celle-transplantat ved anvendelse af oplöselige CTLA4-mutantmolekyler
CN1195779C (zh) 2001-05-24 2005-04-06 中国科学院遗传与发育生物学研究所 抗人卵巢癌抗人cd3双特异性抗体
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
GT200200234A (es) 2001-12-06 2003-06-27 Compuestos cristalinos novedosos
US7323440B2 (en) 2002-02-13 2008-01-29 Micromet Ag De-immunized MOG (poly)peptide constructs
US20030216551A1 (en) 2002-03-08 2003-11-20 Diabetogen Biosciences Inc. Fully human anti-CD3 monoclonal antibodies
KR100517056B1 (ko) 2002-04-15 2005-09-27 재단법인 목암생명공학연구소 하이드록실 페닐 유도체, 그의 제조방법 및 그를 포함하는약학적 조성물
JP2005533775A (ja) 2002-06-07 2005-11-10 ワラタ ファーマシューティカルズ， インコーポレイテッド 糖尿病を処置するための組成物および方法
EP1837031B1 (en) 2002-06-07 2009-10-14 Waratah Pharmaceuticals, Inc. Compositions and methods for treating diabetes
AU2003232172A1 (en) 2002-06-14 2003-12-31 Novo Nordisk A/S Combined use of a modulator of cd3 and a glp-1 compound
US20040037826A1 (en) 2002-06-14 2004-02-26 Michelsen Birgitte Koch Combined use of a modulator of CD3 and a GLP-1 compound
US20030235583A1 (en) 2002-06-14 2003-12-25 Jeppe Sturis Combined use of a modulator of CD3 and a beta cell resting compound
ES2559763T3 (es) 2002-09-10 2016-02-15 Affimed Gmbh Anticuerpo humano específico de CD3 con propiedades inmunosupresoras
US7820166B2 (en) 2002-10-11 2010-10-26 Micromet Ag Potent T cell modulating molecules
BR0315523A (pt) 2002-10-22 2005-08-30 Waratah Pharmaceuticals Inc Tratamento de diabetes
ES2401136T3 (es) 2002-11-15 2013-04-17 Genmab A/S Anticuerpos monoclonales humanos contra CD25
EP2270051B1 (en) 2003-01-23 2019-05-15 Ono Pharmaceutical Co., Ltd. Antibody specific for human PD-1 and CD3
AU2004210088A1 (en) 2003-02-06 2004-08-19 Micromet Ag Trimeric polypeptide construct to induce an enduring T cell response
US7196093B2 (en) 2003-04-09 2007-03-27 General Atomics Reversible inhibitors of SAH hydrolase and uses thereof
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
CA2522586C (en) 2003-05-31 2017-02-21 Micromet Ag Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
JP5010281B2 (ja) 2003-05-31 2012-08-29 マイクロメット アクツィエン ゲゼルシャフト Ｅｐｃａｍに対する二重特異性抗体を含む薬学的組成物
US20070292416A1 (en) 2003-06-02 2007-12-20 Alexion Pharmaceuticals, Inc. De-Immunized Anti-Cd3 Antibody
EP1644335A4 (en) 2003-07-11 2008-06-04 Bristol Myers Squibb Co TETRAHYDROQUINOLINE DERIVATIVES COMPRISING MODULATORS OF CANNABINOID RECEPTORS
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
US7326706B2 (en) 2003-08-15 2008-02-05 Bristol-Myers Squibb Company Pyrazine modulators of cannabinoid receptors
US7517900B2 (en) 2003-10-10 2009-04-14 Bristol-Myers Squibb Company Pyrazole derivatives as cannabinoid receptor modulators
NZ546173A (en) 2003-10-16 2009-04-30 Micromet Ag Multispecific deimmunized CD3-binders
US20050176028A1 (en) 2003-10-16 2005-08-11 Robert Hofmeister Deimmunized binding molecules to CD3
US20070053954A1 (en) 2003-10-24 2007-03-08 Rowe Stephen C Macromer-melt formulations
WO2005040163A1 (en) 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
EP2397189B1 (en) 2003-11-14 2015-03-18 Brigham and Women's Hospital, Inc. Methods of modulating immunity
US20050147581A1 (en) 2003-11-19 2005-07-07 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes having improved stability and therapeutic use of the same
ATE459374T1 (de) 2003-11-28 2010-03-15 Micromet Ag Polypeptide enthaltende zusammensetzungen
DK1697371T3 (da) 2003-12-19 2007-09-17 Bristol Myers Squibb Co Azabicykliske heterocykliske forbindelser som cannabinoidreceptormodulatorer
CA2550435A1 (en) 2003-12-19 2005-07-14 Bristol-Myers Squibb Company Azabicyclic heterocycles as cannabinoid receptor modulators
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
EP1725254A4 (en) 2004-02-04 2008-02-13 Univ Columbia ANTI-CD3 IMMUNOTHERAPY AND SPECIFIC ANTIGENS FOR THE TREATMENT OF AUTOIMMUNITY
SI1716178T1 (sl) 2004-02-16 2010-11-30 Micromet Ag Manj imunogene vezne molekule
ATE549352T1 (de) 2004-02-20 2012-03-15 Develogen Ag Verwendung sekretierter proteinprodukte zur prävention und behandlung von erkrankungen der bauchspeicheldrüse und/oder adipositas und/oder des metabolischen syndroms
EP1755631A2 (en) 2004-03-03 2007-02-28 Diamyd Medical AB Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
US20050250691A1 (en) 2004-05-10 2005-11-10 Diamyd Therapeutics Ab Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
JP5848861B2 (ja) 2004-04-20 2016-01-27 ジェンマブ エー／エスＧｅｎｍａｂ Ａ／Ｓ Ｃｄ２０に対するヒトモノクローナル抗体
US20060194725A1 (en) 2004-05-07 2006-08-31 James Rasmussen Methods of treating disease with random copolymers
US7592313B2 (en) 2004-05-17 2009-09-22 Board Of Trustees Of The University Of Illinois Method of stimulating proliferation of regulatory T cells in a diabetic mammal
EA010350B1 (ru) 2004-06-03 2008-08-29 Новиммун С.А. Антитела против cd3 и способы их применения
CA2571957A1 (en) 2004-07-01 2006-01-12 Waratah Pharmaceuticals, Inc. Methods and compositions using cd3 agonists
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
RU2393872C2 (ru) 2004-08-30 2010-07-10 Шеринг Акциенгезельшафт Лечение вич инфекции посредством т-клеточной модуляции
EP1799840A4 (en) 2004-09-03 2009-02-18 Univ Columbia ILT3-POLYPEPTIDES AND USES THEREOF
US20070264229A1 (en) 2004-09-13 2007-11-15 Strominger Jack L Peptides for Treatment of Autoimmune Disease
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
WO2006057152A1 (ja) 2004-11-08 2006-06-01 Ono Pharmaceutical Co., Ltd. タンパク質分解酵素阻害化合物からなる糖尿病治療剤
EP2842571A1 (en) 2004-11-30 2015-03-04 Celldex Therapeutics, Inc. Antibodies directed to GPNMB and uses thereof
US20080253991A1 (en) 2005-02-04 2008-10-16 Anthony Jevnikar Anti-T Cell and Autoantigen Treatment of Autoimmune Disease
US20090142338A1 (en) 2005-03-04 2009-06-04 Curedm, Inc. Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions
US8211430B2 (en) 2005-03-04 2012-07-03 Curedm Group Holdings, Llc Methods and pharmaceutical compositions for treating type 1 diabetes mellitus and other conditions
US20130039861A1 (en) 2005-04-06 2013-02-14 Immunomedics, Inc. Dye Conjugated Peptides for Fluorescent Imaging
ES2634260T3 (es) 2005-04-06 2017-09-27 Bristol-Myers Squibb Company Métodos para tratar trastornos inmunitarios asociados a trasplante de injertos con moléculas de CTLA4 mutantes solubles
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
ATE542535T1 (de) 2005-05-04 2012-02-15 Develogen Ag Verwendung von azapaullonen zur vorbeugung und behandlung pankreatischer autoimmunkrankheiten
EA013821B1 (ru) 2005-05-25 2010-08-30 Кьюрдм, Инк. Проостровковые пептиды человека, их производные и аналоги и способы их применения
SG177944A1 (en) 2005-07-11 2012-02-28 Macrogenics Inc Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
US20100209437A1 (en) 2005-09-12 2010-08-19 Greg Elson Anti-CD3 Antibody Fromulations
US20070190052A1 (en) 2005-09-14 2007-08-16 The Trustees Of Columbia University In The City Of New York Regulatory CD8cells induced with anti-CD3 antibody
US20070082841A1 (en) 2005-09-27 2007-04-12 Aciont, Inc. Ocular administration of immunosuppressive agents
CN101316611B (zh) 2005-11-29 2017-05-03 英特瑞克斯顿阿克图比奥帝克斯有限公司 诱导对抗原的粘膜耐受
WO2007065027A2 (en) 2005-12-02 2007-06-07 Dana Farber Cancer Institute Carbonic anhydrase ix (g250) antibodies and methods of use thereof
MX2008007287A (es) 2005-12-08 2008-10-27 Univ Louisville Res Found Metodos y composiciones para expandir celulas reguladoras t.
