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ATE441702T1 - Verfahren zur herstellung eines hmg-coa reduktase hemmers - Google Patents

Verfahren zur herstellung eines hmg-coa reduktase hemmers

Info

Publication number
ATE441702T1
ATE441702T1 AT00901980T AT00901980T ATE441702T1 AT E441702 T1 ATE441702 T1 AT E441702T1 AT 00901980 T AT00901980 T AT 00901980T AT 00901980 T AT00901980 T AT 00901980T AT E441702 T1 ATE441702 T1 AT E441702T1
Authority
AT
Austria
Prior art keywords
substituted
hmg
producing
coa reductase
reductase inhibitor
Prior art date
Application number
AT00901980T
Other languages
English (en)
Inventor
Hirofumi Endo
Yoshiyuki Yonetani
Hiroshi Mizoguchi
Shin-Ichi Hashimoto
Akio Ozaki
Original Assignee
Kyowa Hakko Bio Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Bio Co Ltd filed Critical Kyowa Hakko Bio Co Ltd
Application granted granted Critical
Publication of ATE441702T1 publication Critical patent/ATE441702T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Plant Substances (AREA)
AT00901980T 1999-01-29 2000-01-28 Verfahren zur herstellung eines hmg-coa reduktase hemmers ATE441702T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2170799 1999-01-29
PCT/JP2000/000472 WO2000044886A1 (fr) 1999-01-29 2000-01-28 TECHNIQUE DE PRODUCTION D'INHIBITEUR DE HMG-CoA REDUCTASE

Publications (1)

Publication Number Publication Date
ATE441702T1 true ATE441702T1 (de) 2009-09-15

Family

ID=12062541

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901980T ATE441702T1 (de) 1999-01-29 2000-01-28 Verfahren zur herstellung eines hmg-coa reduktase hemmers

Country Status (14)

Country Link
US (4) US7049111B1 (de)
EP (1) EP1148122B1 (de)
JP (1) JP4668420B2 (de)
KR (1) KR20010108139A (de)
CN (1) CN1329508C (de)
AT (1) ATE441702T1 (de)
AU (1) AU2321600A (de)
CA (1) CA2360080A1 (de)
CZ (1) CZ20012728A3 (de)
DE (1) DE60042879D1 (de)
HK (1) HK1040530A1 (de)
HU (1) HUP0105145A3 (de)
IL (1) IL144526A0 (de)
WO (1) WO2000044886A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100633867B1 (ko) 1999-01-20 2006-10-16 교와 핫꼬 고교 가부시끼가이샤 히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법
CN1329508C (zh) * 1999-01-29 2007-08-01 协和发酵工业株式会社 HMG－CoA还原酶抑制剂的制备方法
CN101351551A (zh) 2005-11-29 2009-01-21 协和发酵工业株式会社 新型蛋白质和编码该蛋白质的dna
WO2008071673A1 (en) * 2006-12-13 2008-06-19 Dsm Ip Assets B.V. Process for preparing pravastatin
US8383381B2 (en) 2007-09-27 2013-02-26 Shjonogi & Co., Ltd. Method for producing hydroxylated adaivjantane using cytochrome P450

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750894A (en) 1980-09-08 1982-03-25 Sankyo Co Ltd Preparation of ml-236b derivative
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5720894A (en) 1980-07-15 1982-02-03 Nippon Keibi Hosho Kk Fault diagnozing method for ultrasonic alarm unit
US4356621A (en) 1980-07-25 1982-11-02 Toyoda Koki Kabushiki Kaisha Machine tool with automatic tool change
JPS5889191A (ja) 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JP2672551B2 (ja) 1987-03-02 1997-11-05 三共株式会社 チトクロームｐ−４５０遺伝子を含有するｄｎａ
US6043064A (en) 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
CA2299634C (en) 1997-08-07 2007-10-16 Kyowa Hakko Kogyo Co., Ltd. Process for the preparation of hmg-coa reductase inhibitors
EP1015600A1 (de) 1997-08-22 2000-07-05 Dsm N.V. Fermentative herstellung von statin
SI9800144A (sl) 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
KR100633867B1 (ko) 1999-01-20 2006-10-16 교와 핫꼬 고교 가부시끼가이샤 히드록시메틸글루타릴 코에이 환원효소 저해제의 제조방법
CN1329508C (zh) 1999-01-29 2007-08-01 协和发酵工业株式会社 HMG－CoA还原酶抑制剂的制备方法

Also Published As

Publication number Publication date
US20090148916A1 (en) 2009-06-11
US7049111B1 (en) 2006-05-23
US7470528B2 (en) 2008-12-30
EP1148122B1 (de) 2009-09-02
EP1148122A4 (de) 2008-02-13
EP1148122A1 (de) 2001-10-24
CZ20012728A3 (cs) 2002-02-13
HUP0105145A2 (hu) 2002-04-29
CA2360080A1 (en) 2000-08-03
DE60042879D1 (de) 2009-10-15
KR20010108139A (ko) 2001-12-07
HUP0105145A3 (en) 2006-02-28
CN1345371A (zh) 2002-04-17
US20060154348A1 (en) 2006-07-13
US20080261273A1 (en) 2008-10-23
IL144526A0 (en) 2002-05-23
JP4668420B2 (ja) 2011-04-13
CN1329508C (zh) 2007-08-01
US7897370B2 (en) 2011-03-01
AU2321600A (en) 2000-08-18
HK1040530A1 (zh) 2002-06-14
WO2000044886A1 (fr) 2000-08-03

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Legal Events

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RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties