[go: up one dir, main page]

AU2003290518A1 - Methods and compositions concerning designed highly-specific nucleic acid binding proteins - Google Patents

Methods and compositions concerning designed highly-specific nucleic acid binding proteins

Info

Publication number
AU2003290518A1
AU2003290518A1 AU2003290518A AU2003290518A AU2003290518A1 AU 2003290518 A1 AU2003290518 A1 AU 2003290518A1 AU 2003290518 A AU2003290518 A AU 2003290518A AU 2003290518 A AU2003290518 A AU 2003290518A AU 2003290518 A1 AU2003290518 A1 AU 2003290518A1
Authority
AU
Australia
Prior art keywords
methods
nucleic acid
binding proteins
acid binding
specific nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003290518A
Other versions
AU2003290518A8 (en
Inventor
David Baker
Meggan Chadsey
Brett Chevalier
Tania Kortemme
Raymond J. Monnat Jr.
Barry L. Stoddard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fred Hutchinson Cancer Center
Original Assignee
Fred Hutchinson Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fred Hutchinson Cancer Center filed Critical Fred Hutchinson Cancer Center
Publication of AU2003290518A1 publication Critical patent/AU2003290518A1/en
Publication of AU2003290518A8 publication Critical patent/AU2003290518A8/en
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22Ribonucleases [RNase]; Deoxyribonucleases [DNase]

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
AU2003290518A 2002-09-06 2003-09-05 Methods and compositions concerning designed highly-specific nucleic acid binding proteins Abandoned AU2003290518A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40884702P 2002-09-06 2002-09-06
US60/408,847 2002-09-06
PCT/US2003/027875 WO2004031346A2 (en) 2002-09-06 2003-09-05 Methods and compositions concerning designed highly-specific nucleic acid binding proteins

Publications (2)

Publication Number Publication Date
AU2003290518A1 true AU2003290518A1 (en) 2004-04-23
AU2003290518A8 AU2003290518A8 (en) 2004-04-23

Family

ID=32069688

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003290518A Abandoned AU2003290518A1 (en) 2002-09-06 2003-09-05 Methods and compositions concerning designed highly-specific nucleic acid binding proteins

Country Status (2)

Country Link
AU (1) AU2003290518A1 (en)
WO (1) WO2004031346A2 (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009095742A1 (en) 2008-01-31 2009-08-06 Cellectis New i-crei derived single-chain meganuclease and uses thereof
EP1591521A1 (en) * 2004-04-30 2005-11-02 Cellectis I-Dmo I derivatives with enhanced activity at 37 degrees C and use thereof
EP2327773A1 (en) * 2005-03-15 2011-06-01 Cellectis I-crel meganuclease variants with modified specificity, method of preparation and uses thereof
WO2007034262A1 (en) * 2005-09-19 2007-03-29 Cellectis Heterodimeric meganucleases and use thereof
ES2539616T3 (en) 2005-10-18 2015-07-02 Precision Biosciences Rationally designed meganuclease with impaired dimer formation affinity
WO2007049095A1 (en) 2005-10-25 2007-05-03 Cellectis Laglidadg homing endonuclease variants having mutations in two functional subdomains and use thereof
WO2007060495A1 (en) 2005-10-25 2007-05-31 Cellectis I-crei homing endonuclease variants having novel cleavage specificity and use thereof
WO2008093152A1 (en) * 2007-02-01 2008-08-07 Cellectis Obligate heterodimer meganucleases and uses thereof
AU2008263502A1 (en) 2007-06-06 2008-12-18 Cellectis Method for enhancing the cleavage activity of I-Crei derived meganucleases
EP2568048A1 (en) 2007-06-29 2013-03-13 Pioneer Hi-Bred International, Inc. Methods for altering the genome of a monocot plant cell
WO2009013559A1 (en) 2007-07-23 2009-01-29 Cellectis Meganuclease variants cleaving a dna target sequence from the human hemoglobin beta gene and uses thereof
WO2009114321A2 (en) 2008-03-11 2009-09-17 Precision Biosciencs, Inc. Rationally-designed meganucleases for maize genome engineering
WO2010001189A1 (en) * 2008-07-03 2010-01-07 Cellectis The crystal structure of i-dmoi in complex with its dna target, improved chimeric meganucleases and uses thereof
DK3211075T3 (en) 2008-07-14 2019-01-21 Prec Biosciences Inc RECOGNITION SEQUENCES FOR I-CREI-DERIVED MECHANUCLEASES AND APPLICATIONS THEREOF
WO2010136981A2 (en) 2009-05-26 2010-12-02 Cellectis Meganuclease variants cleaving the genome of a pathogenic non-integrating virus and uses thereof
WO2011007193A1 (en) 2009-07-17 2011-01-20 Cellectis Viral vectors encoding a dna repair matrix and containing a virion-associated site specific meganuclease for gene targeting
WO2011021062A1 (en) 2009-08-21 2011-02-24 Cellectis Meganuclease variants cleaving a dna target sequence from the human lysosomal acid alpha-glucosidase gene and uses thereof
CN102686726B (en) * 2009-11-27 2015-12-16 巴斯夫植物科学有限公司 Chimeric endonucleases and uses thereof
CA2781835A1 (en) * 2009-11-27 2011-06-03 Basf Plant Science Company Gmbh Chimeric endonucleases and uses thereof
WO2011082310A2 (en) 2009-12-30 2011-07-07 Pioneer Hi-Bred International, Inc. Methods and compositions for targeted polynucleotide modification
WO2011101696A1 (en) 2010-02-18 2011-08-25 Cellectis Improved meganuclease recombination system
CA2799095A1 (en) 2010-05-12 2011-11-17 Cellectis Meganuclease variants cleaving a dna target sequence from the dystrophin gene and uses thereof
US20130183282A1 (en) 2010-05-12 2013-07-18 Cellectis Meganuclease variants cleaving a DNA target sequence from the rhodopsin gene and uses thereof
CA2802822A1 (en) 2010-06-15 2012-01-05 Cellectis Method for improving cleavage of dna by endonuclease sensitive to methylation
WO2012004671A2 (en) 2010-07-07 2012-01-12 Cellectis Meganucleases variants cleaving a dna target sequence in the nanog gene and uses thereof
WO2012010976A2 (en) 2010-07-15 2012-01-26 Cellectis Meganuclease variants cleaving a dna target sequence in the tert gene and uses thereof
WO2012007848A2 (en) 2010-07-16 2012-01-19 Cellectis Meganuclease variants cleaving a dna target sequence in the was gene and uses thereof
EP2633040B1 (en) 2010-10-27 2019-07-10 Cellectis Method for increasing the efficiency of double-strand break-induced mutagenesis
BR112013024337A2 (en) 2011-03-23 2017-09-26 Du Pont complex transgenic trace locus in a plant, plant or seed, method for producing in a plant a complex transgenic trace locus and expression construct
SG194115A1 (en) 2011-04-05 2013-11-29 Cellectis Method for the generation of compact tale-nucleases and uses thereof
WO2012138901A1 (en) 2011-04-05 2012-10-11 Cellectis Sa Method for enhancing rare-cutting endonuclease efficiency and uses thereof
BR112013025567B1 (en) 2011-04-27 2021-09-21 Amyris, Inc METHODS FOR GENOMIC MODIFICATION
WO2012168910A1 (en) * 2011-06-10 2012-12-13 Basf Plant Science Company Gmbh Nuclease fusion protein and uses thereof
BR112013033176A2 (en) 2011-06-21 2018-06-12 E I Du Pont De Nemouras And Company method for producing a targeted modification on a male fertility gene, plant, isolated nucleic acid molecule, expression construct
EP2729567B1 (en) 2011-07-08 2016-10-05 Cellectis Method for increasing the efficiency of double-strand break-induced mutagenssis
CA2844101A1 (en) 2011-08-03 2013-02-07 E. I. Du Pont De Nemours And Company Methods and compositions for targeted integration in a plant
US20150184173A1 (en) 2012-05-04 2015-07-02 E I Du Pont De Nemours And Company Compositions and methods comprising sequences having meganuclease activity
AU2014218931C1 (en) 2013-02-20 2020-05-14 Regeneron Pharmaceuticals, Inc. Genetic modification of rats
WO2014164466A1 (en) 2013-03-12 2014-10-09 E. I. Du Pont De Nemours And Company Methods for the identification of variant recognition sites for rare-cutting engineered double-strand-break-inducing agents and compositions and uses thereof
HRP20181648T1 (en) 2013-04-16 2019-01-25 Regeneron Pharmaceuticals, Inc. TARGET GENOMIC TARGET MODIFICATION
MX388127B (en) 2013-12-11 2025-03-19 Regeneron Pharma METHODS AND COMPOSITIONS FOR THE TARGETED MODIFICATION OF A GENOME.
RS58159B1 (en) 2013-12-11 2019-03-29 Regeneron Pharma Methods and compositions for the targeted modification of a genome
AU2014368982B2 (en) 2013-12-19 2021-03-25 Amyris, Inc. Methods for genomic integration
CA2950173C (en) 2014-06-06 2023-10-10 Regeneron Pharmaceuticals, Inc. Methods and compositions for modifying a targeted locus
ES2781323T3 (en) 2014-06-23 2020-09-01 Regeneron Pharma Nuclease-mediated DNA assembly
KR102386101B1 (en) 2014-06-26 2022-04-14 리제너론 파마슈티칼스 인코포레이티드 Methods and compositions for targeted genetic modifications and methods of use
PL3207124T3 (en) 2014-10-15 2019-11-29 Regeneron Pharma Methods and compositions for generating or maintaining pluripotent cells
CN107208113A (en) 2014-12-19 2017-09-26 瑞泽恩制药公司 Method and composition for carrying out targeting genetic modification by the multiple targeting of single step
JP7093310B2 (en) 2016-05-18 2022-06-29 アミリス, インコーポレイテッド Compositions and Methods for Genome Integration of Nucleic Acids into Exogenous Landing Pads
MX2019001211A (en) 2016-07-29 2019-09-16 Regeneron Pharma Mice comprising mutations resulting in expression of c-truncated fibrillin-1.
AU2018325363B2 (en) 2017-08-29 2025-01-23 Global Crop Innovations Pty. Ltd. Improved BLue Aleurone and other segregation systems
EP3585162B1 (en) 2017-09-29 2023-08-30 Regeneron Pharmaceuticals, Inc. Rodents comprising a humanized ttr locus and methods of use
WO2019177976A1 (en) 2018-03-12 2019-09-19 Pioneer Hi-Bred International, Inc. Methods for plant transformation
KR20200071198A (en) 2018-12-10 2020-06-19 네오이뮨텍, 인코퍼레이티드 Development of new adoptive T cell immunotherapy by modification of Nrf2 expression
AU2019403015B2 (en) 2018-12-20 2024-01-18 Regeneron Pharmaceuticals, Inc. Nuclease-mediated repeat expansion
ES2966625T3 (en) 2019-04-04 2024-04-23 Regeneron Pharma Rodents comprising a humanized coagulation factor 12 locus
AU2020253531C1 (en) 2019-04-04 2022-06-16 Regeneron Pharmaceuticals, Inc. Methods for scarless introduction of targeted modifications into targeting vectors
JP7610339B2 (en) 2019-06-04 2025-01-08 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Non-human animals containing a humanized TTR locus with a beta slip mutation and methods of use
CA3137764A1 (en) 2019-06-07 2020-12-10 Regeneron Pharmaceuticals, Inc. Non-human animals comprising a humanized albumin locus
WO2021108363A1 (en) 2019-11-25 2021-06-03 Regeneron Pharmaceuticals, Inc. Crispr/cas-mediated upregulation of humanized ttr allele
EP4337769A1 (en) 2021-05-10 2024-03-20 SQZ Biotechnologies Company Methods for delivering genome editing molecules to the nucleus or cytosol of a cell and uses thereof
WO2022251644A1 (en) 2021-05-28 2022-12-01 Lyell Immunopharma, Inc. Nr4a3-deficient immune cells and uses thereof
EP4347826A1 (en) 2021-06-02 2024-04-10 Lyell Immunopharma, Inc. Nr4a3-deficient immune cells and uses thereof
KR20240082391A (en) 2021-10-14 2024-06-10 론자 세일즈 아게 Modified producer cells for extracellular vesicle production
JP2025501221A (en) 2021-12-29 2025-01-17 ブリストル-マイヤーズ スクイブ カンパニー Generation of landing pad cell lines
CA3256953A1 (en) 2022-05-09 2023-11-16 Regeneron Pharmaceuticals, Inc. Vectors and methods for in vivo antibody production
JP2025516823A (en) 2022-05-19 2025-05-30 ライエル・イミュノファーマ・インコーポレイテッド Polynucleotides targeting NR4A3 and uses thereof
WO2024064958A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2024064952A1 (en) 2022-09-23 2024-03-28 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells overexpressing c-jun
WO2024077174A1 (en) 2022-10-05 2024-04-11 Lyell Immunopharma, Inc. Methods for culturing nr4a-deficient cells
WO2025217398A1 (en) 2024-04-10 2025-10-16 Lyell Immunopharma, Inc. Methods for culturing cells with improved culture medium

Also Published As

Publication number Publication date
WO2004031346A3 (en) 2006-10-26
AU2003290518A8 (en) 2004-04-23
WO2004031346A2 (en) 2004-04-15

Similar Documents

Publication Publication Date Title
AU2003290518A1 (en) Methods and compositions concerning designed highly-specific nucleic acid binding proteins
AU2003209272A1 (en) Engineered binding proteins
AU2003239129A1 (en) Methods and compositions for dna manipulation
AU2003239841A1 (en) Cgrp binding nucleic acids
AU2003303588A1 (en) Methods and compositions for sequencing nucleic acid molecules
AU2003284127A1 (en) Nucleic acid supported protein complementation
AU2002311759A1 (en) Methods and compositions for analyzing nucleic acids
AU2003235096A1 (en) Novel protein and dna thereof
AUPS036402A0 (en) Rhamnose binding protein
AU2003236196A1 (en) Nucleic acid library and protein library
AU2002316178A1 (en) Compositions and methods for binding agglomeration proteins
AU2001260313A1 (en) Compositions and methods for nucleic acid analyses
AU2003210572A1 (en) Compositions and methods for regulating rna stability using polypyrimidine tract proteins
AU2003258658A1 (en) Improved dna and proteins
AU2003222173A1 (en) Nucleic acid compositions and methods for use
AU2003231342A1 (en) Resistin binding proteins, their preparation and use
AU2003231343A1 (en) Resistin binding proteins, their preparation and use
AU2003262080A1 (en) Novel protein and dna thereof
AU2003265635A1 (en) Nphp nucleic acids and proteins
AU2002324847A1 (en) Dna binding protein
AU2003236041A1 (en) Novel protein and dna thereof
AU2002246555A1 (en) Methods and compositions for binding nucleic acid molecules
AU2003276850A1 (en) Compositions and methods used for identifying factors required for the agglomeration of proteins
EP1570235A3 (en) Compositions and methods used for identifying factors required for the agglomeration of proteins
AU2002317313A1 (en) Materials and methods relating to protein and nucleic acid evolution

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase