ATE184284T1 - Antifungale sordaridin-derivate - Google Patents

Antifungale sordaridin-derivate

Info

Publication number: ATE184284T1
Authority: AT; Austria
Prior art keywords: sordaridine; antifungal; derivatives; sordaridine derivatives; antifungal sordaridine
Prior art date: 1994-11-08

Application number

AT95938406T

Other languages

English (en)

Inventor

Jose Ramon Ruiz Gomez

Jose Maria Bueno Calderon

Dorado Silvestre Garcia-Ochoa

Gabaldon Maria Teresa G Fraile

Julia Castro Pichel

Roman Jose Fiandor

Viola Domingo Garsallo

Zurita Juan Carlos Cueva

Diaz Jose Luis Lavandera

Sophie Huss

Original Assignee

Glaxo Wellcome Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-11-08

Filing date

1995-11-06

Publication date

1999-09-15

1994-11-08 Priority claimed from EP94500173A external-priority patent/EP0712859A1/de

1994-11-08 Priority claimed from EP94500175A external-priority patent/EP0711784A1/de

1995-11-06 Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa

1999-09-15 Application granted granted Critical

1999-09-15 Publication of ATE184284T1 publication Critical patent/ATE184284T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Microbiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)

AT95938406T 1994-11-08 1995-11-06 Antifungale sordaridin-derivate ATE184284T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP94500173A EP0712859A1 (de)	1994-11-08	1994-11-08	Antifungale Sordarinderivate
EP94500175A EP0711784A1 (de)	1994-11-08	1994-11-08	Antifungale Sordarinderivate

Publications (1)

Publication Number	Publication Date
ATE184284T1 true ATE184284T1 (de)	1999-09-15

Family

ID=26137608

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95938406T ATE184284T1 (de)	1994-11-08	1995-11-06	Antifungale sordaridin-derivate

Country Status (35)

Country	Link
US (2)	US5854280A (de)
EP (1)	EP0753001B1 (de)
JP (1)	JPH09508144A (de)
KR (1)	KR100391401B1 (de)
CN (1)	CN1056849C (de)
AP (1)	AP614A (de)
AR (1)	AR013815A1 (de)
AT (1)	ATE184284T1 (de)
AU (1)	AU704405B2 (de)
BG (1)	BG62620B1 (de)
BR (1)	BR9506473A (de)
CA (1)	CA2179403A1 (de)
CO (1)	CO4520226A1 (de)
CZ (1)	CZ202796A3 (de)
DE (1)	DE69512041T2 (de)
DK (1)	DK0753001T3 (de)
EE (1)	EE9600117A (de)
ES (1)	ES2137549T3 (de)
FI (1)	FI962773L (de)
GR (1)	GR3031677T3 (de)
HK (1)	HK1004222A1 (de)
HU (1)	HU218611B (de)
IL (1)	IL115905A0 (de)
IS (1)	IS4352A (de)
MX (1)	MX9602563A (de)
NO (1)	NO307092B1 (de)
NZ (1)	NZ296091A (de)
OA (1)	OA10303A (de)
PE (1)	PE49696A1 (de)
RU (1)	RU2152398C1 (de)
SI (1)	SI0753001T1 (de)
SK (1)	SK88496A3 (de)
TW (1)	TW321644B (de)
WO (1)	WO1996014326A1 (de)
ZA (1)	ZA959362B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0901493A1 (de) *	1996-05-08	1999-03-17	Glaxo Wellcome S.A.	Verfahren zur herstellung von einer indacenverbindung
US6436395B1 (en) *	1996-09-18	2002-08-20	Merck & Co., Inc.	Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) *	1996-10-07	2000-03-21	Merck & Co., Inc.	Sordarin derivatives
US6096511A (en) *	1997-06-10	2000-08-01	Merck & Co., Inc.	Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5972996A (en) *	1997-08-22	1999-10-26	Merck & Co., Inc.	4-cyano-4-deformylsordarin derivatives
ATE241979T1 (de) *	1997-08-22	2003-06-15	Merck & Co Inc	4-cyano-4-deformylsordarinderivate
US5965612A (en) *	1997-08-22	1999-10-12	Merck & Co., Inc.	4-cyano-4-deformylsordaricin derivatives
US6136853A (en) *	1997-10-03	2000-10-24	Merck & Co., Inc.	Sordarin derivatives
FI974385A0 (fi) *	1997-12-01	1997-12-01	Xyrofin Oy	Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) *	1998-04-14	2006-07-04	Zhenhua Yang	Small molecule anticancer compounds and related production process
MA26628A1 (fr) *	1998-05-11	2004-12-20	Glaxo Wellcome Sa	Morpholino ethers
JP2002528444A (ja)	1998-10-26	2002-09-03	メルクエンドカムパニーインコーポレーテッド	微生物変換産物
WO2000076556A2 (en) *	1999-06-11	2000-12-21	Neorx Corporation	High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en)	1999-07-11	2006-08-22	Neorx Corporation	Skeletal-targeted radiation to treat bone-associated pathologies
AU1520601A (en)	1999-11-11	2001-06-06	Glaxo Wellcome S.A.	Antifungal sordaricin derivatives
AU2001289063A1 (en) *	2000-09-15	2002-03-26	Bristol-Myers Squibb Company	Novel thio derivatives of sordarin as antifungal agents
JP2004536034A (ja)	2001-01-08	2004-12-02	ネオルクスコーポレイション	治療的および診断的化合物、組成物および方法
WO2003007878A2 (en)	2001-07-18	2003-01-30	Merck & Co., Inc.	Antifungal agents of sordarin derivatives
WO2003051403A1 (en)	2001-12-13	2003-06-26	Dow Global Technologies Inc.	Treatment of osteomyelitis with radiopharmaceuticals
EP1458725B1 (de) *	2001-12-14	2007-02-21	Merck & Co., Inc.	Neues, aus kulturfermentierungen isoliertes sordarinderivat und wirkungen als antipilzmittel
MXPA05007156A (es) *	2002-12-31	2005-09-21	Nektar Therapeutics	Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas.
US9314524B2 (en)	2007-12-31	2016-04-19	Calla Therapeutics Llc	Topical formulations of Flucytosine
US8419948B2 (en) *	2009-11-22	2013-04-16	United Laboratories International, Llc	Wastewater treatment
WO2012033427A1 (ru) *	2010-09-08	2012-03-15	Dalin Mikhail Viktorovich	Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) *	2016-02-25	2017-09-07	Жанна Владимировна Вараткова	Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH465771A (de) *	1965-12-06	1968-11-30	Sandoz Ag	Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) *	1985-08-14	1994-03-02	三共株式会社	抗生物質ゾフイマリン
JP3189443B2 (ja) *	1992-11-20	2001-07-16	萬有製薬株式会社	抗真菌性物質ｂｅ−３１４０５
ES2203819T3 (es) *	1996-09-12	2004-04-16	MERCK & CO., INC.	Terapia antifungica combinada.

1995
- 1995-11-06 SK SK884-96A patent/SK88496A3/sk unknown
- 1995-11-06 RU RU96115273/04A patent/RU2152398C1/ru active
- 1995-11-06 CZ CZ962027A patent/CZ202796A3/cs unknown
- 1995-11-06 MX MX9602563A patent/MX9602563A/es not_active IP Right Cessation
- 1995-11-06 DK DK95938406T patent/DK0753001T3/da active
- 1995-11-06 WO PCT/EP1995/004331 patent/WO1996014326A1/en not_active Application Discontinuation
- 1995-11-06 ES ES95938406T patent/ES2137549T3/es not_active Expired - Lifetime
- 1995-11-06 KR KR1019960703661A patent/KR100391401B1/ko not_active IP Right Cessation
- 1995-11-06 EE EE9600117A patent/EE9600117A/xx unknown
- 1995-11-06 ZA ZA959362A patent/ZA959362B/xx unknown
- 1995-11-06 DE DE69512041T patent/DE69512041T2/de not_active Expired - Fee Related
- 1995-11-06 AP APAP/P/1996/000824A patent/AP614A/en active
- 1995-11-06 BR BR9506473A patent/BR9506473A/pt not_active IP Right Cessation
- 1995-11-06 AU AU39809/95A patent/AU704405B2/en not_active Ceased
- 1995-11-06 AT AT95938406T patent/ATE184284T1/de not_active IP Right Cessation
- 1995-11-06 CN CN95192028A patent/CN1056849C/zh not_active Expired - Fee Related
- 1995-11-06 HU HU9701865A patent/HU218611B/hu not_active IP Right Cessation
- 1995-11-06 EP EP95938406A patent/EP0753001B1/de not_active Expired - Lifetime
- 1995-11-06 CA CA002179403A patent/CA2179403A1/en not_active Abandoned
- 1995-11-06 SI SI9530311T patent/SI0753001T1/xx not_active IP Right Cessation
- 1995-11-06 JP JP8515051A patent/JPH09508144A/ja not_active Ceased
- 1995-11-06 PE PE1995283875A patent/PE49696A1/es not_active Application Discontinuation
- 1995-11-06 US US08/669,441 patent/US5854280A/en not_active Expired - Fee Related
- 1995-11-06 NZ NZ296091A patent/NZ296091A/en unknown
- 1995-11-07 CO CO95052481A patent/CO4520226A1/es unknown
- 1995-11-07 IL IL11590595A patent/IL115905A0/xx unknown
- 1995-11-07 AR ARP950100073A patent/AR013815A1/es unknown
- 1995-11-18 TW TW084112259A patent/TW321644B/zh active
1996
- 1996-06-10 IS IS4352A patent/IS4352A/is unknown
- 1996-07-03 OA OA60855A patent/OA10303A/en unknown
- 1996-07-05 BG BG100699A patent/BG62620B1/xx unknown
- 1996-07-05 NO NO962856A patent/NO307092B1/no not_active IP Right Cessation
- 1996-07-05 FI FI962773A patent/FI962773L/fi not_active IP Right Cessation
1998
- 1998-04-21 HK HK98103335A patent/HK1004222A1/xx not_active IP Right Cessation
- 1998-05-19 US US09/081,090 patent/US5952334A/en not_active Expired - Fee Related
1999
- 1999-10-27 GR GR990402767T patent/GR3031677T3/el unknown

Also Published As

Publication number	Publication date
RU2152398C1 (ru)	2000-07-10
US5952334A (en)	1999-09-14
SI0753001T1 (en)	1999-12-31
EP0753001A1 (de)	1997-01-15
BR9506473A (pt)	1997-10-07
FI962773A0 (fi)	1996-07-05
AP9600824A0 (en)	1996-07-31
NZ296091A (en)	1998-06-26
DK0753001T3 (da)	2000-05-08
FI962773L (fi)	1996-08-26
IL115905A0 (en)	1996-01-31
JPH09508144A (ja)	1997-08-19
HUT76292A (en)	1997-07-28
ZA959362B (en)	1996-05-08
CN1056849C (zh)	2000-09-27
AU704405B2 (en)	1999-04-22
MX9602563A (es)	1997-05-31
KR100391401B1 (ko)	2003-12-31
AU3980995A (en)	1996-05-31
AR013815A1 (es)	2001-01-31
CA2179403A1 (en)	1996-05-17
DE69512041T2 (de)	2000-02-03
DE69512041D1 (de)	1999-10-14
BG62620B1 (en)	2000-03-31
AP614A (en)	1997-09-05
IS4352A (is)	1996-06-10
CO4520226A1 (es)	1997-10-15
NO962856D0 (no)	1996-07-05
CN1143965A (zh)	1997-02-26
GR3031677T3 (en)	2000-02-29
NO307092B1 (no)	2000-02-07
CZ202796A3 (en)	1997-02-12
ES2137549T3 (es)	1999-12-16
BG100699A (bg)	1997-02-28
HK1004222A1 (en)	1998-11-20
PE49696A1 (es)	1996-12-05
NO962856L (no)	1996-09-05
HU218611B (hu)	2000-10-28
SK88496A3 (en)	1997-04-09
EP0753001B1 (de)	1999-09-08
TW321644B (de)	1997-12-01
EE9600117A (et)	1997-04-15
HU9601865D0 (en)	1996-11-28
OA10303A (en)	1997-10-07
WO1996014326A1 (en)	1996-05-17
US5854280A (en)	1998-12-29

Publication	Publication Date	Title
NO304430B1 (no)	1998-12-14	Antifungale midler
FI954829L (fi)	1996-04-15	Aroyylipiperidiinijohdannaiset
NO952854D0 (no)	1995-07-18	1-arylpyrimidin-derivater
DE59508427D1 (de)	2000-07-06	3-aryl-4-hydroxy-delta 3 -dihydrothiophenon-derivate
DK0753001T3 (da)	2000-05-08	Antifungale sordaridinderivater
ATA147195A (de)	1996-08-15	Alkoxyphenyl-substituierte bisbenzoylphosphinoxide
ATA163695A (de)	1999-01-15	2-hydroxyphenyltriazine
EP0708091A3 (de)	1996-07-17	Indoloylguanidin-Derivate
DE69430587D1 (de)	2002-06-13	Pyrimidin-acyclonukleosid-derivate
BR9509793A (pt)	1997-09-30	Derivados de tiofeneno
FI971227L (fi)	1997-05-23	Pyramidinyylipyratsolijohdannaisia
FI960367L (fi)	1996-01-26	Uusia dialkoksipyridinyylibentsimidatsolijohdannaisia
FI950710A0 (fi)	1995-02-16	Fungisidisia 2-imidatsoliini-5-onejohdannaisia
DE69527786D1 (de)	2002-09-19	Diaminomethyliden-derivate
FI964853L (fi)	1997-02-07	Deasetoksitaksolijohdannaiset
ATA108995A (de)	2005-07-15	Differenzdruckakkumulator
KR950033309U (ko)	1995-12-16	줄연장
DE59509209D1 (de)	2001-05-23	Diphenyloxazolin-derivate
FI955026L (fi)	1996-04-23	Alkyyli-5-metyylisulfonyylibentsoyyliguanidiinijohdannaisia
NO970144D0 (no)	1997-01-14	Trifluormetylkinolinkarboksylsyre-derivat
DE69510792D1 (de)	1999-08-19	Naphtochinonderivate
BR9509877A (pt)	1997-09-30	Novos derivados de pirimidinilóxi-e piridimidinilamino- etilfenil-dioxolano
FI963122L (fi)	1996-08-09	Karbamoyylimetyyliureajohdannaiset
BR9506613A (pt)	1997-09-16	Derivados de feniltio-oxazolinas
BR9508450A (pt)	1997-11-25	Derivados de n-alcóxi-amidina

Legal Events

Date	Code	Title	Description
2000-02-15	UEP	Publication of translation of european patent specification
2006-08-15	REN	Ceased due to non-payment of the annual fee