ATE370142T1 - Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3 - Google Patents

Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3

Info

Publication number: ATE370142T1
Authority: AT; Austria
Prior art keywords: triazolopyrimidene; inhibitors; derivatives; glycogen synthase; synthase kinase
Prior art date: 2003-07-16

Application number

AT04766189T

Other languages

English (en)

Inventor

Eddy Jean Edgard Freyne

Christopher John Love

Ludwig Paul Cooymans

Nele Vandermaesen

Peter J J A Buijnsters

Marc Willems

Werner C J Embrechts

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-16

Filing date

2004-07-12

Publication date

2007-09-15

2004-07-12 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE370142T1 publication Critical patent/ATE370142T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Hematology (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Psychology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT04766189T 2003-07-16 2004-07-12 Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3 ATE370142T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP0350310		2003-07-16

Publications (1)

Publication Number	Publication Date
ATE370142T1 true ATE370142T1 (de)	2007-09-15

Family

ID=34112425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04766189T ATE370142T1 (de)	2003-07-16	2004-07-12	Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3

Country Status (26)

Country	Link
US (2)	US7560458B2 (de)
EP (1)	EP1658292B1 (de)
JP (1)	JP2009514782A (de)
KR (1)	KR20060120393A (de)
CN (1)	CN100404536C (de)
AP (1)	AP2006003486A0 (de)
AR (1)	AR045698A1 (de)
AT (1)	ATE370142T1 (de)
AU (1)	AU2004260738B2 (de)
BR (1)	BRPI0412596A (de)
CA (1)	CA2531333A1 (de)
DE (1)	DE602004008303T2 (de)
DK (1)	DK1658292T3 (de)
EA (1)	EA010109B1 (de)
ES (1)	ES2290754T3 (de)
IL (1)	IL173139A (de)
JO (1)	JO2460B1 (de)
MX (1)	MXPA06000540A (de)
NO (1)	NO20060678L (de)
NZ (1)	NZ545058A (de)
PA (1)	PA8607001A1 (de)
PL (1)	PL1658292T3 (de)
PT (1)	PT1658292E (de)
TW (1)	TW200524935A (de)
WO (1)	WO2005012307A1 (de)
ZA (1)	ZA200600385B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
WO2004014382A1 (en)	2002-07-29	2004-02-19	Rigel Pharmaceuticals	Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds
ES2290754T3 (es) *	2003-07-16	2008-02-16	Janssen Pharmaceutica N.V.	Derivados de triazolopirimidina como inhibidores de la glucogeno sintasa cinasa 3.
ES2421139T3 (es)	2003-07-30	2013-08-29	Rigel Pharmaceuticals, Inc.	Compuestos de 2,4-pirimidindiamina para su uso en el tratamiento o la prevención de enfermedades autoinmunitarias
MXPA06001759A (es) *	2003-08-15	2006-05-12	Novartis Ag	2,4-pirimidinadiaminas utiles en el tratamiento de enfermedades neoplasticas, desordenes del sistema inmune e inflamatorios.
MXPA06002997A (es) *	2003-09-18	2007-02-08	Conforma Therapeutics Corp	Novedosos compuestos heterociclicos como inhibidores- hsp90.
AU2005286728A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase
WO2006034341A2 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase
US7767677B2 (en)	2004-09-20	2010-08-03	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors
EP1799667B1 (de)	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterozyklische derivate und ihre verwendung als therapeutische wirkstoffe
WO2006034441A1 (en)	2004-09-20	2006-03-30	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
JP4958785B2 (ja)	2004-09-20	2012-06-20	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼインヒビターとしてのそれらの使用
US7919496B2 (en)	2004-09-20	2011-04-05	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-CoA desaturase enzymes
EP1812439B2 (de)	2004-10-15	2017-12-06	Takeda Pharmaceutical Company Limited	Kinaseinhibitoren
KR20070085286A (ko)	2004-10-29	2007-08-27	티보텍 파마슈티칼즈 리미티드	Ｈｉｖ를 저해하는 바이사이클릭 피리미딘 유도체
US7563781B2 (en)	2005-01-14	2009-07-21	Janssen Pharmaceutica Nv	Triazolopyrimidine derivatives
EP2029138A1 (de)	2005-06-03	2009-03-04	Xenon Pharmaceuticals Inc.	Aminothiazolderivate als humane stearoyl-coa desaturasehemmer
US20070203161A1 (en)	2006-02-24	2007-08-30	Rigel Pharmaceuticals, Inc.	Compositions and methods for inhibition of the jak pathway
SG137989A1 (en)	2005-06-08	2008-01-28	Rigel Pharmaceuticals Inc	Compositions and methods for inhibition of the JAK pathway
WO2007025177A2 (en)	2005-08-26	2007-03-01	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
EP1940389A2 (de)	2005-10-21	2008-07-09	Braincells, Inc.	Modulation von neurogenese durch pde-hemmung
EP1942879A1 (de)	2005-10-31	2008-07-16	Braincells, Inc.	Gaba-rezeptor-vermittelte modulation von neurogenese
ES2622493T3 (es)	2006-02-24	2017-07-06	Rigel Pharmaceuticals, Inc.	Composiciones y métodos para la inhibición de la ruta de JAK
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
JP2009536669A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	アンジオテンシン調節による神経新生
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
MX2009003793A (es)	2006-10-09	2009-12-14	Takeda Pharmaceutical	Inhibidores de cinasa.
TWI444379B (zh) *	2007-06-29	2014-07-11	Sunesis Pharmaceuticals Inc	有用於作為Ｒａｆ激酶抑制劑之化合物
US7968536B2 (en) *	2007-06-29	2011-06-28	Millennium Pharmaceuticals, Inc.	Heterocyclic compounds useful as RAF kinase inhibitors
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
RU2528386C2 (ru)	2010-05-21	2014-09-20	Кемилиа Аб	Новые производные пиримидина
AU2012230229A1 (en)	2011-03-24	2013-10-10	Noviga Research Ab	Novel pyrimidine derivatives
WO2013110309A1 (en) *	2012-01-28	2013-08-01	Merck Patent Gmbh	Triazolo[4,5-d]pyrimidine derivatives
WO2013131609A1 (en)	2012-03-07	2013-09-12	Merck Patent Gmbh	Triazolopyrazine derivatives
US9617266B2 (en)	2013-03-05	2017-04-11	Merck Patent Gmbh	Imidazopyrimidine derivatives
CA2903903C (en) *	2013-03-05	2021-05-04	Merck Patent Gmbh	Triazolo[4,5-d]pyrimidine derivatives for the treatment of diseases such as cancer
CA2911259A1 (en)	2013-05-06	2014-11-13	Merck Patent Gmbh	Macrocycles as kinase inhibitors
WO2016087665A2 (en) *	2014-12-05	2016-06-09	Centre National De La Recherche Scientifique (Cnrs)	Compounds for treating cystic fibrosis
US11370793B2 (en)	2015-08-27	2022-06-28	Nantneuro, Llc	Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau
WO2017156527A1 (en) *	2016-03-11	2017-09-14	H. Lee Moffitt Cancer Center And Research Institute, Inc.	Aurora kinase and janus kinase inhibitors for prevention of graft versus host disease
AU2020218366A1 (en)	2019-02-08	2021-09-16	Frequency Therapeutics, Inc.	Valproic acid compounds and Wnt agonists for treating ear disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5962594A (ja) *	1982-09-30	1984-04-10	Ss Pharmaceut Co Ltd	３，５―ジ置換―トリアゾロピリミジン誘導体
US20020040031A1 (en) *	2000-07-07	2002-04-04	Glasky Michelle S.	Methods for prevention of accumulation of amyloid beta peptide in the central nervous system
US6737085B2 (en) *	2000-11-01	2004-05-18	Tokiwa Phytochemical Co., Ltd.	Apocynum venetum extract for use as antidepressant
EP1347972A1 (de) *	2000-12-19	2003-10-01	Smithkline Beecham Plc	PYRAZOLO-ç3,4-C!PYRIDINE ALS GSK3-INHIBITOREN
ES2290754T3 (es) *	2003-07-16	2008-02-16	Janssen Pharmaceutica N.V.	Derivados de triazolopirimidina como inhibidores de la glucogeno sintasa cinasa 3.

2004
- 2004-07-12 ES ES04766189T patent/ES2290754T3/es not_active Expired - Lifetime
- 2004-07-12 MX MXPA06000540A patent/MXPA06000540A/es active IP Right Grant
- 2004-07-12 AP AP2006003486A patent/AP2006003486A0/xx unknown
- 2004-07-12 AU AU2004260738A patent/AU2004260738B2/en not_active Ceased
- 2004-07-12 DE DE602004008303T patent/DE602004008303T2/de not_active Expired - Lifetime
- 2004-07-12 JP JP2006519926A patent/JP2009514782A/ja not_active Withdrawn
- 2004-07-12 EA EA200600258A patent/EA010109B1/ru not_active IP Right Cessation
- 2004-07-12 WO PCT/EP2004/051455 patent/WO2005012307A1/en active IP Right Grant
- 2004-07-12 PL PL04766189T patent/PL1658292T3/pl unknown
- 2004-07-12 EP EP04766189A patent/EP1658292B1/de not_active Expired - Lifetime
- 2004-07-12 PT PT04766189T patent/PT1658292E/pt unknown
- 2004-07-12 CA CA002531333A patent/CA2531333A1/en not_active Abandoned
- 2004-07-12 AT AT04766189T patent/ATE370142T1/de active
- 2004-07-12 DK DK04766189T patent/DK1658292T3/da active
- 2004-07-12 CN CNB2004800201486A patent/CN100404536C/zh not_active Expired - Fee Related
- 2004-07-12 BR BRPI0412596-7A patent/BRPI0412596A/pt not_active IP Right Cessation
- 2004-07-12 JO JO200496A patent/JO2460B1/en active
- 2004-07-12 US US10/564,844 patent/US7560458B2/en not_active Expired - Fee Related
- 2004-07-12 NZ NZ545058A patent/NZ545058A/en not_active IP Right Cessation
- 2004-07-12 KR KR1020057024541A patent/KR20060120393A/ko not_active Application Discontinuation
- 2004-07-15 PA PA20048607001A patent/PA8607001A1/es unknown
- 2004-07-15 TW TW093121066A patent/TW200524935A/zh unknown
- 2004-07-15 AR ARP040102496A patent/AR045698A1/es not_active Application Discontinuation
2006
- 2006-01-12 IL IL173139A patent/IL173139A/en not_active IP Right Cessation
- 2006-01-13 ZA ZA200600385A patent/ZA200600385B/en unknown
- 2006-02-10 NO NO20060678A patent/NO20060678L/no not_active Application Discontinuation
2008
- 2008-09-16 US US12/211,361 patent/US20090036471A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2290754T3 (es)	2008-02-16
CA2531333A1 (en)	2005-02-10
IL173139A0 (en)	2006-06-11
EP1658292B1 (de)	2007-08-15
DK1658292T3 (da)	2007-11-12
US20090036471A1 (en)	2009-02-05
AU2004260738A1 (en)	2005-02-10
BRPI0412596A (pt)	2006-09-19
US7560458B2 (en)	2009-07-14
DE602004008303D1 (de)	2007-09-27
DE602004008303T2 (de)	2008-05-08
AU2004260738B2 (en)	2009-07-16
PT1658292E (pt)	2007-10-25
AR045698A1 (es)	2005-11-09
PL1658292T3 (pl)	2008-01-31
ZA200600385B (en)	2007-05-30
US20060205721A1 (en)	2006-09-14
CN1823068A (zh)	2006-08-23
EP1658292A1 (de)	2006-05-24
IL173139A (en)	2010-04-29
JP2009514782A (ja)	2009-04-09
WO2005012307A1 (en)	2005-02-10
NO20060678L (no)	2006-02-10
EA010109B1 (ru)	2008-06-30
TW200524935A (en)	2005-08-01
EA200600258A1 (ru)	2006-06-30
KR20060120393A (ko)	2006-11-27
CN100404536C (zh)	2008-07-23
MXPA06000540A (es)	2006-03-30
NZ545058A (en)	2008-05-30
PA8607001A1 (es)	2005-05-10
JO2460B1 (en)	2009-01-20
AP2006003486A0 (en)	2006-02-28

Publication	Publication Date	Title
ATE370142T1 (de)	2007-09-15	Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3
ATE413404T1 (de)	2008-11-15	Triazolopyrimidin derivate als inhibitoren von glycogen synthase kinase-3
ATE369356T1 (de)	2007-08-15	Pyridazinon-derivate als cdk2-hemmer
ATE404564T1 (de)	2008-08-15	Diazepinoindolderivate als kinaseinhibitoren
ATE402934T1 (de)	2008-08-15	Malonamidderivate als gamma-secretaseinhibitoren
ATE388148T1 (de)	2008-03-15	Chinolinderivate als phosphodiesterase inhibitoren
DE60321808D1 (de)	2008-08-07	Flavon derivate als inhibitoren von cyclin-abhängigen kinasen
DE60325032D1 (de)	2009-01-15	2-hydroxy-3-heteroarylindole derivate als gsk3 inhibitoren
DE60313872D1 (de)	2007-06-28	Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen
DE602005025733D1 (de)	2011-02-17	Pyrazolopyrimidinderivate als inhibitoren der cyclinabhängigen kinase
NL1027811A1 (nl)	2005-06-21	Heterocyclische aminen als remmers 11- -hydroxy-steroïd-dehydrogenase type 1.
SE0701538L (sv)	2007-06-26	Azaspiroalkanderivat som hämmare av metalloproteaser
IL183188A0 (en)	2007-08-19	Pyrrolidyl derivatives of heteroaromatic compounds as phosphodiesterase inhibitors
ATE437876T1 (de)	2009-08-15	Hexahydropyridoisochinoline als dpp-iv- inhibitoren
ATE520671T1 (de)	2011-09-15	Pyrimidin-harnstoff-derivate als kinase-hemmer
DE602004025258D1 (de)	2010-03-11	Aminotriazol-verbindungen als proteinkinase-hemmer
NO20045220L (no)	2005-01-19	Heterocykliske inhibitorer for kinaser
ATE400271T1 (de)	2008-07-15	Aryl-pyridinderivate als 11-beta-hsd1-hemmer
DE60315862D1 (de)	2007-10-04	Dihydropyridinonderivate als hne-inhibitoren
DK1756064T3 (da)	2008-09-22	Pyrazolderivater, sammensætninger indeholdende sådanne forbindelser og anvendelsesmetoder
ATE420076T1 (de)	2009-01-15	Indozolonderivate als 11b-hsd1-inhibitoren
ATE401893T1 (de)	2008-08-15	Thiophenepyrimidinone als 17-beta-hydroxysteroid dehydrogenase inhibitoren
IL178968A0 (en)	2007-03-08	Novel pyridazinone derivatives as inhibitors of cdk2
DE60324208D1 (de)	2008-11-27	Biarylsulfonamide als mmp-inhibitoren
ATE393159T1 (de)	2008-05-15	Heterobicyclische pyrazolderivate als kinaseinhibitoren

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2008-01-15	UEP	Publication of translation of european patent specification	Ref document number: 1658292 Country of ref document: EP

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