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ATE237333T1 - Pharmazeutische mischungen, enthaltend sulphamatderivate als steroidsulfatasehemmende verbindungen - Google Patents

Pharmazeutische mischungen, enthaltend sulphamatderivate als steroidsulfatasehemmende verbindungen

Info

Publication number
ATE237333T1
ATE237333T1 AT98204337T AT98204337T ATE237333T1 AT E237333 T1 ATE237333 T1 AT E237333T1 AT 98204337 T AT98204337 T AT 98204337T AT 98204337 T AT98204337 T AT 98204337T AT E237333 T1 ATE237333 T1 AT E237333T1
Authority
AT
Austria
Prior art keywords
sub
compound
sulphamat
derivatives
mixtures containing
Prior art date
Application number
AT98204337T
Other languages
English (en)
Inventor
Michael John Reed
Barry Victor Llyod Potter
Original Assignee
Sterix Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterix Ltd filed Critical Sterix Ltd
Application granted granted Critical
Publication of ATE237333T1 publication Critical patent/ATE237333T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36Antigestagens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0072Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Surgical Instruments (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98204337T 1991-08-29 1992-08-28 Pharmazeutische mischungen, enthaltend sulphamatderivate als steroidsulfatasehemmende verbindungen ATE237333T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919118478A GB9118478D0 (en) 1991-08-29 1991-08-29 Steroid sulphatase inhibitors

Publications (1)

Publication Number Publication Date
ATE237333T1 true ATE237333T1 (de) 2003-05-15

Family

ID=10700604

Family Applications (5)

Application Number Title Priority Date Filing Date
AT92918285T ATE194843T1 (de) 1991-08-29 1992-08-28 Verwendung von sulphamatederivaten als steroid- sulfatase hemmende verbindungen
AT00204525T ATE278704T1 (de) 1991-08-29 1992-08-28 Estran- sulphamatederivaten als steroid-sulfatase hemmende verbindungen
AT98204340T ATE239753T1 (de) 1991-08-29 1992-08-28 Steroid-sulfatase hemmende verbindungen
AT99203449T ATE246706T1 (de) 1991-08-29 1992-08-28 Verwendung einer sulfamat-ester enthaltenden sterolverbindung zur herstellung eines arzneimittels zur kontrolle der östrogenproduktion
AT98204337T ATE237333T1 (de) 1991-08-29 1992-08-28 Pharmazeutische mischungen, enthaltend sulphamatderivate als steroidsulfatasehemmende verbindungen

Family Applications Before (4)

Application Number Title Priority Date Filing Date
AT92918285T ATE194843T1 (de) 1991-08-29 1992-08-28 Verwendung von sulphamatederivaten als steroid- sulfatase hemmende verbindungen
AT00204525T ATE278704T1 (de) 1991-08-29 1992-08-28 Estran- sulphamatederivaten als steroid-sulfatase hemmende verbindungen
AT98204340T ATE239753T1 (de) 1991-08-29 1992-08-28 Steroid-sulfatase hemmende verbindungen
AT99203449T ATE246706T1 (de) 1991-08-29 1992-08-28 Verwendung einer sulfamat-ester enthaltenden sterolverbindung zur herstellung eines arzneimittels zur kontrolle der östrogenproduktion

Country Status (26)

Country Link
US (3) US5616574A (de)
EP (6) EP0641355B1 (de)
JP (6) JP3219408B2 (de)
KR (4) KR100258396B1 (de)
AT (5) ATE194843T1 (de)
AU (2) AU689043B2 (de)
BR (1) BR9206434A (de)
CA (4) CA2114630C (de)
CY (4) CY2253B1 (de)
CZ (1) CZ295939B6 (de)
DE (5) DE69233149T2 (de)
DK (4) DK0921130T3 (de)
ES (4) ES2196483T3 (de)
FI (5) FI940903A (de)
GB (1) GB9118478D0 (de)
GE (6) GEP20022766B (de)
GR (1) GR3034579T3 (de)
HK (3) HK1020672A1 (de)
HU (1) HUT66097A (de)
LV (1) LV12618B (de)
NO (6) NO307301B1 (de)
RU (4) RU2210574C2 (de)
SG (7) SG103820A1 (de)
SK (4) SK282188B6 (de)
UA (4) UA41875C2 (de)
WO (1) WO1993005064A1 (de)

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US6011024A (en) 1991-08-28 2000-01-04 Imperial College Of Science Technology & Medicine Steroid sulphatase inhibitors
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GB9118478D0 (en) * 1991-08-29 1991-10-16 Imperial College Steroid sulphatase inhibitors
GB9603325D0 (en) * 1996-02-16 1996-04-17 Imperial College A compound
EP0758230B1 (de) * 1994-04-05 2003-06-11 Celltech Therapeutics Limited Verwendung von steroidsulphatase-hemmern
DE4447714C2 (de) * 1994-08-09 1998-02-05 Jenapharm Gmbh Verwendung von Estra-1,3,5(10)-trien-Derivaten zur Hormonsubstitutions-Therapie
DE4429397C2 (de) * 1994-08-09 2003-11-20 Jenapharm Gmbh Estra-1,3,5(10)-trien-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
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US5571933A (en) * 1994-11-17 1996-11-05 Duquesne University Of The Holy Ghost Derivatives of estra 1,3,5(10)triene-17-one, 3-amino compounds and their use
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US6921776B1 (en) 1996-02-16 2005-07-26 Sterix Limited Compound
US6506792B1 (en) 1997-03-04 2003-01-14 Sterix Limited Compounds that inhibit oestrone sulphatase and/or aromatase and methods for making and using
EP0885211B1 (de) * 1996-03-05 2004-12-29 Sterix Limited Verbindungen mit sulfonsäure-amidgruppe
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US6642220B1 (en) * 1996-12-05 2003-11-04 Sterix Limited Compounds that inhibit oestrone sulphatase; compositions thereof; and methods employing the same
US20040127473A1 (en) * 1996-12-05 2004-07-01 Reed Michael John Compound
US5763432A (en) * 1997-01-29 1998-06-09 Sri International Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use
DE19712488A1 (de) 1997-03-25 1998-10-01 Knoell Hans Forschung Ev Steroidsulfamate, Verfahren zu ihrer Herstellung und Anwendung derselben
GB9708716D0 (en) * 1997-04-29 1997-06-18 Imperial College Chronic heart failure
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DE69939171D1 (de) * 1998-06-10 2008-09-04 Sterix Ltd Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern
US6248780B1 (en) 1998-10-01 2001-06-19 Duquesne University Of The Holy Ghost Compounds for the treatment of estrogen-dependent illnesses and methods for making and using the same
US6667299B1 (en) 2000-03-16 2003-12-23 Hollis-Eden Pharmaceuticals, Inc. Pharmaceutical compositions and treatment methods
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JP2000309599A (ja) 1999-04-13 2000-11-07 Kyowa Hakko Kogyo Co Ltd エストラ−1,3,5(10),16−テトラエン誘導体
US7078395B1 (en) 1999-06-16 2006-07-18 Sterix Limited Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling
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WO2001044268A1 (en) * 1999-12-13 2001-06-21 Sterix Limited Halogenated sulphamate-, phosphonate-, thiophosphonate-, sulphonate- and sulphonamide- compounds as inhibitors of steroid sulphatase
US7335650B2 (en) 2000-01-14 2008-02-26 Sterix Limited Composition
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Also Published As

Publication number Publication date
SG73391A1 (en) 2006-08-30
DE69233020T2 (de) 2003-11-06
JPH07501515A (ja) 1995-02-16
DK0921130T3 (da) 2003-07-21
EP1099706B1 (de) 2004-10-06
ATE246706T1 (de) 2003-08-15
SK282186B6 (sk) 2001-12-03
NO2595A (no) 1994-04-29
GEP20022802B (en) 2002-09-25
EP0641355A1 (de) 1995-03-08
HK1020672A1 (en) 2000-05-19
GEP20022637B (en) 2002-02-25
RU2207134C2 (ru) 2003-06-27
GEP20022803B (en) 2002-09-25
ATE278704T1 (de) 2004-10-15
DK0928609T3 (da) 2003-07-21
GEP20063773B (en) 2006-03-27
NO20025725D0 (no) 2002-11-28
NO940635L (de) 1994-04-29
SG103820A1 (en) 2004-05-26
NO995076L (no) 1994-04-29
EP0982032A3 (de) 2002-03-20
EP1099706A2 (de) 2001-05-16
DE69231280D1 (de) 2000-08-24
SK24694A3 (en) 1994-11-09
EP0928609A2 (de) 1999-07-14
JP2003176297A (ja) 2003-06-24
JP3581802B2 (ja) 2004-10-27
UA41875C2 (uk) 2001-10-15
DE69233431D1 (de) 2004-11-11
DK0641355T3 (da) 2000-10-09
RU94019334A (ru) 1996-10-20
UA70958C2 (uk) 2004-11-15
LV12618B (en) 2001-07-20
FI20002261L (fi) 2000-10-13
KR100258396B1 (ko) 2000-08-01
KR100322650B1 (ko) 2002-03-20
EP0921130A2 (de) 1999-06-09
EP0641355B1 (de) 2000-07-19
CZ44094A3 (en) 1995-01-18
CA2114630C (en) 2003-09-30
ES2193475T3 (es) 2003-11-01
UA70957C2 (uk) 2004-11-15
SK282187B6 (sk) 2001-12-03
RU2182152C2 (ru) 2002-05-10
NO995075L (no) 1994-04-29
LV12618A (en) 2001-02-20
EP0982032B1 (de) 2003-08-06
EP1099706A3 (de) 2002-09-04
EP0921130B1 (de) 2003-05-07
SK282188B6 (sk) 2001-12-03
DE69233053D1 (de) 2003-06-12
CZ295939B6 (cs) 2005-12-14
RU2210574C2 (ru) 2003-08-20
NO940635D0 (no) 1994-02-24
ES2196483T3 (es) 2003-12-16
SG103374A1 (en) 2004-04-29
FI940903A (fi) 1994-04-20
ES2148178T3 (es) 2000-10-16
NO314287B1 (no) 2003-03-03
RU2001125673A (ru) 2003-06-27
CA2305758A1 (en) 1993-03-18
SG106116A1 (en) 2004-09-30
SG88783A1 (en) 2002-05-21
DE69233020D1 (de) 2003-05-22
GEP20022766B (en) 2002-08-26
US5830886A (en) 1998-11-03
NO20002595D0 (no) 2000-05-19
AU668882B2 (en) 1996-05-23
EP0928609A3 (de) 2001-11-07
NO995076D0 (no) 1999-10-18
BR9206434A (pt) 1994-09-27
ATE239753T1 (de) 2003-05-15
NO318009B1 (no) 2005-01-17
CA2305767A1 (en) 1993-03-18
EP0982032A2 (de) 2000-03-01
HUT66097A (en) 1994-09-28
NO20025725L (no) 1994-04-29
DE69233053T2 (de) 2003-11-20
CY2398B1 (en) 2004-09-10
JP3581820B2 (ja) 2004-10-27
HU9400583D0 (en) 1994-05-30
CA2114630A1 (en) 1993-03-18
UA70956C2 (uk) 2004-11-15
JP2000355598A (ja) 2000-12-26
NO308774B1 (no) 2000-10-30
AU1007799A (en) 1999-03-04
HK1019753A1 (en) 2000-02-25
AU2490592A (en) 1993-04-05
CY2394B1 (en) 2004-09-10
EP0921130A3 (de) 2001-09-05
US5616574A (en) 1997-04-01
ES2204059T3 (es) 2004-04-16
NO307301B1 (no) 2000-03-13
FI20002260L (fi) 2000-10-13
DE69233431T2 (de) 2006-02-23
KR100321018B1 (ko) 2002-03-20
HK1025051A1 (en) 2000-11-03
GR3034579T3 (en) 2001-01-31
FI20050991L (fi) 2005-10-03
NO308903B1 (no) 2000-11-13
SG115508A1 (en) 2005-10-28
NO995075D0 (no) 1999-10-18
US6159960A (en) 2000-12-12
SK282189B6 (sk) 2001-12-03
NO20044458L (no) 1994-04-29
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