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ME02764B - Kristalni mikronizat tiotropijum bromida - Google Patents

Kristalni mikronizat tiotropijum bromida

Info

Publication number
ME02764B
ME02764B MEP-2008-467A MEP46708A ME02764B ME 02764 B ME02764 B ME 02764B ME P46708 A MEP46708 A ME P46708A ME 02764 B ME02764 B ME 02764B
Authority
ME
Montenegro
Prior art keywords
tiotropium bromide
crystalline tiotropium
micronized crystalline
preparation
bromide
Prior art date
Application number
MEP-2008-467A
Other languages
German (de)
English (en)
French (fr)
Inventor
Michael Walz
Helmut Bender
Hagen Graebner
Konrad Schindler
Michael Josef Friedrich Trunk
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27797948&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ME02764(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP46708A publication Critical patent/MEP46708A/xx
Publication of ME02764B publication Critical patent/ME02764B/me

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Glass Compositions (AREA)
  • Silicates, Zeolites, And Molecular Sieves (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hybrid Cells (AREA)

Abstract

Pronalazak se odnosi na na kristalni mikronizat (lα, 2β, 4β, 5β, 7β)-7-[(hidroksidi-2-tienil-acetil)oksi]-9, 9-dimetil-3-oksa-9-azoniatriciklo[3. 3. 1. 0 2-4 ]nonan-bromida, na postupak za njegovo pripremanje, kao i na njegovu primenu za pripremanje leka, naročito za pripremanje leka sa antiholinergijskim dejstvom.
MEP-2008-467A 2002-03-20 2003-03-10 Kristalni mikronizat tiotropijum bromida ME02764B (me)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10212264A DE10212264A1 (de) 2002-03-20 2002-03-20 Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
PCT/EP2003/002422 WO2003078429A1 (de) 2002-03-20 2003-03-10 Kristallines mikronisat des tiotropiumbromids

Publications (2)

Publication Number Publication Date
MEP46708A MEP46708A (en) 2011-02-10
ME02764B true ME02764B (me) 2011-05-10

Family

ID=27797948

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-467A ME02764B (me) 2002-03-20 2003-03-10 Kristalni mikronizat tiotropijum bromida

Country Status (37)

Country Link
EP (3) EP3053921A1 (me)
JP (1) JP4331619B2 (me)
KR (2) KR101094091B1 (me)
CN (2) CN101220025A (me)
AR (1) AR039017A1 (me)
AT (1) ATE369365T1 (me)
AU (1) AU2003212327B2 (me)
BR (1) BRPI0308513B8 (me)
CA (1) CA2479652C (me)
CO (1) CO5611105A2 (me)
CY (2) CY1106923T1 (me)
DE (2) DE10212264A1 (me)
DK (2) DK1487832T4 (me)
EA (1) EA007064B1 (me)
EC (1) ECSP045310A (me)
ES (2) ES2615460T3 (me)
HK (1) HK1078871A1 (me)
HR (1) HRP20040855B1 (me)
HU (1) HUE031876T2 (me)
IL (2) IL163841A0 (me)
LT (1) LT1785422T (me)
ME (1) ME02764B (me)
MX (1) MXPA04009056A (me)
MY (1) MY139720A (me)
NO (2) NO346754B1 (me)
NZ (1) NZ535808A (me)
PE (1) PE20030838A1 (me)
PL (1) PL220730B1 (me)
PT (2) PT1487832E (me)
RS (1) RS57551B1 (me)
SA (1) SA03240098B1 (me)
SI (1) SI1487832T2 (me)
TW (1) TWI345975B (me)
UA (1) UA78295C2 (me)
UY (1) UY27725A1 (me)
WO (1) WO2003078429A1 (me)
ZA (1) ZA200405636B (me)

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WO2011093815A2 (en) * 2010-01-29 2011-08-04 Mahmut Bilgic Pharmaceutical compositions comprising formoterol and mometasone
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PT106142B (pt) * 2012-02-10 2014-07-18 Hovione Farmaci Ncia S A Processo para a preparação de brometo de tiotrópio
UA115989C2 (uk) 2012-07-05 2018-01-25 Арвен Айлак Санайі Ве Тіджарет А.С. Фармацевтична композиція для інгалятора сухого порошку, що містить антагоністи мускаринових рецепторів тривалої дії
EP2705838A1 (en) * 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
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US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
MY181647A (en) 2014-09-09 2020-12-30 Vectura Ltd Formulation comprising glycopyrrolate, method and apparatus
WO2017068119A1 (en) * 2015-10-23 2017-04-27 Arven Ilac Sanayi Ve Ticaret A.S. Blister for tiotropium bromide inhalable formulation
BR112018008083A2 (pt) * 2015-10-23 2018-10-23 Arven Ilac Sanayi Ve Ticaret As blister para formulação inalável de brometo de tiotrópio
CN115737610B (zh) * 2021-12-13 2024-02-27 苏州欧米尼医药有限公司 一种噻托溴铵吸入粉雾剂及其活性成分的气流粉碎方法

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Also Published As

Publication number Publication date
ECSP045310A (es) 2004-10-26
NZ535808A (en) 2005-09-30
CA2479652C (en) 2012-07-10
SI1487832T1 (sl) 2007-12-31
EP3053921A1 (de) 2016-08-10
HK1078871A1 (en) 2006-03-24
EP1487832B2 (de) 2018-08-29
ATE369365T1 (de) 2007-08-15
DE50307883D1 (de) 2007-09-20
CO5611105A2 (es) 2006-02-28
CA2479652A1 (en) 2003-09-25
JP4331619B2 (ja) 2009-09-16
LT1785422T (lt) 2017-02-10
KR20050008662A (ko) 2005-01-21
CN101220025A (zh) 2008-07-16
KR101021430B1 (ko) 2011-03-15
MEP46708A (en) 2011-02-10
BRPI0308513B8 (pt) 2021-05-25
IL163841A (en) 2015-10-29
BR0308513A (pt) 2005-01-04
NO20044003L (no) 2004-10-14
HUE031876T2 (en) 2017-08-28
EA200401142A1 (ru) 2005-04-28
PT1487832E (pt) 2007-08-27
CY1106923T1 (el) 2012-09-26
SI1487832T2 (sl) 2018-11-30
AU2003212327B2 (en) 2009-02-05
NO346754B1 (no) 2022-12-12
NO344427B1 (no) 2019-12-02
ES2291619T3 (es) 2008-03-01
EP1785422A1 (de) 2007-05-16
EP1785422B1 (de) 2016-11-16
UY27725A1 (es) 2003-10-31
TWI345975B (en) 2011-08-01
DK1785422T3 (en) 2017-02-27
ES2615460T3 (es) 2017-06-07
RS57551B1 (sr) 2018-10-31
WO2003078429A1 (de) 2003-09-25
KR20100135983A (ko) 2010-12-27
EP1487832B1 (de) 2007-08-08
KR101094091B1 (ko) 2011-12-15
BRPI0308513B1 (pt) 2016-04-19
PL371799A1 (en) 2005-06-27
EP1487832A1 (de) 2004-12-22
TW200305421A (en) 2003-11-01
AU2003212327A1 (en) 2003-09-29
PE20030838A1 (es) 2003-11-21
EP1487832B9 (de) 2019-01-23
SA03240098B1 (ar) 2008-03-24
PL220730B1 (pl) 2015-12-31
ZA200405636B (en) 2006-01-25
UA78295C2 (en) 2007-03-15
ES2291619T5 (es) 2018-12-07
NO20190824A1 (no) 2004-10-14
JP2005526776A (ja) 2005-09-08
DK1487832T4 (en) 2018-12-10
EP1785422A8 (de) 2010-06-23
DK1487832T3 (da) 2007-11-05
MY139720A (en) 2009-10-30
CN1642952A (zh) 2005-07-20
CY1118855T1 (el) 2018-01-10
PT1785422T (pt) 2017-02-17
HRP20040855B1 (en) 2012-11-30
AR039017A1 (es) 2005-02-02
MXPA04009056A (es) 2005-01-25
EA007064B1 (ru) 2006-06-30
HRP20040855A2 (en) 2005-06-30
DE10212264A1 (de) 2003-10-02
CN100368410C (zh) 2008-02-13
IL163841A0 (en) 2005-12-18

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