US20070264687A1 (en) 2005-12-15 2007-11-15 Min-Yuan Chou Recombinant triplex scaffold-based polypeptides
CA2633594C (en) 2005-12-16 2021-10-26 Micromet Ag Means and methods for the treatment of tumorous diseases
RU2008129827A (ru) 2005-12-21 2010-01-27 МЕДИММЬЮН, ЭлЭлСи (US) МОЛЕКУЛЫ EphA2-BiTE И ИХ ПРИМЕНЕНИЕ
US8394926B2 (en) 2005-12-21 2013-03-12 Micromet Ag Pharmaceutical compositions with resistance to soluble CEA
WO2007084775A2 (en) 2006-01-20 2007-07-26 The Trustees Of The University Of Pennsylvania Compositions and methods for modulation of suppressor t cell activation
GB0605702D0 (en) 2006-03-21 2006-05-03 Biotransformations Ltd Materials and methods for immune cell stimulation
JO3235B1 (ar) 2006-05-26 2018-03-08 Astex Therapeutics Ltd مركبات بيررولوبيريميدين و استعمالاتها
NZ573132A (en) 2006-06-06 2012-05-25 Glaxo Group Ltd Administration of anti-cd3 antibodies in the treatment of autoimmune diseases
MX2008015771A (es) 2006-06-14 2009-01-27 Macrogenics Inc Metodos para el tratamiento de padecimientos autoinmunes usando anticuerpos monoclonales con toxicidad reducida.
EP1880729A1 (en) 2006-07-20 2008-01-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of soluble CD160 to suppress immunity
US20080026378A1 (en) 2006-07-28 2008-01-31 Gian Franco Bottazzo Prediction and prophylactic treatment of type 1 diabetes
CN101512008B (zh) 2006-09-08 2015-04-01 艾伯维巴哈马有限公司 白介素-13结合蛋白
EP2066174B1 (en) 2006-09-12 2017-11-08 Beth Israel Deaconess Medical Center, Inc. Compositions containing alpha-1-antitrypsin and methods for use
CN101164538B (zh) 2006-10-16 2011-12-14 中国医学科学院基础医学研究所 羧胺三唑类化合物及其盐在制备治疗疼痛性疾病和/或炎症性疾病的药物中的应用
WO2008064306A2 (en) 2006-11-22 2008-05-29 Curedm, Inc. Methods and compositions relating to islet cell neogenesis
EP2815750A1 (en) 2006-12-21 2014-12-24 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3b] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
US20100015142A1 (en) 2006-12-21 2010-01-21 Macrogenics Inc. Methods for the treatment of lada and other adult- onset autoimmune using immunosuppressive monoclonal antibodies with reduced toxicity
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
EP2125895B1 (en) 2007-02-02 2015-04-08 Vegenics Pty Ltd Vegf receptor antagonists for treating organ transplant alloimmunity and arteriosclerosis
US20100129361A1 (en) 2007-05-01 2010-05-27 The Brigham And Women's Hospital Immunosuppression with antibody against itm2a
US20110020269A1 (en) 2007-05-08 2011-01-27 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for modifying t cell immune responses and inflammation
US20110300142A1 (en) 2007-05-25 2011-12-08 Salford Leif G Use of zeburaline for the treatment of autoimmune diseases or immune rejection of transplants
US20090324609A1 (en) 2007-08-09 2009-12-31 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
MY165889A (en) * 2007-08-30 2018-05-18 Curedm Group Holdings Llc Compositions and methods of using proislet peptides and analogs thereof
US9308257B2 (en) 2007-11-28 2016-04-12 Medimmune, Llc Protein formulation
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
KR20210049186A (ko) 2007-11-30 2021-05-04 애브비 바이오테크놀로지 리미티드 단백질 제형 및 이의 제조방법
JP5886523B2 (ja) 2008-01-09 2016-03-16 ザ スキーペンズ アイ リサーチ インスティチュート インコーポレイテッド 眼の炎症性障害を処置するための治療組成物
CA2716919C (en) 2008-03-14 2015-01-20 Biocon Limited An anti-cd6 monoclonal antibody and use thereof
EP2283355A2 (en) 2008-04-25 2011-02-16 Zymogenetics, Inc. Levels of bcma protein expression on b cells and use in diagnostic methods
US20100260668A1 (en) 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
CN102076355B (zh) 2008-04-29 2014-05-07 Abbvie公司 双重可变结构域免疫球蛋白及其用途
DE102008023820A1 (de) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
WO2010042904A2 (en) 2008-10-10 2010-04-15 Trubion Pharmaceuticals, Inc. Tcr complex immunotherapeutics
HRP20150400T1 (hr) 2008-11-07 2015-05-08 Amgen Research (Munich) Gmbh Lijeäśenje pedijatrijske akutne limfoblastiäśne leukemije
EP2982696B1 (en) 2008-11-07 2019-03-27 Amgen Research (Munich) GmbH Treatment of acute lymphoblastic leukemia
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
WO2010065491A2 (en) 2008-12-01 2010-06-10 Carolus Therapeutics, Inc. Methods of treating inflammatory disorders
WO2010088522A2 (en) 2009-01-30 2010-08-05 Ab Biosciences, Inc. Novel lowered affinity antibodies and uses therefor
WO2010106542A2 (en) 2009-03-19 2010-09-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. USE OF NKp46 FOR PREVENTING DIABETES
JP2012525155A (ja) 2009-05-01 2012-10-22 アボット・ラボラトリーズ 二重可変ドメイン免疫グロブリンおよびこの使用
WO2011011706A2 (en) 2009-07-24 2011-01-27 The Johns Hopkins University Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents
NZ598929A (en) 2009-09-01 2014-05-30 Abbvie Inc Dual variable domain immunoglobulins and uses thereof
BR112012007365A2 (pt) 2009-10-15 2016-11-22 Abbott Lab proteínas de ligação à il-1
WO2011050106A2 (en) 2009-10-20 2011-04-28 Tolerx, Inc. Anti-cd3 antibody dosing in autoimmune disease
WO2011050104A2 (en) 2009-10-20 2011-04-28 Tolerx, Inc. Methods of using anti-cd3 antibodies to prevent weight gain
KR102406407B1 (ko) 2009-10-27 2022-06-08 암젠 리서치 (뮌헨) 게엠베하 ＣＤ１９ｘＣＤ３ 이중특이적 항체를 투여하는 투약 용법
WO2011079283A1 (en) 2009-12-23 2011-06-30 Bioalliance C.V. Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same
US20130129723A1 (en) 2009-12-29 2013-05-23 Emergent Product Development Seattle, Llc Heterodimer Binding Proteins and Uses Thereof
HUE029257T2 (en) 2009-12-29 2017-02-28 Aptevo Res And Dev Llc Heterodimer binding proteins and their use
WO2011120135A1 (en) 2010-03-29 2011-10-06 Zymeworks, Inc. Antibodies with enhanced or suppressed effector function
WO2011123830A2 (en) 2010-04-02 2011-10-06 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
PH12012501991A1 (en) 2010-04-07 2017-07-26 Abbvie Inc Tnf-alpha binding proteins
WO2011127299A1 (en) 2010-04-09 2011-10-13 The General Hospital Corporation Methods for the treatment of autoimmune diseases
WO2011135544A2 (en) 2010-04-29 2011-11-03 Nasvax Ltd. Methods and compositions for treating hepatitis with anti-cd3 immune molecule therapy
KR101848225B1 (ko) 2010-05-14 2018-04-12 애브비 인코포레이티드 Ｉｌ－１ 결합 단백질
EP2580593A4 (en) 2010-06-10 2014-04-16 Myra Lipes DIAGNOSIS OF MYOCARDIAL AUTOIMMUNITY IN HEART DISEASES
CA2801210C (en) 2010-06-19 2020-07-21 Memorial Sloan-Kettering Cancer Center Anti-gd2 antibodies
US20130095121A1 (en) 2010-06-25 2013-04-18 Aoife Brennan Methods of treating patients with immune-related diseases
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
BR112013003169B1 (pt) 2010-08-18 2022-05-24 Theresa Deisher Uso de um agente terapêutico que inibe a ligação de células-tronco a tecido linfóide
US20120088678A1 (en) 2010-09-08 2012-04-12 Sanford-Burnham Medical Research Institute Method for prediction of response to rheumatoid arthritis therapeutics
US20130225427A1 (en) 2010-09-08 2013-08-29 Sanford-Burnham Medical Research Institute Method for prediction of response to immune mediated disease therapeutics
CN107050456B (zh) 2010-09-28 2022-08-12 加利福尼亚大学董事会 治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合
WO2012055961A1 (en) 2010-10-27 2012-05-03 Micromet Gmbh Means and methods for treating dlbcl
US20120263722A1 (en) 2010-11-04 2012-10-18 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
KR101891845B1 (ko) 2010-11-10 2018-08-24 암젠 리서치 (뮌헨) 게엠베하 Cd3-특이적 결합 도메인에 의해 유발된 악영향의 예방
AR083847A1 (es) 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
AR084210A1 (es) 2010-12-08 2013-05-02 Abbott Lab PROTEINAS DE UNION AL TNF-a
US20120201746A1 (en) 2010-12-22 2012-08-09 Abbott Laboratories Half immunoglobulin binding proteins and uses thereof
WO2012088290A2 (en) 2010-12-22 2012-06-28 Abbott Laboratories Tri-variable domain binding proteins and uses thereof
TWI531377B (zh) 2011-02-08 2016-05-01 艾伯維有限公司 骨關節炎及疼痛之治療
WO2012118863A1 (en) 2011-02-28 2012-09-07 The Schepens Eye Research Institute, Inc. Therapies that target autoimmunity for treating glaucoma and optic neuropathy
FI3556774T3 (fi) 2011-03-11 2024-03-15 Beth Israel Deaconess Medical Ct Inc Anti-cd40-vasta-aineita ja niiden käyttötapoja
WO2012135842A2 (en) 2011-03-31 2012-10-04 President And Fellows Of Harvard College A unique population of regulatory t cells that regulate tissue regeneration and wound healing
US10239952B2 (en) 2011-04-01 2019-03-26 Memorial Sloan Kettering Cancer Center Anti-WT1/HLA bi-specific antibody
EP3753572A1 (en) 2011-04-28 2020-12-23 Amgen Research (Munich) GmbH Dosage regimen for administering a cd19xcd3 bispecific antibody to patients at risk for potential adverse effects
ES2732213T3 (es) 2011-05-21 2019-11-21 Macrogenics Inc Moléculas que se unen a CD3 capaces de unirse a CD3 humano y no humano
WO2012173819A2 (en) 2011-06-14 2012-12-20 Mayo Foundation For Medical Education And Research Anti-cd3 therapies
EP2723375A4 (en) 2011-06-23 2015-03-11 Univ Florida MATERIALS AND METHOD FOR MODULATING IMMUNE SYSTEM REACTIONS
US20140242081A1 (en) 2011-07-18 2014-08-28 Micromet Ag Dosing regimens for treatment of cea-expressing cancers
CN102898527B (zh) 2011-07-25 2016-12-21 三星电子株式会社 融合蛋白、药物组合物及预防或治疗癌症的方法
US9701749B2 (en) 2011-08-11 2017-07-11 Ono Pharmaceutical Co., Ltd. Therapeutic agent for autoimmune diseases comprising PD-1 agonist
US8932586B2 (en) 2011-09-06 2015-01-13 Intrexon Corporation Modified forms of Pseudomonas exotoxin A
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
CN103906514A (zh) 2011-09-13 2014-07-02 拜奥迈德瓦利探索有限公司 用于治疗代谢障碍的组合物和方法
HK1201466A1 (en) 2011-09-21 2015-09-04 干细胞医药有限公司 Beta-lactam compounds for treating diabetes
CA2850291A1 (en) 2011-09-29 2013-04-04 Apo-T B.V. Multi-specific binding molecules targeting aberrant cells
EP2764362B1 (en) 2011-10-03 2018-09-05 Immunomedics, Inc. Dye conjugated peptides for fluorescent imaging
AU2012332021B8 (en) 2011-11-04 2017-10-12 Zymeworks Bc Inc. Stable heterodimeric antibody design with mutations in the Fc domain
US20140212425A1 (en) 2011-12-05 2014-07-31 Immunomedics, Inc. Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
EP4378534A3 (en) 2011-12-22 2024-08-07 Medizinische Universität Wien Cyclotides as immunosuppressive agents
CN113699105A (zh) 2011-12-23 2021-11-26 人类起源公司 包含脱细胞并再群体化的胎盘血管支架的类器官
PL2802607T3 (pl) 2012-01-13 2018-03-30 Julius-Maximilians-Universität Würzburg Dwuskładnikowa komplementacja funkcjonalna wywoływana przez podwójny antygen
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
CN103382223B (zh) 2012-04-01 2015-06-10 上海益杰生物技术有限公司 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽
CN103372214B (zh) 2012-04-13 2017-09-29 北京艾棣维欣生物技术有限公司 治疗和/或预防ⅰ型糖尿病的药物组合物及其应用
US10081809B2 (en) 2012-04-18 2018-09-25 University Of Miami Methods of treating diabetes and/or promoting survival of pancreatic islets after transplantation
ES2672974T3 (es) 2012-06-01 2018-06-19 Ibc Pharmaceuticals, Inc. Complejos multiméricos con estabilidad in vivo, farmacocinética y eficacia mejoradas
US10000567B2 (en) 2012-06-14 2018-06-19 Therapix Biosciences Ltd. Humanized antibodies to cluster of differentiation 3 (CD3)
EP2895203A4 (en) 2012-06-15 2016-09-28 Imaginab Inc ANTIGENBINDING CONSTRUCTS FOR CD3
KR20150033703A (ko) * 2012-06-27 2015-04-01 오르반 바이오테크 엘엘씨 당뇨병 치료를 위한 ctla4 융합 단백질
US20150231241A1 (en) 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
EP3586874A1 (en) 2012-08-14 2020-01-01 IBC Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
US9511110B2 (en) 2012-09-27 2016-12-06 Perle Bioscience, Inc. Generation of new pancreatic beta cells
US8808689B1 (en) 2012-09-27 2014-08-19 Perle Bioscience, Inc. Insulin independence among patients with diabetes utilizing a PPI in combination with an immune tolerance agent
NZ746691A (en) 2012-11-13 2020-08-28 Astellas Pharma Inc Agents for treatment of claudin expressing cancer diseases
WO2014079000A1 (en) 2012-11-21 2014-05-30 Wuhan Yzy Biopharma Co., Ltd. Bispecific antibody
US10130632B2 (en) 2012-11-27 2018-11-20 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
US10329350B2 (en) 2012-12-26 2019-06-25 Industrial Technology Research Institute Method for producing a multivalent fab fragment with collagen-like peptide
US10261083B2 (en) 2013-01-04 2019-04-16 Cytomx Therapeutics, Inc. Compositions and methods for detecting protease activity in biological systems
EP2948475A2 (en) 2013-01-23 2015-12-02 AbbVie Inc. Methods and compositions for modulating an immune response
JO3529B1 (ar) 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
US20140235552A1 (en) 2013-02-15 2014-08-21 Claresa Levetan Insulin independence among patients with diabetes utilizing a ppi in combination with an immune tolerance agent
US20140234405A1 (en) 2013-02-15 2014-08-21 Claresa Levetan Insulin independence among patients with diabetes utilizing a ppi in combination with an immune tolerance agent
US9732150B2 (en) 2013-03-14 2017-08-15 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
US9693968B2 (en) 2013-03-14 2017-07-04 Jerome J. Schentag Cholestosome vesicles for incorporation of molecules into chylomicrons
CA2903576C (en) 2013-03-15 2021-06-08 Nai-Kong V. Cheung High affinity anti-gd2 antibodies
US20160122436A1 (en) 2013-03-15 2016-05-05 Amgen Research (Munich) Gmbh Single chain binding molecules comprising n-terminal abp
AU2014232383B2 (en) 2013-03-15 2019-01-17 Epigen Biosciences, Inc. Heterocyclic compounds useful in the treatment of disease
CA2902561C (en) 2013-03-15 2022-08-02 Memorial Sloan-Kettering Cancer Center Multimerization technologies
GB201305714D0 (en) 2013-03-28 2013-05-15 Ucl Business Plc Method
CA2812016A1 (en) * 2013-04-05 2014-10-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
BR112015026258A2 (pt) 2013-04-16 2017-10-10 Orbsen Therapeutics Ltd composições e agentes terapêuticos e imunomoduladores, e usos dos mesmos
CN113663077B (zh) 2013-04-29 2024-03-15 美德睿臻有限公司 经由自体干细胞动员的创伤愈合
WO2014191113A1 (en) 2013-05-28 2014-12-04 Numab Ag Novel antibodies
CN114028560A (zh) 2013-07-23 2022-02-11 诺瓦利克有限责任公司 稳定的抗体组合物
KR102216088B1 (ko) 2013-07-25 2021-02-15 싸이톰스 테라퓨틱스, 인크. 다중특이성 항체, 다중특이성 활성화 가능한 항체 및 그의 사용 방법
CN104342453A (zh) 2013-08-06 2015-02-11 深圳先进技术研究院 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用
PT3702373T (pt) 2013-09-13 2022-09-27 Beigene Switzerland Gmbh Anticorpos anti-pd1 e a sua utilização como agentes terapêuticos e de diagnóstico
CA2924252C (en) 2013-09-16 2022-01-04 Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) Bi- or multispecific polypeptides binding immune effector cell surface antigens and hbv antigens for treating hbv infections and associated conditions
GB201317928D0 (en) 2013-10-10 2013-11-27 Ucl Business Plc Molecule
KR20160090308A (ko) 2013-11-04 2016-07-29 그렌마크 파머수티칼스 에스. 아. T 세포 재표적 이형-이량체 면역글로불린의 생산
US20160296632A1 (en) 2013-11-13 2016-10-13 Aequus Biopharma, Inc. Engineered glycoproteins and uses thereof
WO2015073833A1 (en) 2013-11-15 2015-05-21 Pharmacyclics, Inc. Methods for delaying or preventing the onset of type 1 diabetes
WO2015073319A1 (en) 2013-11-18 2015-05-21 Massachusetts Institute Of Technology Compositions and methods for treating immune and viral disorders and modulating protein-rna interaction
EP2878308B1 (en) 2013-12-02 2018-10-31 Thomas Harder Agents and methods for the suppression of T cell activation
ES2654051T3 (es) 2013-12-05 2018-02-12 Pfizer Inc. Pirrolo[2,3-d]pirimidinilo, pirrolo[2,3-b]pirazinilo y pirrolo[2,3-d]piridinil acrilamidas
EP3192812B1 (en) 2013-12-17 2020-05-27 Genentech, Inc. Anti-cd3 antibodies and methods of use
KR20220152546A (ko) 2013-12-24 2022-11-16 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 Fcrn 길항제 및 사용방법
AU2014374055B2 (en) 2013-12-30 2018-11-08 Epimab Biotherapeutics Inc. Fabs-in-tandem immunoglobulin and uses thereof
WO2015103319A1 (en) 2013-12-31 2015-07-09 Heron Therapeutics, Inc. Polymer-based compositions for extended release of proteins
WO2015112534A2 (en) 2014-01-21 2015-07-30 Medimmune, Llc Compositions and methods for modulating and redirecting immune responses
US10106623B2 (en) 2014-02-12 2018-10-23 Michael Uhlin Bispecific antibodies for use in stem cell transplantation
US20160039876A1 (en) 2014-03-28 2016-02-11 Claresa Levetan Insulin independence among patients with diabetes utilizing an optimized hamster reg3 gamma peptide
WO2015154795A1 (en) 2014-04-08 2015-10-15 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Combination therapy for the treatment of autoimmune diseases
EP3143045A1 (en) 2014-05-12 2017-03-22 Numab AG Novel multispecific molecules and novel treatment methods based on such multispecific molecules
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
AP2016009586A0 (en) 2014-05-29 2016-11-30 Macrogenics Inc Tri-specific binding molecules and methods of use thereof
EP2955196A1 (en) 2014-06-10 2015-12-16 Effimune Antibodies directed against CD127
WO2016004389A2 (en) 2014-07-03 2016-01-07 Abbvie Inc. Monovalent binding proteins
US9777073B2 (en) 2014-07-21 2017-10-03 Wuhan Yzy Biopharma Co., Ltd. Construction and application of bispecific antibody EpCAM×CD3
US9611325B2 (en) 2014-07-21 2017-04-04 Wuhan Yzy Biopharma Co., Ltd. Construction and application of bispecific antibody HER2xCD3
WO2016011571A1 (en) 2014-07-21 2016-01-28 Wuhan Yzy Biopharma Co., Ltd. Bispecific antibody-mediated cancer therapy with cytokine-induced killer cell
GB201413240D0 (en) 2014-07-25 2014-09-10 Hansa Medical Ab Method
US11820832B2 (en) 2014-07-25 2023-11-21 Memorial Sloan Kettering Cancer Center Bispecific HER2 and CD3 binding molecules
AU2015292374B2 (en) 2014-07-25 2020-09-03 Memorial Sloan Kettering Cancer Center Bispecific HER2 and CD3 binding molecules
JP6431721B2 (ja) * 2014-08-13 2018-11-28 学校法人大阪医科薬科大学 劇症１型糖尿病の検出方法及びバイオマーカー並びにキット
WO2016027253A1 (en) 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments
US10316093B2 (en) 2014-08-27 2019-06-11 Memorial Sloan Kettering Cancer Center Antibodies, compositions, and uses
ES2845656T3 (es) 2014-09-18 2021-07-27 Immucor Gti Diagnostics Inc Kits y procedimientos para detectar anticuerpos anticélulas endoteliales en rechazo de aloinjertos
ES2908203T3 (es) 2014-09-19 2022-04-28 Siwa Corp Anticuerpos anti-age para el tratamiento de inflamación y trastornos autoinmunes
WO2016061201A1 (en) 2014-10-14 2016-04-21 The Brigham And Women's Hospital, Inc. Nanoparticles and methods of use
US10583091B2 (en) 2014-10-23 2020-03-10 The Brigham And Women's Hospital, Inc. Amphiphile-polymer particles
US11773166B2 (en) 2014-11-04 2023-10-03 Ichnos Sciences SA CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
WO2016077638A1 (en) 2014-11-12 2016-05-19 Memorial Sloan Kettering Cancer Center Anti-chondroitin sulfate proteoglycan 4 antibodies and uses thereof
DK3227297T3 (da) 2014-12-05 2021-04-06 Array Biopharma Inc 4,6-substitueret-pyrazolo[1,5-a]pyraziner som janus kinase-inhibitorer
WO2016089610A1 (en) 2014-12-06 2016-06-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for cancer immunotherapy
AU2015360642B2 (en) 2014-12-08 2019-04-04 1Globe Biomedical Co., Ltd. Soluble universal ADCC-enhancing synthetic fusion gene and peptide technology and its use thereof
JP6709003B2 (ja) 2014-12-19 2020-06-10 株式会社カイオム・バイオサイエンス ５ｔ４及びｃｄ３に対する３つの結合ドメインを含む融合タンパク質
US10022347B2 (en) 2015-01-07 2018-07-17 The United States Of America, As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of metabolic syndrome
CN114230667A (zh) 2015-01-23 2022-03-25 赛诺菲 抗cd3抗体、抗cd123抗体和与cd3和/或cd123特异性结合的双特异性抗体
SG11201706236SA (en) 2015-02-06 2017-08-30 Nat Univ Singapore Methods for enhancing efficacy of therapeutic immune cells
EP3263599A4 (en) 2015-02-16 2018-12-19 Pharma Foods International Co., Ltd. Anti-cancer agent and antimetastatic agent using fstl1, and concomitant drug for same
KR102624023B1 (ko) 2015-02-24 2024-01-11 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 결합-촉발된 전사 스위치 및 이들의 이용 방법
GB201503500D0 (en) 2015-03-02 2015-04-15 Ucl Business Plc Cell
HUE056775T2 (hu) 2015-03-09 2022-03-28 Argenx Bvba Eljárás Fc-tartalmú szerek szérum szintjeinek csökkentésére FcRn-antagonisták alkalmazásával
WO2016144976A1 (en) 2015-03-09 2016-09-15 Kings College London Combination therapy with rar alpha agonists for enhancing th1 response
JP6847044B2 (ja) 2015-03-11 2021-03-24 シーシーエス・ベンチャーズ・リミテッド 肥満及び２型糖尿病（ｔ２ｄ）の治療のための膵内分泌前駆細胞療法
WO2016154047A2 (en) 2015-03-20 2016-09-29 Memorial Sloan-Kettering Cancer Center Monoclonal antigen-binding proteins to intracellular oncogene products
US10378055B2 (en) 2015-04-08 2019-08-13 City Of Hope Methods and compositions for measuring beta cell death
US11000603B2 (en) 2015-04-14 2021-05-11 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
US10449209B2 (en) 2015-04-29 2019-10-22 Arterez, Llc Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage
PT3288573T (pt) 2015-04-30 2020-03-25 Psioxus Therapeutics Ltd Adenovírus oncolítico que codifica uma proteína b7
WO2016178996A1 (en) 2015-05-01 2016-11-10 The Regents Of The University Of California Glycan-dependent immunotherapeutic molecules
HK1252158A1 (zh) 2015-05-01 2019-05-17 Genentech, Inc. 掩蔽抗cd3抗体和使用方法
BR112017024899A2 (pt) 2015-05-21 2018-11-13 Harpoon Therapeutics, Inc. proteínas de ligação trispecíficas e métodos de uso.
PE20180193A1 (es) 2015-05-29 2018-01-26 Abbvie Inc Anticuerpos anti-cd40 y sus usos
JP2018522833A (ja) 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． キメラ抗原受容体（ｃａｒ）コンストラクト、及びｃａｒコンストラクトを発現するｔ細胞（ｃａｒ−ｔ）またはｎｋ細胞（ｃａｒ−ｎｋ）による疾患治療
EP3310811B1 (en) 2015-06-16 2021-06-16 Genentech, Inc. Anti-cd3 antibodies and methods of use
US10975112B2 (en) 2015-06-16 2021-04-13 Hangzhou Dac Biotech Co., Ltd. Linkers for conjugation of cell-binding molecules
US20190135894A1 (en) 2015-06-25 2019-05-09 iCell Gene Therapeuticics LLC COMPOUND CHIMERIC ANTIGEN RECEPTOR (cCAR) TARGETING MULTIPLE ANTIGENS, COMPOSITIONS AND METHODS OF USE THEREOF
US11046745B2 (en) 2015-07-14 2021-06-29 BioNTech SE Peptide mimotopes of the CD3 T-cell co-receptor epsilon chain and uses thereof
CN108137706A (zh) 2015-07-15 2018-06-08 酵活有限公司 药物缀合的双特异性抗原结合构建体
ES2995985T3 (en) 2015-08-13 2025-02-11 Amgen Inc Charged depth filtration of antigen-binding proteins
HUE056769T2 (hu) 2015-09-04 2022-03-28 Primatope Therapeutics Inc Humanizált anti-CD40 antitestek és felhasználásuk
US11833255B2 (en) 2015-10-07 2023-12-05 The Brigham And Women's Hospital, Inc. Nanoparticles with pH triggered drug release
WO2017070943A1 (zh) 2015-10-30 2017-05-04 江苏众红生物工程创药研究院有限公司 双特异性抗体、其制备方法和用途
JP7120765B2 (ja) 2015-11-25 2022-08-17 レゴケム バイオサイエンシズ， インク． ペプチド基を含む複合体及びそれに関連する方法
KR102847350B1 (ko) 2015-11-25 2025-08-19 주식회사 리가켐바이오사이언스 분지된 링커를 포함하는 항체-약물 접합체 및 이의 제조방법
WO2017103291A1 (en) 2015-12-17 2017-06-22 Psioxus Therapeutics Limited Virus encoding an anti-tcr-complex antibody or fragment
US20180291114A1 (en) 2015-12-17 2018-10-11 University Of Maryland, Baltimore County Recombinant bi-specific polypeptide for coordinately activating tumor-reactive t-cells and neutralizing immune suppression
MX2018008345A (es) 2016-01-11 2018-12-06 Univ Leland Stanford Junior Proteínas quiméricas y métodos de inmunoterapia.
CN108883140A (zh) 2016-01-14 2018-11-23 英特瑞克斯顿阿克图比奥帝克斯有限公司 治疗1型糖尿病的组合物和方法
EP3192810A1 (en) 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof
EP3402815B1 (en) 2016-01-15 2023-12-06 University of Maryland, College Park Endo-s2 mutants as glycosynthases, method of making and use for glycoengineering of glycoproteins
ES2847155T3 (es) 2016-01-21 2021-08-02 Novartis Ag Moléculas multiespecíficas que fijan como objetivo CLL-1
US10465003B2 (en) 2016-02-05 2019-11-05 Janssen Biotech, Inc. Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
EP3416981A1 (en) 2016-02-18 2018-12-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Polypeptides for preparing drug conjugates capable of promoting apoptosis in a cell expressing an orexin receptor
EP3416986A4 (en) 2016-02-19 2019-11-13 Dignity Health ANTIBODY PROTEIN PROTEIN AND RELATED COMPOSITIONS FOR TARGETING CANCER
WO2017160717A2 (en) 2016-03-15 2017-09-21 Memorial Sloan Kettering Cancer Center Method of treating diseases using kinase modulators
MX384752B (es) 2016-04-04 2025-03-14 Chemocentryx Inc ANTAGONISTAS SOLUBLES DE RECEPTOR DE C5a (C5aR).
EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
WO2017186928A1 (en) 2016-04-29 2017-11-02 Curevac Ag Rna encoding an antibody
US11339225B2 (en) 2016-05-12 2022-05-24 Asclepius (Suzhou) Technology Company Group, Co., Ltd. Bispecific antigen-binding construct and preparation method and use thereof
CN107365387B (zh) 2016-05-12 2022-03-15 阿思科力(苏州)生物科技有限公司 一种双特异性抗原结合构建体及其制备方法和应用
WO2017201281A1 (en) 2016-05-18 2017-11-23 Mayo Foundation For Medical Education And Research Targeting pd-l1 on tumor cells
EP3464352B1 (en) 2016-05-27 2021-03-24 Altor BioScience Corporation Construction and characterization of multimeric il-15-based molecules with cd3 binding domains
IT201800000534A1 (it) 2018-01-03 2019-07-03 Procedimenti per la promozione della crescita cellulare degli isolotti pancreatici.
US20210347901A9 (en) 2016-06-27 2021-11-11 Agomab Therapeutics Methods for promoting pancreatic islet cell growth
WO2018009466A1 (en) 2016-07-05 2018-01-11 Aduro Biotech, Inc. Locked nucleic acid cyclic dinucleotide compounds and uses thereof
CA3030841A1 (en) 2016-07-14 2018-01-18 Fred Hutchinson Cancer Research Center Multiple bi-specific binding domain constructs with different epitope binding to treat cancer
US11433141B2 (en) 2016-07-26 2022-09-06 Shizuoka Prefecture Anti-B7-H4 antibody
US20190170752A1 (en) 2016-08-08 2019-06-06 Beigene, Ltd. Method for predicting efficacy of immune checkpoint inhibitors in cancer patients
WO2018031734A1 (en) 2016-08-10 2018-02-15 University Of Maryland, College Park DESIGNER α1,6-FUCOSIDASE MUTANTS ENABLE DIRECT CORE FUCOSYLATION OF INTACT N-GLYCOPEPTIDES AND N-GLYCOPROTEINS
WO2018032638A1 (zh) 2016-08-19 2018-02-22 安源医药科技（上海）有限公司 用于构建融合蛋白的连接肽
WO2018037416A1 (en) 2016-08-25 2018-03-01 Yeda Research And Development Co. Ltd. Methods and compositions for treating autoimmune diseases
CN109843920B (zh) 2016-08-29 2023-01-13 迪赞纳生命科学公开有限公司 抗cd3抗体制剂
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
IL264902B2 (en) 2016-08-29 2023-11-01 Akamis Bio Ltd Adenovirus with bispecific T cell activator
WO2018044914A1 (en) 2016-08-29 2018-03-08 Hackensack University Medical Center Methods for treating an immune disorder-related disease by reducing autoreactivity in a t cell compartment
BR112019004042A2 (pt) 2016-08-30 2019-05-28 Dana-Farber Cancer Institute, Inc. composições de liberação de fármaco e usos das mesmas
CA3035377A1 (en) 2016-09-01 2018-03-08 Mayo Foundation For Medical Education And Research Nanoparticle compositions for targeting t-cell cancers
EP3506932B1 (en) 2016-09-02 2025-06-25 Intrexon Actobiotics NV Genetically modified bacteria stably expressing il-10 and insulin
KR20230010817A (ko) 2016-09-06 2023-01-19 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 파클리탁셀-알부민-결합제 조성물 및 그의 사용 및 제조 방법
CN109790215B (zh) 2016-09-29 2023-06-30 北京韩美药品有限公司 异源二聚体免疫球蛋白构建体和其制备方法
US11459401B2 (en) 2016-10-06 2022-10-04 Amgen Inc. Reduced viscosity protein pharmaceutical formulations
CN106632681B (zh) 2016-10-11 2017-11-14 北京东方百泰生物科技有限公司 抗egfr和抗cd3双特异抗体及其应用
EP3529279A4 (en) 2016-10-19 2020-04-29 The Governing Council of the University of Toronto CD133 BINDERS AND USE THEREOF
CN110121553A (zh) 2016-10-27 2019-08-13 纽约哥伦比亚大学董事会 免疫抑制性间充质细胞及其形成方法
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
KR102085798B1 (ko) 2016-12-28 2020-03-06 주식회사 인투셀 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물
EP3575319A4 (en) 2016-12-30 2021-03-10 Shanghai Sinobio Biotech Co., Ltd. BIFUNCTIONAL MOLECULE AND USE OF IT
WO2018120843A1 (zh) 2016-12-30 2018-07-05 上海近岸生物科技有限公司 一种三功能分子及其应用
US11046768B2 (en) 2017-01-27 2021-06-29 Memorial Sloan Kettering Cancer Center Bispecific HER2 and CD3 binding molecules
WO2018156735A1 (en) 2017-02-22 2018-08-30 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for cancer immunotherapy
AU2018243114C1 (en) 2017-03-29 2022-05-05 Cytoarm Co., Ltd. Antigen-specific T cells and uses thereof
WO2018178123A1 (en) 2017-03-29 2018-10-04 Glycotope Gmbh BISPECIFIC MUC-1 x PD-L1 ANTIBODIES
TW202515920A (zh) 2017-04-11 2025-04-16 美商因荷布瑞克斯生物科學公司 具有經受限cd3結合的多重特異性多肽構築體及使用其之方法
CN108728465A (zh) 2017-04-14 2018-11-02 深圳新诺微环生物科技有限公司 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用
CA3059444A1 (en) 2017-04-14 2018-10-18 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
CA3063905A1 (en) 2017-05-16 2018-11-22 The Johns Hopkins University Manabodies and methods of using
US12195529B2 (en) 2017-06-21 2025-01-14 Gsbio, Llc Heterodimeric bispecific antibodies
EP3649142A4 (en) 2017-07-04 2021-09-01 Intocell, Inc. JOINTS WITH SPLITABLE LINKER AND USES THEREOF
GB201710838D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies
CN111247241A (zh) 2017-08-10 2020-06-05 新加坡国立大学 T细胞受体缺陷型嵌合抗原受体t细胞和其使用方法
WO2019033050A1 (en) 2017-08-11 2019-02-14 City Of Hope BISPECIFIC MOLECULE FOR BINDING TO ANTIGEN
BR112020003494A2 (pt) 2017-09-07 2020-08-25 Augusta University Research Institute, Inc composto, métodos para aumentar uma resposta imunossupressora, para tratar um distúrbio inflamatório, uma doença autoimune, doença do enxerto contra hospedeiro, infecção crônica e obesidade e para inibir ou reduzir a rejeição a um transplante, e, composição farmacêutica
IL273016B2 (en) * 2017-09-08 2024-10-01 Diamyd Medical Ab Genotype stratification in diabetes treatment and prevention
US20200281976A1 (en) 2017-10-04 2020-09-10 City Of Hope Prevention and treatment of gvhd and autoimmune diseases
CN111247168B (zh) 2017-10-12 2023-12-29 美商生物细胞基因治疗有限公司 靶向多种抗原的复合嵌合抗原受体(cCAR)及其组成和使用方法
FR3072880A1 (fr) 2017-10-30 2019-05-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Formulation liposomale et son utilisation en therapie anti-tumorale
CN111670051B (zh) 2017-11-08 2024-06-25 亚飞（上海）生物医药科技有限公司 生物分子偶联物及其用途
WO2019094669A2 (en) 2017-11-09 2019-05-16 University Of Washington Self-assembling protein structures and components thereof
US12098162B2 (en) 2017-11-13 2024-09-24 Extremochem, Lda Neutral glycosylated amides and dianionic glucuronidated acids as stabilizers for biological molecules
WO2019126133A1 (en) 2017-12-20 2019-06-27 Alexion Pharmaceuticals, Inc. Liquid formulations of anti-cd200 antibodies
JP7253557B2 (ja) 2017-12-22 2023-04-06 ケモセントリックス，インコーポレイティド Ｃ５ａＲ阻害剤としてのジアリール置換５，５－縮合環化合物
JP2021508477A (ja) 2017-12-29 2021-03-11 オンコラス， インコーポレイテッド 治療用ポリペプチドの腫瘍溶解性ウイルス送達
EP3740505A1 (en) 2018-01-16 2020-11-25 Lakepharma Inc. Bispecific antibody that binds cd3 and another target
TWI804572B (zh) 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體
EP3752170A4 (en) 2018-02-12 2022-03-30 The General Hospital Corporation CHEMERA ANTIGEN RECEPTORS TARGETING THE MICROENVIRONMENT
GB201805329D0 (en) 2018-03-30 2018-05-16 Univ Leuven Kath Biomakers for diabetes therapy
KR102809631B1 (ko) 2018-04-02 2025-05-16 케모센트릭스, 인크. 융합된-바이사이클릭 C5aR 길항제의 프로드러그
AU2019247229A1 (en) 2018-04-05 2020-10-15 Novartis Ag Trispecific binding molecules against cancers and uses thereof
US10640576B2 (en) 2018-04-10 2020-05-05 Y-Biologics Inc. Cell engaging binding molecules
WO2019204434A1 (en) 2018-04-17 2019-10-24 Carnegie Mellon University Compositions and methods for modulating permeability of biological barriers
EP3788149B1 (en) 2018-05-01 2025-08-27 Ambrx, Inc. A method for optimizing antibody expression
IT201800005182A1 (it) 2018-05-09 2019-11-09 siRNA contro la variante C1858T del gene PTPN22
WO2019222082A1 (en) 2018-05-14 2019-11-21 Oncoimmune, Inc. Anti-cd24 compositions and uses thereof
JP7395508B2 (ja) 2018-05-16 2023-12-11 ヤンセン バイオテツク，インコーポレーテツド 癌を治療する方法及びｔ細胞リダイレクト治療薬の有効性を向上させる方法
EP3569617A1 (en) 2018-05-18 2019-11-20 Trion Research GmbH Pharmaceutical preparation for use in treating epstein- barr virus positive patients with reactivation phenomenon- associated diseases
EP3796934A4 (en) 2018-05-23 2022-04-06 Manysmart Therapeutics, Inc. BISPECIFIC T-LYMPHOCYTE ACTIVATOR AND USES THEREOF
TWI869346B (zh) 2018-05-30 2025-01-11 瑞士商諾華公司 Ｅｎｔｐｄ２抗體、組合療法、及使用該等抗體和組合療法之方法
JP2022516389A (ja) 2018-05-31 2022-02-28 ワシントン・ユニバーシティ 血液悪性腫瘍を治療するためのゲノム編集インバリアントナチュラルキラーＴ（ｉＮＫＴ）細胞
EP3802798A4 (en) 2018-05-31 2022-05-11 Washington University CHIMERIC ANTIGEN RECEPTOR T CELLS (CAR-T) FOR TREATMENT OF CANCER
CN112334482A (zh) 2018-06-07 2021-02-05 翁科奥内研发有限责任公司 用于癌症治疗的抗oxMIF/抗CD3抗体
CN112533950B (zh) 2018-06-29 2023-03-10 多玛医药科技(苏州)有限公司 抗CD3e抗体及其用途
US20210261649A1 (en) 2018-06-29 2021-08-26 Krystal Biotech, Inc, Compositions and methods for antibody delivery
US20210236466A1 (en) 2018-07-03 2021-08-05 Ifm Due, Inc. Compounds and compositions for treating conditions associated with sting activity
US20210261646A1 (en) 2018-07-03 2021-08-26 Sotio, LLC Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof
US11952419B2 (en) 2018-07-10 2024-04-09 University Of Connecticut Reagents and methods for treating cancer and autoimmune disease
US10640562B2 (en) 2018-07-17 2020-05-05 Mcmaster University T cell-antigen coupler with various construct optimizations
WO2020023847A1 (en) 2018-07-27 2020-01-30 Ngm Biopharmaceuticals, Inc. Use of glucagon receptor antagonists with immunotherapeutic agent
EP3830112A4 (en) 2018-07-30 2022-12-21 University of Southern California IMPROVING THE EFFICIENCY AND SAFETY OF ADOPTIVE CELLULAR THERAPIES
WO2020033499A1 (en) 2018-08-09 2020-02-13 Duke University Enhanced delivery of drugs and other compounds to the brain and other tissues
US12077785B2 (en) 2018-08-14 2024-09-03 Sotio Biotech Inc. Chimeric antigen receptor polypeptides in combination with trans metabolism molecules modulating Krebs cycle and therapeutic uses thereof
BR112021003843A2 (pt) 2018-08-28 2021-05-25 Ambrx, Inc. biconjugados de folato de anticorpo anti-cd3 e seus usos
US20210340219A1 (en) 2018-09-07 2021-11-04 Sotio, LLC Chimeric receptor polypeptides in combination with trans metabolism molecules modulating intracellular lactate concentrations and therapeutic uses thereof
EP3849513A1 (en) 2018-09-11 2021-07-21 Ichnos Sciences SA Compositions comprising a bispecific antibody, bufffer and one or more stabilizing agents
WO2020056170A1 (en) 2018-09-12 2020-03-19 Fred Hutchinson Cancer Research Center Reducing cd33 expression to selectively protect therapeutic cells
WO2020056037A1 (en) 2018-09-13 2020-03-19 Board Of Regents Of The University Of Nebraska Biomarkers for type 1 diabetes
US11066476B2 (en) 2018-09-14 2021-07-20 Shanghai tongji hospital Asymmetric bispecific antibody
EP3866777A4 (en) 2018-10-18 2022-07-20 The Regents of the University of California COMBINATION THERAPIES FOR THE TREATMENT OF INFLAMMATORY DISEASES
KR20210108944A (ko) 2018-10-22 2021-09-03 아이셀킬렉스 테라퓨틱스 엘엘씨 돌연변이 백시니아 바이러스 및 이의 용도
CA3112868A1 (en) 2018-10-31 2020-05-07 Tiziana Life Sciences Plc Composition and methods of treating inflammatory and autoimmune diseases
MX2021005155A (es) 2018-11-01 2021-09-30 Shandong New Time Pharmaceutical Co Ltd Anticuerpo biespecífico y uso del mismo.
WO2020092743A2 (en) 2018-11-01 2020-05-07 Memorial Sloan Kettering Cancer Center Methods of treating diseases using kinase modulators
TWI850282B (zh) 2018-11-27 2024-08-01 香港商弘年發展有限公司 用於治療癌症之質體建構體和使用方法
US20220098329A1 (en) 2018-11-30 2022-03-31 Memorial Sloan Kettering Cancer Center Heterodimeric tetravalency and specificity antibody compositions and uses thereof
WO2020118136A1 (en) 2018-12-06 2020-06-11 Board Of Regents, The University Of Texas System Selectively cleavable therapeutic nanoparticles
US20220048961A1 (en) 2018-12-14 2022-02-17 Fred Hutchinson Cancer Research Center Transferrin receptor targeting peptides
WO2020123806A1 (en) 2018-12-14 2020-06-18 Beth Israel Deaconess Medical Center. Inc. Modulation of pd-1
CA3123599A1 (en) 2018-12-19 2020-06-25 City Of Hope Baff-r bispecific t-cell engager antibody
US20210393795A1 (en) 2019-01-03 2021-12-23 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
WO2020141459A1 (en) 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
WO2020150402A2 (en) 2019-01-15 2020-07-23 Caerus Therapeutics, Corp. Advanced chimeric antigen receptor vectors for targeting solid tumors
JP7680358B2 (ja) 2019-01-30 2025-05-20 ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー 癌抗原を標的とするｄｎａコード化二重特異性ｔ細胞エンゲージャーおよび癌治療薬における使用方法
WO2020166592A1 (ja) 2019-02-13 2020-08-20 大日本住友製薬株式会社 ヘミアスタリン誘導体とその抗体薬物複合体
KR20210128399A (ko) 2019-02-20 2021-10-26 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 암-표적화되고, 바이러스-암호화된, 조절 가능한 t 세포 (catvert) 또는 nk 세포 (catvern) 링커
WO2020168555A1 (zh) 2019-02-22 2020-08-27 武汉友芝友生物制药有限公司 Cd3抗原结合片段及其应用
EP3929212A4 (en) 2019-02-22 2022-11-23 Wuhan Yzy Biopharma Co., Ltd. MODIFIED FC FRAGMENT, ANTIBODY COMPRISING THEM AND THEIR APPLICATION
WO2020185763A1 (en) 2019-03-11 2020-09-17 Memorial Sloan Kettering Cancer Center Cd22 antibodies and methods of using the same
CN109776683B (zh) 2019-03-19 2020-04-07 益科思特(北京)医药科技发展有限公司 一种双特异性抗体及其制备方法与应用
JP7682797B2 (ja) 2019-03-20 2025-05-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン６二重特異性抗体
SG11202110390XA (en) 2019-03-21 2021-10-28 Agency Science Tech & Res Composition
US20210363270A1 (en) 2019-03-25 2021-11-25 Alteogen Inc. Pharmaceutical composition for subcutaneous injection comprising human hyaluronidase ph20 variant and drug
CA3135044A1 (en) 2019-03-27 2020-10-01 National Research Council Of Canada Antigen-binding agents that specifically bind epidermal growth factor receptor variant iii
MA55529A (fr) 2019-04-03 2022-02-09 Genzyme Corp Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite
EP3953385A4 (en) 2019-04-08 2022-12-21 Memorial Sloan Kettering Cancer Center CD19 ANTIBODIES AND METHODS OF USE THEREOF
WO2020210843A2 (en) 2019-04-12 2020-10-15 The Johns Hopkins University Tolerogenic artificial antigen-presenting cells
US12151000B2 (en) 2019-04-12 2024-11-26 The Johns Hopkins University Tolerogenic artificial antigen-presenting cells
US20220348657A1 (en) 2019-04-18 2022-11-03 Five Prime Therapeutics, Inc. Bioassay for t-cell co-stimulatory proteins containing fc domains
US20230075314A1 (en) 2019-04-29 2023-03-09 Voyager Therapeutics, Inc. VECTORIZED ANTIBODIES (vAb) AND USES THEREOF
US12390437B2 (en) 2019-04-30 2025-08-19 Sitryx Therapeutics Limited Itaconic acid derivatives and uses thereof intreating an inflammatory disease or a disease associated with an undesirable immune response
EP3966248A4 (en) 2019-05-08 2023-04-12 Memorial Sloan Kettering Cancer Center HUMAN ANTIBODIES TO FEL MUCIN-16 AND THEIR METHODS OF USE
GB201906685D0 (en) 2019-05-13 2019-06-26 Ultrahuman Six Ltd Activatable protein constructs and uses thereof
BR112021022682A2 (pt) * 2019-05-14 2022-02-22 Provention Bio Inc Métodos e composições para prevenir diabetes do tipo 1
WO2020247385A1 (en) 2019-06-03 2020-12-10 Immunolux International Corp. Smallpox vaccine and stem cells for treatment of disease
WO2020247871A2 (en) 2019-06-06 2020-12-10 Janux Therapeutics, Inc. Compositions and methods relating to tumor activated t cell engagers
US20220380478A1 (en) 2019-07-01 2022-12-01 Tonix Pharma Holdings Limited Anti-cd154 antibodies and uses thereof
JP2022541645A (ja) 2019-07-22 2022-09-26 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 治療用タンパク質の多機能性および増強された分泌のための多量体タンパク質ドメイン
BR112022001699A2 (pt) 2019-07-30 2022-05-24 Provention Bio Inc Métodos e composições para reduzir imunogenicidade através de inibidores não deplecionais de célula b
US20210130464A1 (en) 2019-07-30 2021-05-06 Provention Bio, Inc. Methods and Compositions for Reducing Immunogenicity By Non-Depletional B Cell Inhibitors
US20210128617A1 (en) 2019-08-27 2021-05-06 The Trustees Of The University Of Pennsylvania SYNTHETIC CARS TO TREAT IL13R-alpha-2 POSITIVE HUMAN AND CANINE TUMORS
US20220281998A1 (en) 2019-08-28 2022-09-08 Azusapharma Sciences, Inc. Bifidobacterium spp. expressing and secreting diabody-type bsab
WO2021041958A1 (en) 2019-08-30 2021-03-04 Shattuck Labs. Inc. Chimeric proteins in autoimmunity
GB201912681D0 (en) 2019-09-04 2019-10-16 Eth Zuerich Bispecific binding agent that binds to cd117/c-kit and cd3
CN112480263A (zh) 2019-09-12 2021-03-12 普米斯生物技术(苏州)有限公司 一种双特异t细胞激活器活化t细胞的设计及其应用
EP3791931A1 (en) 2019-09-13 2021-03-17 Ichnos Sciences SA Bispecific antibodies for the treatment of solid tumors
KR102081418B1 (ko) 2019-09-24 2020-05-26 주식회사 이뮤니스바이오 말초혈액단핵구 유래 조절 t 세포 배양용 조성물 및 이를 이용한 조절 t 세포 배양방법
EP4037774A1 (en) 2019-10-02 2022-08-10 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of adult t-cell leukemia/lymphoma
JP2022551870A (ja) 2019-10-10 2022-12-14 アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティー 多重特異性免疫細胞エンゲージャーを発現する腫瘍溶解性ウイルス
MX2022004218A (es) 2019-10-10 2022-07-19 Y Biologics Inc Proteina de fusion multiespecifica y uso de la misma.
CN115175688A (zh) 2019-11-05 2022-10-11 耶达研究及发展有限公司 在数个t细胞介导的自身免疫性疾病的治疗中的数个否决细胞的用途
CA3154150A1 (en) 2019-11-12 2021-05-20 Keun Ho Lee Antibody-payload conjugates with enhanced delivery domain and uses thereof
US20230039858A1 (en) 2019-12-02 2023-02-09 Intocell, Inc. Compositions and methods related to molecular conjugation
AU2020397229A1 (en) 2019-12-06 2022-06-30 Oncoone Research & Development Gmbh Anti-oxMIF/anti-CD3 bispecific antibody constructs
CN115023422A (zh) 2019-12-12 2022-09-06 德国费森尤斯卡比有限公司 糖基化多肽
US20230023615A1 (en) 2019-12-13 2023-01-26 Dnalite Therapeutics, Inc. Compositions and methods for biological delivery vehicles
CN115023441A (zh) 2019-12-18 2022-09-06 特诺福尔股份有限公司 与cd38结合的重链抗体
WO2021127088A1 (en) 2019-12-18 2021-06-24 Janssen Biotech, Inc. Materials and methods for in vivo biological targeting
PE20221584A1 (es) 2019-12-23 2022-10-06 Sitryx Therapeutics Ltd Derivados carboxi con propiedades antiinflamatorias
US20230331804A1 (en) 2019-12-31 2023-10-19 Fred Hutchinson Cancer Center Nanoparticle systems to stimulate and maintain immune system responsiveness at treatment sites
WO2021146328A1 (en) 2020-01-13 2021-07-22 Aptevo Research And Development Llc Formulations for protein therapeutics
EP4090377A1 (en) 2020-01-13 2022-11-23 Synaffix B.V. Conjugates of antibodies an immune cell engagers
AU2021208642B2 (en) 2020-01-17 2025-06-05 Immunelogic Therapeutics, Inc. Pro-antibody that reduces off-target toxicity
EP4097129A1 (en) 2020-01-29 2022-12-07 Inhibrx, Inc. Cd28 single domain antibodies and multivalent and multispecific constructs thereof
CN115461354B (zh) 2020-02-14 2025-05-09 长庚医疗财团法人林口长庚纪念医院 用于分子缀合或改造的串联重复癌症靶向肽及其在癌症治疗诊断学中的用途
EP3865513A1 (en) 2020-02-17 2021-08-18 Fundación Para La Investigación Biomédica Del Hospital 12 De Octubre Anti-cd19/anti-cd3 bispecific antibody, t cells secreting the same, method of preparation and use thereof
EP4110398A4 (en) 2020-02-27 2024-07-10 Phanes Therapeutics, Inc. ANTIBODIES CONJUGATED WITH FATTY ACID MOLECULES AND THEIR USES
KR20220152316A (ko) 2020-03-12 2022-11-15 이뮨-온크 테라퓨틱스, 인코포레이티드 신규한 항-lilrb4 항체 및 유도체 생성물
EP4121462A4 (en) 2020-03-16 2024-04-24 Magenta Therapeutics, Inc. BISPECIFIC T CELL BINDING PROTEINS
IL296566A (en) 2020-03-23 2022-11-01 Cytoarm Co Ltd Bi-specific antibodies for use in producing armed immune cells
WO2021202726A2 (en) 2020-03-31 2021-10-07 Fred Hutchinson Cancer Research Center Anti-cd33 antibodies and uses thereof
CA3173205A1 (en) 2020-03-31 2021-10-07 Roland B. WALTER Human anti-cd33 antibodies and uses thereof
CN115867275A (zh) 2020-04-13 2023-03-28 大学健康网络 治疗细胞因子释放综合征的方法
US20230193205A1 (en) 2020-04-19 2023-06-22 Figene, Llc Gene modified fibroblasts for therapeutic applications
CN113527510A (zh) 2020-04-22 2021-10-22 上海交通大学 融合蛋白分子及其制备方法和用途
EP4139347A4 (en) 2020-04-24 2024-06-05 Memorial Sloan Kettering Cancer Center Anti-cd3 antibodies and uses thereof
US20230279108A1 (en) 2020-04-30 2023-09-07 Arch Oncology, Inc. Therapeutic sirp-alpha antibodies
WO2021222861A1 (en) 2020-04-30 2021-11-04 Children's Medical Center Corporation Antibodies specific to abcb5 and uses thereof
US20210349094A1 (en) 2020-05-11 2021-11-11 Musc Foundation For Research Development Detection of autoreactive fecal immunoglobulin a (iga) for diagnosis of lupus
CA3180572A1 (en) 2020-05-29 2021-12-02 Johan Skog Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection
WO2021252780A2 (en) 2020-06-11 2021-12-16 Tizona Therapeutics Bispecific immune cell engagers with binding specificity for hla-g and another antigen
CA3182445A1 (en) 2020-06-11 2021-12-16 Francisco Leon Methods and compositions for preventing type 1 diabetes
WO2021254574A2 (en) 2020-06-17 2021-12-23 Y-Mabs Therapeutics, Inc. Cd38 antibodies for the treatment of human diseases
EP4182447A4 (en) 2020-07-14 2024-10-23 Ichilov Tech Ltd. PSEUDOTYPED VIRUSES WITH CONFIGURATION FOR EXPRESSION OF CAR IN T CELLS
EP4185616A1 (en) 2020-07-24 2023-05-31 Cellectis S.A. T-cells expressing immune cell engagers in allogenic settings
EP4188442A4 (en) 2020-07-28 2025-01-01 Memorial Sloan Kettering Cancer Center COMPOSITIONS CONTAINING EX-VIVO-DEPLEATED T CELLS WITH MULTI-SPECIFIC ANTIBODIES AND USES THEREOF
CN116234828A (zh) 2020-07-29 2023-06-06 米纳瓦生物技术公司 抗可变muc1*抗体及其用途
WO2022026939A2 (en) 2020-07-31 2022-02-03 Soteria Biotherapeutics, Inc. Single and dual targeting ligand induced t-cell engager compositions
US12459908B2 (en) 2020-08-05 2025-11-04 Sitryx Therapeutics Limited Alpha, beta unsaturated methacrylic esters with anti-inflammatory properties
WO2022032003A2 (en) 2020-08-06 2022-02-10 Abpro Corporation Anti-claudin 18.2 antibodies and uses thereof
AU2021325225A1 (en) 2020-08-10 2023-03-23 Gv20 Therapeutics Llc Compositions and methods for treating autoimmune diseases and cancers by targeting IGSF8
WO2022035888A2 (en) 2020-08-10 2022-02-17 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Sars-cov-2-neutralizing antibodies, biomarkers to predict protection from re-infection, and high efficiency antibody screening methods
WO2022036495A1 (en) 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
US11124568B1 (en) 2020-08-19 2021-09-21 Vitruviae LLC CD3/CD25 antibodies for neuro-immune diseases
CA3189708A1 (en) 2020-08-19 2022-02-24 Mahiuddin Ahmed Vaccine compositions and antibodies for lyme disease
EP4200328A4 (en) 2020-08-21 2025-02-26 The Rockefeller University Single-domain antibodies that bind sars-cov-2
EP4200275A2 (en) 2020-08-21 2023-06-28 Sitryx Therapeutics Limited Fumarate derivatives and their medical use
KR20230057351A (ko) 2020-08-27 2023-04-28 각코우호우진 쥰텐도 항절단형 변이 calr-cd3 이중특이성 항체 및 의약 조성물
EP4178986A4 (en) 2020-09-13 2024-01-10 Shandong Boan Biotechnology Co., Ltd. DOWN-REGULATION OF MEMBRANE-BONDED PROTEINS THROUGH RECEPTOR TAC TECHNOLOGY
TW202227478A (zh) 2020-09-15 2022-07-16 德商拜恩迪克公司 對細胞靶向遞送的藥劑及方法
WO2022060832A1 (en) 2020-09-15 2022-03-24 University Of Florida Research Foundation, Incorporated Cd33 antibodies
WO2022063302A1 (zh) 2020-09-25 2022-03-31 克莱格医学有限公司 免疫细胞活性调节
EP4217009A4 (en) 2020-09-28 2025-09-24 Navrogen Inc COMPOSITION AND USE OF OTHERWISE FORMATTED ANTI-MESOTHELIN ANTIBODIES IN THE TREATMENT OF CANCER
US20240026012A1 (en) 2020-10-09 2024-01-25 Seattle Children's Hospital (Dba Seattle Children's Research Institute Binders and chimeric antigen receptors which specifically bind fibroblast growth factor receptor 4
WO2022081794A1 (en) 2020-10-15 2022-04-21 Tavotek Biotherapeutics (Hong Kong) Limited Shielded biologics with masking domains to shield antigen binding capability of biologics and uses thereof
CA3196009A1 (en) 2020-10-20 2022-04-28 Mikhail SHAFEEV Agonists of free fatty acid receptor 1 and their use in diseases associated with said receptor
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法

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