BE2013C038I2 - - Google Patents
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- Publication number
- BE2013C038I2 BE2013C038I2 BE2013C038C BE2013C038C BE2013C038I2 BE 2013C038 I2 BE2013C038 I2 BE 2013C038I2 BE 2013C038 C BE2013C038 C BE 2013C038C BE 2013C038 C BE2013C038 C BE 2013C038C BE 2013C038 I2 BE2013C038 I2 BE 2013C038I2
- Authority
- BE
- Belgium
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200301129 | 2003-08-05 | ||
| US49545103P | 2003-08-14 | 2003-08-14 | |
| EP04739008A EP1660531A2 (fr) | 2003-08-05 | 2004-07-22 | Nouveaux derives de l'insuline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BE2013C038I2 true BE2013C038I2 (fr) | 2023-12-14 |
Family
ID=34117520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2013C035C BE2013C035I2 (fr) | 2003-08-05 | 2013-06-11 | |
| BE2013C038C BE2013C038I2 (fr) | 2003-08-05 | 2013-06-19 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BE2013C035C BE2013C035I2 (fr) | 2003-08-05 | 2013-06-11 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US7615532B2 (fr) |
| EP (3) | EP2264065B1 (fr) |
| JP (1) | JP4463814B2 (fr) |
| KR (1) | KR101159559B1 (fr) |
| AU (2) | AU2004261353B2 (fr) |
| BE (2) | BE2013C035I2 (fr) |
| BR (1) | BRPI0413276B8 (fr) |
| CA (1) | CA2531988C (fr) |
| CY (5) | CY1113850T1 (fr) |
| FR (2) | FR13C0035I2 (fr) |
| HU (1) | HUS1300033I1 (fr) |
| IL (1) | IL172980A (fr) |
| LU (2) | LU92213I2 (fr) |
| MX (1) | MXPA06001283A (fr) |
| NO (5) | NO340925B1 (fr) |
| PL (1) | PL2107069T3 (fr) |
| RU (1) | RU2518460C2 (fr) |
| WO (1) | WO2005012347A2 (fr) |
Families Citing this family (96)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1648933B1 (fr) * | 2003-07-25 | 2009-06-17 | ConjuChem Biotechnologies Inc. | Derives de l'insuline longue duree et procedes associes |
| EP2264065B1 (fr) | 2003-08-05 | 2017-03-08 | Novo Nordisk A/S | Nouveaux derives de l'insuline |
| WO2006082205A1 (fr) | 2005-02-02 | 2006-08-10 | Novo Nordisk A/S | Dérivés d'insuline |
| ES2428510T3 (es) | 2005-02-02 | 2013-11-08 | Novo Nordisk A/S | Derivados de insulina |
| US20090074882A1 (en) | 2005-12-28 | 2009-03-19 | Novo Nordisk A/S | Insulin compositions and method of making a composition |
| EP1991576B1 (fr) * | 2006-02-27 | 2010-09-29 | Novo Nordisk A/S | Dérivés d'insuline |
| WO2007104736A2 (fr) * | 2006-03-13 | 2007-09-20 | Novo Nordisk A/S | Insuline monocaténaire acylée |
| US8293965B2 (en) | 2006-04-28 | 2012-10-23 | Kimberly-Clark Worldwide, Inc. | Antimicrobial site dressings |
| CN101437849B (zh) * | 2006-05-09 | 2015-09-30 | 诺沃-诺迪斯克有限公司 | 胰岛素衍生物 |
| EP2024390B1 (fr) | 2006-05-09 | 2015-08-19 | Novo Nordisk A/S | Dérivé insulinique |
| AU2007247109B2 (en) * | 2006-05-09 | 2012-03-15 | Novo Nordisk A/S | Insulin derivative |
| JP5097900B2 (ja) * | 2006-06-27 | 2012-12-12 | 独立行政法人物質・材料研究機構 | 有機酸又はこれらの誘導体の活性エステル体の製造方法 |
| WO2008015099A2 (fr) | 2006-07-31 | 2008-02-07 | Novo Nordisk A/S | Insulines pegylées à extensions |
| KR101699370B1 (ko) | 2006-09-22 | 2017-02-14 | 노보 노르디스크 에이/에스 | 프로테아제 내성 인슐린 유사체 |
| EP2502618A3 (fr) | 2007-04-30 | 2012-10-03 | Novo Nordisk A/S | Procédé de séchage d'une composition de protéines, composition de protéines séchées et composition pharmaceutique comprenant la protéine déshydratée |
| EP2164466A1 (fr) | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Préconcentrés spontanément dispersibles comprenant un médicament peptidique dans un excipient solide ou semi-solide |
| EP2164459A1 (fr) * | 2007-06-01 | 2010-03-24 | Novo Nordisk A/S | Compositions pharmaceutiques non aqueuses stables |
| ES2744384T3 (es) * | 2007-06-13 | 2020-02-24 | Novo Nordisk As | Formulación farmacéutica que comprende un derivado de insulina |
| EP2178912B1 (fr) | 2007-08-15 | 2015-07-08 | Novo Nordisk A/S | Analogues de l'insuline comprenant un fragment acyle et alkylène glycol |
| CN101784563B (zh) | 2007-08-15 | 2015-02-04 | 诺沃-诺迪斯克有限公司 | 具有包括含亚烷基二醇的氨基酸的重复单位的酰基部分的胰岛素 |
| CN101157725B (zh) * | 2007-10-24 | 2012-07-25 | 中国药科大学 | 人胰岛素类似物的制备方法及用途 |
| US8710000B2 (en) | 2007-11-08 | 2014-04-29 | Novo Nordisk A/S | Insulin derivative |
| PT2597103T (pt) | 2007-11-16 | 2017-02-08 | Novo Nordisk As | Composições farmacêuticas contendo insulina e um péptido insulinotrófico |
| US9260502B2 (en) | 2008-03-14 | 2016-02-16 | Novo Nordisk A/S | Protease-stabilized insulin analogues |
| US8691759B2 (en) | 2008-03-18 | 2014-04-08 | Novo Nordisk A/S | Protease stabilized, acylated insulin analogues |
| ES2561208T3 (es) | 2008-09-12 | 2016-02-25 | Novo Nordisk A/S | Método de acilación de un péptido o una proteína |
| JP4959005B2 (ja) * | 2008-10-30 | 2012-06-20 | ノボ・ノルデイスク・エー／エス | 毎日の注射頻度より少ないインスリン注射での真性糖尿病の治療 |
| MX2011007544A (es) | 2009-01-23 | 2011-08-12 | Novo Nordisk As | Derivados de factor de crecimiento de fibroblastos 21 (fgf21) con ligante de albumina a-b-c-d-e- y su uso. |
| EP2493919A1 (fr) | 2009-10-30 | 2012-09-05 | Novo Nordisk A/S | Dérivés du peptide cgrp |
| MX2012007806A (es) * | 2010-01-12 | 2012-08-01 | Novo Nordisk As | Composiciones farmaceuticas para administracion oral de peptidos de insulina. |
| US9234192B2 (en) | 2010-02-16 | 2016-01-12 | Novo Nordisk A/S | Conjugated proteins |
| WO2011101261A2 (fr) | 2010-02-16 | 2011-08-25 | Novo Nordisk A/S | Procédé de purification |
| EP2569002B1 (fr) | 2010-05-10 | 2016-10-26 | Novo Nordisk A/S | Procédé de préparation de complexes d'insuline et de zinc |
| WO2011146974A1 (fr) | 2010-05-25 | 2011-12-01 | Monash University | Procédés de synthèse de ponts dicarba contenant des alcynes dans des peptides |
| JP5973427B2 (ja) | 2010-06-23 | 2016-08-23 | ノヴォ ノルディスク アー／エス | 追加のジスルフィド結合を含有するインスリン類似体 |
| MX337549B (es) * | 2010-06-23 | 2016-03-10 | Novo Nordisk As | Derivados de insulina que contienen enlaces disulfuro adicionales. |
| WO2011161083A1 (fr) | 2010-06-23 | 2011-12-29 | Novo Nordisk A/S | Insuline humaine contenant des liaisons disulfures supplémentaires |
| US20140315797A1 (en) | 2010-10-15 | 2014-10-23 | Peter Madsen | Novel N-Terminally Modified Insulin Derivatives |
| DK2632478T3 (da) * | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| AU2011322495A1 (en) * | 2010-10-27 | 2013-04-11 | Novo Nordisk A/S | Treating diabetes melitus using insulin injections administered with varying injection intervals |
| JP2013545782A (ja) | 2010-12-14 | 2013-12-26 | ノヴォ ノルディスク アー／エス | 長時間作用型インスリンと組み合わせた速効型インスリン |
| WO2012110422A1 (fr) | 2011-02-15 | 2012-08-23 | Novo Nordisk A/S | Antagonistes du récepteur il-1 à action prolongée |
| AU2012234276A1 (en) * | 2011-03-28 | 2013-08-29 | Novo Nordisk A/S | Novel glucagon analogues |
| JP6030630B2 (ja) | 2011-04-14 | 2016-11-24 | ノヴォ ノルディスク アー／エス | 経口ペプチド送達のための脂肪酸アシル化アミノ酸 |
| US9260503B2 (en) | 2011-06-15 | 2016-02-16 | Novo Nordisk A/S | Multi-substituted insulins |
| RU2610175C2 (ru) | 2011-09-23 | 2017-02-08 | Ново Нордиск А/С | Новые аналоги глюкагона |
| KR20140104994A (ko) * | 2011-12-15 | 2014-08-29 | 샹하이 헨그루이 파마수티컬 컴퍼니 리미티드 | 인간 인슐린 유사체 및 이의 아실화 유도체 |
| EP2794648A1 (fr) | 2011-12-21 | 2014-10-29 | Novo Nordisk A/S | Dérivés de l'insuline modifiés à leur extrémité n-terminale |
| KR20150002777A (ko) | 2012-04-11 | 2015-01-07 | 노보 노르디스크 에이/에스 | 인슐린 제제 |
| US20160031962A1 (en) * | 2012-04-20 | 2016-02-04 | Kleomenis K. Barlos | Solid phase peptide synthesis of insulin using side chain achored lysine |
| AU2013255880B2 (en) | 2012-05-01 | 2017-07-20 | Novo Nordisk A/S | Pharmaceutical composition |
| WO2014009316A1 (fr) | 2012-07-09 | 2014-01-16 | Novo Nordisk A/S | Nouvelle utilisation de dérivés d'insuline |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| JP6285447B2 (ja) | 2012-10-17 | 2018-02-28 | ノヴォ ノルディスク アー／エス | 経口ペプチド送達用の脂肪酸アシル化ｄ−アミノ酸 |
| CA2894765A1 (fr) | 2012-12-21 | 2014-06-26 | Sanofi | Derives de l'exendine 4 utilises comme agonistes de glp1/gip ou de glp1/gip/glucagon |
| EP2976096B1 (fr) * | 2013-03-20 | 2019-02-27 | Novo Nordisk A/S | Régime de dosage pour insuline |
| MY174727A (en) | 2013-04-18 | 2020-05-11 | Novo Nordisk As | Stable, protracted glp-1/glucagon receptor co-agonists for medical use |
| EP2991672A1 (fr) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Schéma d'administration d'un nouveau type |
| GB201315335D0 (en) | 2013-08-29 | 2013-10-09 | Of Singapore | Amino diacids containing peptide modifiers |
| ES2676065T3 (es) | 2013-10-07 | 2018-07-16 | Novo Nordisk A/S | Nuevo derivado de un análogo de la insulina |
| FR3013049B1 (fr) | 2013-11-14 | 2015-11-13 | You-Ping Chan | Analogue de l'insuline glargine |
| TW201609796A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 非醯化之艾塞那肽－４（ｅｘｅｎｄｉｎ－４）胜肽類似物 |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| EP3080150B1 (fr) | 2013-12-13 | 2018-08-01 | Sanofi | Analogues peptidiques d'exendine-4 en tant qu'agonistes du récepteur gip/glp-1 double |
| TW201609797A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／升糖素受體促效劑 |
| CA2939763A1 (fr) | 2014-02-18 | 2015-08-27 | Novo Nordisk A/S | Analogues du glucagon stables et leur utilisation dans le traitement de l'hypoglycemie |
| AR099569A1 (es) | 2014-02-28 | 2016-08-03 | Novo Nordisk As | Derivados de insulina y los usos médicos de estos |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| CN106536547A (zh) | 2014-06-04 | 2017-03-22 | 诺和诺德股份有限公司 | 用于医疗用途的glp‑1/胰高血糖素受体共激动剂 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| WO2017032795A1 (fr) | 2015-08-25 | 2017-03-02 | Novo Nordisk A/S | Nouveaux dérivés de l'insuline et leurs utilisations médicales |
| EP3341402A1 (fr) | 2015-08-25 | 2018-07-04 | Novo Nordisk A/S | Nouveaux dérivés de l'insuline et leurs utilisations médicales |
| WO2018024186A1 (fr) | 2016-08-02 | 2018-02-08 | 江苏恒瑞医药股份有限公司 | Dérivé acylé de l'insuline humaine ou son analogue |
| EP3544683A1 (fr) | 2016-11-28 | 2019-10-02 | Novo Nordisk A/S | Insuline dégludec utilisée dans des conditions cardiovasculaires |
| CN110099719A (zh) | 2016-11-28 | 2019-08-06 | 诺和诺德股份有限公司 | 用于改善血糖控制以及减少急性和长期糖尿病并发症的德谷胰岛素 |
| WO2018096164A1 (fr) | 2016-11-28 | 2018-05-31 | Novo Nordisk A/S | Insuline dégludec pour le traitement du diabète |
| PE20210857A1 (es) | 2016-12-16 | 2021-05-18 | Novo Nordisk As | Composiciones farmaceuticas que contienen insulina |
| JOP20190273A1 (ar) | 2017-05-26 | 2019-11-24 | Lilly Co Eli | مركب إنسولين معالج بأسيل |
| JP2021513330A (ja) | 2018-02-09 | 2021-05-27 | 江蘇恒瑞医薬股▲ふん▼有限公司 | ヒトインスリンアナログのコドン最適化前駆体遺伝子およびシグナルペプチド遺伝子 |
| EP3805257A4 (fr) | 2018-05-24 | 2022-03-16 | Jiangsu Hengrui Medicine Co., Ltd. | Procédé de préparation d'un précurseur d'insuline humaine recombinée ou d'un analogue associé |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| JP7410891B2 (ja) | 2018-06-26 | 2024-01-10 | ノボ・ノルデイスク・エー／エス | 基礎インスリン滴定のための投与推奨を提供するシステム |
| KR102666154B1 (ko) | 2018-08-08 | 2024-05-20 | 주식회사 대웅제약 | 지속형 인슐린 아날로그 및 그 복합체 |
| KR20200080748A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 음이온 교환 크로마토그래피를 이용한 인슐린 전구체의 정제방법 |
| KR20200080747A (ko) | 2018-12-27 | 2020-07-07 | 주식회사 폴루스 | 인슐린 전구체의 인슐린 효소 전환용 조성물 및 이를 이용하여 인슐린 전구체를 인슐린으로 전환하는 방법 |
| TWI844709B (zh) | 2019-07-31 | 2024-06-11 | 美商美國禮來大藥廠 | 鬆弛素(relaxin)類似物及其使用方法 |
| CN118480114A (zh) | 2019-12-30 | 2024-08-13 | 甘李药业股份有限公司 | 胰岛素衍生物 |
| US20250000948A1 (en) | 2021-11-15 | 2025-01-02 | Adocia | Solid compositions comprising a peptide or a protein and an acylated amino acid |
| EP4299057A1 (fr) | 2022-06-30 | 2024-01-03 | Adocia | Compositions solides comportant un peptide ou une protéine et un acide aminé acylé |
| EP4180060A1 (fr) | 2021-11-15 | 2023-05-17 | Adocia | Compositions solides comportant un peptide ou une protéine et un acide aminé acylé |
| WO2023143458A1 (fr) | 2022-01-28 | 2023-08-03 | 甘李药业股份有限公司 | Insuline acylée |
| EP4299071A1 (fr) | 2022-07-01 | 2024-01-03 | Adocia | Compositions comprenant un peptide ou une protéine et un acide aminé acylé |
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2004
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