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BR0110139A - Formulações farmacêuticas para inaladores de pó seco - Google Patents

Formulações farmacêuticas para inaladores de pó seco

Info

Publication number
BR0110139A
BR0110139A BR0110139-0A BR0110139A BR0110139A BR 0110139 A BR0110139 A BR 0110139A BR 0110139 A BR0110139 A BR 0110139A BR 0110139 A BR0110139 A BR 0110139A
Authority
BR
Brazil
Prior art keywords
fraction
dry powder
powder
pharmaceutical formulations
fine particle
Prior art date
Application number
BR0110139-0A
Other languages
English (en)
Inventor
John Nicholas Staniforth
David Alexander Vodden Morton
Rajbir Gill
Gaetano Brambilla
Rosella Musa
Lorenzo Ferrarini
Original Assignee
Vectura Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26071084&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0110139(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB0009469.8A external-priority patent/GB0009469D0/en
Application filed by Vectura Ltd filed Critical Vectura Ltd
Publication of BR0110139A publication Critical patent/BR0110139A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Dispersion Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"FORMULAçõES FARMACêUTICAS PARA INALADORES DE Pó SECO". Pó para uso em um inalador de pó seco que compreende: i) uma fração n de tamanho de partícula fina constituída por uma mistura de um excipiente fisiologicamente aceitável e um aditivo; ii) uma fração de partículas grossas; e iii) pelo menos um ingrediente ativo. O pó é adequado para a liberação eficaz de ingredientes ativos no trato respiratório inferior de pacientes que sofram de doenças pulmonares tais como a asma. Em particular, a invenção fornece uma formulação a ser administrada como pó seco para inalação que é livremente fluível, pode ser produzida em uma maneira simples, é física e quimicamente estável e capaz de liberar doses exatas e/ou fração elevada de partícula fina de ingredientes ativos de intensidade baixa mediante o uso de um dispositivo de resistência elevada ou média.
BR0110139-0A 2000-04-17 2001-04-17 Formulações farmacêuticas para inaladores de pó seco BR0110139A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0009469.8A GB0009469D0 (en) 2000-04-17 2000-04-17 Improvements in or relating to formalities for use in inhaler devices
EP00113608 2000-06-27
PCT/GB2001/001751 WO2001078695A2 (en) 2000-04-17 2001-04-17 Pharmaceutical formulations for dry powder inhalers

Publications (1)

Publication Number Publication Date
BR0110139A true BR0110139A (pt) 2002-12-31

Family

ID=26071084

Family Applications (3)

Application Number Title Priority Date Filing Date
BR0110301-6A BR0110301A (pt) 2000-04-17 2001-04-17 Formulações farmacêuticas para inaladores de pó seco na forma de péllets duros
BR0110141-2A BR0110141A (pt) 2000-04-17 2001-04-17 Melhorias em ou relacionando-se a formulações para uso em dispositivos inaladores
BR0110139-0A BR0110139A (pt) 2000-04-17 2001-04-17 Formulações farmacêuticas para inaladores de pó seco

Family Applications Before (2)

Application Number Title Priority Date Filing Date
BR0110301-6A BR0110301A (pt) 2000-04-17 2001-04-17 Formulações farmacêuticas para inaladores de pó seco na forma de péllets duros
BR0110141-2A BR0110141A (pt) 2000-04-17 2001-04-17 Melhorias em ou relacionando-se a formulações para uso em dispositivos inaladores

Country Status (32)

Country Link
US (4) US6884794B2 (pt)
EP (6) EP1719505B1 (pt)
JP (2) JP2003530425A (pt)
KR (1) KR20030069047A (pt)
CN (1) CN1424909A (pt)
AT (5) ATE513542T1 (pt)
AU (3) AU4859501A (pt)
BR (3) BR0110301A (pt)
CA (3) CA2405767C (pt)
CY (1) CY1107315T1 (pt)
CZ (1) CZ301904B6 (pt)
DE (3) DE60125344T2 (pt)
DK (3) DK1276472T3 (pt)
DZ (1) DZ3315A1 (pt)
EE (1) EE05257B1 (pt)
ES (3) ES2292576T3 (pt)
GB (2) GB2363987A (pt)
HU (4) HUP0300490A2 (pt)
IL (1) IL152306A0 (pt)
MA (1) MA26892A1 (pt)
MX (3) MXPA02010218A (pt)
MY (1) MY129384A (pt)
NO (4) NO20024971L (pt)
NZ (1) NZ521887A (pt)
PE (1) PE20011227A1 (pt)
PL (3) PL204251B1 (pt)
PT (3) PT1276472E (pt)
SA (1) SA01220062B1 (pt)
SI (2) SI1719505T1 (pt)
SK (1) SK284248B6 (pt)
TN (1) TNSN01060A1 (pt)
WO (3) WO2001078694A2 (pt)

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