DE69939171D1 - Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern - Google Patents
Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmernInfo
- Publication number
- DE69939171D1 DE69939171D1 DE69939171T DE69939171T DE69939171D1 DE 69939171 D1 DE69939171 D1 DE 69939171D1 DE 69939171 T DE69939171 T DE 69939171T DE 69939171 T DE69939171 T DE 69939171T DE 69939171 D1 DE69939171 D1 DE 69939171D1
- Authority
- DE
- Germany
- Prior art keywords
- sulphamate
- methoxyestron
- factor
- pharmaceutical compositions
- sulphatase inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 title 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 title 1
- 206010054094 Tumour necrosis Diseases 0.000 title 1
- 229960003399 estrone Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000008512 biological response Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003607 modifier Substances 0.000 abstract 1
- IIACRCGMVDHOTQ-UHFFFAOYSA-N sulfamic acid Chemical group NS(O)(=O)=O IIACRCGMVDHOTQ-UHFFFAOYSA-N 0.000 abstract 1
- -1 sulphamate compound Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9812535.4A GB9812535D0 (en) | 1998-06-10 | 1998-06-10 | Composition |
| GBGB9910167.7A GB9910167D0 (en) | 1999-04-30 | 1999-04-30 | Composition |
| PCT/GB1999/001835 WO1999064013A1 (en) | 1998-06-10 | 1999-06-10 | Pharmaceutical composition with tumor necrosis factor a and 2-methoxyestrone-3-o-sulphamate for inhibition of estrone sulphatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69939171D1 true DE69939171D1 (de) | 2008-09-04 |
Family
ID=26313837
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69939171T Expired - Lifetime DE69939171D1 (de) | 1998-06-10 | 1999-06-10 | Pharmazeutische zusammensetzungen mit tumor nekrose faktor und 2-methoxyestron-3-o-sulphamat als estrone sulphatasehemmern |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6676934B1 (de) |
| EP (1) | EP1085876B1 (de) |
| JP (1) | JP2002517449A (de) |
| AT (1) | ATE401896T1 (de) |
| AU (1) | AU765386B2 (de) |
| CA (1) | CA2334119C (de) |
| DE (1) | DE69939171D1 (de) |
| ES (1) | ES2310943T3 (de) |
| WO (1) | WO1999064013A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040127473A1 (en) * | 1996-12-05 | 2004-07-01 | Reed Michael John | Compound |
| US7078395B1 (en) | 1999-06-16 | 2006-07-18 | Sterix Limited | Methods for treating or preventing cancer by preventing, inhibiting or arresting cell cycling |
| NZ515061A (en) | 1999-04-30 | 2004-04-30 | Sterix Ltd | Use of a cyclic compound in cell cycling |
| GB9913536D0 (en) * | 1999-06-10 | 1999-08-11 | Sterix Ltd | Use |
| US7335650B2 (en) | 2000-01-14 | 2008-02-26 | Sterix Limited | Composition |
| FR2806303B1 (fr) * | 2000-03-17 | 2002-09-27 | Inst Nat Sante Rech Med | Composes capables de se lier a des proteines constituantes ou associees aux elements du cytosquelette et leurs applications pour la fabrication de medicaments |
| US20020106348A1 (en) * | 2000-07-12 | 2002-08-08 | Peng Huang | Cancer therapeutics involving the administration of 2-methoxyestradiol and an agent that increases intracellular superoxide anion |
| WO2002015910A1 (en) * | 2000-08-18 | 2002-02-28 | Sterix Limited | 2-substituted estradiol derivative for inhibiting superoxid dismutase |
| GB0020498D0 (en) | 2000-08-18 | 2000-10-11 | Sterix Ltd | Compound |
| GB0113920D0 (en) * | 2001-06-07 | 2001-08-01 | Sterix Ltd | Composition |
| WO2004000345A1 (ja) * | 2002-06-19 | 2003-12-31 | Takeda Pharmaceutical Company Limited | 骨・関節疾患の予防・治療剤 |
| DE10307104A1 (de) * | 2003-02-19 | 2004-09-23 | Schering Ag | Antitumor wirksame 2-substituierte Estra-1,3,5(10)-trien-3-yl sulfamate |
| DE10307103A1 (de) | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte D-Homostra-1,3,5(10)-trien-3-yl sulfamate |
| DE10307105A1 (de) * | 2003-02-19 | 2004-09-09 | Schering Ag | Antitumor wirksame 2-substituierte 18a-Homoestra-1,3,5(10)-trien-3-yl sulfamate |
| DE602004024966D1 (de) * | 2003-03-24 | 2010-02-25 | Sterix Ltd | Oestrogenderivate als steroid sulphatase inhibitoren |
| GB0306717D0 (en) * | 2003-03-24 | 2003-04-30 | Sterix Ltd | Compound |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011024A (en) * | 1991-08-28 | 2000-01-04 | Imperial College Of Science Technology & Medicine | Steroid sulphatase inhibitors |
| GB9118478D0 (en) * | 1991-08-29 | 1991-10-16 | Imperial College | Steroid sulphatase inhibitors |
| GB9625334D0 (en) * | 1996-12-05 | 1997-01-22 | Imperial College | Compound |
| JPH0912596A (ja) * | 1995-06-23 | 1997-01-14 | Meiji Milk Prod Co Ltd | 抗癌剤の腫瘍細胞障害作用を増強する新規な蛋白性因子 |
| DE19540233B4 (de) * | 1995-10-19 | 2005-08-25 | Schering Ag | Sulfamat-Derivate von 1,3,5(10)-Estratrien-Derivaten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| EP0934949A1 (de) * | 1996-09-12 | 1999-08-11 | Teikoku Hormone Mfg. Co., Ltd. | 3-substituierte-d-homo-1,3,5,(10)-oestratrien-derivate |
| US5880115A (en) * | 1997-07-18 | 1999-03-09 | Duquesne University Of The Holy Ghost | Steroid sulfatase inhibitors and methods for making and using the same |
| GB2331988B (en) * | 1997-12-04 | 2003-04-16 | Imperial College | Polycyclic sulphamate inhibitors or oestrone sulphatase |
| US6046186A (en) * | 1997-12-24 | 2000-04-04 | Sri International | Estrone sulfamate inhibitors of estrone sulfatase, and associated pharmaceutical compositions and methods of use |
-
1999
- 1999-06-10 CA CA2334119A patent/CA2334119C/en not_active Expired - Fee Related
- 1999-06-10 DE DE69939171T patent/DE69939171D1/de not_active Expired - Lifetime
- 1999-06-10 AT AT99955428T patent/ATE401896T1/de not_active IP Right Cessation
- 1999-06-10 WO PCT/GB1999/001835 patent/WO1999064013A1/en active IP Right Grant
- 1999-06-10 EP EP99955428A patent/EP1085876B1/de not_active Expired - Lifetime
- 1999-06-10 JP JP2000553081A patent/JP2002517449A/ja active Pending
- 1999-06-10 AU AU42807/99A patent/AU765386B2/en not_active Ceased
- 1999-06-10 ES ES99955428T patent/ES2310943T3/es not_active Expired - Lifetime
-
2000
- 2000-11-28 US US09/724,986 patent/US6676934B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6676934B1 (en) | 2004-01-13 |
| AU765386B2 (en) | 2003-09-18 |
| ES2310943T3 (es) | 2009-01-16 |
| WO1999064013A1 (en) | 1999-12-16 |
| EP1085876A1 (de) | 2001-03-28 |
| JP2002517449A (ja) | 2002-06-18 |
| ATE401896T1 (de) | 2008-08-15 |
| CA2334119C (en) | 2011-09-13 |
| CA2334119A1 (en) | 1999-12-16 |
| EP1085876B1 (de) | 2008-07-23 |
| AU4280799A (en) | 1999-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |