ATE524472T1 - Als plk1-inhibitoren geeignete substituierte pyrimidodiazepine - Google Patents

Als plk1-inhibitoren geeignete substituierte pyrimidodiazepine

Info

Publication number: ATE524472T1
Authority: AT; Austria
Prior art keywords: substituted; pyrimidodiazepines; plk1 inhibitors; plk1; inhibitors
Prior art date: 2007-03-22

Application number

AT08717594T

Other languages

English (en)

Inventor

Jianping Cai

Shaoqing Chen

Xin-Jie Chu

Kang Le

Kin-Chun Thomas Luk

Peter Michael Wovkulich

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-22

Filing date

2008-03-11

Publication date

2011-09-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39415299&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE524472(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-03-11 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE524472T1 publication Critical patent/ATE524472T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/18—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AT08717594T 2007-03-22 2008-03-11 Als plk1-inhibitoren geeignete substituierte pyrimidodiazepine ATE524472T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US91935807P	2007-03-22	2007-03-22
PCT/EP2008/052847 WO2008113711A1 (en)	2007-03-22	2008-03-11	Substituted pyrimidodiazepines useful as plk1 inhibitors

Publications (1)

Publication Number	Publication Date
ATE524472T1 true ATE524472T1 (de)	2011-09-15

Family

ID=39415299

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08717594T ATE524472T1 (de)	2007-03-22	2008-03-11	Als plk1-inhibitoren geeignete substituierte pyrimidodiazepine

Country Status (24)

Country	Link
US (1)	US7517873B2 (de)
EP (1)	EP2139892B1 (de)
JP (1)	JP5087640B2 (de)
KR (1)	KR101157848B1 (de)
CN (2)	CN101636399B (de)
AR (1)	AR065794A1 (de)
AT (1)	ATE524472T1 (de)
AU (1)	AU2008228303B2 (de)
BR (1)	BRPI0809088A2 (de)
CA (1)	CA2680757A1 (de)
CL (1)	CL2008000785A1 (de)
CY (1)	CY1112102T1 (de)
DK (1)	DK2139892T3 (de)
ES (1)	ES2371832T3 (de)
HK (1)	HK1139936A1 (de)
HR (1)	HRP20110807T1 (de)
IL (1)	IL200617A (de)
MX (1)	MX2009010034A (de)
PE (1)	PE20120495A1 (de)
PL (1)	PL2139892T3 (de)
PT (1)	PT2139892E (de)
SI (1)	SI2139892T1 (de)
TW (1)	TWI363629B (de)
WO (1)	WO2008113711A1 (de)

Families Citing this family (35)

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JP5380447B2 (ja) *	2007-08-15	2014-01-08	バーテックスファーマシューティカルズインコーポレイテッド	増殖性疾患の処置のための、ヒトタンパク質キナーゼｐｌｋ１ないしｐｌｋ４の阻害剤としての４−（９−（３，３−ジフルオロシクロペンチル）−５，７，７−トリメチル−６−オキソ−６，７，８，９−テトラヒドロ−５ｈ−ピリミド［４，５−ｂ［１，４］ジアゼパン−２−イルアミノ］−３−メトキシベンザミド誘導体
JP5372939B2 (ja) *	2007-09-25	2013-12-18	武田薬品工業株式会社	ポロ様キナーゼ阻害剤
EP2610256B1 (de)	2007-09-28	2016-04-27	Cyclacel Limited	Pyrimidinderivate als Proteinkinase-Inhibitoren
US20090291938A1 (en) *	2007-11-19	2009-11-26	Takeda Pharmaceutical Company Limited	Polo-like kinase inhibitors
TWI490214B (zh)	2008-05-30	2015-07-01	艾德克上野股份有限公司	苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
WO2009153197A1 (en) *	2008-06-18	2009-12-23	F. Hoffmann-La Roche Ag	Halo-substituted pyrimidodiazepines as plkl inhibitors
AP2011005745A0 (en)	2008-12-09	2011-06-30	Gilead Sciences Inc	Modulators of toll-like receptors.
WO2010080712A2 (en)	2009-01-06	2010-07-15	Dana Farber Cancer Institute	Pyrimido-diazepinone kinase scaffold compounds and methods of treating disorders
SI2442809T1 (sl)	2009-06-17	2017-01-31	Vertex Pharmaceuticals Incorporated	Inhibitorji replikacije virusov gripe
ES2661850T3 (es)	2009-09-14	2018-04-04	Gilead Sciences, Inc.	Moduladores de receptores del tipo toll
WO2012083117A1 (en)	2010-12-16	2012-06-21	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
EP3738964A1 (de)	2013-03-15	2020-11-18	Dana Farber Cancer Institute, Inc.	Pyrimidodiazepinonverbindungen und verfahren zur behandlung von erkrankungen
CA2918910A1 (en)	2013-07-25	2015-01-29	Dana-Farber Cancer Institute, Inc.	Inhibitors of transcription factors and uses thereof
TWI652014B (zh)	2013-09-13	2019-03-01	美商艾佛艾姆希公司	雜環取代之雙環唑殺蟲劑
AU2014348752C1 (en)	2013-11-13	2019-11-21	Vertex Pharmaceuticals Incorporated	Methods of preparing inhibitors of influenza viruses replication
MX382171B (es)	2013-11-13	2025-03-13	Vertex Pharmaceuticals Incorporated	Inhibidores de replicacion del virus de influenza.
WO2015117087A1 (en)	2014-01-31	2015-08-06	Dana-Farber Cancer Institute, Inc.	Uses of diazepane derivatives
EP3099677A4 (de)	2014-01-31	2017-07-26	Dana-Farber Cancer Institute, Inc.	Diaminopyrimidinbenzolsulfonderivate und verwendungen davon
PL3166607T3 (pl)	2014-07-11	2023-02-20	Gilead Sciences, Inc.	Modulatory receptorów toll-podobnych do leczenia hiv
JP2017526741A (ja)	2014-08-08	2017-09-14	ダナ−ファーバーキャンサーインスティテュート，インコーポレイテッド	ジアゼパン誘導体およびその使用
SI3194401T1 (sl)	2014-09-16	2020-12-31	Gilead Sciences, Inc.	Trdne oblike modulatorja toličnega receptorja
PT3194402T (pt)	2014-09-16	2019-02-11	Gilead Sciences Inc	Métodos de preparação de moduladores dos recetores tipo toll
WO2016183116A1 (en)	2015-05-13	2016-11-17	Vertex Pharmaceuticals Incorporated	Methods of preparing inhibitors of influenza viruses replication
MA42422A (fr)	2015-05-13	2018-05-23	Vertex Pharma	Inhibiteurs de la réplication des virus de la grippe
US10702527B2 (en)	2015-06-12	2020-07-07	Dana-Farber Cancer Institute, Inc.	Combination therapy of transcription inhibitors and kinase inhibitors
SG10202007099TA (en)	2015-09-11	2020-08-28	Dana Farber Cancer Inst Inc	Acetamide thienotriazoldiazepines and uses thereof
EP3347021A4 (de)	2015-09-11	2019-07-24	Dana-Farber Cancer Institute, Inc.	Cyanothienotriazoldiazepine und verwendungen davon
SG11201803210YA (en)	2015-11-25	2018-05-30	Dana Farber Cancer Inst Inc	Bivalent bromodomain inhibitors and uses thereof
EP3440084B1 (de) *	2016-04-07	2022-12-21	Dana-Farber Cancer Institute, Inc.	Pyrimido-diazepinon-kinase-gerüstverbindungen und verfahren zur behandlung von pi3k-vermittelten erkrankungen
AU2020356484A1 (en) *	2019-09-27	2022-03-17	Dana-Farber Cancer Institute, Inc.	ERK5 degraders as therapeutics in cancer and inflammatory diseases
KR102313753B1 (ko) *	2020-03-27	2021-10-19	(주) 업테라	Plk1의 선택적 분해를 유도하는 바닐린 유도체 화합물
WO2022145989A1 (ko) *	2020-12-31	2022-07-07	(주) 업테라	선택적 plk1 억제제로서의 피리미도디아제핀 유도체
KR102604801B1 (ko)	2021-08-10	2023-11-22	(주) 업테라	신규 plk1 분해 유도 화합물
GB202313514D0 (en)	2023-09-05	2023-10-18	Cambridge Entpr Ltd	Treatment of inflammatory diseases

