ATE324464T1 - Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren - Google Patents
Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäurenInfo
- Publication number
- ATE324464T1 ATE324464T1 AT03000499T AT03000499T ATE324464T1 AT E324464 T1 ATE324464 T1 AT E324464T1 AT 03000499 T AT03000499 T AT 03000499T AT 03000499 T AT03000499 T AT 03000499T AT E324464 T1 ATE324464 T1 AT E324464T1
- Authority
- AT
- Austria
- Prior art keywords
- oligonucleotide
- cascade
- nucleic acids
- circular
- reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/682—Signal amplification
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Ceramic Products (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK137995 | 1995-12-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE324464T1 true ATE324464T1 (de) | 2006-05-15 |
Family
ID=8104224
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03000499T ATE324464T1 (de) | 1995-12-05 | 1996-12-05 | Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren |
| AT96939821T ATE238434T1 (de) | 1995-12-05 | 1996-12-05 | Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT96939821T ATE238434T1 (de) | 1995-12-05 | 1996-12-05 | Eine in kaskaden verlaufende vervielfältigungsreaktion von nukleinsäuren |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6610481B2 (de) |
| EP (2) | EP0868530B1 (de) |
| AT (2) | ATE324464T1 (de) |
| AU (1) | AU704750B2 (de) |
| CA (1) | CA2239287C (de) |
| DE (2) | DE69627698T2 (de) |
| DK (2) | DK0868530T3 (de) |
| ES (1) | ES2262902T3 (de) |
| WO (1) | WO1997020948A1 (de) |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077668A (en) * | 1993-04-15 | 2000-06-20 | University Of Rochester | Highly sensitive multimeric nucleic acid probes |
| US7135312B2 (en) | 1993-04-15 | 2006-11-14 | University Of Rochester | Circular DNA vectors for synthesis of RNA and DNA |
| JP3974941B2 (ja) | 1995-11-21 | 2007-09-12 | イェール ユニバーシティ | 単分子セグメントの増幅および検出 |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| CA2342837A1 (en) * | 1998-09-15 | 2000-03-23 | Yale University | Artificial long terminal repeat vectors |
| WO2000015779A2 (en) * | 1998-09-15 | 2000-03-23 | Yale University | Molecular cloning using rolling circle amplification |
| US6986990B1 (en) * | 1999-04-27 | 2006-01-17 | Genox Research, Inc. | Pollen allergy-related gene 513 |
| US6368801B1 (en) | 2000-04-12 | 2002-04-09 | Molecular Staging, Inc. | Detection and amplification of RNA using target-mediated ligation of DNA by RNA ligase |
| AU7172201A (en) | 2000-06-30 | 2002-01-14 | Molecular Staging Inc | Signal amplification with lollipop probes |
| GB0025144D0 (en) * | 2000-10-13 | 2000-11-29 | Medical Res Council | Concatenated nucleic acid sequences |
| US6573051B2 (en) | 2001-03-09 | 2003-06-03 | Molecular Staging, Inc. | Open circle probes with intramolecular stem structures |
| WO2003002761A1 (en) * | 2001-06-29 | 2003-01-09 | Novozymes A/S | Method of multimerization and site-directed mutagenesis |
| GB2378245A (en) | 2001-08-03 | 2003-02-05 | Mats Nilsson | Nucleic acid amplification method |
| GB2382137A (en) | 2001-11-20 | 2003-05-21 | Mats Gullberg | Nucleic acid enrichment |
| US7553619B2 (en) | 2002-02-08 | 2009-06-30 | Qiagen Gmbh | Detection method using dissociated rolling circle amplification |
| US8394944B2 (en) * | 2002-09-20 | 2013-03-12 | Siemens Healthcare Diagnostics Inc. | Dual-purpose primers and probes for providing enhanced hybridization assays by disruption of secondary structure formation |
| ATE411400T1 (de) | 2002-11-21 | 2008-10-15 | Epict Technologies | Verfahren zur verwendung von riboprimern zur strangverdrängungsreplikation von zielsequenzen |
| US9487823B2 (en) | 2002-12-20 | 2016-11-08 | Qiagen Gmbh | Nucleic acid amplification |
| US6977153B2 (en) | 2002-12-31 | 2005-12-20 | Qiagen Gmbh | Rolling circle amplification of RNA |
| CN100480760C (zh) * | 2004-09-27 | 2009-04-22 | 古河电气工业株式会社 | 连接部件 |
| AU2005314431B2 (en) * | 2004-12-11 | 2011-02-17 | Cytogenix, Inc. | Cell free biosynthesis of high-quality nucleic acid and uses thereof |
| GB0504774D0 (en) * | 2005-03-08 | 2005-04-13 | Lingvitae As | Method |
| DE602006017192D1 (de) | 2005-04-12 | 2010-11-11 | Olink Ab | Verfahren zur herstellung von oligonukleotiden |
| US7989166B2 (en) | 2005-04-12 | 2011-08-02 | In Situ Rcp A/S | Circle probes and their use in the identification of biomolecules |
| EP3257949A1 (de) | 2005-06-15 | 2017-12-20 | Complete Genomics Inc. | Nukleinsäureanalyse durch zufällige mischungen von nichtüberlappenden fragmenten |
| EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
| WO2007044671A2 (en) | 2005-10-06 | 2007-04-19 | Lucigen Corporation | Thermostable viral polymerases and methods of use |
| US7960104B2 (en) * | 2005-10-07 | 2011-06-14 | Callida Genomics, Inc. | Self-assembled single molecule arrays and uses thereof |
| WO2007133831A2 (en) | 2006-02-24 | 2007-11-22 | Callida Genomics, Inc. | High throughput genome sequencing on dna arrays |
| US20070168197A1 (en) * | 2006-01-18 | 2007-07-19 | Nokia Corporation | Audio coding |
| SG10201405158QA (en) * | 2006-02-24 | 2014-10-30 | Callida Genomics Inc | High throughput genome sequencing on dna arrays |
| GB0621361D0 (en) * | 2006-10-26 | 2006-12-06 | Fermentas Uab | Use of DNA polymerases |
| WO2008070352A2 (en) | 2006-10-27 | 2008-06-12 | Complete Genomics, Inc. | Efficient arrays of amplified polynucleotides |
| US20090105961A1 (en) * | 2006-11-09 | 2009-04-23 | Complete Genomics, Inc. | Methods of nucleic acid identification in large-scale sequencing |
| US20090111705A1 (en) | 2006-11-09 | 2009-04-30 | Complete Genomics, Inc. | Selection of dna adaptor orientation by hybrid capture |
| RU2414510C2 (ru) * | 2007-06-14 | 2011-03-20 | Институт биохимии и генетики Уфимского научного центра РАН | Способ амплификации специфичных фрагментов нуклеиновых кислот с помощью рекуррентной цепной реакции |
| US8518640B2 (en) * | 2007-10-29 | 2013-08-27 | Complete Genomics, Inc. | Nucleic acid sequencing and process |
| US20090263872A1 (en) * | 2008-01-23 | 2009-10-22 | Complete Genomics Inc. | Methods and compositions for preventing bias in amplification and sequencing reactions |
| US8298768B2 (en) | 2007-11-29 | 2012-10-30 | Complete Genomics, Inc. | Efficient shotgun sequencing methods |
| US8617811B2 (en) | 2008-01-28 | 2013-12-31 | Complete Genomics, Inc. | Methods and compositions for efficient base calling in sequencing reactions |
| US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| US7897344B2 (en) * | 2007-11-06 | 2011-03-01 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors into library constructs |
| WO2009061840A1 (en) * | 2007-11-05 | 2009-05-14 | Complete Genomics, Inc. | Methods and oligonucleotide designs for insertion of multiple adaptors employing selective methylation |
| US8592150B2 (en) | 2007-12-05 | 2013-11-26 | Complete Genomics, Inc. | Methods and compositions for long fragment read sequencing |
| WO2009132028A1 (en) * | 2008-04-21 | 2009-10-29 | Complete Genomics, Inc. | Array structures for nucleic acid detection |
| US9524369B2 (en) | 2009-06-15 | 2016-12-20 | Complete Genomics, Inc. | Processing and analysis of complex nucleic acid sequence data |
| EP2675916B1 (de) | 2011-02-15 | 2016-08-24 | Leica Biosystems Newcastle Limited | Verfahren für den in situ nachweis von mrna |
| US9556473B2 (en) | 2011-02-15 | 2017-01-31 | Leica Biosystems Newcastle Ltd | Methods for identifying nucleic acid sequences |
| WO2012170936A2 (en) | 2011-06-09 | 2012-12-13 | Illumina, Inc. | Patterned flow-cells useful for nucleic acid analysis |
| WO2013063382A2 (en) | 2011-10-28 | 2013-05-02 | Illumina, Inc. | Microarray fabrication system and method |
| CN104955963A (zh) | 2012-11-14 | 2015-09-30 | 欧凌科公司 | Rca报告探针及其用于检测核酸分子的用途 |
| WO2014076209A1 (en) | 2012-11-14 | 2014-05-22 | Olink Ab | Localised rca-based amplification method |
| GB201320145D0 (en) | 2013-11-14 | 2014-01-01 | Olink Ab | Localised RCA-based amplification method using a padlock-probe |
| AU2015259024B2 (en) | 2014-05-16 | 2021-07-01 | Illumina, Inc. | Nucleic acid synthesis techniques |
