ATE485041T1 - Indomethacin-präparat zur topischen anwendung - Google Patents
Indomethacin-präparat zur topischen anwendungInfo
- Publication number
- ATE485041T1 ATE485041T1 AT03741534T AT03741534T ATE485041T1 AT E485041 T1 ATE485041 T1 AT E485041T1 AT 03741534 T AT03741534 T AT 03741534T AT 03741534 T AT03741534 T AT 03741534T AT E485041 T1 ATE485041 T1 AT E485041T1
- Authority
- AT
- Austria
- Prior art keywords
- indomethacin
- preparation
- topical use
- monostearate
- external preparation
- Prior art date
Links
- CGIGDMFJXJATDK-UHFFFAOYSA-N indomethacin Chemical compound CC1=C(CC(O)=O)C2=CC(OC)=CC=C2N1C(=O)C1=CC=C(Cl)C=C1 CGIGDMFJXJATDK-UHFFFAOYSA-N 0.000 title abstract 8
- 229960000905 indomethacin Drugs 0.000 title abstract 4
- 230000000699 topical effect Effects 0.000 title 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 abstract 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 abstract 2
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 abstract 1
- 230000001747 exhibiting effect Effects 0.000 abstract 1
- 239000003349 gelling agent Substances 0.000 abstract 1
- 229940075507 glyceryl monostearate Drugs 0.000 abstract 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 abstract 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 abstract 1
- 238000005191 phase separation Methods 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- 239000001587 sorbitan monostearate Substances 0.000 abstract 1
- 229940035048 sorbitan monostearate Drugs 0.000 abstract 1
- 235000011076 sorbitan monostearate Nutrition 0.000 abstract 1
- 229940012831 stearyl alcohol Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002219315 | 2002-07-29 | ||
| PCT/JP2003/009273 WO2004010994A1 (ja) | 2002-07-29 | 2003-07-22 | インドメタシン外用剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE485041T1 true ATE485041T1 (de) | 2010-11-15 |
Family
ID=31184731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03741534T ATE485041T1 (de) | 2002-07-29 | 2003-07-22 | Indomethacin-präparat zur topischen anwendung |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7553865B2 (de) |
| EP (1) | EP1541144B8 (de) |
| JP (2) | JP4494202B2 (de) |
| KR (1) | KR100996086B1 (de) |
| CN (1) | CN100438869C (de) |
| AT (1) | ATE485041T1 (de) |
| AU (1) | AU2003281770A1 (de) |
| DE (1) | DE60334630D1 (de) |
| ES (1) | ES2357229T3 (de) |
| HK (1) | HK1076256A1 (de) |
| MY (1) | MY141808A (de) |
| PT (1) | PT1541144E (de) |
| TW (1) | TWI299269B (de) |
| WO (1) | WO2004010994A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5011118B2 (ja) * | 2005-10-17 | 2012-08-29 | 興和株式会社 | インドメタシンを含有する外用液剤 |
| US9012477B2 (en) * | 2009-01-06 | 2015-04-21 | Nuvo Research Inc. | Method of treating neuropathic pain |
| EP2523660A4 (de) | 2010-01-14 | 2013-07-10 | Nuvo Res Inc | Bildung fester formen von lokalanästhesieformulierungen zur schmerzbekämpfung |
| CN105663030A (zh) * | 2012-06-29 | 2016-06-15 | 生春堂制药工业股份有限公司 | 水凝胶组成物及由其所组成的敷剂 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2023000B (en) * | 1978-06-17 | 1982-10-13 | Kowa Co | Antinflammatory analgesic gelled ointments |
| JPS5798209A (en) | 1980-12-09 | 1982-06-18 | Kowa Co | Remedy for dermatopathy for external use |
| JPS57126414A (en) | 1981-01-28 | 1982-08-06 | Sumitomo Chem Co Ltd | Ointment |
| JPS5829706A (ja) | 1981-08-14 | 1983-02-22 | Toko Yakuhin Kogyo Kk | 消炎鎮痛外用剤 |
| JPS58185514A (ja) | 1982-04-22 | 1983-10-29 | Hisamitsu Pharmaceut Co Inc | 新規な局所用消炎鎮痛ゲル状クリ−ム剤 |
| JPS58189115A (ja) | 1982-04-30 | 1983-11-04 | Kowa Co | 外用剤 |
| JPS59227818A (ja) * | 1983-06-09 | 1984-12-21 | Mitsubishi Chem Ind Ltd | ゲル状軟膏剤 |
| JPS61200907A (ja) | 1985-03-04 | 1986-09-05 | Taisho Pharmaceut Co Ltd | 坐剤 |
| JPS6261918A (ja) | 1985-09-12 | 1987-03-18 | Sumitomo Pharmaceut Co Ltd | 吸収の良好な外用剤 |
| JPH01279831A (ja) * | 1988-04-30 | 1989-11-10 | Doujin Iyaku Kako Kk | インドメタシン軟膏剤 |
| JPH05271075A (ja) | 1992-03-26 | 1993-10-19 | Taisho Pharmaceut Co Ltd | 消炎鎮痛クリーム製剤 |
| JPH05331066A (ja) * | 1992-05-25 | 1993-12-14 | Toko Yakuhin Kogyo Kk | 尋常性ざ瘡治療用組成物 |
| JP3964484B2 (ja) * | 1996-10-01 | 2007-08-22 | ワイス株式会社 | ゲルクリーム剤 |
| JPH10182458A (ja) * | 1996-12-26 | 1998-07-07 | Taisho Pharmaceut Co Ltd | インドメタシン含有外用剤組成物 |
| JP2001035458A (ja) * | 1999-07-23 | 2001-02-09 | Sony Corp | 扁平形有機電解液電池 |
| JP4590067B2 (ja) | 2000-06-09 | 2010-12-01 | 株式会社資生堂 | 乳化組成物 |
| JP2003095985A (ja) | 2001-09-26 | 2003-04-03 | Lion Corp | 血行促進組成物 |
-
2003
- 2003-07-22 ES ES03741534T patent/ES2357229T3/es not_active Expired - Lifetime
- 2003-07-22 KR KR1020057001674A patent/KR100996086B1/ko active IP Right Grant
- 2003-07-22 JP JP2004524120A patent/JP4494202B2/ja not_active Expired - Lifetime
- 2003-07-22 CN CNB038205483A patent/CN100438869C/zh not_active Expired - Fee Related
- 2003-07-22 AT AT03741534T patent/ATE485041T1/de not_active IP Right Cessation
- 2003-07-22 DE DE60334630T patent/DE60334630D1/de not_active Expired - Lifetime
- 2003-07-22 US US10/521,958 patent/US7553865B2/en not_active Expired - Fee Related
- 2003-07-22 AU AU2003281770A patent/AU2003281770A1/en not_active Abandoned
- 2003-07-22 PT PT03741534T patent/PT1541144E/pt unknown
- 2003-07-22 EP EP03741534A patent/EP1541144B8/de not_active Expired - Lifetime
- 2003-07-22 WO PCT/JP2003/009273 patent/WO2004010994A1/ja active Application Filing
- 2003-07-25 MY MYPI20032800A patent/MY141808A/en unknown
- 2003-07-28 TW TW092120541A patent/TWI299269B/zh not_active IP Right Cessation
-
2005
- 2005-11-29 HK HK05110853.0A patent/HK1076256A1/xx unknown
-
2010
- 2010-03-15 JP JP2010058017A patent/JP5209653B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN100438869C (zh) | 2008-12-03 |
| JP5209653B2 (ja) | 2013-06-12 |
| AU2003281770A1 (en) | 2004-02-16 |
| JP4494202B2 (ja) | 2010-06-30 |
| PT1541144E (pt) | 2011-01-24 |
| TWI299269B (en) | 2008-08-01 |
| US7553865B2 (en) | 2009-06-30 |
| KR20050026061A (ko) | 2005-03-14 |
| JP2010163454A (ja) | 2010-07-29 |
| EP1541144B1 (de) | 2010-10-20 |
| EP1541144B8 (de) | 2011-09-21 |
| CN1678308A (zh) | 2005-10-05 |
| JPWO2004010994A1 (ja) | 2005-11-24 |
| WO2004010994A1 (ja) | 2004-02-05 |
| KR100996086B1 (ko) | 2010-11-22 |
| MY141808A (en) | 2010-06-30 |
| DE60334630D1 (de) | 2010-12-02 |
| HK1076256A1 (en) | 2006-01-13 |
| ES2357229T3 (es) | 2011-04-20 |
| EP1541144A1 (de) | 2005-06-15 |
| EP1541144A4 (de) | 2007-08-08 |
| US20050239868A1 (en) | 2005-10-27 |
| TW200405819A (en) | 2004-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |