[go: up one dir, main page]

BR112013027065A2 - processo para a preparação de sais de 3-carboxi-n-etil-n,n-dimetilpropan-1amínio, compostos e seus usos - Google Patents

processo para a preparação de sais de 3-carboxi-n-etil-n,n-dimetilpropan-1amínio, compostos e seus usos

Info

Publication number
BR112013027065A2
BR112013027065A2 BR112013027065A BR112013027065A BR112013027065A2 BR 112013027065 A2 BR112013027065 A2 BR 112013027065A2 BR 112013027065 A BR112013027065 A BR 112013027065A BR 112013027065 A BR112013027065 A BR 112013027065A BR 112013027065 A2 BR112013027065 A2 BR 112013027065A2
Authority
BR
Brazil
Prior art keywords
dimethylpropan
carboxy
ethyl
preparation
compounds
Prior art date
Application number
BR112013027065A
Other languages
English (en)
Other versions
BR112013027065B1 (pt
Inventor
Daina Lola
Edgars Liepins
Einars Loza
Ilmars Stonans
Ivars Kalvins
Janis Kuka
Maija Dambrova
Osvalds Pugovics
Reinis Vilskersts
Solveiga Grinberga
Original Assignee
Grindeks Jsc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grindeks Jsc filed Critical Grindeks Jsc
Publication of BR112013027065A2 publication Critical patent/BR112013027065A2/pt
Publication of BR112013027065B1 publication Critical patent/BR112013027065B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/10—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/04—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated
    • C07C225/06—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/15—Fumaric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
    • C07C69/12—Acetic acid esters
    • C07C69/14—Acetic acid esters of monohydroxylic compounds
    • C07C69/145—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols
    • C07C69/157—Acetic acid esters of monohydroxylic compounds of unsaturated alcohols containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

resumo "processo para a preparação de sais de 3-carboxi-n-etil-n,n-dimetilpropan-1- amínio, compostos e seus usos" a presente invenção refere-se a sais de 3-carboxi-n-etil-n,n- dimetilpropan-1-amínio, método de preparação dos mesmos e utilização no tratamento de doenças cardiovasculares.
BR112013027065A 2011-04-27 2012-04-27 processo para a preparação de sais de 3-carboxi-n-etil-n,n-dimetilpropan-1amínio, compostos e seus usos BR112013027065B1 (pt)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP11163840 2011-04-27
EP11163872 2011-04-27
EP11163841 2011-04-27
EP11163871 2011-04-27
EP11163839 2011-04-27
PCT/EP2012/057806 WO2012146736A1 (en) 2011-04-27 2012-04-27 Use of 3-carboxy-n-ethyl-n,n-dimethylpropan-1-aminium salts in the treatment of cardiovascular disease

Publications (2)

Publication Number Publication Date
BR112013027065A2 true BR112013027065A2 (pt) 2016-12-27
BR112013027065B1 BR112013027065B1 (pt) 2019-12-03

Family

ID=46062261

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013027065A BR112013027065B1 (pt) 2011-04-27 2012-04-27 processo para a preparação de sais de 3-carboxi-n-etil-n,n-dimetilpropan-1amínio, compostos e seus usos

Country Status (25)

Country Link
US (2) US20140088125A1 (pt)
EP (1) EP2702033B1 (pt)
JP (1) JP5997762B2 (pt)
KR (1) KR20130138827A (pt)
CN (1) CN103608326B (pt)
AU (1) AU2012247467B2 (pt)
BR (1) BR112013027065B1 (pt)
CA (1) CA2832693C (pt)
CY (1) CY1117890T1 (pt)
DK (1) DK2702033T3 (pt)
EA (1) EA023547B1 (pt)
ES (1) ES2585558T3 (pt)
GE (1) GEP20156373B (pt)
HR (1) HRP20160998T1 (pt)
HU (1) HUE030415T2 (pt)
IL (1) IL228891A (pt)
LT (1) LT2702033T (pt)
MX (1) MX351765B (pt)
PE (1) PE20140777A1 (pt)
PL (1) PL2702033T3 (pt)
PT (1) PT2702033T (pt)
RS (1) RS55092B1 (pt)
SI (1) SI2702033T1 (pt)
SM (1) SMT201600416B (pt)
WO (1) WO2012146736A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JO3117B1 (ar) * 2012-12-20 2017-09-20 Grindeks Jsc استعمال 3- كربوكسي- ن-إيثيل- ن، ن- ثاني ميثيل بروبان-1– أمينيوم أو ملح منه مقبول صيدلانياً في معالجة تصلب الشرايين
JO3333B1 (ar) * 2013-09-26 2019-03-13 Grindeks Jsc استعمال 3-carboxy-N-ethyl-N,N-dimethylpropan-1-aminium أو ملح مقبول دوائيا منه للوقاية من السكري وعلاجه

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1103259A (en) * 1913-04-23 1914-07-14 John J Buckley Fly-paper holder.
GB1238868A (pt) 1967-08-08 1971-07-14
SU997646A1 (ru) 1978-11-27 1983-02-23 Ордена Трудового Красного Знамени Институт Органического Синтеза Ан Латвсср Кормова добавка
IT1210935B (it) 1981-09-17 1989-09-29 Inst Orch Sinteza Akademi Nauk Composizione farmaceutica per il trattamento di malattie cardiovascolari.
SU1680693A1 (ru) * 1987-03-25 1991-09-30 Институт Органического Синтеза Ан Латвсср Этил-3-(2,2-диметил-2-этилгидразиний)пропионат иодистый, про вл ющий антиаритмическую активность
JP3119430B2 (ja) * 1995-07-25 2000-12-18 大鵬薬品工業株式会社 水酸基ラジカル消去剤
LV11727B (en) * 1995-08-21 1997-08-20 Kalvins Ivars Pharmaceutical composition
LV11728B (en) 1995-08-21 1997-08-20 Kalvins Ivars Pharmaceutical composition
US5973026A (en) 1998-02-02 1999-10-26 Xerox Corporation Ink jet inks
DE19956772A1 (de) * 1999-11-25 2001-06-07 Basf Ag Verwendung von y-Butyrobetain Salzen zur Herstellung von Zubereitungen für die menschliche und tierische Ernährung
EP1667960B1 (en) * 2003-08-04 2008-02-13 "Joint Stock Company Grindeks" Meldonium salts, method of their preparation and pharmaceutical composition on their basis
CA2508094A1 (en) 2005-05-20 2006-11-20 Vivier Canada Inc. Composition for accelerating collagen synthesis
US7863274B2 (en) 2005-07-29 2011-01-04 Concert Pharmaceuticals Inc. Deuterium enriched analogues of tadalafil as PDE5 inhibitors
LV13705B (en) 2006-11-06 2008-07-20 Ivars Kalvins Process for producing high purity intermolecular salt of 3-carboxy-n,n,n-trimethyl-propane-1-amine hydroxide
JP4761265B2 (ja) 2007-10-17 2011-08-31 学校法人甲南学園 核酸合成を促進する化合物を含む組成物およびその利用、並びに当該化合物の製造方法
TWI391131B (zh) * 2007-12-05 2013-04-01 Grindeks Jsc ３－（２，２，２－三甲基肼）丙酸鹽的新用途
ATE527996T1 (de) * 2007-12-12 2011-10-15 Grindeks Jsc Medizinische verwendung von 3-(2,2,2- trimethylhydrazinium)propionat-orotat
US8889902B2 (en) * 2009-06-25 2014-11-18 Tetra, Sia Acetylsalicylic acid salts
WO2010149654A1 (en) * 2009-06-25 2010-12-29 Grindeks, A Joint Stock Company Pharmaceutical composition of gamma-butyrobetaine or a pharmaceutically acceptable salt and meldonium or a pharmaceutically acceptable salt
LV14345B (lv) * 2009-10-22 2011-07-20 Grindeks, A/S 4-[Etil(dimetil)amonija]butanoāts un tā izmantošana kardiovaskulāro slimību ārstēšanai

Also Published As

Publication number Publication date
WO2012146736A4 (en) 2013-01-31
CA2832693A1 (en) 2012-11-01
KR20130138827A (ko) 2013-12-19
US10351534B2 (en) 2019-07-16
SI2702033T1 (sl) 2016-09-30
NZ616467A (en) 2015-10-30
CA2832693C (en) 2018-10-02
HRP20160998T1 (hr) 2016-10-21
MX351765B (es) 2017-10-26
HUE030415T2 (en) 2017-05-29
RS55092B1 (sr) 2016-12-30
IL228891A0 (en) 2013-12-31
AU2012247467B2 (en) 2016-07-28
WO2012146736A1 (en) 2012-11-01
WO2012146736A8 (en) 2013-03-28
CN103608326B (zh) 2016-01-20
EP2702033A1 (en) 2014-03-05
CY1117890T1 (el) 2017-05-17
DK2702033T3 (en) 2016-08-29
EA023547B1 (ru) 2016-06-30
MX2013012551A (es) 2015-04-10
SMT201600416B (it) 2017-01-10
JP5997762B2 (ja) 2016-09-28
PE20140777A1 (es) 2014-07-20
US20140088125A1 (en) 2014-03-27
US20180079728A1 (en) 2018-03-22
AU2012247467A1 (en) 2013-11-14
EP2702033B1 (en) 2016-06-08
ES2585558T3 (es) 2016-10-06
GEP20156373B (en) 2015-09-25
EA201301080A1 (ru) 2014-02-28
PL2702033T3 (pl) 2017-04-28
IL228891A (en) 2015-11-30
BR112013027065B1 (pt) 2019-12-03
JP2014523403A (ja) 2014-09-11
PT2702033T (pt) 2016-08-17
LT2702033T (lt) 2016-09-12
CN103608326A (zh) 2014-02-26

Similar Documents

Publication Publication Date Title
JO3091B1 (ar) مشتقات حمض 3- فنيل بروبيونيك متفرعة واستخداماتها
BR112015001101A2 (pt) formas cristalinas de um inibidor de prolil hidroxilase
CO6940374A2 (es) Composiciones, usos y métodos para tratamiento de trastornos y enfermedades metabólicas
CL2013001947A1 (es) Composicion farmaceutica que comprende pioglitazona; uso de pioglitazona para tratar alzheimer; composicion que comprende pioglitazona.
BR112014013108A2 (pt) compostos tricíclicos fundidos como inibidores da quinase raf
BR112013025769A2 (pt) inibidores de replicação viral, seu processo de preparação e seus usos terapêuticos
JO3204B1 (ar) 4- أريل-n- فنيل-5،3،1- ترايازين-2- أمينات محتوية على مجموعة سلفوكسيمين
EA201491339A1 (ru) Замещенные аннеллированные пиримидины и триазины и их применение
RU2018145985A (ru) Антагонисты активина-actrii и их применение для лечения нарушений костной ткани и других нарушений
BR112012032778A2 (pt) "proteínas multiespecíficas e multivalentes"
BR112013026427A2 (pt) inibidores de replicação viral, seu processo de preparação e seus usos terapêuticos
BR112014005389A8 (pt) Sal cloridrato de 4- (3-metanossulfonil-fenil) -1- propil-piperidina em uma forma cristalina, composição farmacêutica compreendendo o mesmo e usos do dito sal
EA201492040A1 (ru) Бициклически замещённые урацилы и их применение
EA201690520A1 (ru) Способ получения замещенных 5-фтор-1h-пиразолопиридинов
BR112014003079A2 (pt) derivado de 1,2,3,4-tetra-hidroquinolina útil para o tratamento de diabetes
UA116999C2 (uk) Виділене антитіло до гемаглютиніну та фармацевтична композиція, що його містить
UA113627C2 (xx) Кристалічна форма циклоспорину a, фармацевтична композиція та спосіб лікування
CR20140325A (es) Nuevos derivados de morofolinilo útiles como inhibodores de mogat-2-
BR112014004224A2 (pt) aparelhos e métodos para tratamento de estacas de caules de cana-de açúcar
BR112014000889A2 (pt) tratamento para hipoxia
BR112013028789A2 (pt) processo
BR112013018296A2 (pt) tratamento de disfunções cognitivas em esquizofrenia
BR112013019775A2 (pt) composto, composição farmacêutica e método para tratar declínio cognitivo ou doença de alzheimer em um paciente
BR112014004437A8 (pt) composto, composição farmacêutica, preparação farmacêutica, processo para o preparo de um composto de fórmula, intermediário, métodos para a prevenção ou tratamento de malária e para inativação de infecção parasítica em uma célula.
BRPI1010972A2 (pt) composição tópica sob a forma de uma solução e método para tratar acne ou outros distúrbios relacionados à pele

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/04/2012, OBSERVADAS AS CONDICOES LEGAIS. (CO) 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/04/2012, OBSERVADAS AS CONDICOES LEGAIS