| US10604790B2 (en) * | 2014-12-24 | 2020-03-31 | Abbott Laboratories | Sequence conversion and signal amplifier DNA cascade reactions and detection methods using same |
| GB201614023D0 (en) | 2016-08-16 | 2016-09-28 | Olink Bioscience Ab | Double-stranded circle probes |
| WO2018107054A1 (en) | 2016-12-09 | 2018-06-14 | Ultivue, Inc. | Improved methods for multiplex imaging using labeled nucleic acid imaging agents |
| CN110446719B (zh) | 2017-03-31 | 2023-10-03 | 乌尔蒂维尤股份有限公司 | Dna-抗原交换和扩增 |
| CN116218893A (zh) * | 2023-03-24 | 2023-06-06 | 哈尔滨医科大学 | 一种通过体外扩增重组质粒在其编码基因上生成短片段串联重复序列的方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| CA2087256A1 (en) * | 1990-07-25 | 1992-01-26 | Jerry L. Ruth | Circular extension for generating multiple nucleic acid complements |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| AU8997991A (en) | 1991-01-31 | 1992-08-06 | Becton Dickinson & Company | Exonuclease mediated strand displacement amplification |
| JP3080178B2 (ja) | 1991-02-18 | 2000-08-21 | 東洋紡績株式会社 | 核酸配列の増幅方法およびそのための試薬キット |
| JP3085409B2 (ja) * | 1991-03-29 | 2000-09-11 | 東洋紡績株式会社 | 標的核酸配列の検出方法およびそのための試薬キット |
| GB9117910D0 (en) * | 1991-08-20 | 1991-10-09 | Nat Res Dev | Oligonucleotides and their use in an assay |
| WO1993009245A1 (en) * | 1991-10-31 | 1993-05-13 | University Of Pittsburgh | Reverse dot blot hybridization using tandem head-to-tail monomers containing probes synthesized by staggered complementary primers |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US6180338B1 (en) * | 1992-08-04 | 2001-01-30 | Beckman Coulter, Inc. | Method, reagent and kit for the detection and amplification of nucleic acid sequences |
| US5942391A (en) | 1994-06-22 | 1999-08-24 | Mount Sinai School Of Medicine | Nucleic acid amplification method: ramification-extension amplification method (RAM) |
| US5876924A (en) | 1994-06-22 | 1999-03-02 | Mount Sinai School Of Medicine | Nucleic acid amplification method hybridization signal amplification method (HSAM) |
| WO1995035390A1 (en) * | 1994-06-22 | 1995-12-28 | Mount Sinai School Of Medicine Of The City University Of New York | Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes |
| JP3974941B2 (ja) * | 1995-11-21 | 2007-09-12 | イェール ユニバーシティ | 単分子セグメントの増幅および検出 |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
-
1996
- 1996-12-05 AT AT03000499T patent/ATE324464T1/de not_active IP Right Cessation
- 1996-12-05 CA CA002239287A patent/CA2239287C/en not_active Expired - Fee Related
- 1996-12-05 DE DE69627698T patent/DE69627698T2/de not_active Expired - Lifetime
- 1996-12-05 EP EP96939821A patent/EP0868530B1/de not_active Expired - Lifetime
- 1996-12-05 WO PCT/DK1996/000513 patent/WO1997020948A1/en active IP Right Grant
- 1996-12-05 EP EP03000499A patent/EP1300466B1/de not_active Expired - Lifetime
- 1996-12-05 DK DK96939821T patent/DK0868530T3/da active
- 1996-12-05 DK DK03000499T patent/DK1300466T3/da active
- 1996-12-05 AT AT96939821T patent/ATE238434T1/de not_active IP Right Cessation
- 1996-12-05 DE DE69636080T patent/DE69636080T2/de not_active Expired - Lifetime
- 1996-12-05 AU AU76917/96A patent/AU704750B2/en not_active Ceased
- 1996-12-05 ES ES03000499T patent/ES2262902T3/es not_active Expired - Lifetime
-
1999
- 1999-12-17 US US09/465,589 patent/US6610481B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69627698T2 (de) | 2004-01-15 |
| CA2239287A1 (en) | 1997-06-12 |
| CA2239287C (en) | 2008-02-26 |
| EP1300466B1 (de) | 2006-04-26 |
| EP0868530B1 (de) | 2003-04-23 |
| US20020031764A1 (en) | 2002-03-14 |
| ATE238434T1 (de) | 2003-05-15 |
| EP0868530A1 (de) | 1998-10-07 |
| DE69636080D1 (de) | 2006-06-01 |
| EP1300466A3 (de) | 2004-01-02 |
| WO1997020948A1 (en) | 1997-06-12 |
| US6610481B2 (en) | 2003-08-26 |
| DK0868530T3 (da) | 2003-07-21 |
| ES2262902T3 (es) | 2006-12-01 |
| EP1300466A2 (de) | 2003-04-09 |
| AU7691796A (en) | 1997-06-27 |
| DE69636080T2 (de) | 2006-11-30 |
| DK1300466T3 (da) | 2006-08-28 |
| DE69627698D1 (de) | 2003-05-28 |
| AU704750B2 (en) | 1999-05-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1300466 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |