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BR112015028764A2 - derivados de nucleosídeo substituído 4'-fluoro-2'-metil - Google Patents

derivados de nucleosídeo substituído 4'-fluoro-2'-metil

Info

Publication number
BR112015028764A2
BR112015028764A2 BR112015028764A BR112015028764A BR112015028764A2 BR 112015028764 A2 BR112015028764 A2 BR 112015028764A2 BR 112015028764 A BR112015028764 A BR 112015028764A BR 112015028764 A BR112015028764 A BR 112015028764A BR 112015028764 A2 BR112015028764 A2 BR 112015028764A2
Authority
BR
Brazil
Prior art keywords
fluoro
methyl substituted
substituted nucleoside
nucleoside derivatives
derivatives
Prior art date
Application number
BR112015028764A
Other languages
English (en)
Other versions
BR112015028764B1 (pt
Inventor
G Klumpp Klaus
Smith Mark
Original Assignee
Riboscience Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riboscience Llc filed Critical Riboscience Llc
Publication of BR112015028764A2 publication Critical patent/BR112015028764A2/pt
Publication of BR112015028764B1 publication Critical patent/BR112015028764B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/11—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids containing cyclic phosphate

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analyzing Materials Using Thermal Means (AREA)
BR112015028764-6A 2013-05-16 2014-05-15 Derivados de nucleosídeo de 4-fluoro-2-metil substituídos como inibidores de replicação de rna do hcv BR112015028764B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361824030P 2013-05-16 2013-05-16
US61/824,030 2013-05-16
PCT/US2014/038287 WO2014186637A1 (en) 2013-05-16 2014-05-15 4'-fluor0-2'-methyl substituted nucleoside derivatives

Publications (2)

Publication Number Publication Date
BR112015028764A2 true BR112015028764A2 (pt) 2017-07-25
BR112015028764B1 BR112015028764B1 (pt) 2022-09-27

Family

ID=51895938

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015028764-6A BR112015028764B1 (pt) 2013-05-16 2014-05-15 Derivados de nucleosídeo de 4-fluoro-2-metil substituídos como inibidores de replicação de rna do hcv

Country Status (23)

Country Link
US (1) US9895442B2 (pt)
EP (1) EP2996695B1 (pt)
JP (1) JP6366693B2 (pt)
KR (1) KR102241198B1 (pt)
CN (1) CN105307662B (pt)
AU (1) AU2014265293B2 (pt)
BR (1) BR112015028764B1 (pt)
CA (1) CA2912682C (pt)
CL (1) CL2015003357A1 (pt)
CR (1) CR20150648A (pt)
EA (1) EA035301B1 (pt)
HK (1) HK1217294A1 (pt)
IL (1) IL242605B (pt)
MA (2) MA38675A1 (pt)
MX (1) MX2015015782A (pt)
MY (1) MY186547A (pt)
NZ (1) NZ714927A (pt)
PE (1) PE20160120A1 (pt)
PH (1) PH12015502588A1 (pt)
SG (1) SG11201509424VA (pt)
UA (1) UA123533C2 (pt)
WO (1) WO2014186637A1 (pt)
ZA (1) ZA201509056B (pt)

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KR102788773B1 (ko) 2012-12-21 2025-03-28 얀센 바이오파마, 인코퍼레이트. 치환된 뉴클레오사이드, 뉴클레오타이드 및 그것의 유사체
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GB2611644B (en) * 2018-03-07 2023-07-26 Univ Emory 4'-halogen containing nucleotide and nucleoside therapeutic compositions and uses related thereto
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Also Published As

Publication number Publication date
UA123533C2 (uk) 2021-04-21
PH12015502588B1 (en) 2016-02-29
EP2996695B1 (en) 2022-04-13
US9895442B2 (en) 2018-02-20
AU2014265293A1 (en) 2015-12-24
HK1217294A1 (zh) 2017-01-06
EA201592184A1 (ru) 2016-04-29
KR102241198B1 (ko) 2021-04-15
PE20160120A1 (es) 2016-02-24
JP2016518453A (ja) 2016-06-23
EP2996695A4 (en) 2016-12-14
AU2014265293B2 (en) 2019-07-18
JP6366693B2 (ja) 2018-08-01
MX2015015782A (es) 2016-06-02
CR20150648A (es) 2016-03-09
MY186547A (en) 2021-07-26
BR112015028764B1 (pt) 2022-09-27
CA2912682C (en) 2021-07-06
CL2015003357A1 (es) 2016-11-04
MA38675A1 (fr) 2017-12-29
EA035301B1 (ru) 2020-05-26
CN105307662A (zh) 2016-02-03
MA46490A1 (fr) 2021-04-30
EP2996695A1 (en) 2016-03-23
HK1219900A1 (zh) 2017-04-21
NZ714927A (en) 2020-09-25
US20140341847A1 (en) 2014-11-20
ZA201509056B (en) 2016-11-30
IL242605B (en) 2018-08-30
CA2912682A1 (en) 2014-11-20
PH12015502588A1 (en) 2016-02-29
SG11201509424VA (en) 2015-12-30
CN105307662B (zh) 2019-06-04
WO2014186637A1 (en) 2014-11-20
KR20160040141A (ko) 2016-04-12

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
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