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ATE518952T1 - Bispezifischer antikörper als ersatz für factor viii - Google Patents

Bispezifischer antikörper als ersatz für factor viii

Info

Publication number
ATE518952T1
ATE518952T1 AT04792180T AT04792180T ATE518952T1 AT E518952 T1 ATE518952 T1 AT E518952T1 AT 04792180 T AT04792180 T AT 04792180T AT 04792180 T AT04792180 T AT 04792180T AT E518952 T1 ATE518952 T1 AT E518952T1
Authority
AT
Austria
Prior art keywords
factor viii
replacement
blood coagulation
bispecific antibody
coagulation factor
Prior art date
Application number
AT04792180T
Other languages
English (en)
Inventor
Kunihiro Hattori
Tetsuo Kojima
Taro Miyazaki
Tetsuhiro Soeda
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2003/013123 external-priority patent/WO2005035754A1/ja
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ATE518952T1 publication Critical patent/ATE518952T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT04792180T 2003-10-10 2004-10-08 Bispezifischer antikörper als ersatz für factor viii ATE518952T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2003/013062 WO2005035753A1 (ja) 2003-10-10 2003-10-10 機能蛋白質を代替する二重特異性抗体
PCT/JP2003/013123 WO2005035754A1 (ja) 2003-10-14 2003-10-14 機能蛋白質を代替する二重特異性抗体
PCT/JP2004/014911 WO2005035756A1 (ja) 2003-10-10 2004-10-08 機能蛋白質を代替する二種特異性抗体

Publications (1)

Publication Number Publication Date
ATE518952T1 true ATE518952T1 (de) 2011-08-15

Family

ID=34430861

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04792180T ATE518952T1 (de) 2003-10-10 2004-10-08 Bispezifischer antikörper als ersatz für factor viii

Country Status (20)

Country Link
US (1) US8062635B2 (de)
EP (3) EP1688488B9 (de)
KR (2) KR101361437B1 (de)
CN (1) CN1890369B (de)
AT (1) ATE518952T1 (de)
AU (2) AU2003271174A1 (de)
BR (1) BRPI0415230B1 (de)
CA (1) CA2541671C (de)
DK (2) DK1688488T3 (de)
ES (1) ES2370250T3 (de)
IL (1) IL174794A (de)
MX (1) MXPA06003831A (de)
NO (2) NO345624B1 (de)
NZ (1) NZ546509A (de)
PL (1) PL3085783T3 (de)
RU (1) RU2339696C2 (de)
SI (1) SI3085783T1 (de)
TW (1) TW200514790A (de)
UA (1) UA95438C2 (de)
WO (2) WO2005035753A1 (de)

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CN1890369B (zh) 2017-07-28
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CN1890369A (zh) 2007-01-03
NO338686B1 (no) 2016-09-26
IL174794A (en) 2011-11-30
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