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BR0308513A - Micronizado cristalino de brometo de tiotrópio - Google Patents

Micronizado cristalino de brometo de tiotrópio

Info

Publication number
BR0308513A
BR0308513A BR0308513-9A BR0308513A BR0308513A BR 0308513 A BR0308513 A BR 0308513A BR 0308513 A BR0308513 A BR 0308513A BR 0308513 A BR0308513 A BR 0308513A
Authority
BR
Brazil
Prior art keywords
tiotropium bromide
crystalline
beta
preparation
crystalline micronized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
BR0308513-9A
Other languages
English (en)
Other versions
BRPI0308513B8 (pt
BRPI0308513B1 (pt
Inventor
Helmut Bender
Hagen Graebner
Konrad Schindler
Michael Josef Friedrich Trunk
Michael Walz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH Co KG
Original Assignee
Boehringer Ingelheim Pharma GmbH Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0308513(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma GmbH Co KG filed Critical Boehringer Ingelheim Pharma GmbH Co KG
Publication of BR0308513A publication Critical patent/BR0308513A/pt
Publication of BRPI0308513B1 publication Critical patent/BRPI0308513B1/pt
Publication of BRPI0308513B8 publication Critical patent/BRPI0308513B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hybrid Cells (AREA)

Abstract

"MICRONIZADO CRISTALINO DE BROMETO DE TIOTRóPIO". A presente invenção refere-se a um micronisado cristalino de brometo de (1alfa, 2beta, 4beta, 5alfa, 7beta)-7-[(hidroxidi-2-tienilacetil)óxi]-9,9-dimetil-3-oxa-9-azoniatriciclo [3.3.1.0^ 2,4^]nonano, ao processo para sua preparação, bem como ao seu uso para preparação de um medicamento, particularmente para preparação de um medicamento com efeito anticolinérgico.
BRPI0308513A 2002-03-20 2003-03-10 micronizado cristalino de brometo de tiotrópio, processo para sua preparação, uso do mesmo, composição farmacêutica, pó para inalação, processo para sua preparação e cápsula que o contém BRPI0308513B8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212264A DE10212264A1 (de) 2002-03-20 2002-03-20 Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
PCT/EP2003/002422 WO2003078429A1 (de) 2002-03-20 2003-03-10 Kristallines mikronisat des tiotropiumbromids

Publications (3)

Publication Number Publication Date
BR0308513A true BR0308513A (pt) 2005-01-04
BRPI0308513B1 BRPI0308513B1 (pt) 2016-04-19
BRPI0308513B8 BRPI0308513B8 (pt) 2021-05-25

Family

ID=27797948

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0308513A BRPI0308513B8 (pt) 2002-03-20 2003-03-10 micronizado cristalino de brometo de tiotrópio, processo para sua preparação, uso do mesmo, composição farmacêutica, pó para inalação, processo para sua preparação e cápsula que o contém

Country Status (37)

Country Link
EP (3) EP3053921A1 (pt)
JP (1) JP4331619B2 (pt)
KR (2) KR101094091B1 (pt)
CN (2) CN101220025A (pt)
AR (1) AR039017A1 (pt)
AT (1) ATE369365T1 (pt)
AU (1) AU2003212327B2 (pt)
BR (1) BRPI0308513B8 (pt)
CA (1) CA2479652C (pt)
CO (1) CO5611105A2 (pt)
CY (2) CY1106923T1 (pt)
DE (2) DE10212264A1 (pt)
DK (2) DK1487832T4 (pt)
EA (1) EA007064B1 (pt)
EC (1) ECSP045310A (pt)
ES (2) ES2615460T3 (pt)
HK (1) HK1078871A1 (pt)
HR (1) HRP20040855B1 (pt)
HU (1) HUE031876T2 (pt)
IL (2) IL163841A0 (pt)
LT (1) LT1785422T (pt)
ME (1) ME02764B (pt)
MX (1) MXPA04009056A (pt)
MY (1) MY139720A (pt)
NO (2) NO346754B1 (pt)
NZ (1) NZ535808A (pt)
PE (1) PE20030838A1 (pt)
PL (1) PL220730B1 (pt)
PT (2) PT1487832E (pt)
RS (1) RS57551B1 (pt)
SA (1) SA03240098B1 (pt)
SI (1) SI1487832T2 (pt)
TW (1) TWI345975B (pt)
UA (1) UA78295C2 (pt)
UY (1) UY27725A1 (pt)
WO (1) WO2003078429A1 (pt)
ZA (1) ZA200405636B (pt)

Families Citing this family (25)

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US7220742B2 (en) 2004-05-14 2007-05-22 Boehringer Ingelheim International Gmbh Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE102004024451A1 (de) 2004-05-14 2005-12-22 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierungen für die Inhalation, die Enantiomerenreine Betaagonisten enthalten
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PL1881980T3 (pl) 2005-05-02 2013-01-31 Boehringer Ingelheim Int Nowe krystaliczne formy bromku tiotropium
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DE102005059602A1 (de) 2005-12-14 2007-06-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mikronisierung
WO2007075858A2 (en) * 2005-12-19 2007-07-05 Sicor Inc. Novel forms of tiotropium bromide and processes for preparation thereof
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) * 2006-01-13 2010-12-08 江苏正大天晴药业股份有限公司 结晶性抗胆碱药噻托溴铵
GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
WO2011093815A2 (en) * 2010-01-29 2011-08-04 Mahmut Bilgic Pharmaceutical compositions comprising formoterol and mometasone
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
UA115989C2 (uk) 2012-07-05 2018-01-25 Арвен Айлак Санайі Ве Тіджарет А.С. Фармацевтична композиція для інгалятора сухого порошку, що містить антагоністи мускаринових рецепторів тривалої дії
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
WO2014042605A1 (en) * 2012-09-11 2014-03-20 Mahmut Bilgic New tiotropium bromide crystalline form
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
MY181647A (en) 2014-09-09 2020-12-30 Vectura Ltd Formulation comprising glycopyrrolate, method and apparatus
WO2017068119A1 (en) * 2015-10-23 2017-04-27 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
BR112018008083A2 (pt) * 2015-10-23 2018-10-23 Arven Ilac Sanayi Ve Ticaret As blister para formulação inalável de brometo de tiotrópio
CN115737610B (zh) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

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Also Published As

Publication number Publication date
ECSP045310A (es) 2004-10-26
NZ535808A (en) 2005-09-30
CA2479652C (en) 2012-07-10
SI1487832T1 (sl) 2007-12-31
EP3053921A1 (de) 2016-08-10
HK1078871A1 (en) 2006-03-24
EP1487832B2 (de) 2018-08-29
ATE369365T1 (de) 2007-08-15
DE50307883D1 (de) 2007-09-20
CO5611105A2 (es) 2006-02-28
CA2479652A1 (en) 2003-09-25
JP4331619B2 (ja) 2009-09-16
LT1785422T (lt) 2017-02-10
KR20050008662A (ko) 2005-01-21
CN101220025A (zh) 2008-07-16
KR101021430B1 (ko) 2011-03-15
MEP46708A (en) 2011-02-10
BRPI0308513B8 (pt) 2021-05-25
IL163841A (en) 2015-10-29
NO20044003L (no) 2004-10-14
HUE031876T2 (en) 2017-08-28
EA200401142A1 (ru) 2005-04-28
PT1487832E (pt) 2007-08-27
CY1106923T1 (el) 2012-09-26
SI1487832T2 (sl) 2018-11-30
AU2003212327B2 (en) 2009-02-05
NO346754B1 (no) 2022-12-12
NO344427B1 (no) 2019-12-02
ES2291619T3 (es) 2008-03-01
EP1785422A1 (de) 2007-05-16
EP1785422B1 (de) 2016-11-16
UY27725A1 (es) 2003-10-31
TWI345975B (en) 2011-08-01
DK1785422T3 (en) 2017-02-27
ES2615460T3 (es) 2017-06-07
RS57551B1 (sr) 2018-10-31
WO2003078429A1 (de) 2003-09-25
KR20100135983A (ko) 2010-12-27
EP1487832B1 (de) 2007-08-08
KR101094091B1 (ko) 2011-12-15
BRPI0308513B1 (pt) 2016-04-19
PL371799A1 (en) 2005-06-27
EP1487832A1 (de) 2004-12-22
TW200305421A (en) 2003-11-01
AU2003212327A1 (en) 2003-09-29
PE20030838A1 (es) 2003-11-21
EP1487832B9 (de) 2019-01-23
SA03240098B1 (ar) 2008-03-24
PL220730B1 (pl) 2015-12-31
ZA200405636B (en) 2006-01-25
UA78295C2 (en) 2007-03-15
ES2291619T5 (es) 2018-12-07
NO20190824A1 (no) 2004-10-14
JP2005526776A (ja) 2005-09-08
DK1487832T4 (en) 2018-12-10
EP1785422A8 (de) 2010-06-23
DK1487832T3 (da) 2007-11-05
MY139720A (en) 2009-10-30
CN1642952A (zh) 2005-07-20
CY1118855T1 (el) 2018-01-10
PT1785422T (pt) 2017-02-17
HRP20040855B1 (en) 2012-11-30
AR039017A1 (es) 2005-02-02
ME02764B (me) 2011-05-10
MXPA04009056A (es) 2005-01-25
EA007064B1 (ru) 2006-06-30
HRP20040855A2 (en) 2005-06-30
DE10212264A1 (de) 2003-10-02
CN100368410C (zh) 2008-02-13
IL163841A0 (en) 2005-12-18

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