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ATE360703T1 - Verfahren zur herstellung von hemmern der hmg-coa reduktase - Google Patents

Verfahren zur herstellung von hemmern der hmg-coa reduktase

Info

Publication number
ATE360703T1
ATE360703T1 AT00900832T AT00900832T ATE360703T1 AT E360703 T1 ATE360703 T1 AT E360703T1 AT 00900832 T AT00900832 T AT 00900832T AT 00900832 T AT00900832 T AT 00900832T AT E360703 T1 ATE360703 T1 AT E360703T1
Authority
AT
Austria
Prior art keywords
compound
substituted
coa reductase
reductase inhibitors
culture
Prior art date
Application number
AT00900832T
Other languages
English (en)
Inventor
Shin-Ichi Hashimoto
Yoshiyuki Yonetani
Akio Ozaki
Kyowa-Cho
Original Assignee
Kyowa Hakko Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Kk filed Critical Kyowa Hakko Kogyo Kk
Application granted granted Critical
Publication of ATE360703T1 publication Critical patent/ATE360703T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT00900832T 1999-01-20 2000-01-20 Verfahren zur herstellung von hemmern der hmg-coa reduktase ATE360703T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1239299 1999-01-20

Publications (1)

Publication Number Publication Date
ATE360703T1 true ATE360703T1 (de) 2007-05-15

Family

ID=11804010

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900832T ATE360703T1 (de) 1999-01-20 2000-01-20 Verfahren zur herstellung von hemmern der hmg-coa reduktase

Country Status (14)

Country Link
US (1) US6946270B1 (de)
EP (1) EP1146126B1 (de)
JP (1) JP4428866B2 (de)
KR (1) KR100633867B1 (de)
CN (1) CN1240844C (de)
AT (1) ATE360703T1 (de)
AU (1) AU3074300A (de)
CA (1) CA2358927A1 (de)
CZ (1) CZ20012622A3 (de)
DE (1) DE60034547T8 (de)
HK (1) HK1040419B (de)
HU (1) HUP0105000A3 (de)
IL (1) IL144405A0 (de)
WO (1) WO2000043533A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1329508C (zh) * 1999-01-29 2007-08-01 协和发酵工业株式会社 HMG－CoA还原酶抑制剂的制备方法
CN101351551A (zh) * 2005-11-29 2009-01-21 协和发酵工业株式会社 新型蛋白质和编码该蛋白质的dna
WO2008071673A1 (en) * 2006-12-13 2008-06-19 Dsm Ip Assets B.V. Process for preparing pravastatin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5750894A (en) 1980-09-08 1982-03-25 Sankyo Co Ltd Preparation of ml-236b derivative
DK149080C (da) 1980-06-06 1986-07-28 Sankyo Co Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre
JPS5889191A (ja) * 1981-11-20 1983-05-27 Sankyo Co Ltd ３−ヒドロキシ−ｍｌ−２３６ｂ誘導体の製造法
JP2672551B2 (ja) 1987-03-02 1997-11-05 三共株式会社 チトクロームｐ−４５０遺伝子を含有するｄｎａ
US6043064A (en) 1993-10-22 2000-03-28 Bristol-Myers Squibb Company Enzymatic hydroxylation process for the preparation of HMG-CoA reductase inhibitors and intermediates thereof
US5942423A (en) * 1995-06-07 1999-08-24 Massachusetts Institute Of Technology Conversion of compactin to pravastatin by actinomadura
CA2299634C (en) * 1997-08-07 2007-10-16 Kyowa Hakko Kogyo Co., Ltd. Process for the preparation of hmg-coa reductase inhibitors
EP1015600A1 (de) 1997-08-22 2000-07-05 Dsm N.V. Fermentative herstellung von statin
SI9800144A (sl) * 1998-05-21 1999-12-31 LEK, tovarna farmacevtskih in kemičnih izdelkov, d.d. Nov biotehnološki postopek pridobivanja 3-hidroksi-ML-236B derivatov poznanih kot M-4 in M-4'
CN1329508C (zh) 1999-01-29 2007-08-01 协和发酵工业株式会社 HMG－CoA还原酶抑制剂的制备方法

Also Published As

Publication number Publication date
HUP0105000A3 (en) 2004-03-01
JP4428866B2 (ja) 2010-03-10
CN1344328A (zh) 2002-04-10
WO2000043533A1 (fr) 2000-07-27
AU3074300A (en) 2000-08-07
HK1040419B (zh) 2007-12-14
CA2358927A1 (en) 2000-07-27
US6946270B1 (en) 2005-09-20
DE60034547T8 (de) 2008-04-30
DE60034547T2 (de) 2008-01-10
HK1040419A1 (en) 2002-06-07
KR20020002375A (ko) 2002-01-09
CZ20012622A3 (cs) 2002-01-16
IL144405A0 (en) 2002-05-23
KR100633867B1 (ko) 2006-10-16
CN1240844C (zh) 2006-02-08
HUP0105000A2 (hu) 2002-04-29
EP1146126A1 (de) 2001-10-17
EP1146126A4 (de) 2004-05-19
EP1146126B1 (de) 2007-04-25
DE60034547D1 (de) 2007-06-06

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Legal Events

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