Family Cites Families (4)

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Publication number	Priority date	Publication date	Assignee	Title
BR0014075A (pt) *	1999-09-17	2002-07-16	Abbott Gmbh & Co Kg	Inibidores de quinase como agentes terapêuticos
JP3876254B2 (ja)	2001-09-04	2007-01-31	ベーリンガーインゲルハイムファルマゲゼルシャフトミットベシュレンクテルハフツングウントコンパニーコマンディトゲゼルシャフト	新規なジヒドロプテリジノン、その製造方法及びその医薬組成物としての使用
WO2007095188A2 (en) *	2006-02-14	2007-08-23	Vertex Pharmaceuticals Incorporated	Dihydrodiazepines useful as inhibitors of protein kinases
TW200808325A (en) *	2006-07-06	2008-02-16	Astrazeneca Ab	Novel compounds

2008
- 2008-03-11 CN CN2008800088890A patent/CN101636399B/zh not_active Expired - Fee Related
- 2008-03-11 CA CA002680757A patent/CA2680757A1/en not_active Abandoned
- 2008-03-11 PL PL08717594T patent/PL2139892T3/pl unknown
- 2008-03-11 DK DK08717594.9T patent/DK2139892T3/da active
- 2008-03-11 EP EP08717594A patent/EP2139892B1/de not_active Not-in-force
- 2008-03-11 MX MX2009010034A patent/MX2009010034A/es active IP Right Grant
- 2008-03-11 KR KR1020097019761A patent/KR101157848B1/ko not_active IP Right Cessation
- 2008-03-11 ES ES08717594T patent/ES2371832T3/es active Active
- 2008-03-11 CN CN201210030872.3A patent/CN102746175B/zh not_active Expired - Fee Related
- 2008-03-11 BR BRPI0809088-2A patent/BRPI0809088A2/pt not_active IP Right Cessation
- 2008-03-11 SI SI200830445T patent/SI2139892T1/sl unknown
- 2008-03-11 PT PT08717594T patent/PT2139892E/pt unknown
- 2008-03-11 WO PCT/EP2008/052847 patent/WO2008113711A1/en active Search and Examination
- 2008-03-11 JP JP2009553997A patent/JP5087640B2/ja not_active Expired - Fee Related
- 2008-03-11 AT AT08717594T patent/ATE524472T1/de active
- 2008-03-11 AU AU2008228303A patent/AU2008228303B2/en not_active Ceased
- 2008-03-18 CL CL2008000785A patent/CL2008000785A1/es unknown
- 2008-03-19 TW TW097109660A patent/TWI363629B/zh not_active IP Right Cessation
- 2008-03-19 US US12/051,000 patent/US7517873B2/en not_active Expired - Fee Related
- 2008-03-19 PE PE2011001933A patent/PE20120495A1/es not_active Application Discontinuation
- 2008-03-19 AR ARP080101142A patent/AR065794A1/es unknown
2009
- 2009-08-27 IL IL200617A patent/IL200617A/en not_active IP Right Cessation
2010
- 2010-07-05 HK HK10106507.1A patent/HK1139936A1/xx not_active IP Right Cessation
2011
- 2011-11-02 HR HR20110807T patent/HRP20110807T1/hr unknown
- 2011-11-30 CY CY20111101174T patent/CY1112102T1/el unknown

Also Published As

Publication number	Publication date
PE20120495A1 (es)	2012-05-12
AU2008228303A1 (en)	2008-09-25
DK2139892T3 (da)	2011-12-12
US7517873B2 (en)	2009-04-14
ES2371832T3 (es)	2012-01-10
KR20090119913A (ko)	2009-11-20
EP2139892A1 (de)	2010-01-06
US20080234255A1 (en)	2008-09-25
JP2010521514A (ja)	2010-06-24
HK1139936A1 (en)	2010-09-30
CA2680757A1 (en)	2008-09-25
PL2139892T3 (pl)	2012-03-30
KR101157848B1 (ko)	2012-07-11
IL200617A0 (en)	2010-05-17
AR065794A1 (es)	2009-07-01
PT2139892E (pt)	2011-11-21
MX2009010034A (es)	2009-10-12
CL2008000785A1 (es)	2009-03-27
TWI363629B (en)	2012-05-11
AU2008228303B2 (en)	2012-04-19
CY1112102T1 (el)	2015-11-04
HRP20110807T1 (hr)	2011-12-31
SI2139892T1 (sl)	2011-12-30
CN102746175A (zh)	2012-10-24
EP2139892B1 (de)	2011-09-14
CN101636399B (zh)	2012-04-18
IL200617A (en)	2014-02-27
CN102746175B (zh)	2014-01-15
CN101636399A (zh)	2010-01-27
WO2008113711A1 (en)	2008-09-25
TW200843781A (en)	2008-11-16
BRPI0809088A2 (pt)	2014-09-09
JP5087640B2 (ja)	2012-12-05

Publication	Publication Date	Title
ATE524472T1 (de)	2011-09-15	Als plk1-inhibitoren geeignete substituierte pyrimidodiazepine
CY2020024I2 (el)	2020-11-25	Αναστολεiς βητα-λακταμασων
CY2017016I1 (el)	2017-07-12	Αναστολεις πρωτεασωματος
EP2170076A4 (de)	2011-09-07	4-carboxybenzylamino-derivate als histondeacetylase-hemmer
ATE522535T1 (de)	2011-09-15	Pyrrolotriazin-kinasehemmer
ATE502948T1 (de)	2011-04-15	Substituierte bicyclolactamverbindungen
DK2288375T3 (da)	2012-05-21	Pegylerede insulin-lispro-forbindelser
BRPI0920707A2 (pt)	2015-12-29	compostos
BRPI0813500A2 (pt)	2015-01-06	Compostos antivirais
DK2242759T3 (da)	2012-12-17	Forbindelser
BRPI0821086A2 (pt)	2014-10-07	Compostos inseticidas
BRPI0811264A2 (pt)	2014-11-04	Compostos
UY3776Q (es)	2008-09-02	Reloj pulsera
DK2323972T3 (da)	2013-10-07	C7-fluor-substituerede tetracylinforbindelser
BRPI0918564A2 (pt)	2015-12-01	inibidores
DK2297162T3 (da)	2012-11-26	Forbindelser
BRPI0814424A2 (pt)	2015-01-06	Compostos heterociclila
BRPI0809996A2 (pt)	2014-10-14	Compostos
BRPI0916432A2 (pt)	2016-02-16	compostos
BRPI0815181A2 (pt)	2015-03-31	Compostos
DE112008002921A5 (de)	2010-07-29	Bohrfutter
DK2206698T3 (da)	2012-08-27	Ethynylindolforbindelser
BRPI0922152A2 (pt)	2015-08-18	Compostos
EP2177529A4 (de)	2011-04-20	Neuer sekretasehemmer
BRPI0814613A2 (pt)	2015-01-27	Compostos

Legal Events

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